HUGO ID Detailed Result 11609

PMID	Match String	Actual String	Score	Flanking text	Edited by	Edit
16647138	cytochrome p450	cytochrome p450	1.0	cytochrome p450 epoxygenases epox
16647138	cytochrome p450	cytochrome p450	1.0	in addition to the cox and lox pathways the cytochrome p450 cyp450 pathways also catalyze arachidonic acid conversion to biologically active compounds by an nadph dependent oxidative reaction coon 2005 and kroetz and xu 2005 .
16647138	cytochrome p450	cytochrome p450	1.0	although the levels of various cytochrome p450 enzymes in brain are low it has been shown that these enzymes are expressed at relatively high levels in astrocytes peng et al. 2004 .
16647138	cytochrome p450	cytochrome p450	1.0	studies on astroglial cytochrome p450 expression suggest a putative capacity of these enzymes to metabolize in situ psychoactive or lipophilic xenobiotics that are associated with pharmacological and/or toxicological consequences.
16647138	cytochrome p450	cytochrome p450	1.0	astrocytes appear to be the most active steroidogenic cells in the brain expressing neurosteroidogenic cytochrome p450 and producing various neurosteroids.
16647138	cytochrome p450	cytochrome p450	1.0	brain parenchymal tissue metabolizes arachidonic acid via the cytochrome p450 epoxygenase to epoxyeicosatrienoic acids eets which can dilate cerebral arterioles and increase k + currents in cerebral arteriolar smooth muscle cells.
16647138	cytochrome p450	cytochrome p450	1.0	treatment of the donor vessels with a cytochrome p450 epoxygenase inhibitor ppoh eliminated dilator responses in both donor and detector vessels as well as hyperpolarization of detector vessels.
16647138	cytochrome p450	cytochrome p450	1.0	in this instance they presented evidence that cytochrome p450 derived epoxyeicosatrienoic acids induced the vasodilation as well as an increase in capillary density.
16647138	cytochrome p450	cytochrome p450	1.0	the cox 2 inhibitor ns 398 was ineffective as were two cytochrome p450 antagonists ms ppoh and miconazole suggesting that cox 2 and p450 metabolites do not play a significant role in vasodilation as compared to cox 1 metabolites.
16647138	cytochrome p450	cytochrome p450	1.0	in contrast to the cyclo and lipo oxygenases there is currently little evidence that the metabolites of arachidonic acid generated by cytochrome p450 epoxygenase play a significant role in the modulation of synaptic transmission in the cns.
16647138	cytochrome p450	cytochrome p450	1.0	inhibitors of phospholipase a 2 and cytochrome p450 epoxygenase blocked this capacitative ca 2+ entry from the extracellular space indicating a role for these enzymes in capacitative ca 2+ influx with the restoration of normal intracellular ca 2+ leve
16647138	cytochrome p450	cytochrome p450	1.0	they ascertained the abilities of inhibitors of pla 2 as well as inhibitors of cox lox and cytochrome p450 isozymes to reverse the depolarization.
16647138	cytochrome p450	cytochrome p450	1.0	pretreatment of slice preparations with the pla 2 inhibitor 4 bromophenylacyl bromide pbpb or the cytochrome p450 inhibitor 17 octadecynoic acid 17 oda significantly restored the membrane potential to pre exposure levels after the reintroduction of oxygen and glucose.
16647138	cytochrome p450	cytochrome p450	1.0	iments was that activation of the arachidonic acid cascade via pla 2 and free radical production by arachidonic acid metabolism contribute to the irreversible depolarization by in vitro ischemia with cytochrome p450 isozymes making a major contribution.
16647138	cytochrome p450	cytochrome p450	1.0	eets are the only cytochrome p450 metabolites of arachidonic acid produced by endothelial cells.
16647138	cytochrome p450	cytochrome p450	1.0	however it is reported that g protein coupled metabotropic glutamate receptors are functionally linked to plc and cytochrome p450 arachidonate epoxygenase activity gebremedhin et al. 2003 indicating that excitotoxicity may also involve epox activity.
18513389	cytochrome p450	cytochrome p450	1.0	among the genetic factors that may predispose to sporadic als neurofilaments apolipoprotein epsilon 4 genotype excitotoxicity genes ciliary neurotrophic factor ctnf cytochrome p450 debrisoquine hydroxylase cyp2d6 apurinic apyrimidinic endonuclease apex mitochondrial manganese superoxide dismutase sod2 monoamine oxidase allele b and paraoxonases have been reported in different s