HUGO ID Detailed Result 2169


HUGO ID 2169
Symbol CNTF
Name ciliary neurotrophic factor
#Occurrence 22
#Paper 7

 


PMID Match String Actual String Score Flanking text Edited by Edit
9086508CNTFCNTF1.9brain-derived neurotrophic factor (BDNF) BDNF and ciliary neurotrophic factor (CNTF) CNTF are currently being explored as novel therapeutics in a range 
9086508CNTFCNTF1.9response to NTFs with a rank order of BDNF > CNTF > NGF in contrast RPMC were refractory to the effects 
9086508CNTFCNTF1.9contrast RPMC were refractory to the effects of BDNF and CNTF 
11173059CNTFCNTF2.9as brain-derived neurotrophic factor (BDNF), BDNF ciliary neurotrophic factor (CNTF), CNTF and insulin-like growth factor-1 (IGF-1) IGF-1 enhance motor neuron survival 
11173059CNTFCNTF2.9A mutation of the CNTF gene occurs in 2_amp_#x2013 3% of the human population leading 
11173059CNTFCNTF2.9However the mutation of the CNTF gene may be deleterious when associated with mutations of other 
15210305CNTFCNTF1.9Recently Ciliary Neurotrophic factor (CNTF) CNTF has been proposed as a modifier gene since the rare 
15210305CNTFCNTF-deficient1.9Similarly when CNTF-deficient mice are crossed with SOD1 G93A transgenic mice an earlier 
15210305CNTFCNTF1.9CNTF initially reported as a potent survival factor in spinal motor 
15210305CNTFCNTF1.9CNTF expression was down-regulated in the lateral corticospinal tracts of spinal 
15210305CNTFCNTF1.9compared to control particularly in those patients exhibiting a specific CNTF null allele 77 
15210305CNTFCNTF1.9However genotyping of the CNTF receptor alpha (CNTFR-alpha) CNTFR-alpha has failed to show any significant 
15668976CNTFCNTF1.9Moreover neuroprotective neurotrophic factors such as ciliary neurotrophic factor (CNTF), CNTF Hepatocyte growth factor (HGF), HGF and glial cell line-derived neurotrophic 
17015226CNTFCNTF0.3no benefit for BDNF ( BDNF Study Group 1999 or CNTF ( ALS CNTF Treatment Study Group 1996 
17015226CNTFCNTF0.3BDNF ( BDNF Study Group 1999 or CNTF ( ALS CNTF Treatment Study Group 1996 
17418957CNTFCNTF0.1B27 (Invitrogen), Invitrogen 10 ng/ml ng ml each of BDNF CNTF and GDNF (Peprotech, Peprotech Rocky Hill NJ USA 100 _amp_#x3bc;g/ml 
9086508ciliary neurotrophic factorciliary neurotrophic factor1.0neurotrophic factors ntfs such as nerve growth factor ngf brain derived neurotrophic factor bdnf and ciliary neurotrophic factor cntf are currently being explored as novel therapeutics in a range of neurodegenerative disorders such as amyotrophic lateral sclerosis als and alzheimer's disease.  
11173059ciliary neurotrophic factorciliary neurotrophic factor1.0neurotrophic factors such as brain derived neurotrophic factor bdnf ciliary neurotrophic factor cntf and insulin like growth factor 1 igf 1 enhance motor neuron survival in vitro and can also exert beneficial effects in mouse models of amyotrophic lateral sclerosis reviewed in yuen and mobley 1 
11173059ciliary neurotrophic factorciliary neurotrophic factor1.0ffects on dopaminergic neurons in vivo including glial cell line derived neurotrophic factor gdnf basic fibroblast growth factor bfgf brain derived neurotrophic factor neurotrophin 3 neurotrophin 4/5 ciliary neurotrophic factor and transforming growth factor tgf _amp_#x3b2; dunnett and bj_amp_#xf6;rklund 1999 .  
15210305ciliary neurotrophic factorciliary neurotrophic factor1.0recently ciliary neurotrophic factor cntf has been proposed as a modifier gene since the rare null mutations cause an earlier age of onset of disease in fals cases carrying a sod1 mutation.  
15668976ciliary neurotrophic factorciliary neurotrophic factor1.0moreover neuroprotective neurotrophic factors such as ciliary neurotrophic factor cntf hepatocyte growth factor hgf and glial cell line derived neurotrophic factor were upregulated.  
18513389ciliary neurotrophic factorciliary neurotrophic factor1.0among the genetic factors that may predispose to sporadic als neurofilaments apolipoprotein epsilon 4 genotype excitotoxicity genes ciliary neurotrophic factor ctnf cytochrome p450 debrisoquine hydroxylase cyp2d6 apurinic apyrimidinic endonuclease apex mitochondrial manganese superoxide dismutase sod2 monoamine oxidase allele b and paraoxonases have been re