HUGO ID Detailed Result 3401

PMID	Match String	Actual String	Score	Flanking text	Edited by	Edit
16647138	EPOX	EPOX	2.9	Thus cyclooxygenases (COX), COX lipoxygenases (LOX), LOX and epoxygenases (EPOX) EPOX metabolize AA to prostaglandins thromboxanes leukotrienes and epoxyeicosatrienoic acid respectively
16647138	EPOX	EPOX-catalyzed	1.6	In addition to the abovementioned lipid mediators COX LOX and EPOX-catalyzed reactions also produce reactive oxygen species (ROS) ROS
16647138	EPOX	EPOX	2.9	the multiplicity properties regulation and roles of COX LOX and EPOX in brain tissue
16647138	EPOX	EPOX	2.9	would initiate more studies on the importance of COX LOX EPOX and their lipid mediators in neurological disorders
16647138	EPOX	EPOX	2.9	The inhibition of COX LOX and EPOX activities may provide an attractive approach for designing novel drugs
16647138	EPOX	EPOX	2.9	Cytochrome P450 epoxygenases (EPOX) EPOX
16647138	EPOX	EPOX	2.9	EPOX are enzymes that in the presence of NADPH and molecular
16647138	EPOX	EPOX	2.9	Recent in situ hybridization studies of EPOX mRNA have confirmed its localization in astrocytes specifically those situated
16647138	EPOX	EPOX	2.9	In addition adenovirus-mediated CYP2C9 gene transfection and EPOX overexpression in endothelial cells result in endothelial cell tube formation
16647138	EPOX	EPOX	2.9	In endothelial cell cultures the overexpression of EPOX upregulates both endothelial nitric oxide synthase (eNOS) eNOS and PI3-kinase/Akt
16647138	EPOX	EPOX	2.9	PI3-kinase Akt signaling pathway inhibitors can prevent this upregulation by EPOX
16647138	EPOX	EPOX	2.9	EPOX gene transfection activates the MARK pathway in endothelial cells
16647138	EPOX	EPOX-derived	1.6	Collectively these studies suggest that EPOX-derived EETs modulate angiogenesis via a nitric-oxide-dependent mechanism as well as
16647138	EPOX	EPOX	2.9	Roles of COX LOX and EPOX in brain tissue
16647138	EPOX	EPOX	2.9	COX LOX and EPOX are important enzymes involved in the generation of oxygenated derivatives
16647138	EPOX	EPOX	2.9	into prostaglandins and thromboxanes LOX generates leukotrienes and lipoxins and EPOX activity produces epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids
16647138	EPOX	EPOX	2.9	metabolites by reactions catalyzed by PLA 2 COX LOX and EPOX depends upon not only on neural cell type but also
16647138	EPOX	EPOX	2.9	Role of COX LOX and EPOX in excitotoxic injury
16647138	EPOX	EPOX	2.9	These enzymes include PLA 2 COX-2 LOX and EPOX
16647138	EPOX	EPOX	2.9	Nothing is known about the effect of glutamate on EPOX activity and expression
16647138	EPOX	EPOX	2.9	Gebremedhin et al. 2003 indicating that excitotoxicity may also involve EPOX activity
16647138	EPOX	EPOX	2.9	At present no information is available on EPOX activity and expression in AD brain
16647138	EPOX	EPOX	2.9	the LOX inhibitors nordihydroguaiaretic acid AA861 and baicalein and the EPOX inhibitors SKF25A and metyrapone but not by the COX inhibitors
16647138	EPOX	EPOX	2.9	This suggests that LOX and EPOX pathways may also be involved in LOX- and EPOX-generated metabolite-induced
16647138	EPOX	EPOX-generated	1.6	and EPOX pathways may also be involved in LOX- and EPOX-generated metabolite-induced neurodegeneration ( Kwon et al. 2005
16647138	EPOX	EPOX	2.9	The neuroprotective effects of LOX and EPOX inhibitors may relate to downregulation of free radical formation under
16647138	EPOX	EPOX	2.9	At present information on LOX and EPOX expression and their activities is not available for the ALS
16647138	EPOX	EPOX	2.9	No information is available on LOX and EPOX expression and activities in PD brains
16647138	EPOX	EPOX	2.9	The involvement of LOX and EPOX in the pathogenesis of PD has been studied in glutathione
16647138	EPOX	EPOX	2.9	Involvement of EPOX in the pathogenesis of PD has also been studied
16647138	EPOX	EPOX	2.9	Collective evidence suggests that changes in COX LOX and EPOX activities may not be the primary effect but a secondary
16647138	EPOX	EPOX	2.9	Information on the involvement of EPOX in CJD is not available
16647138	EPOX	EPOX	2.9	Future perspectives interactions among multiple forms of COX LOX and EPOX and their relationship to upstream PLA 2 isoforms and downstream
16647138	EPOX	EPOX	2.9	Although transcripts activities and immunoreactive proteins for COX LOX and EPOX are widely expressed throughout the brain very little is known
16647138	EPOX	EPOX	2.9	The occurrence of isoforms of COX LOX and EPOX enzymes in cytoplasm and other subcellular organelles (plasma plasma and
16647138	EPOX	EPOX	2.9	The multiplicity of COX LOX and EPOX enzymes in brain tissue provides diversity in their function and
16647138	EPOX	EPOX	2.9	Similarly neuronal and astrocytic 5-LOX 12-LOX and 15-LOX and EPOX isozymes differ considerably in responses to exogenous stimuli ( Funk
16647138	EPOX	EPOX	2.9	This behavior complicates the analysis of COX LOX and EPOX function at cellular and subcellular levels
16647138	EPOX	EPOX	2.9	the coupling mechanisms of various isoforms of COX LOX and EPOX with different receptors at cellular and subcellular levels and tries
16647138	EPOX	EPOX	2.9	Some isoforms of COX LOX and EPOX are constitutively expressed while others are inducible in response to
16647138	EPOX	EPOX	2.9	The isoforms of COX LOX and EPOX may not function interchangeably but act in parallel to transducer
16647138	EPOX	EPOX	2.9	It is likely that various isoforms of COX LOX and EPOX act on different cellular pools of arachidonic acid located in
16647138	EPOX	EPOX-generated	1.6	Thus the interactions among COX LOX and EPOX-generated metabolites at plasma membrane cytoplasmic and nuclear membrane levels may
16647138	EPOX	EPOX	2.9	that coordinated cross talk not only among COX LOX and EPOX isozymes but also with upstream PLA 2 isozymes and downstream
16647138	EPOX	EPOX-mediated	1.6	In the nuclear membrane and nucleus COX LOX and EPOX-mediated signaling has the advantage over plasma membrane signaling in that
16647138	EPOX	EPOX	2.9	In brain tissue the activities of COX LOX and EPOX isoforms may depend not only on the structural physico-chemical and
16647138	EPOX	EPOX	2.9	The ability of COX LOX and EPOX isoforms to orchestrate complex prostaglandin leukotriene HETE and EET-mediated physiologic
16647138	EPOX	EPOX	2.9	The activation of COX LOX and EPOX isoforms at a subcellular level in neural cells is the
16647138	EPOX	EPOX	2.9	Therefore a strict regulation of COX LOX and EPOX isozymes is very important for normal brain function
16647138	EPOX	EPOX	2.9	As stated above the regulation of COX LOX and EPOX activities is complex and mediated by several factors including translocation
16647138	EPOX	EPOX	2.9	To understand the contribution of isoforms of COX LOX and EPOX in physiological and disease processes a systematic approach will be
16647138	EPOX	EPOX	2.9	prostaglandins LOX isozymes which generate hydroxyl derivatives and leukotrienes and EPOX isozymes which produce epoxyeicosatrienoic products
16647138	EPOX	EPOX	2.9	ALS and CJD stimulation and upregulation of COX LOX and EPOX isozyme activities and the generation of excessive amounts of prostaglandins
16647138	EPOX	EPOX-generated	1.6	metabolites not only antagonize the effect of COX LOX and EPOX-generated products but also counteract leukocyte infiltration and proinflammatory gene expression
16647138	EPOX	EPOX	2.9	Elevated activities of isoforms of COX LOX and EPOX at cellular and subcellular levels in ischemia and neurodegenerative diseases