HUGO ID Detailed Result 19986


HUGO ID 19986
Symbol CYCS
Name cytochrome c, somatic
#Occurrence 9
#Paper 6

 


PMID Match String Actual String Score Flanking text Edited by Edit
18464922CYCSCYCS0.3et al found that PGC-1 _amp_#x003b1 target genes (NDUFS3, NDUFS3 CYCS COX6A1 NDUFB5 ACADM TFAM and LDHB had reduced expression in 
14739060cytochrome ccytochrome c1.0_amp_#x2022; cytochrome c a member of the mitochondrial electron chain required for the generation of atp when it is released from the mitochondria into cytoplasm trigger the caspase chain _amp_#x2022; smac/diablo binds to in 
14739060cytochrome ccytochrome c1.0this results in the collapse of trans membrane electrochemical gradient the loss of matrix solutes the swelling of mitochondria causing the release of cytochrome c procapases 2 3 and 9 apoptosis initiating factor and caspase activated dnase.  
14739060cytochrome ccytochrome c1.0cytochrome c and the cytosolic factor apaf1 activate the caspases while apoptosis initiating factor and caspase activated dnase move to the nucleus initiating apoptosis or programmed cell death [ 27 ].  
15571972cytochrome ccytochrome c1.0ts beneficial effect was accompanied by a decrease in the level of interleukin 1_amp_#x3b2; and in the cytosolic release of apoptogenic mitochondrial factors for a review see blum et al. 2001 such as cytochrome c smac/diablo or apoptosis inducing factor aif; wang et al. 2003a .  
15571972cytochrome ccytochrome c1.0the mitochondrial level to rescue the collapse of transmembrane potential and the alterations of permeability transition which are responsible for the cytosolic release of apoptogenic factors such as cytochrome c aif or smac/diablo mediating caspase dependent and independent cell death matsuki et al. 2003 and wang et al. 2003b _amp_#x2014;5 mg/kg i.p.; zhu et al. 2002 _amp_#x2014;22.5 to 45 mg/kg i.p. .  
16624536cytochrome ccytochrome c1.0the site of action of minocycline appears to be at both the level of the microglia in which the up regulation of inos is inhibited and at the target cell where the release of mitochondrial cytochrome c and thus the initiation of a pro apoptotic pathway is inhibited [127] [128] [129] and [130] .  
17015226cytochrome ccytochrome c1.0mitochondria are the gatekeepers of apoptosis with opening of the permeability transition pore and release of cytochrome c central to the cascade of caspase activation.  
17350694cytochrome ccytochrome c1.0activation of non selective ion channels activation of protein kinases opening of intracellular ca 2+ stores dissipation of mitochondrial membrane potential mitochondrial uncoupling cytochrome c release from mitochondria activation of caspases.