HUGO ID Detailed Result 12435

HUGO ID 12435
Symbol TXN
Name thioredoxin
#Occurrence 59
#Paper 2

 

PMID Match String Actual String Score Flanking text Edited by Edit
17191135TRXTRX2.5TRX Thioredoxin SH (reduced reduced form S-S oxidized form 
17191135TRXTrx2.5The thioredoxin system The thioredoxin (Trx) Trx system (Trx Trx and Trx reductase has received a considerable 
17191135TRXTrx2.5The thioredoxin system The thioredoxin (Trx) Trx system (Trx Trx and Trx reductase has received a considerable attention in the 
17191135TRXTrx2.5thioredoxin system The thioredoxin (Trx) Trx system (Trx Trx and Trx reductase has received a considerable attention in the last years 
17191135TRXTrx2.5Trx is a ubiquitous thiol oxidoreductase system that regulates cellular redox 
17191135TRXTrx2.5a hydrogen donor for ribonucleotide reductase required for DNA synthesis Trx plays an essential role in cell function by limiting oxidative 
17191135TRXTrx2.5of many processes is provided by an interaction between the Trx and GSH systems 62 
17191135TRXTrx2.5In fact Trx and GSH systems are involved in a variety of redox-dependent 
17191135TRXTrx2.5The Trx system rather may play a critical role in the redox 
17191135TRXTrx2.5reduced form by TrxR and NADPH collectively known as the Trx system 
17191135TRXTrx2.5Trx reductase belongs to the flavoprotein family of pyridine nucleotide disulfide 
17191135TRXTrx2.5the catalytic activity of mammalian TrxR toward reduction of oxidized Trx and various antioxidant molecules such as lipoic acid ascorbic acid 
17191135TRXTrx2.5Trx which behaves as a soluble protein after disruption of cells 
17191135TRX1Trx-13.0of cells exists as one of the cytoplasmic proteins (Trx-1) Trx-1 and a mitochondrial (Trx-2) Trx-2 isoform 60 
17191135TRX1Trx-13.0A growing number of studies report a striking association between Trx-1 up-regulation in the CNS and neuron survival following various injuries 
17191135TRX1Trx-13.0Trx-1 and TrxR the most extensively studied eukaryotic thioredoxin proteins were 
17191135TRX1Trx-13.0Trx-1 has been then found widely expressed in rat brain especially 
17191135TRX1Trx-13.0Immunohistochemical analysis of Trx-1 in human brain showed positive Trx1-like staining in white matter 
17191135TRXTrx2.5The promoter of the Trx gene contains a series of stress-responsive elements various transcription factor 
17191135TRX1Trx-13.0ARE-mediated Trx-1 induction involves the transcription factor Nfr2 
17191135TRXTrx2.5Moreover it has been reported that Trx is constitutively present as a surface-associated sulfhydryl protein in plasma 
17191135TRXTrx2.5UV irradiation and hydrogen peroxide have been shown to induce Trx expression and secretion as a redox-sensitive molecule with cytokine-like and 
17191135TRXTrx2.5and hemin has been reported to cause the translocation of Trx from the cytoplasm to the nucleus where it regulates the 
17191135TRXTrx2.5Plasma levels of Trx in normal individuals vary between 10 and 80 ng/ml; ng 
17191135TRX1Trx-13.0Of note several studies reported increased Trx-1 expression in many human primary cancers and tumor cell lines 
17191135TRXTrx2.5Elevated Trx levels may contribute to increased cancer cell proliferation and resistance 
17191135TRX1Trx-13.0Recent work suggests that Trx-1 play a key role in NGF signaling pathways 74 
17191135TRX1Trx-13.0and function of the CNS has been shown to activate Trx-1 expression via cyclic AMP (cAMP)-response cAMP -response elements (CREs) CREs 
17191135TRX1Trx-13.0AMP (cAMP)-response cAMP -response elements (CREs) CREs present in the Trx-1 gene promoter and also to induce nuclear translocation of Trx1 
17191135TRX1Trx12.5Trx-1 gene promoter and also to induce nuclear translocation of Trx1 75 
17191135TRXTrx2.5to regulate the function of proteins through thiol-disulfide exchange reactions Trx may also have beneficial effects during oxidative stress by transcriptionally 
17191135TRXTrx2.5Besides the role as a source of reducing equivalents Trx by itself acts as antioxidant or ROS scavenger 
17191135TRXTrx2.5In fact Trx eliminates singlet oxygen hydroxyl radical and hydrogen peroxide 78 
17191135TRXTrx2.5Another family of proteins acting in conjunction with Trx is the peroxide scavenger Peroxiredoxin (Prx) Prx 
17191135TRXTrx2.5antioxidant enzymes most of which use the reducing activity of Trx or other electron donors to catalyze the reduction of peroxides 
17191135TRXTrx2.5As for cytosolic Trx (Trx-1), Trx-1 the induction of Prx-1 appears to involve the 
17191135TRX1Trx-13.0As for cytosolic Trx (Trx-1), Trx-1 the induction of Prx-1 appears to involve the transcription factor 
17191135TRXTrx2.5A second slightly larger Trx isoform (Trx-2), Trx-2 is also present in mammalian cells where 
17191135TRXTrx2.5inactivation studies in DT-40 chicken cells suggest that this mitochondrial Trx isoenzyme is essential for cell survival 
17191135TRXTrx2.5Among the very few studies available on the expression of Trx cycle enzymes in neurodegenerative processes one report indicated increased Trx1 
17191135TRX1Trx12.5Trx cycle enzymes in neurodegenerative processes one report indicated increased Trx1 protein and RNA levels in the grey and white matter 
17191135TRXTrx2.5that treatments of primary rat hippocampal cell cultures with exogenous Trx enhanced their survival against B-amyloid cytotoxicity 97 
17191135TRXTrx2.5Thus it has been suggested that Trx might play a protective role in AD and Trx-1 deficit 
17191135TRX1Trx-13.0that Trx might play a protective role in AD and Trx-1 deficit might eventually contribute to increased oxidative stress and subsequent 
17191135TRX1Trx-13.0In contrast to low Trx-1 protein levels TrxR activity was significantly elevated in the amygdala 
17191135TRXTrx2.5It is likely that the expression of the Trx cycle enzymes must be tightly regulated in order to maintain 
15210305thioredoxinthioredoxin1.0these _amp_#x201c;inducible_amp_#x201d; elements by virtue of their responsiveness to a wide range of cell _amp_#x201c;injury_amp_#x201d; events include thioredoxin lysyl oxidase lo flavin containing monooxygenase fmo1 interleukin i receptor accessory protein il 1racp and a transcript representing a possible 14 3 3 spinal cord isoform [ 59 and 60 ].  
15210305thioredoxinthioredoxin1.0thioredoxin lo and fmo exert a powerful antioxidant function counteracting the copper catalysed oxidation of proteins in als tissue.  
15210305thioredoxinthioredoxin1.0thioredoxin has been previously reported to be remarkably over expressed in adult rat motor neurones following hypoglossal nerve axotomy [ 61 ] and to be strongly induced in erythrocytes from patients with famil 
15210305thioredoxinthioredoxin1.0thioredoxin known to promote cell survival by suppressing caspase dependent apoptosis was found to be differentially regulated in a post mortem expression study of spinal cord from als cases in adult rat motor n 
17191135thioredoxinthioredoxin1.0oxs oxidative stress; ho 1 heme oxygenase; trxr thioredoxin reductase.  
17191135thioredoxinthioredoxin1.0trx thioredoxin sh reduced form s s oxidized form.  
17191135thioredoxinthioredoxin1.0in addition the key role played by members of the vitagene system such as ho 1 and thioredoxin fig 1 a in modulating the onset and progression of major neurodegenerative diseases such as ad and pd are discussed.  
17191135thioredoxinthioredoxin1.0in eukaryotes typical examples are genes such as heme oxygenase thioredoxin and detoxificant enzymes mn sod glutathione s transferase nadph: quinone reductase cytokine immunoreceptors and growth factors.  
17191135thioredoxinthioredoxin1.0the thioredoxin system the thioredoxin trx system trx and trx reductase has received a considerable attention in the last years as a stress responsive gene [ 60 ] fig 1 a .  
17191135thioredoxinthioredoxin1.0thioredoxin itself is kept in a reduced form by trxr and nadph collectively known as the trx system.  
17191135thioredoxinthioredoxin1.0trx 1 and trxr the most extensively studied eukaryotic thioredoxin proteins were first localized immunohistochemically in the rat sciatic nerve.  
17191135thioredoxinthioredoxin1.0the prxs also called thioredoxin peroxidases are a relatively newly discovered family of antioxidant enzymes most of which use the reducing activity of trx or other electron donors to catalyze the reduction of peroxides including h  
17191135thioredoxinthioredoxin1.0these observations strongly support a role for nitrosative stress in the pathogenesis of ad and indicate that the stress responsive genes such as heme oxygenase and thioredoxin reductase may represent important targets for novel cytoprotective strategies [ 96 ].