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| 16647138 | LOX | LOX | 3.3 | Thus cyclooxygenases (COX), COX lipoxygenases (LOX), LOX and epoxygenases (EPOX) EPOX metabolize AA to prostaglandins thromboxanes leukotrienes | |  |
| 16647138 | LOX | LOX | 3.3 | In contrast COX and LOX metabolize DHA to resolvins docosatrienes and neuroprotectins | | |
| 16647138 | LOX | LOX | 3.3 | tissues express several different isoforms of PLA 2 COX and LOX under normal or stimulated situations ( Kis et al. 2003 | | |
| 16647138 | LOX | LOX | 3.3 | How the isoforms of PLA 2 COX and LOX enzymes interact with each other remains to be elucidated | | |
| 16647138 | LOX | LOX | 3.3 | Eicosanoid synthesis through COX and LOX enzymes may involve different AA substrate pools and may be | | |
| 16647138 | LOX | LOX | 3.3 | In addition to the abovementioned lipid mediators COX LOX and EPOX-catalyzed reactions also produce reactive oxygen species (ROS) ROS | | |
| 16647138 | LOX | LOX | 3.3 | studies on the multiplicity properties regulation and roles of COX LOX and EPOX in brain tissue | | |
| 16647138 | LOX | LOX | 3.3 | discussion would initiate more studies on the importance of COX LOX EPOX and their lipid mediators in neurological disorders | | |
| 16647138 | LOX | LOX | 3.3 | The inhibition of COX LOX and EPOX activities may provide an attractive approach for designing | | |
| 16647138 | LOX | LOX | 3.3 | Lipoxygenases (LOX) LOX | | |
| 16647138 | LOX | LOX | 3.3 | at which they oxidize arachidonic acid characterizes the lipoxygenases (LOX) LOX | | |
| 16647138 | LOX | LOX | 3.3 | 5-hydroxyeicosatetraenoic acid (5-HETE), 5-HETE involves 5-LOX 12-LOX the most common LOX in the brain ( Hambrecht et al. 1987 with its | | |
| 16647138 | LOX | LOX | 3.3 | LOX are non-heme iron-containing dioxygenases that insert molecular oxygen into arachidonic | | |
| 16647138 | LOX | LOX | 3.3 | LOX have a molecular mass of 75 to 78 kDa | | |
| 16647138 | LOX | LOX | 3.3 | Like non-neural tissues three forms of LOX are present in the brain | | |
| 16647138 | LOX | LOX | 3.3 | LOX also catalyze a dehydration reaction generating an unstable epoxide intermediate | | |
| 16647138 | LOX | LOX | 3.3 | In addition to the COX and LOX pathways the cytochrome P450 (CYP450) CYP450 pathways also catalyze arachidonic | | |
| 16647138 | LOX | LOX | 3.3 | Roles of COX LOX and EPOX in brain tissue | | |
| 16647138 | LOX | LOX | 3.3 | COX LOX and EPOX are important enzymes involved in the generation of | | |
| 16647138 | LOX | LOX | 3.3 | enzymes catalyze the conversion of AA into prostaglandins and thromboxanes LOX generates leukotrienes and lipoxins and EPOX activity produces epoxyeicosatrienoic acids | | |
| 16647138 | LOX | LOX | 3.3 | release AA metabolites by reactions catalyzed by PLA 2 COX LOX and EPOX depends upon not only on neural cell type | | |
| 16647138 | LOX | LOX | 3.3 | generation of PGE 2 LTB 4 and PAF through COX-2 LOX and acetyl-CoA acetyltransferase reactions respectively | | |
| 16647138 | LOX | LOX | 3.3 | PLA 2 COX-2 and LOX inhibitors have been used to treat acute inflammation and pain | | |
| 16647138 | LOX | LOX | 3.3 | Involvement of COX and LOX in neurodegeneration | | |
| 16647138 | LOX | LOX | 3.3 | degeneration by the activation of caspases PLA 2 COX and LOX resulting in apoptotic cell death | | |
| 16647138 | LOX | LOX | 3.3 | the observation that inhibitors of caspases PLA 2 COX and LOX block apoptosis ( Farooqui et al. 2004 Farooqui and Horrocks | | |
| 16647138 | LOX | LOX | 3.3 | evidence suggests that all isoforms of PLA 2 COX and LOX along with caspases are involved in apoptotic cell death | | |
| 16647138 | LOX | LOX | 3.3 | The stimulation of COX and LOX isoforms and oxidation of arachidonic acid is harmful to neurons | | |
| 16647138 | LOX | LOX | 3.3 | Involvement of COX and LOX in pain state | | |
| 16647138 | LOX | LOX | 3.3 | Involvement of COX and LOX in synaptic plasticity | | |
| 16647138 | LOX | LOX-generated | 0.1 | In brain tissue COX- and LOX-generated metabolites of AA may modulate synaptic plasticity not only through | | |
| 16647138 | LOX | LOX | 3.3 | effects of arachidonic acid were antagonized by nordihydroguaiaretic acid a LOX inhibitor indicating that its metabolites were responsible for these effects | | |
| 16647138 | LOX | LOX | 3.3 | Gene deletion studies_amp_#x2014 COX and LOX | | |
| 16647138 | LOX | LOX | 3.3 | Early indications of an involvement of COX and LOX in traumatic brain injury arose from studies on feline cerebral | | |
| 16647138 | LOX | LOX | 3.3 | inhibitors of PLA 2 as well as inhibitors of COX LOX and cytochrome P450 isozymes to reverse the depolarization | | |
| 16647138 | LOX | LOX | 3.3 | of CA1 pyramidal cells following the application of two non-selective LOX inhibitors nordihydroguaiaretic acid and esculentin a selective 5-LOX inhibitor AA861 | | |
| 16647138 | LOX | LOX | 3.3 | cultured neurons to arachidonic acid caused apoptotic neuronal death which LOX and CY450 inhibitors greatly reduced with COX inhibitors having less | | |
| 16647138 | LOX | LOX | 3.3 | Role of COX LOX and EPOX in excitotoxic injury | | |
| 16647138 | LOX | LOX | 3.3 | These enzymes include PLA 2 COX-2 LOX and EPOX | | |
| 16647138 | LOX | LOX | 3.3 | and Bazan 1987 indicating the stimulation of both COX and LOX activity | | |
| 16647138 | LOX | LOX | 3.3 | The involvement of COX and LOX pathways in AD has been extensively studied in brain tissue | | |
| 16647138 | LOX | LOX | 3.3 | indicate that arachidonic-acid-mediated neuronal death can be prevented by the LOX inhibitors nordihydroguaiaretic acid AA861 and baicalein and the EPOX inhibitors | | |
| 16647138 | LOX | LOX | 3.3 | This suggests that LOX and EPOX pathways may also be involved in LOX- and | | |
| 16647138 | LOX | LOX- | 0.1 | that LOX and EPOX pathways may also be involved in LOX- and EPOX-generated metabolite-induced neurodegeneration ( Kwon et al. 2005 | | |
| 16647138 | LOX | LOX | 3.3 | The neuroprotective effects of LOX and EPOX inhibitors may relate to downregulation of free radical | | |
| 16647138 | LOX | LOX | 3.3 | At present information on LOX and EPOX expression and their activities is not available for | | |
| 16647138 | LOX | LOX | 3.3 | No information is available on LOX and EPOX expression and activities in PD brains | | |
| 16647138 | LOX | LOX | 3.3 | The involvement of LOX and EPOX in the pathogenesis of PD has been studied | | |
| 16647138 | LOX | LOX | 3.3 | This suggests that a LOX pathway is associated with neuronal degeneration in PD | | |
| 16647138 | LOX | LOX | 3.3 | Collective evidence suggests that changes in COX LOX and EPOX activities may not be the primary effect but | | |
| 16647138 | LOX | LOX | 3.3 | Future perspectives interactions among multiple forms of COX LOX and EPOX and their relationship to upstream PLA 2 isoforms | | |
| 16647138 | LOX | LOX | 3.3 | Although transcripts activities and immunoreactive proteins for COX LOX and EPOX are widely expressed throughout the brain very little | | |
| 16647138 | LOX | LOX | 3.3 | The occurrence of isoforms of COX LOX and EPOX enzymes in cytoplasm and other subcellular organelles (plasma | | |
| 16647138 | LOX | LOX | 3.3 | The multiplicity of COX LOX and EPOX enzymes in brain tissue provides diversity in their | | |
| 16647138 | LOX | LOX | 3.3 | This behavior complicates the analysis of COX LOX and EPOX function at cellular and subcellular levels | | |
| 16647138 | LOX | LOX | 3.3 | one considers the coupling mechanisms of various isoforms of COX LOX and EPOX with different receptors at cellular and subcellular levels | | |
| 16647138 | LOX | LOX | 3.3 | Some isoforms of COX LOX and EPOX are constitutively expressed while others are inducible in | | |
| 16647138 | LOX | LOX | 3.3 | The isoforms of COX LOX and EPOX may not function interchangeably but act in parallel | | |
| 16647138 | LOX | LOX | 3.3 | It is likely that various isoforms of COX LOX and EPOX act on different cellular pools of arachidonic acid | | |
| 16647138 | LOX | LOX | 3.3 | Thus the interactions among COX LOX and EPOX-generated metabolites at plasma membrane cytoplasmic and nuclear membrane | | |
| 16647138 | LOX | LOX | 3.3 | to speculate that coordinated cross talk not only among COX LOX and EPOX isozymes but also with upstream PLA 2 isozymes | | |
| 16647138 | LOX | LOX | 3.3 | In the nuclear membrane and nucleus COX LOX and EPOX-mediated signaling has the advantage over plasma membrane signaling | | |
| 16647138 | LOX | LOX | 3.3 | In brain tissue the activities of COX LOX and EPOX isoforms may depend not only on the structural | | |
| 16647138 | LOX | LOX | 3.3 | The ability of COX LOX and EPOX isoforms to orchestrate complex prostaglandin leukotriene HETE and | | |
| 16647138 | LOX | LOX | 3.3 | The activation of COX LOX and EPOX isoforms at a subcellular level in neural cells | | |
| 16647138 | LOX | LOX | 3.3 | Therefore a strict regulation of COX LOX and EPOX isozymes is very important for normal brain function | | |
| 16647138 | LOX | LOX | 3.3 | As stated above the regulation of COX LOX and EPOX activities is complex and mediated by several factors | | |
| 16647138 | LOX | LOX | 3.3 | To understand the contribution of isoforms of COX LOX and EPOX in physiological and disease processes a systematic approach | | |
| 16647138 | LOX | LOX | 3.3 | enzymic mechanisms include three systems COX isozymes which synthesize prostaglandins LOX isozymes which generate hydroxyl derivatives and leukotrienes and EPOX isozymes | | |
| 16647138 | LOX | LOX | 3.3 | AD PD ALS and CJD stimulation and upregulation of COX LOX and EPOX isozyme activities and the generation of excessive amounts | | |
| 16647138 | LOX | LOX | 3.3 | These metabolites not only antagonize the effect of COX LOX and EPOX-generated products but also counteract leukocyte infiltration and proinflammatory | | |
| 16647138 | LOX | LOX | 3.3 | Elevated activities of isoforms of COX LOX and EPOX at cellular and subcellular levels in ischemia and | | |
| 15210305 | lysyl oxidase | lysyl oxidase | 1.0 | these _amp_#x201c;inducible_amp_#x201d; elements by virtue of their responsiveness to a wide range of cell _amp_#x201c;injury_amp_#x201d; events include thioredoxin lysyl oxidase lo flavin containing monooxygenase fmo1 interleukin i receptor accessory protein il 1racp and a transcript representing a possible 14 3 3 spinal cord isoform [ 59 and 60 ]. | | |