HUGO ID Detailed Result 9801

PMID	Match String	Actual String	Score	Flanking text	Edited by	Edit
18219386	RAC1	Rac1	1.0	lines directly stimulate NADPH oxidase (Nox) Nox by binding to Rac1 resulting in overproduction of damaging ROS (see see the related
18219386	RAC1	Rac1	1.0	Nox2 during inflammation is amplified by mutant SOD1 binding to Rac1 in ALS
18219386	RAC1	Rac1	1.0	by microglial cells through SOD1 binding to the Nox activator Rac1 thereby influencing the non_amp_#x02013 cell autonomous killing of motor neurons
18219386	RAC1	Rac1	1.0	Using an approach involving immunoprecipitation of Rac1 from different mouse tissues Harraz and colleagues proposed that SOD1
18219386	RAC1	Rac1	1.0	tissues Harraz and colleagues proposed that SOD1 interacts directly with Rac1 but not with the other Nox2 cytosolic regulators ( 20
18219386	RAC1	Rac1	1.0	for SOD1-interacting proteins including yeast 2-hybrid approaches did not identify Rac1
18219386	RAC1	Rac1	1.0	of SOD1 was important for this interaction of SOD1 with Rac1
18219386	RAC1	Rac1	1.0	Only the metalated (native) native form of SOD1 bound to Rac1 while the demetalated (enzymatically enzymatically inactive SOD1 did not
18219386	RAC1	Rac1	1.0	In addition the binding of SOD1 to Rac1 was redox sensitive and could be cycled between bound and
18219386	RAC1	Rac1	1.0	bound and unbound states depending on the redox state of Rac1
18219386	RAC1	Rac1	1.0	Under reducing conditions SOD1 efficiently bound Rac1-GTP the form of Rac1 that is recruited to Nox2 upon activation
18219386	RAC1	Rac1	1.0	inhibited the intrinsic and/or and or GAP-facilitated GTPase activity of Rac1 (Figure Figure 1
18219386	RAC1	Rac1	1.0	activity independently of their metalated state could mutant SOD1_amp_#x02013 enhanced Rac1 activation and Nox-dependent O 2 _amp_#x02022 _amp_#x02013 production be a
18219386	RAC1	Rac1	1.0	With this new finding that interaction of metalated SOD1 with Rac1 serves to activate Nox2 and that mutant forms of SOD1