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| 16436205 | 5-LOX | 5-LOX | 2.3 | Insets show western blot analysis of basal COX-II and 5-LOX (more more ... | |  |
| 16647138 | 5-LOX | 5-LOX | 4.7 | The biosynthesis of leukotrienes including 5-hydroxyeicosatetraenoic acid (5-HETE), 5-HETE involves 5-LOX 12-LOX the most common LOX in the brain ( Hambrecht | | |
| 16647138 | 5-LOX | 5-LOX | 4.7 | They include 5-LOX 12-LOX and 15-LOX 12-LOX catalyzes the stereospecific incorporation of molecular | | |
| 16647138 | 5-LOX | 5-LOX | 4.7 | 5-LOX and 15-LOX have also been sequenced from several non-neural sources | | |
| 16647138 | 5-LOX | 5-LOX | 4.7 | molecular mass of 78 kDa and share considerable homology with 5-LOX and 15-LOX from soybean | | |
| 16647138 | 5-LOX | 5-LOX | 4.7 | 5-LOX is present in brain tissue and neural cells in the | | |
| 16647138 | 5-LOX | 5-LOX | 4.7 | Upon cell activation leading to leukotriene synthesis 5-LOX translocates from the cytoplasm to the nuclear envelope | | |
| 16647138 | 5-LOX | 5-LOX | 4.7 | other microsomal glutathione transferases but has no enzymic activity itself 5-LOX also contains an Src homology 3 (SH3) SH3 binding motif | | |
| 16647138 | 5-LOX | 5-LOX | 4.7 | binding motif which may be involved in the interaction of 5-LOX protein with growth-factor-receptor-bound protein 2 (Grb2) Grb2 ( Lepley et | | |
| 16647138 | 5-LOX | 5-LOX | 4.7 | In cerebellar granule neurons dexamethasone a glucocorticoid increases 5-LOX mRNA and protein contents 3 h after treatment and this | | |
| 16647138 | 5-LOX | 5-LOX | 4.7 | glucocorticoid antagonist RU486 blocks the stimulatory effect of dexamethasone on 5-LOX expression indicating that dexamethasone increases 5-LOX expression in a glucocorticoid-receptor-dependent | | |
| 16647138 | 5-LOX | 5-LOX | 4.7 | effect of dexamethasone on 5-LOX expression indicating that dexamethasone increases 5-LOX expression in a glucocorticoid-receptor-dependent manner ( Uz et al. 2001 | | |
| 16647138 | 5-LOX | 5-LOX | 4.7 | These studies also indicate that dexamethasone increases the stability of 5-LOX mRNA | | |
| 16647138 | 5-LOX | 5-LOX | 4.7 | HPETEs and leukotrienes generated by 5-LOX and 12-LOX inhibit neurotransmitter release by modulating calcium and protein | | |
| 16647138 | 5-LOX | 5-LOX | 4.7 | Further evidence for an involvement of 12-LOX rather than 5-LOX or a cyclooxygenase in homosynaptic long-term depression of the hippocampus | | |
| 16647138 | 5-LOX | 5-LOX | 4.7 | Although the treatment of SLS patients with the 5-LOX inhibitor (Zileuton) Zileuton blocks peripheral SLS symptoms and inhibits LTB | | |
| 16647138 | 5-LOX | 5-LOX | 4.7 | Neurons immunostaining for 5-LOX were upregulated in sites of focal ischemic damage of human | | |
| 16647138 | 5-LOX | 5-LOX | 4.7 | gerbil brain of 5-min duration led to an upregulation of 5-LOX immunoreactivity in neurons and an increase in LTC 4 in | | |
| 16647138 | 5-LOX | 5-LOX | 4.7 | two non-selective LOX inhibitors nordihydroguaiaretic acid and esculentin a selective 5-LOX inhibitor AA861 and two selective 12-LOX inhibitors baicalein and cinnamyl-3 | | |
| 16647138 | 5-LOX | 5-LOX | 4.7 | The importance of 5-LOX is further supported by evidence indicating that the gene encoding | | |
| 16647138 | 5-LOX | 5-LOX | 4.7 | is further supported by evidence indicating that the gene encoding 5-LOX activating protein confers a risk of stroke in humans ( | | |
| 16647138 | 5-LOX | 5-LOX | 4.7 | min cerebral ischemia ( Kitagawa et al. 2004 indicating that 5-LOX is not essential for ischemic injury to the brain | | |
| 16647138 | 5-LOX | 5-LOX | 4.7 | Marked increases in COX-2 and 5-LOX mRNA and protein levels occur following kainate injections in rat | | |
| 16647138 | 5-LOX | 5-LOX | 4.7 | This increase in COX-2 and 5-LOX can be prevented by not only glutamate receptor antagonists ( | | |
| 16647138 | 5-LOX | 5-LOX | 4.7 | and Pepicelli et al. 2002 but also by COX-2 and 5-LOX inhibitors ( Manev et al. 2000a and Pepicelli et al. | | |
| 16647138 | 5-LOX | 5-LOX | 4.7 | The role of COX-2 and 5-LOX in excitotoxicity is also supported by microdialysis studies in vivo | | |
| 16647138 | 5-LOX | 5-LOX | 4.7 | neuronal injury that depends on the magnitude of COX-2 and 5-LOX expression ( Iadecola et al. 2001a Nakayama et al. 1998 | | |
| 16647138 | 5-LOX | 5-LOX | 4.7 | It is likely that increased COX-2 and 5-LOX activities and high levels of their reaction products are involved | | |
| 16647138 | 5-LOX | 5-LOX | 4.7 | The neurochemical consequences of increased COX-2 and 5-LOX activities and high levels of their products include not only | | |
| 16647138 | 5-LOX | 5-LOX | 4.7 | emphasis on the interaction between glutamate receptors and COX-2 and 5-LOX activities and their reaction products does not rule out the | | |
| 16647138 | 5-LOX | 5-LOX | 4.7 | Upregulation of 5-LOX expression has also been reported to occur in various regions | | |
| 16647138 | 5-LOX | 5-LOX | 4.7 | The significance of 5-LOX upregulation in aged rat brain remains unknown | | |
| 16647138 | 5-LOX | 5-LOX | 4.7 | However increased 5-LOX activity may make neurons vulnerable to various insults including excitotoxicity | | |
| 16647138 | 5-LOX | 5-LOX | 4.7 | Based on these findings 5-LOX gene polymorphism has been proposed for the onset of AD | | |
| 16647138 | 5-LOX | 5-LOX | 4.7 | The 5-LOX pathway may mediate the PrP106_amp_#x2013 126 toxicity | | |
| 16647138 | 5-LOX | 5-LOX | 4.7 | the observation that PrP106_amp_#x2013 126-mediated neurodegeneration can be blocked by 5-LOX inhibitors such as nordihydroguaiaretic acid and caffeic acid | | |
| 16647138 | 5-LOX | 5-LOX-mediated | 1.6 | PrP106_amp_#x2013 126-induced caspase-3 activation and annexin V binding involved in 5-LOX-mediated apoptosis | | |
| 16647138 | 5-LOX | 5-LOX | 4.7 | These observations implicate 5-LOX in the pathophysiology of CJD | | |
| 16647138 | 5-LOX | 5-LOX | 4.7 | Similarly neuronal and astrocytic 5-LOX 12-LOX and 15-LOX and EPOX isozymes differ considerably in responses | | |
| 16436205 | arachidonic acid 5-lipoxygenase | arachidonic acid 5 lipoxygenase | 1.0 | likewise arachidonic acid 5 lipoxygenase 5lox is elevated in g93a sod1 spinal cords and the 5lox antagonist nordihydroguaiaretic acid ndga slows disease progression in the als mouse [ 14 ]. | | |
| 16436205 | 5 lox | 5 lox | 1.0 | insets show western blot analysis of basal cox ii and 5 lox more ... | | |
| 16647138 | 5 lox | 5 lox | 1.0 | the biosynthesis of leukotrienes including 5 hydroxyeicosatetraenoic acid 5 hete involves 5 lox. 12 lox the most common lox in the brain hambrecht et al. 1987 with its mrna present in rat cortical neurons astrocytes and oligodendrocytes bendani et al. 1995 generates predominantly 12 hydroxyeico | | |
| 16647138 | 5 lox | 5 lox | 1.0 | they include 5 lox 12 lox and 15 lox. 12 lox catalyzes the stereospecific incorporation of molecular oxygen into the c 12 position of aa to generate 12 hpete which is reduced by cellular glutathione peroxidase to 12 he | | |
| 16647138 | 5 lox | 5 lox | 1.0 | 5 lox and 15 lox have also been sequenced from several non neural sources dixon et al. 1988 matsumoto et al. 1988 and sigal et al. 1988 . | | |
| 16647138 | 5 lox | 5 lox | 1.0 | they have a molecular mass of 78 kda and share considerable homology with 5 lox and 15 lox from soybean. | | |
| 16647138 | 5 lox | 5 lox | 1.0 | 5 lox is present in brain tissue and neural cells in the cytoplasm. | | |
| 16647138 | 5 lox | 5 lox | 1.0 | upon cell activation leading to leukotriene synthesis 5 lox translocates from the cytoplasm to the nuclear envelope. | | |
| 16647138 | 5 lox | 5 lox | 1.0 | flap shows homology with ltc 4 synthase and other microsomal glutathione transferases but has no enzymic activity itself. 5 lox also contains an src homology 3 sh3 binding motif which may be involved in the interaction of 5 lox protein with growth factor receptor bound protein 2 grb2 lepley et al. 1996 . | | |
| 16647138 | 5 lox | 5 lox | 1.0 | also contains an src homology 3 sh3 binding motif which may be involved in the interaction of 5 lox protein with growth factor receptor bound protein 2 grb2 lepley et al. 1996 . | | |
| 16647138 | 5 lox | 5 lox | 1.0 | in cerebellar granule neurons dexamethasone a glucocorticoid increases 5 lox mrna and protein contents 3 h after treatment and this increase persists for at least 24 h. | | |
| 16647138 | 5 lox | 5 lox | 1.0 | the glucocorticoid antagonist ru486 blocks the stimulatory effect of dexamethasone on 5 lox expression indicating that dexamethasone increases 5 lox expression in a glucocorticoid receptor dependent manner uz et al. 2001 . | | |
| 16647138 | 5 lox | 5 lox | 1.0 | these studies also indicate that dexamethasone increases the stability of 5 lox mrna. | | |
| 16647138 | 5 lox | 5 lox | 1.0 | hpetes and leukotrienes generated by 5 lox and 12 lox inhibit neurotransmitter release by modulating calcium and protein kinase c activity and affect synaptic activity and efficacy wolfe and horrocks 1994 . | | |
| 16647138 | 5 lox | 5 lox | 1.0 | further evidence for an involvement of 12 lox rather than 5 lox or a cyclooxygenase in homosynaptic long term depression of the hippocampus was obtained using selective inhibitors for each of these enzymes. | | |
| 16647138 | 5 lox | 5 lox | 1.0 | studies with 5 lox deficient transgenic animals suggest that this enzyme may contribute to anxiety and depression like behaviors manev and manev 2004 . | | |
| 16647138 | 5 lox | 5 lox | 1.0 | although the treatment of sls patients with the 5 lox inhibitor zileuton blocks peripheral sls symptoms and inhibits ltb 4 synthesis it does not improve cns symptoms willemsen et al. 2001b . | | |
| 16647138 | 5 lox | 5 lox | 1.0 | neurons immunostaining for 5 lox were upregulated in sites of focal ischemic damage of human brains tomimoto et al. 2002 and immunoreactive glial cells appeared in injured areas. 5 lox immunoreactive leukocytes infiltrated small blood vessels. | | |
| 16647138 | 5 lox | 5 lox | 1.0 | cerebral ischemia in the gerbil brain of 5 min duration led to an upregulation of 5 lox immunoreactivity in neurons and an increase in ltc 4 in all regions of the forebrain with the largest increase in the hippocampus ohtsuki et al. 1995 . | | |
| 16647138 | 5 lox | 5 lox | 1.0 | 2001 demonstrated significant protection of ca1 pyramidal cells following the application of two non selective lox inhibitors nordihydroguaiaretic acid and esculentin a selective 5 lox inhibitor aa861 and two selective 12 lox inhibitors baicalein and cinnamyl 3 4 dihydroxy _amp_#x3b1; cyanocinnamate. | | |
| 16647138 | 5 lox | 5 lox | 1.0 | the importance of 5 lox is further supported by evidence indicating that the gene encoding 5 lox activating protein confers a risk of stroke in humans helgadottir et al. 2004 and lohmussaar et al. 2005 . | | |
| 16647138 | 5 lox | 5 lox | 1.0 | no significant differences in infarct size between control and 5 lipoxygenase ko mice were evident after permanent or transient 60 min cerebral ischemia kitagawa et al. 2004 indicating that 5 lox is not essential for ischemic injury to the brain. | | |
| 16647138 | 5 lox | 5 lox | 1.0 | marked increases in cox 2 and 5 lox mrna and protein levels occur following kainate injections in rat brain adams et al. 1996 manev et al. 1998 and sandhya et al. 1998 . | | |
| 16647138 | 5 lox | 5 lox | 1.0 | this increase in cox 2 and 5 lox can be prevented by not only glutamate receptor antagonists koistinaho et al. 1999 and pepicelli et al. 2002 but also by cox 2 and 5 lox inhibitors manev et al. 2000a and pepicelli et al. 2002 indicating that generation of prostaglandins thromboxanes and leukotrienes is a receptor mediated process. | | |
| 16647138 | 5 lox | 5 lox | 1.0 | the role of cox 2 and 5 lox in excitotoxicity is also supported by microdialysis studies in vivo in hippocampus of freely moving rats pepicelli et al. 2005 . | | |
| 16647138 | 5 lox | 5 lox | 1.0 | talk refines communication among glutamate prostaglandin leukotriene and thromboxane receptors but under pathological situations it promotes neuronal injury that depends on the magnitude of cox 2 and 5 lox expression iadecola et al. 2001a nakayama et al. 1998 and pepicelli et al. 2005 . | | |
| 16647138 | 5 lox | 5 lox | 1.0 | it is likely that increased cox 2 and 5 lox activities and high levels of their reaction products are involved in extending excitotoxicity and oxidative stress during neurodegeneration. | | |
| 16647138 | 5 lox | 5 lox | 1.0 | the neurochemical consequences of increased cox 2 and 5 lox activities and high levels of their products include not only the generation of highly reactive oxygen free radical species with their potent damaging effects on neural membrane phospholipids protein | | |
| 16647138 | 5 lox | 5 lox | 1.0 | our emphasis on the interaction between glutamate receptors and cox 2 and 5 lox activities and their reaction products does not rule out the participation of other mechanisms involved in neural cell injury. | | |
| 16647138 | 5 lox | 5 lox | 1.0 | however it is timely and appropriate to apply the concept of synergism between glutamate and cox 2 and 5 lox generated products and their receptors to neural cell injury. | | |
| 16647138 | 5 lox | 5 lox | 1.0 | the synergistic actions of glutamate and cox 2 and 5 lox generated products may be rapid whereas in neurodegenerative disorders in which oxygen and nutrients are available to the nerve cell and ionic gradients are maintained to a limited extent due to the | | |
| 16647138 | 5 lox | 5 lox | 1.0 | neurodegenerative disorders in which oxygen and nutrients are available to the nerve cell and ionic gradients are maintained to a limited extent due to the availability of atp glutamate and cox 2 and 5 lox product mediated damage may take a longer time to develop. | | |
| 16647138 | 5 lox | 5 lox | 1.0 | these studies suggest that cox 2 and 5 lox generated products along with free radical formation play critical roles in brain damage mediated by the excitotoxicity. | | |
| 16647138 | 5 lox | 5 lox | 1.0 | upregulation of 5 lox expression has also been reported to occur in various regions of older rat brain compared to younger animals manev et al. 2000b and uz et al. 1998 . | | |
| 16647138 | 5 lox | 5 lox | 1.0 | the significance of 5 lox upregulation in aged rat brain remains unknown. | | |
| 16647138 | 5 lox | 5 lox | 1.0 | however increased 5 lox activity may make neurons vulnerable to various insults including excitotoxicity and oxidative stress uz et al. 1998 . | | |
| 16647138 | 5 lox | 5 lox | 1.0 | based on these findings 5 lox gene polymorphism has been proposed for the onset of ad manev 2000 and qu et al. 2001 . | | |
| 16647138 | 5 lox | 5 lox | 1.0 | the 5 lox pathway may mediate the prp106_amp_#x2013;126 toxicity. | | |
| 16647138 | 5 lox | 5 lox | 1.0 | this suggestion is based on the observation that prp106_amp_#x2013;126 mediated neurodegeneration can be blocked by 5 lox inhibitors such as nordihydroguaiaretic acid and caffeic acid. | | |
| 16647138 | 5 lox | 5 lox | 1.0 | these inhibitors also prevent the prp106_amp_#x2013;126 induced caspase 3 activation and annexin v binding involved in 5 lox mediated apoptosis. | | |
| 16647138 | 5 lox | 5 lox | 1.0 | these observations implicate 5 lox in the pathophysiology of cjd. | | |
| 16647138 | 5 lox | 5 lox | 1.0 | similarly neuronal and astrocytic 5 lox 12 lox and 15 lox and epox isozymes differ considerably in responses to exogenous stimuli funk 1996 and kwon et al. 2005 . | | |