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| 10671549 | p21 | p21 | 1.4 | Tumor suppressor protein p53 and cell cycle inhibitor p21 accumulate as an early sign of S -nitrosoglutathione-mediated toxicity | |  |
| 10671549 | p21 | p21 | 1.4 | with a canonical sequence of events including Bcl-2 p53 and p21 modulation cytochrome c release in the cytosol and caspase 3 | |  |
| 10671549 | p21 | p21 | 1.4 | p53 p21 and Bcl-2 Proteins Detection--Cell pellet was resuspended in lysis buffer | |  |
| 10671549 | p21 | p21 | 1.4 | on a 10 (for for p53 or 12% (for for p21 and Bcl-2 polyacrylamide gel | |  |
| 10671549 | p21 | p21 | 1.4 | binding and transcriptional activation of p53 target genes such as p21 which is an inhibitor of cyclin-dependent kinases and thereby blocks | |  |
| 10671549 | p21 | p21 | 1.4 | Furthermore p53 accumulation and activation leads to p21 increase in all the three cell types however the cleavage | |  |
| 10671549 | p21 | p21 | 1.4 | all the three cell types however the cleavage product of p21 was observed only in the G93A and SH-SY5Y cells at | |  |
| 10671549 | p21 | p21 | 1.4 | It has been demonstrated that p21 cleavage could be reproduced in extracts prepared from irradiated cells | |  |
| 10671549 | p21 | p21 | 1.4 | From these observations it was suggested that p21 may serve as a critical checkpoint regulator for both cell | |  |
| 10671549 | p21 | p21 | 1.4 | Immunoreactive p53 protein ( C and immunoreactive p21 protein ( D were measured by Western blotting using monoclonal | |  |
| 10671549 | p21 | p21 | 1.4 | Apoptotic Markers Cytochrome c Release Caspase Activation p53 Accumulation p21 Increase and Bcl2 Down-regulation-- To examine the sequence of events | |  |
| 10671549 | p21 | p21 | 1.4 | activation in the GSNO-mediated toxicity we analyze the expression of p21 which is a potent inhibitor of cell cycle kinases also | |  |
| 10671549 | p21 | p21 | 1.4 | been demonstrated that ectopic expression of p53 alone could induce p21 expression followed by p21 cleavage and apoptosis ( 43 | |  |
| 10671549 | p21 | p21 | 1.4 | expression of p53 alone could induce p21 expression followed by p21 cleavage and apoptosis ( 43 | |  |
| 10671549 | p21 | p21 | 1.4 | Fig 3 D shows that p21 is expressed in SH-SY5Y cells and that the protein accumulated | |  |
| 17496232 | p21 | p21 | 0.6 | and to resulting changes in cell cycle regulators such as p21 p27 cyclins and retinoblastoma protein | |  |
| 17496232 | p21 | p21 | 0.6 | NO-mediated p53 accumulation induces cell cycle arrest by p21 upregulation or apoptosis by increase in Bax/Bcl-xL, Bax Bcl-xL cytochrome | |  |