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| 11679167 | HSP | HSP | 0.9 | the Hsf1p increase the expression of heat shock proteins (HSP) HSP and chaperones Yap1p and Skn7p upregulate antioxidant genes | |  |
| 15896810 | HSP | HSP | 3.4 | In the central nervous system heat shock protein (HSP) HSP synthesis is induced not only after hyperthermia but also following | | |
| 15896810 | HSP | HSPs | 3.7 | Among the various HSPs HSP32 also known as heme oxygenase I (HO-1), HO-1 has | | |
| 15896810 | HSP | HSP | 3.4 | the central nervous system (CNS), CNS heat shock protein (HSP) HSP synthesis is induced not only after hyperthermia but also following | | |
| 15896810 | HSP | HSP | 3.4 | is harmful and can lead to cell death induction of HSP synthesis can result in stress tolerance and cytoprotection in a | | |
| 15896810 | HSP | HSP | 3.4 | In mammalian cells HSP synthesis is induced not only after hyperthermia but also following | | |
| 15896810 | HSP | HSP | 3.4 | is harmful and can lead to cell death induction of HSP synthesis can result in stress tolerance and cytoprotection against stress-induced | | |
| 15896810 | HSP | HSPs | 3.7 | Some of the known HSPs include ubiquitin HSP10 HSP27 HSP32 (or or HO-1 HSP47 HSP60 | | |
| 15896810 | HSP70 | HSP70 | 5.5 | ubiquitin HSP10 HSP27 HSP32 (or or HO-1 HSP47 HSP60 HSC70 HSP70 (or or HSP72 HSP90 and HSP100/105 HSP100 105 | | |
| 15896810 | HSP72 | HSP72 | 3.4 | HSP32 (or or HO-1 HSP47 HSP60 HSC70 HSP70 (or or HSP72 HSP90 and HSP100/105 HSP100 105 | | |
| 15896810 | HSP70 | HSP70 | 5.5 | HSP70 | | |
| 15896810 | HSP70 | HSP70 | 5.5 | family are HSC70 (heat heat shock cognate the constitutive form HSP70 (the the inducible form also referred to as HSP72 GRP75 | | |
| 15896810 | HSP72 | HSP72 | 3.4 | form HSP70 (the the inducible form also referred to as HSP72 GRP75 (a a constitutively expressed glucose-regulated protein found in the | | |
| 15896810 | HSP70 | HSP70 | 5.5 | After a variety of central nervous system (CNS) CNS insults HSP70 is synthesized at high levels and is present in the | | |
| 15896810 | HSP | HSPs | 3.7 | shock factors (HSFs) HSFs within the cytosol by dissociating other HSPs that are normally bound to HSF 132 | | |
| 15896810 | HSP | HSPs | 3.7 | different heat shock genes leading to transcription and synthesis of HSPs | | |
| 15896810 | HSP70 | HSP70 | 5.5 | After heat shock for instance the synthesis of HSP70 increases to a point to where it becomes the most | | |
| 15896810 | HSP70 | HSP70 | 5.5 | Once synthesized HSP70 binds to denaturated proteins in an ATP-dependent manner | | |
| 15896810 | HSP | HSPs | 3.7 | In the nervous system HSPs are induced in a variety of pathological conditions including cerebral | | |
| 15896810 | HSP | HSPs | 3.7 | Expression of the gene encoding HSPs has been found in various cell populations within the nervous | | |
| 15896810 | HSP | HSPs | 3.7 | HSPs consist of both stress-inducible and constitutive family members | | |
| 15896810 | HSP70 | HSP70 | 5.5 | gene transfer has become possible to overexpress the gene encoding HSP70 to test directly the hypothesis that stress proteins protects cells | | |
| 15896810 | HSP70 | HSP70 | 5.5 | from injury and it has been demonstrated that overproduction of HSP70 leads to protection in several different models of nervous system | | |
| 15896810 | HSP70 | HSP70 | 5.5 | Following focal cerebral ischemia mRNA encoding HSP70 is synthesized in most ischemic cells except in areas of | | |
| 15896810 | HSP70 | HSP70 | 5.5 | HSP70 proteins is produced mainly in endothelial cells in the core | | |
| 15896810 | HSP70 | HSP70 | 5.5 | It has been suggested that this neuronal expression of HSP70 outside an infarct can be used to define the ischemic | | |
| 15896810 | HSP | HSP | 3.4 | of in vitro studies show that both heat shock and HSP overproduction protect CNS cells against both necrosis and apoptosis | | |
| 15896810 | HSP70 | HSP70 | 5.5 | Transfection of cultured astrocytes with HSP70 protects them from ischemia or glucose deprivation 140 | | |
| 15896810 | HSP70 | HSP70 | 5.5 | HSP70 has been demonstrated to inhibit caspase-3 activation caused by ceramide | | |
| 15896810 | HSP70 | HSP70 | 5.5 | In addition HSP70 binds to and modulates the function of BAG-1 the bcl-2 | | |
| 15896810 | HSP | HSP | 3.4 | between mechanisms of oxidative and/or and or nitrosative stress and HSP induction 143 | | |
| 15896810 | HSP70 | Hsp70 | 5.5 | cytokine-induced nitrosative stress is associated with an increased synthesis of Hsp70 stress proteins | | |
| 15896810 | HSP70 | Hsp70 | 5.5 | Increase in Hsp70 protein expression was also found after treatment of cells with | | |
| 15896810 | hsp70 | hsp70 | 5.5 | (SNP), SNP thus suggesting a role for NO in inducing hsp70 proteins | | |
| 15896810 | HSP | HSPs | 3.7 | Ubiquitin is one of the smallest HSPs and is expressed throughout brain in response to ischemia | | |
| 16043017 | HSP | HSPs | 1.2 | HSPs are cellular constituents synthesized by living organisms under stress conditions | | |
| 16043017 | HSP | HSPs | 1.2 | to stabilize other proteins under stress conditions whereas the high-molecular-weight HSPs normally play roles in protein folding during biosynthesis 83 and | | |
| 17191135 | HSP | Hsp | 1.9 | Hsp response is also involved in cellular homeostasis during various physiological | | |
| 17191135 | HSP70 | Hsp70 | 3.5 | evidence that different NO-releasing agents can markedly increase HO-1 and Hsp70 in a variety of tissues including brain cells 19 20 | | |
| 17191135 | HSP70 | Hsp70 | 3.5 | both iNOS expression and nitrite levels followed by enhancement of Hsp70 3 20 whereas the modulation of HO-1 mRNA expression by | | |
| 17191135 | HSP70 | Hsp70 | 3.5 | by triggering expression of cytoprotective genes such as HO-1 and Hsp70 may lead to adaptation and resistance of brain cells to | | |
| 17191135 | HSP70 | Hsp70 | 3.5 | ubiquitin Hsp10 Hsp27 Hsp32 (or or HO-1 Hsp47 Hsp60 Hsc70 Hsp70 (or or Hsp72 Hsp90 and Hsp100/105 Hsp100 105 | | |
| 17191135 | HSP72 | Hsp72 | 2.9 | Hsp32 (or or HO-1 Hsp47 Hsp60 Hsc70 Hsp70 (or or Hsp72 Hsp90 and Hsp100/105 Hsp100 105 | | |
| 17191135 | HSP70 | Hsp70 | 3.5 | family are Hsc70 (heat heat shock cognate the constitutive form Hsp70 (the the inducible form also referred to as Hsp72 GRP75 | | |
| 17191135 | HSP72 | Hsp72 | 2.9 | form Hsp70 (the the inducible form also referred to as Hsp72 GRP75 (a a constitutively expressed glucose-regulated protein found in the | | |
| 17191135 | HSP70 | Hsp70 | 3.5 | After a variety of central nervous system (CNS) CNS insults Hsp70 is synthesized at high levels and is present in cytosol | | |
| 17191135 | HSP70 | Hsp70 | 3.5 | After heat shock synthesis of Hsp70 may increase to become the most abundant protein in the | | |
| 17191135 | HSP70 | Hsp70 | 3.5 | Once synthesized Hsp70 binds to denaturated proteins in an ATP-dependent manner | | |
| 17191135 | HSP70 | Hsp70 | 3.5 | cytokine-induced nitrosative stress is associated with an increased synthesis of Hsp70 | | |
| 17191135 | HSP70 | Hsp70 | 3.5 | Increase in Hsp70 protein expression was also found after treatment of cells with | | |
| 17191135 | HSP70 | Hsp70 | 3.5 | (SNP), SNP thus suggesting a role for NO in inducing Hsp70 proteins | | |
| 17191135 | HSP72 | Hsp72 | 2.9 | Induction of Hsp72 under stress conditions is often accompanied by the induction of | | |
| 17191135 | HSP72 | Hsp72 | 2.9 | acting at three different levels (i) i inducing HO-1 and Hsp72 proteins (ii) ii decreasing the neuronal 3-nitrotyrosine levels and therefore | | |
| 17191135 | HSP70 | Hsp70 | 3.5 | During translocation this proteins interact with Hsp70 ATP-dependent binding and the release of Hsp70 provide the major | | |
| 17191135 | HSP70 | Hsp70 | 3.5 | proteins interact with Hsp70 ATP-dependent binding and the release of Hsp70 provide the major driving force for complete transport of polypeptides | | |
| 17191135 | HSP70 | Hsp70 | 3.5 | Although most imported polypeptides are released from soluble Hsp70 however a subset of aggregation-sensitive polypeptides must be transferred from | | |
| 17191135 | HSP70 | Hsp70 | 3.5 | however a subset of aggregation-sensitive polypeptides must be transferred from Hsp70 to Hsp60 for folding 40 | | |
| 17191135 | HSP70 | Hsp70 | 3.5 | the close functional interaction between this chaperonin system and the Hsp70 system it is likely that up-regulation of Hsp60 may be | | |
| 17191135 | HSP70 | Hsp70 | 3.5 | from the cellular machinery and recruitment of chaperone pairs including Hsp70 and Hsp27 endowed with anti-apoptotic properties 85 | | |
| 17191135 | HSP70 | Hsp70 | 3.5 | Binding of phosphorylated tau to Hsp70 implies that the complex may be a substrate for the | | |
| 17191135 | HSP70 | Hsp70 | 3.5 | Together with Hsp70 CHIP can regulate tau ubiquitination and degradation in a cell | | |
| 17191135 | HSP70 | Hsp70 | 3.5 | Increased levels of CHIP and Hsp70 has ben detected in AD compared with normal controls 86 | | |
| 17191135 | HSP70 | Hsp70 | 3.5 | specifically coimmunoprecipitate with AB has identified chaperone proteins such as Hsp70 and alpha B-crystallin-related small Hsp (Hsp16) Hsp16 | | |
| 17191135 | HSP | Hsp | 1.9 | identified chaperone proteins such as Hsp70 and alpha B-crystallin-related small Hsp (Hsp16) Hsp16 | | |
| 17191135 | HSP72 | Hsp72 | 2.9 | showed an increased expression of inducible nitric oxide synthase HO-1 Hsp72 Hsp60 and TrxR 96 | | |
| 17191135 | HSP72 | hsp72 | 2.9 | modulates specific genes in the rat CNS such as the hsp72 gene the gene for the isoform of 14-3-3 protein and | | |
| 17496232 | HSP | HSP | 0.9 | cardiac muscles (dystrophin) dystrophin and to heat shock protein (HSP) HSP 90 or 70 chaperones ( 79 | | |
| 17496232 | HSP | HSPs | 0.9 | effects include S -nitrosylation and inhibition of caspases increase of HSPs and Bcl-2 and activation of Akt/PKB, Akt PKB which induces | | |
| 17496232 | HSP70 | Hsp70 | 0.9 | antiapoptotic genes like that of heme oxygenase ( 127 and Hsp70 which protects hepatocytes from apoptosis induced by oxidative and nitrative | | |
| 12125078 | heat shock protein 70 | heat shock protein 70 | 1.0 | gga was found to induce the expression of heat shock protein 70 as well as thioredoxin which may partly contribute to the protective effect of gga. | | |
| 15896810 | hsp 70 | hsp70 | 1.0 | some of the known hsps include ubiquitin hsp10 hsp27 hsp32 or ho 1 hsp47 hsp60 hsc70 hsp70 or hsp72 hsp90 and hsp100/105. | | |
| 15896810 | hsp 70 | hsp70 | 1.0 | hsp70 . | | |
| 15896810 | hsp 70 | hsp70 | 1.0 | included in this family are hsc70 heat shock cognate the constitutive form hsp70 the inducible form also referred to as hsp72 grp75 a constitutively expressed glucose regulated protein found in the endoplasmic reticulum . | | |
| 15896810 | hsp 70 | hsp70 | 1.0 | after a variety of central nervous system cns insults hsp70 is synthesized at high levels and is present in the cytosol nucleus and endoplasmic reticulum . | | |
| 15896810 | hsp 70 | hsp70 | 1.0 | after heat shock for instance the synthesis of hsp70 increases to a point to where it becomes the most abundant single protein in a cell. | | |
| 15896810 | hsp 70 | hsp70 | 1.0 | once synthesized hsp70 binds to denaturated proteins in an atp dependent manner. | | |
| 15896810 | hsp 70 | hsp70 | 1.0 | only recently however with the availability of transgenic animals and gene transfer has become possible to overexpress the gene encoding hsp70 to test directly the hypothesis that stress proteins protects cells from injury and it has been demonstrated that overproduction of hsp70 leads to protection in several different models of nervous sy | | |
| 15896810 | hsp 70 | hsp70 | 1.0 | to test directly the hypothesis that stress proteins protects cells from injury and it has been demonstrated that overproduction of hsp70 leads to protection in several different models of nervous system injury [136] and [137] . | | |
| 15896810 | hsp 70 | hsp70 | 1.0 | following focal cerebral ischemia mrna encoding hsp70 is synthesized in most ischemic cells except in areas of very low blood flow because of limited atp levels. | | |
| 15896810 | hsp 70 | hsp70 | 1.0 | hsp70 proteins is produced mainly in endothelial cells in the core of infarcts in the cells that are most resistant to ischemia in glial cells at the edges of infarcts and in neurons outside the areas of i | | |
| 15896810 | hsp 70 | hsp70 | 1.0 | it has been suggested that this neuronal expression of hsp70 outside an infarct can be used to define the ischemic penumbras which means the zone of protein denaturation in the ischemic areas [138] . | | |
| 15896810 | hsp 70 | hsp70 | 1.0 | transfection of cultured astrocytes with hsp70 protects them from ischemia or glucose deprivation [140] . | | |
| 15896810 | hsp 70 | hsp70 | 1.0 | hsp70 has been demonstrated to inhibit caspase 3 activation caused by ceramide and also affect jun kinase and p38 kinase activation [141] . | | |
| 15896810 | hsp 70 | hsp70 | 1.0 | in addition hsp70 binds to and modulates the function of bag 1 the bcl 2 binding protein [142] thus modulating some type of apoptosis related cell death. | | |
| 15896810 | hsp 70 | hsp70 | 1.0 | we have demonstrated in astroglial cell cultures that cytokine induced nitrosative stress is associated with an increased synthesis of hsp70 stress proteins. | | |
| 15896810 | hsp 70 | hsp70 | 1.0 | increase in hsp70 protein expression was also found after treatment of cells with the no generating compound sodium nitroprusside snp thus suggesting a role for no in inducing hsp70 proteins. | | |
| 17191135 | hsp 70 | hsp70 | 1.0 | the conception that no and rns can be directly involved in the modulation of ho 1 expression in eukaryotes is based on the evidence that different no releasing agents can markedly increase ho 1 and hsp70 in a variety of tissues including brain cells [ 19 20 ]. | | |
| 17191135 | hsp 70 | hsp70 | 1.0 | in rat glial cells treatment with lipopolysaccaride lps and interferon g ifn g promotes a rapid increase in both inos expression and nitrite levels followed by enhancement of hsp70 [ 3 20 ] whereas the modulation of ho 1 mrna expression by inos derived no following stimulation with lps has also been reported in different brain regions particularly in the hippocampus and substan | | |
| 17191135 | hsp 70 | hsp70 | 1.0 | taken together these findings point to a possible role of the no as a signaling molecule which by triggering expression of cytoprotective genes such as ho 1 and hsp70 may lead to adaptation and resistance of brain cells to subsequent more severe nitrosative and oxidative stress [ 21 23 ]. | | |
| 17191135 | hsp 70 | hsp70 | 1.0 | some of the known hsps include ubiquitin hsp10 hsp27 hsp32 or ho 1 hsp47 hsp60 hsc70 hsp70 or hsp72 hsp90 and hsp100/105. | | |
| 17191135 | hsp 70 | hsp70 | 1.0 | included in this family are hsc70 heat shock cognate the constitutive form hsp70 the inducible form also referred to as hsp72 grp75 a constitutively expressed glucose regulated protein found in the endoplasmic reticulum . | | |
| 17191135 | hsp 70 | hsp70 | 1.0 | after a variety of central nervous system cns insults hsp70 is synthesized at high levels and is present in cytosol nucleus and endoplasmic reticulum [ 24 32 ]. | | |
| 17191135 | hsp 70 | hsp70 | 1.0 | after heat shock synthesis of hsp70 may increase to become the most abundant protein in the cell. | | |
| 17191135 | hsp 70 | hsp70 | 1.0 | once synthesized hsp70 binds to denaturated proteins in an atp dependent manner. | | |
| 17191135 | hsp 70 | hsp70 | 1.0 | increase in hsp70 protein expression was also found after treatment of cells with the no generating compound sodium nitroprusside snp thus suggesting a role for no in inducing hsp70 proteins. | | |
| 17191135 | hsp 70 | hsp70 | 1.0 | during translocation this proteins interact with hsp70 atp dependent binding and the release of hsp70 provide the major driving force for complete transport of polypeptides into the matrix. | | |
| 17191135 | hsp 70 | hsp70 | 1.0 | although most imported polypeptides are released from soluble hsp70 however a subset of aggregation sensitive polypeptides must be transferred from hsp70 to hsp60 for folding [ 40 ]. | | |
| 17191135 | hsp 70 | hsp70 | 1.0 | owing to the close functional interaction between this chaperonin system and the hsp70 system it is likely that up regulation of hsp60 may be a fundamental site targeted by lac action with consequent restoration of complex iv function under conditions of nitrosative stress dependent pe | | |
| 17191135 | hsp 70 | hsp70 | 1.0 | onal changes of the protein and ubiquitination clearing misfolded proteins to the proteasome and segregation of tau aggregates from the cellular machinery and recruitment of chaperone pairs including hsp70 and hsp27 endowed with anti apoptotic properties [ 85 ]. | | |
| 17191135 | hsp 70 | hsp70 | 1.0 | binding of phosphorylated tau to hsp70 implies that the complex may be a substrate for the e3 ligase carboxyl terminus of heat shock cognate hsc 70 interacting protein chip [ 86 88 ]. | | |
| 17191135 | hsp 70 | hsp70 | 1.0 | together with hsp70 chip can regulate tau ubiquitination and degradation in a cell culture system [ 87 ]. | | |
| 17191135 | hsp 70 | hsp70 | 1.0 | increased levels of chip and hsp70 has ben detected in ad compared with normal controls [ 86 ]. | | |
| 17191135 | hsp 70 | hsp70 | 1.0 | mass spectrometry analysis of proteins that specifically coimmunoprecipitate with ab has identified chaperone proteins such as hsp70 and alpha b crystallin related small hsp hsp16 . | | |
| 17496232 | hsp 70 | hsp70 | 1.0 | other antiapoptotic no pathways include s nitrosylation and inactivation of caspases thiols and upregulation of antiapoptotic genes like that of heme oxygenase 127 and hsp70 which protects hepatocytes from apoptosis induced by oxidative and nitrative stress 46 . | | |