HUGO ID Detailed Result 11998

PMID	Match String	Actual String	Score	Flanking text	Edited by	Edit
10671549	p53	p53	5.8	Tumor suppressor protein p53 and cell cycle inhibitor p21 accumulate as an early sign
10671549	p53	p53	5.8	The tumor suppressor gene product p53 is able to modulate apoptosis in DNA-damaged cell ( 17
10671549	p53	p53	5.8	is associated with a canonical sequence of events including Bcl-2 p53 and p21 modulation cytochrome c release in the cytosol and
10671549	p53	p53	5.8	p53 p21 and Bcl-2 Proteins Detection--Cell pellet was resuspended in lysis
10671549	p53	p53	5.8	microg of proteins were loaded on a 10 (for for p53 or 12% (for for p21 and Bcl-2 polyacrylamide gel
10671549	p53	p53	5.8	In our model apoptosis was characterized by an induction of p53 protein which is able to induce either growth arrest or
10671549	p53	p53	5.8	is dependent upon sequence-specific DNA binding and transcriptional activation of p53 target genes such as p21 which is an inhibitor of
10671549	p53	p53	5.8	cyclin-dependent kinases and thereby blocks cell cycle progression ( 42 p53 increase was an early response to GSNO treatment in fact
10671549	p53	p53	5.8	entered the apoptotic pathway they showed the same degree of p53 accumulation as the other cell lines tested
10671549	p53	p53	5.8	Furthermore p53 accumulation and activation leads to p21 increase in all the
10671549	p53	p53-mediated	0.6	regulator for both cell cycle arrest and apoptosis during the p53-mediated DNA damage response ( 42
10671549	p53	p53	5.8	Immunoreactive p53 protein ( C and immunoreactive p21 protein ( D were
10671549	p53	p53	5.8	Apoptotic Markers Cytochrome c Release Caspase Activation p53 Accumulation p21 Increase and Bcl2 Down-regulation-- To examine the sequence
10671549	p53	p53	5.8	The tumor suppressor gene p53 is known to be a member of the DNA damage-response
10671549	p53	p53	5.8	It has been demonstrated that p53 protein increases in response to NO donors and that it
10671549	p53	p53	5.8	Fig 3 C shows that the p53 protein was stably expressed in neuroblastoma cells to a varying
10671549	p53	p53	5.8	a varying extent in particular WT cells showed a lower p53 protein level with respect to SH-SY5Y cells and G93A cells
10671549	p53	p53	5.8	Upon GSNO treatment p53 significantly accumulated even in the WT cells reaching comparable values
10671549	p53	p53	5.8	almost disappeared after GSNO treatment supporting the current opinion that p53 activation involves phosphorylation of the protein
10671549	p53	p53	5.8	In response to DNA damage human p53 is phosphorylated within its transactivation domain at serine 15 and
10671549	p53	p53	5.8	In order to confirm further a role for p53 activation in the GSNO-mediated toxicity we analyze the expression of
10671549	p53	p53	5.8	It has been demonstrated that ectopic expression of p53 alone could induce p21 expression followed by p21 cleavage and
10671549	p53	p53	5.8	a 2-fold indication as follows first it is confirmatory of p53 activation and second it indicates that G93A (at at higher
16227974	p53	p53	0.3	For example there is evidence that p53 Myc ataxia telangiectasia mutated ( ATM and Ras can all
16227974	p53	p53	0.3	the nucleus where it seems to bind to and stabilize p53
17099894	p53	p53	0.3	prior to double-strand breaks occurring in nuclear and mitochondrial DNA p53 and p73 are activated in degenerating MNs but without nuclear
17174478	p53	p53	0.6	activity is regulated through the interaction of its C-terminus with p53 ( Blander et al. 1999 Ku70/80 Ku70 80 ( Cooper
17191135	p53	p53	0.6	factors such as the AP-1 family members NF-kB Jun Fos p53 CREB PEBP2/CBF, PEBP2 CBF Myb all involved in fundamental processes
17496232	p53	p53	1.6	programmed cell death via apoptotic protease-activating factor-1 and activation of p53
17496232	p53	p53	1.6	Increased NO and ONOO result in DNA damage p53 accumulation increased Bax/Bcl-2, Bax Bcl-2 cytochrome c (cyt cyt c
17496232	p53	p53	1.6	Moreover JNK phosphorylation of p53 is important for the stabilization of proapoptotic p53 protein (
17496232	p53	p53	1.6	phosphorylation of p53 is important for the stabilization of proapoptotic p53 protein ( 28
17496232	p53	p53	1.6	NF-kappaB decreased Bcl-2 expression ( 87 -89 118 and increased p53 expression both by NO-mediated inhibition of proteasome degradation and by
17496232	p53	p53	1.6	For instance proapoptotic p53 protein induces gene transcription of redox-related genes encoding proteins that
17496232	p53	p53	1.6	the result of DNA damage which induces the accumulation of p53
17496232	p53	p53	1.6	NO-mediated p53 accumulation induces cell cycle arrest by p21 upregulation or apoptosis