HUGO ID Detailed Result 1784


HUGO ID 1784
Symbol CDKN1A
Name cyclin-dependent kinase inhibitor 1A (p21, Cip1)
#Occurrence 17
#Paper 2

 


PMID Match String Actual String Score Flanking text Edited by Edit
10671549p21p211.4Tumor suppressor protein p53 and cell cycle inhibitor p21 accumulate as an early sign of S -nitrosoglutathione-mediated toxicity 
10671549p21p211.4with a canonical sequence of events including Bcl-2 p53 and p21 modulation cytochrome c release in the cytosol and caspase 3 
10671549p21p211.4p53 p21 and Bcl-2 Proteins Detection--Cell pellet was resuspended in lysis buffer 
10671549p21p211.4on a 10 (for for p53 or 12% (for for p21 and Bcl-2 polyacrylamide gel 
10671549p21p211.4binding and transcriptional activation of p53 target genes such as p21 which is an inhibitor of cyclin-dependent kinases and thereby blocks 
10671549p21p211.4Furthermore p53 accumulation and activation leads to p21 increase in all the three cell types however the cleavage 
10671549p21p211.4all the three cell types however the cleavage product of p21 was observed only in the G93A and SH-SY5Y cells at 
10671549p21p211.4It has been demonstrated that p21 cleavage could be reproduced in extracts prepared from irradiated cells 
10671549p21p211.4From these observations it was suggested that p21 may serve as a critical checkpoint regulator for both cell 
10671549p21p211.4Immunoreactive p53 protein ( C and immunoreactive p21 protein ( D were measured by Western blotting using monoclonal 
10671549p21p211.4Apoptotic Markers Cytochrome c Release Caspase Activation p53 Accumulation p21 Increase and Bcl2 Down-regulation-- To examine the sequence of events 
10671549p21p211.4activation in the GSNO-mediated toxicity we analyze the expression of p21 which is a potent inhibitor of cell cycle kinases also 
10671549p21p211.4been demonstrated that ectopic expression of p53 alone could induce p21 expression followed by p21 cleavage and apoptosis ( 43 
10671549p21p211.4expression of p53 alone could induce p21 expression followed by p21 cleavage and apoptosis ( 43 
10671549p21p211.4Fig 3 D shows that p21 is expressed in SH-SY5Y cells and that the protein accumulated 
17496232p21p210.6and to resulting changes in cell cycle regulators such as p21 p27 cyclins and retinoblastoma protein 
17496232p21p210.6NO-mediated p53 accumulation induces cell cycle arrest by p21 upregulation or apoptosis by increase in Bax/Bcl-xL, Bax Bcl-xL cytochrome