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| 16120782 | SOCS-1 | SOCS-1 | 3.5 | 5'-TCA-CCA-GGG-CTG-CCA-TTT-GC-3' and reverse 5'-GAC-TCC-ACG-ACA-TAC-TCA-GC-3' were used as housekeeping control for SOCS-1 and 3 beta-actin forward 5'-CAC-AGC-TTC-TTT-GCA-GCT-CCT-T-3' and reverse 5'-TCA-GGA-TAC-CTC-TCT-TGC-TCT-GG-3' were used | |  |
| 16120782 | SOCS-1 | SOCS-1 | 3.5 | reduction was paralleled by a marked transcriptional upregulation of anti-inflammatory SOCS-1 and SOCS-3 genes ( Fig 3 c in both Pio-treated | | |
| 16120782 | SOCS-1 | SOCS-1 | 3.5 | 0.001 compared with the respective nontreated group c Quantification of SOCS-1 and SOCS-3 mRNA levels in the spinal cord at day | | |
| 16120782 | SOCS-1 | SOCS-1 | 3.5 | Interestingly SOCS-1 and SOCS-3 have been reported to increase in response to | | |
| 16120782 | SOCS-1 | SOCS-1 | 3.5 | Because the ability of SOCS-1 and SOCS-3 to suppress cytokine stimulation has also been confirmed | | |
| 16120782 | SOCS-1 | SOCS-1 | 3.5 | Suzuki et al. 2001 it seems likely that upregulation of SOCS-1 and SOCS-3 levels in response to Pio treatment reflects one | | |
| 17555556 | SOCS-1 | SOCS-1 | 2.5 | SOCS-1 and SOCS-3 are critical factors down-regulating the toxic effects of | | |
| 18464922 | SOCS-1 | SOCS-1 | 3.5 | suppressor genes suppressor of cytokine signaling 1 and 3 (SOCS-1 SOCS-1 and -3 were increased as assessed by semiquantitative RT-PCR 39 | | |
| 18464922 | SOCS-1 | SOCS-1 | 3.5 | Others have reported similar increase in SOCS-1 and -3 in response to TZDs in microglia and astrocytes | | |
| 18464922 | SOCS-1 | SOCS-1 | 3.5 | The increase in SOCS-1 and -3 is implicated with the inhibition of Janus kinase-signal | | |
| 16120782 | suppressor of cytokine signaling 1 | suppressor of cytokine signaling 1 | 1.0 | interestingly mrna levels of the suppressor of cytokine signaling 1 and 3 genes were increased by pio whereas both the mrna and protein levels of endogenous mouse sod1 and of transgenic human sod1 remained unaffected. | | |
| 16120782 | socs 1 | socs 1 | 1.0 | the primers were the following: suppressor of cytokine signaling socs 1 forward 5' agc agc tcg aaa agg cag tc 3' and reverse 5' aca ctc act tcc gca cct tc 3'; socs 3 forward 5' acc agc gcc act tct tca cg 3' and reverse 5' gtg gag cat cat act gat cc 3'; mouse sod1 forward | | |
| 16120782 | socs 1 | socs 1 | 1.0 | glyceraldehyde 3 phosphate dehydrogenase forward 5' tca cca ggg ctg cca ttt gc 3' and reverse 5' gac tcc acg aca tac tca gc 3' were used as housekeeping control for socs 1 and 3; beta actin forward 5' cac agc ttc ttt gca gct cct t 3' and reverse 5' tca gga tac ctc tct tgc tct gg 3' were used as housekeeping control for mouse and human sod1. | | |
| 16120782 | socs 1 | socs 1 | 1.0 | notably this reduction was paralleled by a marked transcriptional upregulation of anti inflammatory socs 1 and socs 3 genes fig 3 c in both pio treated groups n = 5 for all groups . | | |
| 16120782 | socs 1 | socs 1 | 1.0 | nos western blots n = 4 for all groups from spinal cord samples derived from 90 d old mice b are shown. p _lt_ 0.01 and p _lt_ 0.001 compared with the respective nontreated group. c quantification of socs 1 and socs 3 mrna levels in the spinal cord at day 90 of life n = 5 for all groups . | | |
| 16120782 | socs 1 | socs 1 | 1.0 | interestingly socs 1 and socs 3 have been reported to increase in response to tzds in microglia and astrocytes in vitro which in turn inhibit janus kinase signal transducer and activator of transcription jak stat inflamm | | |
| 16120782 | socs 1 | socs 1 | 1.0 | because the ability of socs 1 and socs 3 to suppress cytokine stimulation has also been confirmed by in vivo experiments using knock out mice shouda et al. 2001 ; suzuki et al. 2001 it seems likely that upregulation of socs 1 and | | |
| 16120782 | socs 1 | socs 1 | 1.0 | and socs 3 to suppress cytokine stimulation has also been confirmed by in vivo experiments using knock out mice shouda et al. 2001 ; suzuki et al. 2001 it seems likely that upregulation of socs 1 and socs 3 levels in response to pio treatment reflects one mechanism of the anti inflammatory effect observed and antagonizing the jak stat pathway contributes to the observed suppression of inos an | | |
| 16753239 | socs 1 | socs 1 | 1.0 | the authors further demonstrated that these agonists induce the expression of suppressor of cytokine signaling socs 1 and 3 which alters jak/stat phosphorylation and jak/stat mediated signaling. | | |
| 16753239 | suppressor of cytokine signaling 1 | suppressor of cytokine signaling 1 | 1.0 | finally these studies demonstrated reduced gliosis decreased nf _amp_#x3ba;b and increased suppressor of cytokine signaling 1 and 3 expression in pioglitazone treated animals kiaei et al. 2005 and sch_amp_#xfc;tz et al. 2005 . | | |
| 17555556 | socs 1 | socs 1 | 1.0 | socs 1 and socs 3 are critical factors down regulating the toxic effects of lps berlato et al 2002 ; nakagawa et al 2002 and may well influence the toxic effects of msod1 microglia. | | |
| 17569578 | suppressor of cytokine signaling 1 | suppressor of cytokine signaling 1 | 1.0 | interestingly mrna levels of the suppressor of cytokine signaling 1 and 3 genes were increased by pioglitazone whereas both the mrna and protein levels of endogenous mouse sod1 and of transgenic human sod1 remained unaffected [154] . | | |
| 18464922 | socs 1 | socs 1 | 1.0 | ulation of proinflammatory markers by pioglitazone were reported by sch_amp_#x000fc;tz et al. which suggests that mrna levels of two cytokine suppressor genes suppressor of cytokine signaling 1 and 3 socs 1 and 3 were increased as assessed by semiquantitative rt pcr [ 39 ]. | | |
| 18464922 | suppressor of cytokine signaling 1 | suppressor of cytokine signaling 1 | 1.0 | further evidence in the modulation of proinflammatory markers by pioglitazone were reported by sch_amp_#x000fc;tz et al. which suggests that mrna levels of two cytokine suppressor genes suppressor of cytokine signaling 1 and 3 socs 1 and 3 were increased as assessed by semiquantitative rt pcr [ 39 ]. | | |
| 18464922 | socs 1 | socs 1 | 1.0 | others have reported similar increase in socs 1 and 3 in response to tzds in microglia and astrocytes in vitro [ 40 ]. | | |
| 18464922 | socs 1 | socs 1 | 1.0 | the increase in socs 1 and 3 is implicated with the inhibition of janus kinase signal transducer and activator of transcription jak stat in inflammatory signal transduction. | | |