HUGO ID Detailed Result 1511

HUGO ID 1511
Symbol CASP9
Name caspase 9, apoptosis-related cysteine peptidase
#Occurrence 17
#Paper 6

 

PMID Match String Actual String Score Flanking text Edited by Edit
12368231caspase 9caspase 91.0superoxide production mitochondrial release of cytochrome c and activation of caspase 9 were examined and apoptotic dna injury was also characterized.  
12368231caspase 9caspase 91.0in the wild type animals increased superoxide production mitochondrial release of cytochrome c and cleaved caspase 9 were observed exclusively in vmn after sci.  
12368231caspase 9caspase 91.0transgenic animals showed less superoxide production mitochondrial cytochrome c release and caspase 9 activation resulting in death of only 45% of the vmn.  
12654515caspase 9caspase 91.0horylated akt has been demonstrated to promote cell survival by inactivation of one or more apoptotic factors [ 1 14 15 and 22 ] glycogen synthase kinase 3 forkhead transcription factors [ 8 ] and/or caspase 9 [ 9 ].  
16046141caspase 9caspase 91.0t al. 1997 and prolongs life in a transgenic mouse model kostic et al. 1997 ; caspases 1 and 3 have consistently been shown to play an important role in the death of motor neurons in this disease and caspase 9 is activated in spinal motor neurons of human als subjects inoue et al. 2003 .  
16046141caspase 9caspase 91.0upon release from mitochondria cytochrome c becomes part of the apoptosome a complex in which apaf1 serves as a scaffold protein also for the binding of pro caspase 9 the apoptosome recruits and processes caspase 9 to form a holoenzyme complex which in turn recruits and activates the effector caspases cecconi 1999 .  
16046141caspase 9caspase 91.0 the apoptosome recruits and processes caspase 9 to form a holoenzyme complex which in turn recruits and activates the effector caspases cecconi 1999 .  
16046141caspase 9caspase 91.0the broad caspase inhibitor zvad fmk 100 _amp_#x3bc;m; calbiochem and the caspase 9 specific inhibitor zlehd fmk 100 _amp_#x3bc;m; calbiochem were added at this time.  
16046141caspase 9caspase 91.0caspase 9 activity was detected using a rabbit polyclonal antibody cell signaling specifically reacting with the cleaved fragments of active caspase 9.  
16046141caspase 9caspase 91.0onspicuous considering that the percentage of transfected cells was estimated around 30% see materials and methods . 48 h after transfection expression of mutant sod1s induces activation of caspase 3 caspase 9 but not caspase 1 fig 1 c .  
16046141caspase 9caspase 91.0cell death induced by mutant sod1 is prevented by treatment both with pan caspase inhibitor z vad and by caspase 9 inhibitor lehd fig 1 d .  
16046141caspase 9caspase 91.0it is widely believed that activation of the apoptosome followed by caspase 9 and caspase 3 activation plays a central role in cell death in the nervous system yuan and yankner 2000 .  
16046141caspase 9caspase 91.0right panel: caspase 1 caspase 3 and caspase 9 activity were also assessed by western blot.  
16046141caspase 9caspase 91.0ication of apoptotic nuclei of sh sy5y transfected with wtsod1 or g37r g85r and i113t sod1 for the indicated periods of time in the absence or in the presence of 100 _amp_#x3bc;m zlehd fmk a specific caspase 9 inhibitor or zvad fmk a pan caspase inhibitor.  
16050975caspase 9caspase 91.0in spinal motor neurons of g93a transgenic mice cytochrome c is released from mitochondria leading to caspase 9 activation guegan et al. 2001 .  
17105868caspase 9caspase 91.0altered expression and dysfunction of bcl 2 may contribute to the activation of mitochondrial apoptosis machinery such as caspase 9 caspase 3 and cytochrome c in spinal motor neurons of als transgenic mice and humans with als guegan et al. 2001 ; inoue et al. 2003 .  
17496232caspase 9caspase 91.0hondrial damage results in the release of cytochrome c triggering the assembly of the apoptosome complex with apoptotic protease activating factor 1 as central scaffold protein that directly recruits caspase 9 which in turn elicits caspase 3 effects 31 .