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| 16647138 | 12-LOX | 12-LOX | 3.1 | biosynthesis of leukotrienes including 5-hydroxyeicosatetraenoic acid (5-HETE), 5-HETE involves 5-LOX 12-LOX the most common LOX in the brain ( Hambrecht et | |  |
| 16647138 | 12-LOX | 12-LOX | 3.1 | They include 5-LOX 12-LOX and 15-LOX 12-LOX catalyzes the stereospecific incorporation of molecular oxygen | | |
| 16647138 | 12-LOX | 12-LOX | 3.1 | They include 5-LOX 12-LOX and 15-LOX 12-LOX catalyzes the stereospecific incorporation of molecular oxygen into the C-12 | | |
| 16647138 | 12-LOX | 12-LOX | 3.1 | cellular glutathione peroxidase to 12-HETE ( Li et al. 1997 12-LOX has been cloned and characterized from rat brain ( Watanabe | | |
| 16647138 | 12-LOX | 12-LOX | 3.1 | The action of 12-LOX produces lipid hydroperoxides | | |
| 16647138 | 12-LOX | 12-LOX | 3.1 | Thus in mechanosensory neurons of the marine mollusk Aplysia californica 12-LOX metabolites act as second messengers and participate in communication with | | |
| 16647138 | 12-LOX | 12-LOX | 3.1 | HPETEs and leukotrienes generated by 5-LOX and 12-LOX inhibit neurotransmitter release by modulating calcium and protein kinase C | | |
| 16647138 | 12-LOX | 12-LOX | 3.1 | Cloned rat brain 12-LOX generates some 15-HETE ( Watanabe et al. 1993 15-LOX also | | |
| 16647138 | 12-LOX | 12-LOX | 3.1 | function in the central nervous system has been focused on 12-LOX | | |
| 16647138 | 12-LOX | 12-LOX | 3.1 | Detection of 12-LOX mRNA was reported in neuronal cultures ( Palluy et al. | | |
| 16647138 | 12-LOX | 12-LOX | 3.1 | several groups suggested that arachidonic acid or one of its 12-LOX metabolites might function as a retrograde messenger in long-term potentiation | | |
| 16647138 | 12-LOX | 12-LOX | 3.1 | Two 12-LOX metabolites of arachidonic acid 12-hydroxyeicosatrienoic acid (HETE) HETE and 12-hydroperoxyeicosatetraenoic | | |
| 16647138 | 12-LOX | 12-LOX | 3.1 | (1990) 1990 demonstrated that the 12-LOX pathway of arachidonic acid metabolism in cerebral cortical slices was | | |
| 16647138 | 12-LOX | 12-LOX | 3.1 | However in this instance 12-LOX products attenuated depolarization-evoked accumulation of intraterminal free Ca 2 and | | |
| 16647138 | 12-LOX | 12-LOX | 3.1 | positive modulator of the glutamate release involved in long-term potentiation 12-LOX metabolites provide signals designed to limit neurotransmitter release | | |
| 16647138 | 12-LOX | 12-LOX | 3.1 | Further evidence for an involvement of 12-LOX rather than 5-LOX or a cyclooxygenase in homosynaptic long-term depression | | |
| 16647138 | 12-LOX | 12-LOX | 3.1 | The 12-LOX inhibitor baicalein was the most effective in blocking hippocampal LTD | | |
| 16647138 | 12-LOX | 12-LOX | 3.1 | blocking hippocampal LTD ( Normandin et al. 1996 indicating that 12-LOX metabolites may be important factors controlling the expression of hippocampal | | |
| 16647138 | 12-LOX | 12-LOX | 3.1 | and not to changes in the number of binding sites 12-LOX inhibitors preferentially reduced the PLA 2 -induced decrease in AMPA | | |
| 16647138 | 12-LOX | 12-LOX | 3.1 | The 12-LOX inhibitor baicalein totally blocked LTD in the CA1 region of | | |
| 16647138 | 12-LOX | 12-LOX | 3.1 | with the concept that arachidonic acid metabolites produced by the 12-LOX pathway could account for AMPA receptor alterations for both LTP | | |
| 16647138 | 12-LOX | 12-LOX | 3.1 | a recent multidisciplinary study gave evidence for a role of 12-LOX metabolites in metabotropic-glutamate receptor-dependent long-term depression at hippocampal CA3_amp_#x2013 CA1 | | |
| 16647138 | 12-LOX | 12-LOX | 3.1 | Their results strongly support the hypothesis that a 12-LOX pathway is required for the induction of metabotropic-glutamate-receptor-dependent LTD but | | |
| 16647138 | 12-LOX | 12-LOX | 3.1 | The 12-LOX metabolite of arachidonic acid 12(s)-HPETE 12 s -HPETE appeared to | | |
| 16647138 | 12-LOX | 12-LOX | 3.1 | in locomotor activity were augmented acutely but not chronically in 12-LOX _amp_#x2212;/_amp_#x2212; _amp_#x2212 _amp_#x2212 mice ( Walters et al. 2003 | | |
| 16647138 | 12-LOX | 12-LOX | 3.1 | Together these results suggest a role for 12-LOX products in morphine and cocaine behavioral responses | | |
| 16647138 | 12-LOX | 12-LOX | 3.1 | post-injury confirmed the previous observations and demonstrated an involvement of 12-LOX in the injury process | | |
| 16647138 | 12-LOX | 12-LOX | 3.1 | and esculentin a selective 5-LOX inhibitor AA861 and two selective 12-LOX inhibitors baicalein and cinnamyl-3 4-dihydroxy-_amp_#x3b1 -cyanocinnamate | | |
| 16647138 | 12-LOX | 12-LOX | 3.1 | A decrease in GSH triggers the activation of neuronal 12-LOX resulting in the production of 12-LOX-generated products and peroxides ( | | |
| 16647138 | 12-LOX | 12-LOX | 3.1 | Treatment of cell cultures with 12-LOX inhibitors blocks neuronal cell death induced by GSH depletion | | |
| 16647138 | 12-LOX | 12-LOX | 3.1 | contrast indomethacin a COX-1 and COX-2 inhibitor and baicalein a 12-LOX inhibitor do not affect PrP106_amp_#x2013 126-induced neurotoxicity in cerebellar granule | | |
| 16647138 | 12-LOX | 12-LOX | 3.1 | Similarly neuronal and astrocytic 5-LOX 12-LOX and 15-LOX and EPOX isozymes differ considerably in responses to | | |
| 16647138 | 12 lox | 12 lox | 1.0 | the biosynthesis of leukotrienes including 5 hydroxyeicosatetraenoic acid 5 hete involves 5 lox. 12 lox the most common lox in the brain hambrecht et al. 1987 with its mrna present in rat cortical neurons astrocytes and oligodendrocytes bendani et al. 1995 generates predominantly 12 hydroxyeicosatetrae | | |
| 16647138 | 12 lox | 12 lox | 1.0 | they include 5 lox 12 lox and 15 lox. 12 lox catalyzes the stereospecific incorporation of molecular oxygen into the c 12 position of aa to generate 12 hpete which is reduced by cellular glutathione peroxidase to 12 hete li et al. 1997 . 12 lox | | |
| 16647138 | 12 lox | 12 lox | 1.0 | catalyzes the stereospecific incorporation of molecular oxygen into the c 12 position of aa to generate 12 hpete which is reduced by cellular glutathione peroxidase to 12 hete li et al. 1997 . 12 lox has been cloned and characterized from rat brain watanabe et al. 1993 . | | |
| 16647138 | 12-lipoxygenase | 12 lipoxygenase | 1.0 | rat brain 12 lipoxygenase contains six conserved histidines characteristic for all cloned lipoxygenases. | | |
| 16647138 | 12-lipoxygenase | 12 lipoxygenase | 1.0 | it displays the highest degree of identity to porcine leukocyte 12 lipoxygenase 71% and to human 15 lipoxygenase 75% but has less resemblance to human platelet 12 lipoxygenase 59% or rat leukocyte 5 lipoxygenase 41% . | | |
| 16647138 | 12-lipoxygenase | 12 lipoxygenase | 1.0 | a part of the brain 12 lipoxygenase cdna is used as a probe in northern blots. | | |
| 16647138 | 12-lipoxygenase | 12 lipoxygenase | 1.0 | sequencing of parts of the corresponding cdnas from other rat tissues and their comparison with brain 12 lipoxygenase indicates that mrnas from the different rat tissues are identical watanabe et al. 1993 . | | |
| 16647138 | 12 lox | 12 lox | 1.0 | the action of 12 lox produces lipid hydroperoxides. | | |
| 16647138 | 12 lox | 12 lox | 1.0 | thus in mechanosensory neurons of the marine mollusk aplysia californica 12 lox metabolites act as second messengers and participate in communication with local groups of cells. | | |
| 16647138 | 12 lox | 12 lox | 1.0 | hpetes and leukotrienes generated by 5 lox and 12 lox inhibit neurotransmitter release by modulating calcium and protein kinase c activity and affect synaptic activity and efficacy wolfe and horrocks 1994 . | | |
| 16647138 | 12-lipoxygenase | 12 lipoxygenase | 1.0 | 12 hydroxyeicosatetraenoic acid 12 hete is a product of 12 lipoxygenase's action on arachidonic acid. | | |
| 16647138 | arachidonate 12-lipoxygenase | arachidonate 12 lipoxygenase | 1.0 | a cdna encoding for arachidonate 12 lipoxygenase was identified in rat brain. | | |
| 16647138 | 12-lipoxygenase | 12 lipoxygenase | 1.0 | a cdna encoding for arachidonate 12 lipoxygenase was identified in rat brain. | | |
| 16647138 | 12 lox | 12 lox | 1.0 | cloned rat brain 12 lox generates some 15 hete watanabe et al. 1993 . 15 lox also synthesizes 12 and 15 hete from arachidonic acid kuhn et al. 2002 . | | |
| 16647138 | 12 lox | 12 lox | 1.0 | much of the interest in the role of lipoxygenases as modulators of synaptic function in the central nervous system has been focused on 12 lox. | | |
| 16647138 | 12 lox | 12 lox | 1.0 | detection of 12 lox mrna was reported in neuronal cultures palluy et al. 1994 . | | |
| 16647138 | 12 lox | 12 lox | 1.0 | in 1990 several groups suggested that arachidonic acid or one of its 12 lox metabolites might function as a retrograde messenger in long term potentiation ltp and long term depression ltd in the hippocampus. | | |
| 16647138 | 12 lox | 12 lox | 1.0 | two 12 lox metabolites of arachidonic acid 12 hydroxyeicosatrienoic acid hete and 12 hydroperoxyeicosatetraenoic acid 12 hpete significantly increased k + stimulated release of glutamate from hippocampal synapt | | |
| 16647138 | 12 lox | 12 lox | 1.0 | 1990 demonstrated that the 12 lox pathway of arachidonic acid metabolism in cerebral cortical slices was stimulated by glutamate and n methyl d aspartate with the formation of 12 hete. | | |
| 16647138 | 12 lox | 12 lox | 1.0 | however in this instance 12 lox products attenuated depolarization evoked accumulation of intraterminal free ca 2+ and glutamate. | | |
| 16647138 | 12 lox | 12 lox | 1.0 | they proposed that while arachidonic acid acts as a positive modulator of the glutamate release involved in long term potentiation 12 lox metabolites provide signals designed to limit neurotransmitter release. | | |
| 16647138 | 12 lox | 12 lox | 1.0 | further evidence for an involvement of 12 lox rather than 5 lox or a cyclooxygenase in homosynaptic long term depression of the hippocampus was obtained using selective inhibitors for each of these enzymes. | | |
| 16647138 | 12 lox | 12 lox | 1.0 | the 12 lox inhibitor baicalein was the most effective in blocking hippocampal ltd normandin et al. 1996 indicating that 12 lox metabolites may be important factors controlling the expression of hippocampal ltd. | | |
| 16647138 | 12 lox | 12 lox | 1.0 | oncentrations caused a decrease and high concentrations an increase in agonist binding which was a consequence of modifications to receptor affinity and not to changes in the number of binding sites. 12 lox inhibitors preferentially reduced the pla 2 induced decrease in ampa binding and the addition of 12 hpete decreased ampa binding. | | |
| 16647138 | 12 lox | 12 lox | 1.0 | the 12 lox inhibitor baicalein totally blocked ltd in the ca1 region of hippocampal slices. | | |
| 16647138 | 12 lox | 12 lox | 1.0 | overall these results were consistent with the concept that arachidonic acid metabolites produced by the 12 lox pathway could account for ampa receptor alterations for both ltp and ltd. | | |
| 16647138 | 12 lox | 12 lox | 1.0 | 2003 in a recent multidisciplinary study gave evidence for a role of 12 lox metabolites in metabotropic glutamate receptor dependent long term depression at hippocampal ca3_amp_#x2013;ca1 synapses. | | |
| 16647138 | 12 lox | 12 lox | 1.0 | their results strongly support the hypothesis that a 12 lox pathway is required for the induction of metabotropic glutamate receptor dependent ltd but is not required for ltp. | | |
| 16647138 | 12 lox | 12 lox | 1.0 | the 12 lox metabolite of arachidonic acid 12 s hpete appeared to satisfy all the requirements of a messenger molecule that is actively recruited for the induction of metabotropic glutamate receptor dependent lt | | |
| 16647138 | 12-lipoxygenase | 12 lipoxygenase | 1.0 | experiments on 12 lipoxygenase deficient mice indicate that this enzyme may depress responses to morphine and cocaine. | | |
| 16647138 | 12 lox | 12 lox | 1.0 | in addition the 12 lox deficient mice demonstrated enhanced signs of opiate withdrawal. | | |
| 16647138 | 12 lox | 12 lox | 1.0 | cocaine mediated increases in locomotor activity were augmented acutely but not chronically in 12 lox _amp_#x2212;/_amp_#x2212; mice walters et al. 2003 . | | |
| 16647138 | 12 lox | 12 lox | 1.0 | together these results suggest a role for 12 lox products in morphine and cocaine behavioral responses. | | |
| 16647138 | 12 lox | 12 lox | 1.0 | these increases sustained at up to 30 min post injury confirmed the previous observations and demonstrated an involvement of 12 lox in the injury process. | | |
| 16647138 | 12 lox | 12 lox | 1.0 | ignificant protection of ca1 pyramidal cells following the application of two non selective lox inhibitors nordihydroguaiaretic acid and esculentin a selective 5 lox inhibitor aa861 and two selective 12 lox inhibitors baicalein and cinnamyl 3 4 dihydroxy _amp_#x3b1; cyanocinnamate. | | |
| 16647138 | 12 lox | 12 lox | 1.0 | a decrease in gsh triggers the activation of neuronal 12 lox resulting in the production of 12 lox generated products and peroxides li et al. 1997 . | | |
| 16647138 | 12 lox | 12 lox | 1.0 | treatment of cell cultures with 12 lox inhibitors blocks neuronal cell death induced by gsh depletion. | | |
| 16647138 | 12 lox | 12 lox | 1.0 | in contrast indomethacin a cox 1 and cox 2 inhibitor and baicalein a 12 lox inhibitor do not affect prp106_amp_#x2013;126 induced neurotoxicity in cerebellar granule neuronal cultures stewart et al. 2001 . | | |
| 16647138 | 12 lox | 12 lox | 1.0 | similarly neuronal and astrocytic 5 lox 12 lox and 15 lox and epox isozymes differ considerably in responses to exogenous stimuli funk 1996 and kwon et al. 2005 . | | |