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| 14739060 | caspase 1 | caspase 1 | 1.0 | the involvement of mitochondria and apoptosis in neuronal death is too revealed by a prolonged period of neuronal caspase activation especially caspase 1 [ 17 ]. | |  |
| 14739060 | caspase 1 | caspase 1 | 1.0 | ice [ 46 and 63 ] revealed an up regulation of gene related to an inflammatory process such as tnf_amp_#x3b1; gene resulting in glial activation together with change in apoptosis related gene such as caspase 1. | | |
| 15208263 | caspase 1 | caspase 1 | 1.0 | we show that human glioblastoma cells expressing g93a sod1 induce activation of caspase 1 release of cytokines and activation of apoptotic pathways in cocultured human neuroblastoma cells also expressing g93a sod1. | | |
| 15208263 | caspase 1 | caspase 1 | 1.0 | activation of caspase 1 and caspase 3 is observed also in neuroblastoma lines expressing other fals sod1s g37r g85r and i113t cocultured with glioblastoma lines expressing the corresponding mutant enzymes. | | |
| 15964487 | caspase 1 | caspase 1 | 1.0 | the exact mechanisms by which minocycline plays these neuroprotective effects remain unknown although a reduced expression of cycloxygenase 2 caspase 1 and inducible nitric oxide synthase inos mrna have been described chen et al. 2000 . | | |
| 16046141 | caspase 1 | caspase 1 | 1.0 | caspase 1 and caspase 3 activities were determined by measuring the rates of 7 amido 4 methylcoumarin amc release from synthetic caspase substrates: ac yvad amc for caspase 1 and ac devd amc for caspase 3 calbiochem . | | |
| 16046141 | caspase 1 | caspase 1 | 1.0 | specific activity was demonstrated by the use of the caspase 1 and caspase 3 inhibitors ac yvad cho and ac devd cho respectively that completely block the development of fluorescence due to the cleaved product. | | |
| 16046141 | caspase 1 | caspase 1 | 1.0 | caspase 1 was detected with a rabbit polyclonal antibody sigma aldrich recognizing the 45 kda pro enzyme and the 20 kda active subunit. | | |
| 16046141 | caspase 1 | caspase 1 | 1.0 | ring that the percentage of transfected cells was estimated around 30% see materials and methods . 48 h after transfection expression of mutant sod1s induces activation of caspase 3 caspase 9 but not caspase 1 fig 1 c . | | |
| 16046141 | caspase 1 | caspase 1 | 1.0 | c left panel: sh sy5y cells were transfected as in panel a. after 48 h equal amounts 30 _amp_#x3bc;g of clear cell lysates were incubated with 20 _amp_#x3bc;m ac yvad amc for caspase 1 and ac devd amc for caspase 3 . | | |
| 16046141 | caspase 1 | caspase 1 | 1.0 | right panel: caspase 1 caspase 3 and caspase 9 activity were also assessed by western blot. | | |
| 16050975 | caspase 1 | caspase 1 | 1.0 | for example caspase 1 and 3 are activated sequentially in differentiated neuroblastoma cells expressing mutant sod1 in response to oxidative stress pasinelli et al. 1998 and pasinelli et al. 2000 . | | |