HUGO ID Detailed Result 4341


HUGO ID 4341
Symbol GLUL
Name glutamate-ammonia ligase (glutamine synthetase)
#Occurrence 7
#Paper 4

 


PMID Match String Actual String Score Flanking text Edited by Edit
11978481glutamine synthetaseglutamine synthetase1.0prior studies showed that glutamine synthetase and creatine kinase are particularly vulnerable to oxidative damage [ 12 and 20 ].  
11978481glutamine synthetaseglutamine synthetase1.0nitration of tyrosine residues in glutamine synthetase by peroxynitrite inhibits oxidation of methione residues and leads to inactivation of the enzyme [ 3 ].  
11978481glutamine synthetaseglutamine synthetase1.0there were also significant decreases in glutamine synthetase and creatine kinase activity and alterations in spin labeled synaptosomes consistent with oxidative damage.  
14739060glutamine synthetaseglutamine synthetase1.0astrocytes take up glutamate convert it to glutamine through the action of glutamine synthetase an enzyme requiring atp and then release it for uptake by neurons.  
14739060glutamine synthetaseglutamine synthetase1.0this cycle can be disrupted by inhibitors of glutamine synthetase an enzyme which can be easily damaged by oxidative stress [ 31 ].  
15896810glutamine synthetaseglutamine synthetase1.0the latter finding that could also be induced by addition of a_amp_#x3b2; to synaptosomes [127] coupled with the reported loss of glutamine synthetase activity in ad brain [127] suggests that glutamate stimulated excitotoxic mechanisms could be important in neurodegeneration in ad.  
16043017glutamine synthetaseglutamine synthetase1.0consistent with this notion inclusions in als patients contain b crystallin metallothionein glutamine synthetase and tubulin immunoreactivities [90] .