HUGO ID Detailed Result 31395

HUGO ID 31395
Symbol COX8B
Name cytochrome c oxidase, subunit 8B pseudogene
#Occurrence 22
#Paper 13

 

PMID Match String Actual String Score Flanking text Edited by Edit
8841988cytochrome c oxidasecytochrome c oxidase1.0decreased cytochrome c oxidase activity but unchanged superoxide dismutase and glutathione peroxidase activities in the spinal cords of patients with amyotrophic lateral sclerosis.  
8841988cytochrome c oxidasecytochrome c oxidase1.0we measured the antioxidant actions of superoxide dismutase sod glutathione peroxidase gsh px and cytochrome c oxidase co of the human spinal cord in patients with als in comparison with those in control patients.  
10671549cytochrome c oxidasecytochrome c oxidase1.0furthermore g93a cells showed a significant decrease of bcl 2 expression and as target of no derived radicals showed lower cytochrome c oxidase activity.  
10671549cytochrome c oxidasecytochrome c oxidase1.0cytochrome c oxidase activity cells attached and detached were washed and collected by centrifugation.  
10671549cytochrome c oxidasecytochrome c oxidase1.0lysates were used for cytochrome c oxidase activity.  
10671549cytochrome c oxidasecytochrome c oxidase1.0a specific marker of no toxicity was the decrease of cytochrome c oxidase activity which paralleled the extent of apoptosis.  
10671549cytochrome c oxidasecytochrome c oxidase1.0b activity of cytochrome c oxidase.  
10671549cytochrome c oxidasecytochrome c oxidase1.0spectrophotometric determination of cytochrome c oxidase activity was performed as described under "experimental procedures."  
10671549cytochrome c oxidasecytochrome c oxidase1.0among the above mentioned molecular target of no toxicity the hemoprotein cytochrome c oxidase appears to be the only one strongly affected by gsno insult and protected by native cu zn sod fig 7 b .  
10742195cytochrome c oxidasecytochrome c oxidase1.0although cu 2+ is essential for life and the function of numerous enzymes of interest to neurobiology such as tyrosinase ceruloplasmin cytochrome c oxidase and dopamine _amp_#x3b2; hydroxylase free or incorrectly bound cu 2+ can also catalyze the generation of the most damaging radicals such as the hydroxyl radical oh _amp_#x2022; [ 10 ].  
11050436cytochrome c oxidasecytochrome c oxidase1.0complex i nadh ubiquinone oxidoreductase complex iii ubiquinol cytochrome c oxidoreductase complex iv cytochrome c oxidase and complex v h + translocating atp synthetase are shown.  
12618129cytochrome c oxidasecytochrome c oxidase1.0the activities of complex i+iii nadh_amp_#x2013;cytochrome c reductase ii+iii succinate_amp_#x2013;cytochrome c reductase iv cytochrome c oxidase cox and the mitochondrial matrix enzyme citrate synthase cs were measured as described elsewhere [ 21 ].  
12618129cytochrome c oxidasecytochrome c oxidase1.0i+iii nadh cytochrome c reductase; ii+iii succinate cytochrome c reductase; cox cytochrome c oxidase.  
12901835cytochrome c oxidasecytochrome c oxidase1.0decreased activity of cytochrome c oxidase was demonstrated in spinal cord motor neurons [ borthwick et al 1999 ] and lymphocytes [ curti et al 1996 ] from sals patients.  
12909279cytochrome c oxidasecytochrome c oxidase1.0 as a chain of consequent events modulating extracellular transport uptake intracellular delivery from chaperones e.g copper chaperone for sod1 ccs cox17 and atx1 to specific targets such as sod1 and cytochrome c oxidase and/or storage in copper scavenging systems such as gsh and metallothioneins [ 72 ].  
14660707cytochrome c oxidasecytochrome c oxidase1.0p experiments were performed on vulnerable hypoglossal motoneurones mns and mitochondrial function was disturbed by bath application of 1_amp_#x02013;2 m m sodium cyanide cn which inhibits complex iv cytochrome c oxidase of the electron transport chain.  
14660707cytochrome c oxidasecytochrome c oxidase1.0we investigated the impact of a disturbed respiratory chain on membrane currents and [ca 2+ ] i using cyanide cn a known inhibitor of cytochrome c oxidase complex iv .  
15038597cytochrome c oxidasecytochrome c oxidase1.0in particular we recently demonstrated that in copper deficiency mitochondrial function is impaired due to decreased activity of cytochrome c oxidase leading to production of reactive oxygen species which in turn triggers mitochondria mediated apoptotic neurodegeneration.  
15812313cytochrome c oxidasecytochrome c oxidase1.0copper is an essential trace metal and is required for the proper functioning of several enzymes including cytochrome c oxidase ceruloplasmin and sod1 _amp_#91; 13 _amp_#93;.  
15896810cytochrome c oxidasecytochrome c oxidase1.0other data are also consistent with these findings as it has been shown both in a patient with cytochrome c oxidase deficiency and in an animal model of copper deficiency that more than a 50% deficit in complex iv activity did not affect the respiratory flux [56] .  
15964487cytochrome c oxidasecytochrome c oxidase1.0complex iv cytochrome c oxidase; e.c.1.9.3.1 activity was determined as described by wharton and tzagoloff 1967 .  
17584954cytochrome c oxidasecytochrome c oxidase1.0for example genes encoding the mitochondrial respiratory chain and the tca cycle are significantly downregulated following denervation 48 60 66 and the levels of cytochrome c oxidase succinate dehydrogenase citrate synthase and cardiolipin are significantly lowered 8 14 days after denervation 18 82 .