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| 17105868 | caspase-8 | caspase-8 | 3.0 | C Western blot analysis showing expression of cleaved caspase-8 cleaved caspase-3 and actin in lumbar segments from control or | |  |
| 17105868 | caspase 8 | caspase 8 | 1.0 | the proapoptotic proteins fas fas associated death domain caspase 8 and caspase 3 were also elevated. | | |
| 17105868 | caspase 8 | caspase 8 | 1.0 | the following primary antibodies were used: fas fadd bd bioscience franklin lakes nj cleaved caspase 3 and cleaved caspase 8 1 microg/ml; cell signaling technology . | | |
| 17105868 | caspase 8 | caspase 8 | 1.0 | we found that expression of fas and fadd were increased selectively in the ventral motor neurons of g93a transgenic mice and that this led to activation of caspase 8 and caspase 3. | | |
| 17105868 | caspase 8 | caspase 8 | 1.0 | in support of this li blocked activation of the fas pathway during serum deprivation induced apoptosis and attenuated motor neuron degeneration as well as activation of fas caspase 8 and caspase 3 in the spinal cords of als mice. | | |
| 17105868 | caspase 8 | caspase 8 | 1.0 | c western blot analysis showing expression of cleaved caspase 8 cleaved caspase 3 and actin in lumbar segments from control or g93a mice at ages indicated a . | | |
| 17105868 | caspase 8 | caspase 8 | 1.0 | levels of cleaved caspase 8 b and caspase 3 c were measured and scaled to actin mean _amp_#177; s.e.m. | | |
| 17105868 | caspase 8 | caspase 8 | 1.0 | c western blot analysis of fadd after immunoprecipitation ip with fas antibody cleaved caspase 8 cleaved caspase 3 and actin in neuron rich cortical cell cultures deprived of serum for 12 h alone or in the presence of 1 microm neu2000 or 5 mm li . | | |
| 17105868 | caspase 8 | caspase 8 | 1.0 | f western blot analysis of fas fadd cleaved caspase 8 cleaved caspase 3 and actin in lumbar segments from control and g93a transgenic mice treated with saline neu2000 30 mg/kg/days or li 200 mg/kg/days for 4 weeks starting from 8 weeks of age a . | | |
| 17105868 | caspase 8 | caspase 8 | 1.0 | increased expression of the apoptosis inducing signaling complex was followed by activation of caspase 8 and caspase 3 in the lumbar spinal cord fig 2c . | | |
| 17105868 | caspase 8 | caspase 8 | 1.0 | these findings suggest that fas fadd caspase 8 and caspase 3 are activated in spinal motor neurons and mediate subsequent neuronal apoptosis in als mice. | | |
| 17105868 | caspase 8 | caspase 8 | 1.0 | interaction of fadd with fas cleaved caspase 8 and cleaved caspase 3 were all increased in neuron rich cortical cell cultures deprived of serum for 8 h and these changes were blocked by the addition of li but not neu2000 fig 3c . | | |
| 17105868 | caspase 8 | caspase 8 | 1.0 | daily administration of neu2000 in the diet slightly but statistically insignificantly attenuated the increase in fas fadd and cleaved caspase 8 and caspase 3 in the lumbar spinal cords of g93a transgenic mice at 12 weeks of age fig 3f . | | |