HUGO ID Detailed Result 587

PMID	Match String	Actual String	Score	Flanking text	Edited by	Edit
9172131	APE	APE	3.9	of the pivotal BER protein apurinic/apyrimidinic apurinic apyrimidinic endonuclease (APE) APE were determined in 11 patients with sporadic ALS and six
9172131	APE	APE	3.9	APE levels ( p _amp_#60 0.003 and activity ( p _amp_#60
9172131	APE	APE	3.9	abasic site is repaired by apurinic/apyrimidinic apurinic apyrimidinic endonuclease (APE) APE
9172131	APE	APE	3.9	APE the pivotal step in BER is found in both the
9172131	APE	APE	3.9	mitochondria (~65 ~65 kDa 10 A reduction or loss of APE would be extremely detrimental to a neuron and could conceivably
9172131	APE	APE	3.9	APE is a bifunctional protein with separate domains for DNA repair
9172131	APE	APE	3.9	Therefore APE possesses multiple cellular functions and its deficiency could have profound
9172131	APE	APE	3.9	In fact lack of the APE gene is lethal to embryonic mutant mice (gestational gestational day
9172131	APE	APE	3.9	The present study aimed to determine whether the BER protein APE is deficient in the brains of ALS subjects
9172131	APE	APE	3.9	APE levels were determined in human brain tissue extracts and compared
9172131	APE	APE	3.9	of HeLa cells (positive positive control and with recombinant human APE (a a hist_amp_#237 dine-tagged full-length human protein provided by Dr
9172131	APE	APE	3.9	APE activity was determined in human brain tissue extracts by measuring
9172131	APE	APE	3.9	APE levels and activity (ability ability to repair apurinic sites in
9172131	APE	APE	3.9	There was no significant correlation between post mortem interval and APE levels in control ( r _amp_#61 _amp_#45 0.5 or ALS
9172131	APE	APE	3.9	Cortical APE levels were reduced by 3-4_amp_#215 3 ( p _amp_#60 0.003
9172131	APE	APE	3.9	In contrast to APE levels cortical MPG levels in ALS subjects were not significantly
9172131	APE	APE	3.9	Like APE levels APE activity was significantly lower ( p _amp_#60 0.000007
9172131	APE	APE	3.9	Like APE levels APE activity was significantly lower ( p _amp_#60 0.000007 in ALS
9172131	APE	APE	3.9	MPG 20 21 and the resulting apurinic site repaired by APE 8-Oxodeoxyguanosine levels are elevated in ALS spinal cord tissue 6
9172131	APE	APE	3.9	from the present studies indicate that the pivotal BER protein APE is severely deficient in ALS brain tissue
9172131	APE	APE	3.9	MPG in ALS brain tissue suggests a selective abnormality in APE
9172131	APE	APE	3.9	Interestingly APE activity has also been examined in lymphocytes from patients with
9172131	APE	APE	3.9	a double-stranded oligonucleotide probe containing a single AP site 22 APE activity was shown to be similarly reduced in lymphocytes of
9172131	APE	APE	3.9	A similar reduction of APE in both ALS brain and lymphocyte tissue 22 suggests that
9172131	APE	APE	3.9	deficit is systemic and possibly due to an abnormality in APE regulation or a gene mutation
9172131	APE	APE	3.9	Detection of several missense APE gene mutations 22 in lymphocyte DNA from patients with sporadic
9172131	apurinic/apyrimidinic endonuclease	apurinic/apyrimidinic endonuclease	1.0	frontal cortical levels and activity of the pivotal ber protein apurinic/apyrimidinic endonuclease ape were determined in 11 patients with sporadic als and six age matched control subjects.
9172131	apurinic/apyrimidinic endonuclease	apurinic/apyrimidinic endonuclease	1.0	frontal cortical levels and activity of the pivotal ber protein apurinic/apyrimidinic endonuclease ape were determined in 11 patients with sporadic als and six age matched control subjects.
9172131	apurinic/apyrimidinic endonuclease	apurinic/apyrimidinic endonuclease	1.0	inant pathway for repair of oxidative dna damage. 9 the damaged base is removed by a glycosylase e.g formamidopyrimidine or n methylpurine dna glycosylase and the resulting abasic site is repaired by apurinic/apyrimidinic endonuclease ape .
9172131	apurinic/apyrimidinic endonuclease	apurinic/apyrimidinic endonuclease	1.0	inant pathway for repair of oxidative dna damage. 9 the damaged base is removed by a glycosylase e.g formamidopyrimidine or n methylpurine dna glycosylase and the resulting abasic site is repaired by apurinic/apyrimidinic endonuclease ape .
9172131	ape 1	ape 1	1.0	membranes were immunoprobed by incubating blots with blocking solution containing anti ape 1:2000 for 1 h at room temperature.