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| 12843244 | caspase-8 | caspase-8 | 2.0 | this regard it is worth noting that the activation of caspase-8 and -9 was found only at the end stage of | |  |
| 15572176 | caspase-8 | caspase-8 | 2.0 | seems to be specific for motor neurons requiring co-activation of caspase-8 and p38 as well as the production of nitric oxide | |  |
| 16510725 | caspase-8 | caspase-8 | 2.0 | Fas then death-inducing signaling complex (DISC) DISC will form and caspase-8 is activated which leads to apoptotic cell death | |  |
| 16510725 | caspase-8 | caspase-8 | 2.0 | kinase 1 and p38 as well as the FADD/caspase-8 FADD caspase-8 pathway (Raoul Raoul et al. 2002 alpha upregulates FasL (Pinkoski | |  |
| 16510725 | caspase-8 | caspase-8 | 2.0 | (TRADD), TRADD forming the DISC that leads to activation of caspase-8 resulting in Bid cleavage and the activation of executioner caspases-3 | |  |
| 16510725 | caspase-8 | caspase-8 | 2.0 | FADD ligation and DISC formation which also leads on to caspase-8 activation Bid cleavage and ultimately activation of caspases-3 -6 and | |  |
| 16510725 | caspase-8 | caspase-8 | 2.0 | Because these two pathways converge on caspase-8 activation they may have synergistic effects | |  |
| 12843244 | caspase 8 | caspase 8 | 1.0 | in this regard it is worth noting that the activation of caspase 8 and 9 was found only at the end stage of mutant sod expressing transgenic mice gu_amp_eacute;gan et al. 2001 2002 . | |  |
| 15210305 | cysteine protease | cysteine protease | 1.0 | another up regulated gene candidate was found to have a high homology with stefin b [stfb also called cystatin b cstb ] which is a member of the superfamily of non caspase cysteine protease inhibitors known to have an anti apoptotic function [ 45 and 85 ]. | |  |
| 15572176 | caspase 8 | caspase 8 | 1.0 | the apoptotic pathway activated by fas seems to be specific for motor neurons requiring co activation of caspase 8 and p38 as well as the production of nitric oxide by neuronal nos [ 101 ]. | |  |
| 16510725 | caspase 8 | caspase 8 | 1.0 | lpha can induce fasl pinkoski et al. 2002 alpha binds to its receptor e.g. tnf r1 similar to the events that take place when fasl binds to fas then death inducing signaling complex disc will form and caspase 8 is activated which leads to apoptotic cell death. | |  |
| 16510725 | caspase 8 | caspase 8 | 1.0 | s triggers cell death in embryonic motoneurons by a pathway requiring upregulation of neuronal nitric oxide synthase and involving daxx apoptosis signal regulated kinase 1 and p38 as well as the fadd/caspase 8 pathway raoul et al. 2002 alpha upregulates fasl pinkoski et al. 2002 alpha immunostaining was found in the neurons of adjacent sections suggesting that fasl and tnf alpha are coexpressed in these ne | |  |
| 16510725 | caspase 8 | caspase 8 | 1.0 | tnf alpha binds to tnf receptor 1 and activates it to ligate with tnf alpha receptor associated death domain tradd forming the disc that leads to activation of caspase 8 resulting in bid cleavage and the activation of executioner caspases 3 6 and 7. | |  |
| 16510725 | caspase 8 | caspase 8 | 1.0 | fasl works in a similar way by binding to fas/cd95 receptor and activate it to cause fadd ligation and disc formation which also leads on to caspase 8 activation bid cleavage and ultimately activation of caspases 3 6 and 7 nagata 1997 1999 ; pinkoski et al. 2000 ; ugolini et al. 2003 . | |  |
| 16510725 | caspase 8 | caspase 8 | 1.0 | because these two pathways converge on caspase 8 activation they may have synergistic effects. | |  |
| 16624536 | caspase 8 | caspase 8 | 1.0 | when signaling through the tnfr1 tnfr1 recruits a tnf receptor associated death domain tradd that can then interact with the fas associated death domain to activate caspase 8 leading to downstream activation of effector caspases. | |  |
| 17306794 | cysteine protease | cysteine protease | 1.0 | in parallel assays the reaction was followed in the presence of the specific catb inhibitor ca 074 1_amp_#xa0;_amp_#x3bc;m bachem weil am rhein germany and the non specific cysteine protease inhibitor e 64 5_amp_#xa0;_amp_#x3bc;m sigma in order to inactivate catb which is also able to hydrolyze the substrate at these conditions and to evaluate the total cysteine protease activity. | |  |
| 17306794 | cysteine protease | cysteine protease | 1.0 | inhibitor e 64 5_amp_#xa0;_amp_#x3bc;m sigma in order to inactivate catb which is also able to hydrolyze the substrate at these conditions and to evaluate the total cysteine protease activity. | |  |
| 17306794 | cysteine protease | cysteine protease | 1.0 | in the present study we characterized the regional and cellular expression as well as the activity of the recently discovered lysosomal cysteine protease cathepsin x in the normal developing and pathological nervous system of the c57bl/6 mouse. | |  |