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| 12909279 | PrP | PrP | 1.1 | from copper bound to peptide A_amp_#x3b2 and to the protein PrP respectively has been provided 11 and 47 | |  |
| 12909279 | PrP | PrP | 1.1 | would not be surprising to learn that copper-bound A_amp_#x3b2 and PrP are also able to induce the formation of the noxious | | |
| 14648077 | PRX2 | Prx2 | 3.9 | 1 (SOD1) SOD1 and a redox system including peroxiredoxin2 (Prx2, Prx2 thioredoxin peroxidase and glutathione peroxidase1 (GPx1): GPx1 SOD1 converts superoxide | | |
| 14648077 | PRX2 | Prx2 | 3.9 | (H H 2 O and oxygen (O O 2 by Prx2 and GPx1 that directly regulate the redox system | | |
| 14648077 | PRX2 | Prx2 | 3.9 | biological significance of the interaction of the redox system (Prx2/GPx1) Prx2 GPx1 with SOD1 in SOD1-mutated motor neurons in vivo we | | |
| 14648077 | PRX2 | Prx2 | 3.9 | neurons in vivo we produced an affinity-purified rabbit antibody against Prx2 and investigated the immunohistochemical localization of Prx2 and GPx1 in | | |
| 14648077 | PRX2 | Prx2 | 3.9 | rabbit antibody against Prx2 and investigated the immunohistochemical localization of Prx2 and GPx1 in neuronal Lewy body-like hyaline inclusions (LBHIs) LBHIs | | |
| 14648077 | PRX2 | Prx2 | 3.9 | SOD1-mutated FALS patients and transgenic rats showed identical immunoreactivities for Prx2 and GPx1 the reaction product deposits with the antibodies against | | |
| 14648077 | PRX2 | Prx2 | 3.9 | and GPx1 the reaction product deposits with the antibodies against Prx2 and GPx1 were localized in the LBHIs | | |
| 14648077 | PRX2 | Prx2 | 3.9 | addition the localizations of the immunoreactivities for SOD1 and Prx2/GPx1 Prx2 GPx1 were similar in the inclusions the co-aggregation of Prx2/GPx1 | | |
| 14648077 | PRX2 | Prx2 | 3.9 | GPx1 were similar in the inclusions the co-aggregation of Prx2/GPx1 Prx2 GPx1 with SOD1 in neuronal LBHIs in mutant SOD1-related FALS | | |
| 14648077 | PRX2 | Prx2 | 3.9 | Based on the fact that Prx2/GPx1 Prx2 GPx1 directly regulates the redox system such co-aggregation of Prx2/GPx1 | | |
| 14648077 | PRX2 | Prx2 | 3.9 | GPx1 directly regulates the redox system such co-aggregation of Prx2/GPx1 Prx2 GPx1 with SOD1 in neuronal LBHIs may lead to the | | |
| 14648077 | PRX2 | Prx2 | 3.9 | Peroxiredoxin2 (Prx2) Prx2 is a novel organ-specific antioxidative enzyme that is mainly expressed | | |
| 14648077 | PRX2 | Prx2 | 3.9 | Prx2 requires thioredoxin reductase (TR) TR as a secondary enzyme as | | |
| 14648077 | PRX2 | Prx2 | 3.9 | as cofactors to function at high efficiency the activity of Prx2 in the thioredoxin/TR/NADPH thioredoxin TR NADPH system is over five | | |
| 14648077 | PRX2 | Prx2 | 3.9 | NADPH system is over five times higher than that of Prx2 by itself 5 | | |
| 14648077 | PRX2 | Prx2 | 3.9 | In this milieu Prx2 is also called thioredoxin peroxidase 1 (thioredoxin-dependent thioredoxin-dependent peroxide reductase | | |
| 14648077 | PRX2 | Prx2 | 3.9 | to controlling the intracellular content of H 2 O 2 Prx2 directly regulates the redox signals of the thioredoxin/TR/NADPH thioredoxin TR | | |
| 14648077 | PRX2 | Prx2 | 3.9 | Like Prx2 GPx1 needs glutathione reductase (GR) GR as a secondary enzyme | | |
| 14648077 | PRX2 | Prx2 | 3.9 | Therefore Prx2 and GPx1 directly control the redox system | | |
| 14648077 | PRX2 | Prx2 | 3.9 | motor neurons induce mutant and wild-type SOD1 as well as Prx2 and GPx1 | | |
| 14648077 | PRX2 | Prx2 | 3.9 | Considering that Prx2 and GPx1 interact not only with wild-type SOD1 but also | | |
| 14648077 | PRX2 | Prx2 | 3.9 | SOD1 but also with mutant SOD1 the interaction of Prx2/GPx1 Prx2 GPx1 with SOD1 has been suggested to contribute to mutant | | |
| 14648077 | PRX2 | Prx2 | 3.9 | been suggested to contribute to mutant SOD1 aggregation toxicity Prx2/GPx1 Prx2 GPx1 possibly aggregate as LBHIs in SOD1-mutated motor neurons | | |
| 14648077 | PRX2 | Prx2 | 3.9 | Furthermore the aggregation of Prx2/GPx1 Prx2 GPx1 might affect the intracytoplasmic redox regulation and amplify mutant | | |
| 14648077 | PRX2 | Prx2 | 3.9 | To clarify the biological significance of the interaction of Prx2/GPx1 Prx2 GPx1 (redox redox system with SOD1 in SOD1-mutated motor neurons | | |
| 14648077 | PRX2 | Prx2 | 3.9 | motor neurons in vivo we first produced an antibody against Prx2 and analyzed the characteristic expressions of both Prx2 and GPx1 | | |
| 14648077 | PRX2 | Prx2 | 3.9 | antibody against Prx2 and analyzed the characteristic expressions of both Prx2 and GPx1 in neuronal LBHIs in SOD1-mutated motor neurons of | | |
| 14648077 | PRX2 | Prx2 | 3.9 | Preparation of polyclonal antibody against Prx2 A synthetic peptide corresponding to the C-terminal region of Prx2 | | |
| 14648077 | PRX2 | Prx2 | 3.9 | Prx2 A synthetic peptide corresponding to the C-terminal region of Prx2 (amino amino acids 184_amp_#x2013 198 NH 2 -KPNVDDSKEYFSKHN-COOH with or | | |
| 14648077 | PRX2 | Prx2 | 3.9 | of the C-terminal region of the human rat or mouse Prx2 | | |
| 14648077 | PRX2 | Prx2 | 3.9 | To prepare immunogen 6 mg synthesized Prx2 peptide was conjugated with 6 mg keyhole limpet hemocyanin (KLH) | | |
| 14648077 | PRX2 | Prx2 | 3.9 | an affinity column of immobilized KLH conjugated with the synthetic Prx2 peptide as described previously 16 | | |
| 14648077 | PRX2 | Prx2 | 3.9 | Fig 1 Specificity of antibody against Prx2 | | |
| 14648077 | PRX2 | Prx2 | 3.9 | The immunoreactivity of the antibody to HSA-conjugated Prx2 peptide ( solid circles and native HSA ( open circles | | |
| 14648077 | PRX2 | Prx2 | 3.9 | The anti-Prx2 antibody recognizes the HSA-conjugated Prx2 peptide but does not react with HAS ( Prx2 peroxiredoxin2 | | |
| 14648077 | PRX2 | Prx2 | 3.9 | HSA-conjugated Prx2 peptide but does not react with HAS ( Prx2 peroxiredoxin2 ELISA enzyme-linked immunosorbent assay HAS human serum albumin | | |
| 14648077 | PRX2 | Prx2 | 3.9 | following primary antibodies were utilized an affinity-purified rabbit antibody against Prx2 (concentration: concentration 1 _amp_micro;g/ml), _amp_micro g ml a polyclonal antibody | | |
| 14648077 | PRX2 | Prx2 | 3.9 | had been preabsorbed with an excess amount of the synthetic Prx2 peptide | | |
| 14648077 | PRX2 | Prx2 | 3.9 | Results We successfully produced an affinity-purified rabbit antibody against Prx2 peptide (amino amino acids 184_amp_#x2013 198 although this amino acid | | |
| 14648077 | PRX2 | Prx2 | 3.9 | of the human rat mouse Chinese hamster or Bos Taurus Prx2 this peptide does not share homology with other members of | | |
| 14648077 | PRX2 | Prx2 | 3.9 | This anti-Prx2 antibody recognized the HSA-conjugated Prx2 peptide but did not react with HSA (Fig Fig 1 | | |
| 14648077 | PRX2 | Prx2 | 3.9 | Prx2 immunoreactivity in normal spinal cords was identified in almost all | | |
| 14648077 | PRX2 | Prx2-immunostaining | 3.3 | In addition Prx2-immunostaining was found throughout the neuropil with considerably lower intensity (Fig | | |
| 14648077 | PRX2 | Prx2 | 3.9 | With respect to the intracellular localization of Prx2 immunostaining of the neuronal cytoplasm and proximal dendrites was specifically | | |
| 14648077 | PRX2 | Prx2 | 3.9 | that had been pretreated with an excess of the synthetic Prx2 produced no staining (Fig Fig 3 D | | |
| 14648077 | PRX2 | Prx2 | 3.9 | B C Immunostaining for GPx1 ( B and Prx2 ( C | | |
| 14648077 | PRX2 | Prx2 | 3.9 | GPx1 and Prx2 immunoreactivities are found diffusely in the neuropil with considerably less | | |
| 14648077 | PRX2 | Prx2 | 3.9 | No counterstaining ( HE hematoxylin and eosin GPx1 glutathione peroxidase1 Prx2 peroxiredoxin2 | | |
| 14648077 | PRX2 | Prx2 | 3.9 | Fig 3 Detection of Prx2 and GPx1 in the normal motor neurons of the human | | |
| 14648077 | PRX2 | Prx2 | 3.9 | C Immunostaining with the antibody to Prx2 | | |
| 14648077 | PRX2 | Prx2 | 3.9 | in the spinal cord co-express both GPx1 ( B and Prx2 ( C although their staining intensities in neurons vary | | |
| 14648077 | PRX2 | Prx2 | 3.9 | with anti-Prx2 antibody pretreated with an excess of the synthetic Prx2 peptide | | |
| 14648077 | PRX2 | Prx2 | 3.9 | F Prx2 immunostaining of the neuronal cytoplasm and proximal dendrites is observed | | |
| 14648077 | PRX2 | Prx2 | 3.9 | No counterstaining ( HE hematoxylin and eosin GPx1 glutathione peroxidase1 Prx2 peroxiredoxin2 | | |
| 14648077 | PRX2 | Prx2 | 3.9 | _amp_micro m A neuropil staining pattern similar to that for Prx2 was observed with GPx1 weak GPx1 immunoreactivity was diffusely seen | | |
| 14648077 | PRX2 | Prx2 | 3.9 | The stainability and intensity of Prx2 and GPx1 in the normal anterior horn cells of the | | |
| 14648077 | PRX2 | Prx2 | 3.9 | the normal motor neurons in the spinal cords co-expressed both Prx2 and GPx1 (Fig Fig 3 A_amp_#x2013 C although the staining | | |
| 14648077 | PRX2 | Prx2 | 3.9 | Most neuronal LBHIs were also immunoreactive for Prx2 although the intensity of Prx2 immunoreactivity in the LBHIs varied | | |
| 14648077 | PRX2 | Prx2 | 3.9 | LBHIs were also immunoreactive for Prx2 although the intensity of Prx2 immunoreactivity in the LBHIs varied (Figs Figs 4 C F | | |
| 14648077 | PRX2 | Prx2 | 3.9 | rats (H46R H46R and G93A showed a similar immunoreactivity for Prx2 | | |
| 14648077 | PRX2 | Prx2 | 3.9 | The Prx2 immunolocalization in many intracytoplasmic and intraneuritic LBHIs was similar to | | |
| 14648077 | PRX2 | Prx2 | 3.9 | halo-type LBHIs the reaction product deposits of the antibody against Prx2 were generally restricted to the periphery (Fig Fig 4 C | | |
| 14648077 | PRX2 | Prx2 | 3.9 | In ill-defined LBHIs Prx2 immunostaining was distributed throughout each inclusion | | |
| 14648077 | PRX2 | Prx2 | 3.9 | In some inclusions however expression of Prx2 was observed in only part of the inclusion (Fig Fig | | |
| 14648077 | PRX2 | Prx2 | 3.9 | immunostaining in the neuronal LBHIs similar stainability and immunolocalization to Prx2 were confirmed in the core and halo types as well | | |
| 14648077 | PRX2 | Prx2 | 3.9 | Like Prx2 the immunolocalization of GPx1 was similar to that of SOD1 | | |
| 14648077 | PRX2 | Prx2 | 3.9 | C Immunoreactivity for Prx2 | | |
| 14648077 | PRX2 | Prx2 | 3.9 | Co-localization of the three proteins SOD1 GPx1 and Prx2 in the LBHI is evident | | |
| 14648077 | PRX2 | Prx2 | 3.9 | Immunostaining for SOD1 ( D GPx1 ( E and Prx2 ( F | | |
| 14648077 | PRX2 | Prx2 | 3.9 | Similar stainability and immunolocalization of SOD1 GPx1 and Prx2 in the LBHI are observed ( LBHI Lewy body-like hyaline | | |
| 14648077 | PRX2 | Prx2 | 3.9 | amyotrophic lateral sclerosis SOD1 superoxide dismutase 1 GPx1 glutathione peroxidase1 Prx2 peroxiredoxin2 | | |
| 14648077 | PRX2 | Prx2 | 3.9 | Immunostaining for SOD1 ( A GPx1 ( B and Prx2 ( C | | |
| 14648077 | PRX2 | Prx2 | 3.9 | Immunostaining for SOD1 ( D GPx1 ( E and Prx2 ( F | | |
| 14648077 | PRX2 | Prx2 | 3.9 | Immunostaining GPx1 ( E and Prx2 ( F are observed in only part of the SOD1-positive | | |
| 14648077 | PRX2 | Prx2 | 3.9 | amyotrophic lateral sclerosis SOD1 superoxide dismutase 1 GPx1 glutathione peroxidase1 Prx2 peroxiredoxin2 | | |
| 14648077 | PRX2 | Prx2 | 3.9 | H46R mutation immunostained with antibodies against SOD1 ( A and Prx2 ( B | | |
| 14648077 | PRX2 | Prx2 | 3.9 | LBHIs in the neuropil are positive for both SOD1 and Prx2 ( arrows ( SOD1 superoxide dismutase1 LBHI Lewy body-like hyaline | | |
| 14648077 | PRX2 | Prx2 | 3.9 | arrows ( SOD1 superoxide dismutase1 LBHI Lewy body-like hyaline inclusion Prx2 peroxiredoxin2 | | |
| 14648077 | PRX2 | Prx2 | 3.9 | _amp_micro m Noticeably the co-localization of the three proteins SOD1 Prx2 and GPx1 in neuronal LBHIs in SOD1-mutated FALS patients and | | |
| 14648077 | PRX2 | Prx2 | 3.9 | LBHIs the precise intra-inclusional immunolocalizations of the three proteins differed Prx2 (Fig Fig 5 D F and GPx1 (Fig Fig 5 | | |
| 14648077 | PRX2 | Prx2 | 3.9 | Discussion Under normal physiological conditions Prx2 and GPx1 immunoreactivities in the spinal cord anterior horns in | | |
| 14648077 | PRX2 | Prx2 | 3.9 | 33 intranuclear localization in some neurons is also observed in Prx2 immunostaining | | |
| 14648077 | PRX2 | Prx2 | 3.9 | Considering that endogenous Prx2 and GPx1 within the neuronal cytoplasm are extremely effective regulators | | |
| 14648077 | PRX2 | Prx2 | 3.9 | almost all of the normal spinal motor neurons co-expressed both Prx2 and GPx1 confirms that these motor neurons maintain themselves using | | |
| 14648077 | PRX2 | Prx2 | 3.9 | that these motor neurons maintain themselves using the intracellular Prx2/GPx1 Prx2 GPx1 system that is the redox system | | |
| 14648077 | PRX2 | Prx2 | 3.9 | Intense co-expression of SOD1 Prx2 and GPx1 in neuronal LBHIs in both diseases was evident | | |
| 14648077 | PRX2 | Prx2 | 3.9 | mutant/wild-type mutant wild-type SOD1 as an antioxidant system and Prx2/GPx1 Prx2 GPx1 as a redox system | | |
| 14648077 | PRX2 | Prx2 | 3.9 | In this in vivo milieu where mutant SOD1 exists Prx2 and GPx1 would aberrantly interact with the mutant SOD1 which | | |
| 14648077 | PRX2 | Prx2 | 3.9 | the facts that there are neuronal LBHIs positive for SOD1 Prx2 and GPx1 in the milieu where mutant SOD1 exists but | | |
| 14648077 | PRX2 | Prx2 | 3.9 | physiological conditions our study demonstrates an aberrant interaction of Prx2/GPx1 Prx2 GPx1 with mutant SOD1 the aggregation of which results in | | |
| 14648077 | PRX2 | Prx2 | 3.9 | In addition intra-inclusional co-aggregation of Prx2/GPx1 Prx2 GPx1 with mutant SOD1 causes the intracytoplasmic reduction of Prx2/GPx1, | | |
| 14648077 | PRX2 | Prx2 | 3.9 | GPx1 with mutant SOD1 causes the intracytoplasmic reduction of Prx2/GPx1, Prx2 GPx1 thereby reducing the availability of the redox system | | |
| 14648077 | PRX2 | Prx2 | 3.9 | with the aberrant interaction of cytotoxic mutant SOD1 with Prx2/GPx1 Prx2 GPx1 directly regulating a redox system our finding leads us | | |
| 14648077 | PRX2 | Prx2 | 3.9 | leads us to speculate that not only co-aggregation of Prx2/GPx1 Prx2 GPx1 and SOD1 into LBHIs but also intracytoplasmic reduction of | | |
| 14648077 | PRX2 | Prx2 | 3.9 | and SOD1 into LBHIs but also intracytoplasmic reduction of Prx2/GPx1 Prx2 GPx1 in both diseases may partly contribute to the breakdown | | |
| 14648077 | PRX2 | Prx2 | 3.9 | remains to be determined whether this aberrant interaction of Prx2/GPx1 Prx2 GPx1 with mutant SOD1 is a direct or an indirect | | |
| 14648077 | PRX2 | Prx2 | 3.9 | on the pathogenesis of SOD1-mutated FALS disease itself or whether Prx2 and GPx1 play a primary or a secondary role to | | |
| 14648077 | PRX2 | Prx2 | 3.9 | to emphasize that the aberrant interaction and co-aggregation of Prx2/GPx1 Prx2 GPx1 and SOD1 (probably probably Prx2/GPx1 Prx2 GPx1 and mutant | | |
| 14648077 | PRX2 | Prx2 | 3.9 | co-aggregation of Prx2/GPx1 Prx2 GPx1 and SOD1 (probably probably Prx2/GPx1 Prx2 GPx1 and mutant SOD1 in FALS patients with SOD1 gene | | |
| 14648077 | peroxiredoxin 2 | peroxiredoxin2 | 1.0 | to protect themselves from these ross the cells have developed both an antioxidant system containing superoxide dismutase 1 sod1 and a redox system including peroxiredoxin2 prx2 thioredoxin peroxidase and glutathione peroxidase1 gpx1 : sod1 converts superoxide radicals into hydrogen peroxide h 2 o 2 and h 2 o 2 is then converted into harmless water h 2 o and oxygen o 2 | | |
| 14648077 | peroxiredoxin 2 | peroxiredoxin 2 | 1.0 | keywords peroxiredoxin 2 glutathione peroxidase 1 redox system superoxide dismutase 1 familial amyotrophic lateral sclerosis | | |
| 14648077 | peroxiredoxin 2 | peroxiredoxin2 | 1.0 | peroxiredoxin2 prx2 is a novel organ specific antioxidative enzyme that is mainly expressed in mammalian brain [ 23 ]. | | |
| 14648077 | thioredoxin-dependent peroxide reductase 1 | thioredoxin dependent peroxide reductase 1 | 1.0 | in this milieu prx2 is also called thioredoxin peroxidase 1 thioredoxin dependent peroxide reductase 1 or thiol specific antioxidant [ 4 5 6 ]. | | |
| 14648077 | thioredoxin peroxidase 1 | thioredoxin peroxidase 1 | 1.0 | in this milieu prx2 is also called thioredoxin peroxidase 1 thioredoxin dependent peroxide reductase 1 or thiol specific antioxidant [ 4 5 6 ]. | | |
| 14648077 | peroxiredoxin 2 | peroxiredoxin2 | 1.0 | the anti prx2 antibody recognizes the hsa conjugated prx2 peptide but does not react with has prx2 peroxiredoxin2 elisa enzyme linked immunosorbent assay has human serum albumin | | |
| 14648077 | peroxiredoxin 2 | peroxiredoxin2 | 1.0 | no counterstaining he hematoxylin and eosin gpx1 glutathione peroxidase1 prx2 peroxiredoxin2 . | | |
| 14648077 | peroxiredoxin 2 | peroxiredoxin2 | 1.0 | b _amp_#x2013; f no counterstaining he hematoxylin and eosin gpx1 glutathione peroxidase1 prx2 peroxiredoxin2 . | | |
| 14648077 | peroxiredoxin 2 | peroxiredoxin2 | 1.0 | lization of sod1 gpx1 and prx2 in the lbhi are observed lbhi lewy body like hyaline inclusion fals familial amyotrophic lateral sclerosis sod1 superoxide dismutase 1 gpx1 glutathione peroxidase1 prx2 peroxiredoxin2 . | | |
| 14648077 | peroxiredoxin 2 | peroxiredoxin2 | 1.0 | hese three proteins differ from each other in this lbhi lbhi lewy body like hyaline inclusion fals familial amyotrophic lateral sclerosis sod1 superoxide dismutase 1 gpx1 glutathione peroxidase1 prx2 peroxiredoxin2 . | | |
| 14648077 | peroxiredoxin 2 | peroxiredoxin2 | 1.0 | round and sausage like lbhis in the neuropil are positive for both sod1 and prx2 arrows sod1 superoxide dismutase1 lbhi lewy body like hyaline inclusion prx2 peroxiredoxin2 . | | |