HUGO ID Detailed Result 118


HUGO ID 118
Symbol ACO2
Name aconitase 2, mitochondrial
#Occurrence 32
#Paper 9

 


PMID Match String Actual String Score Flanking text Edited by Edit
10742195aconitaseaconitase1.3O 2 _amp_#x2212 from reacting with sensitive substrates such as aconitase 
11050436aconitaseaconitase1.3For example damage to the cytosolic isoenzyme of aconitase evident after exposure to superoxide results in the release of 
11050436aconitaseaconitase1.3The damage to other systems such as mitochondrial aconitase complex I and succinate dehydrogenase which also have important functional 
11050436aconitaseaconitase1.3alternative scenario superoxide attacks enzymes (usually usually hydrolyases such as aconitase with 4Fe-4S centres releasing ferrous ions 
11679167aconitaseaconitase1.3oxidise 4Fe_amp_#x2013 4S clusters in enzymes such as the mitochondrial aconitase (citric citric acid cycle homoaconitase (lysine lysine biosynthesis and isopropyl 
11679167aconitaseaconitase1.3The inactivation of mitochondrial enzymes (aconitase) aconitase results in an impaired respiratory activity that limits the capacity 
11679167aconitaseaconitase1.3destroy the 4Fe_amp_#x2013 4S clusters of mitochondrial enzymes (e.g., e.g. aconitase leading to an impaired respiratory activity 
11679167aconitaseaconitase1.3a delay in the reversible inactivation of the superoxide-sensitive enzyme aconitase suggesting that the extension of life-span is associated with the 
11978481aconitaseaconitase1.3immunochemical probe for oxidative damage it was demonstrated that mitochondrial aconitase was particularly vulnerable to oxidative damage accompanying aging in drosophila 
12909279aconitaseaconitase1.3involved in mitochondrial metabolism such as Complex I 53 and aconitase 51 
14739060aconitaseaconitase1.3may prevent the formation of Fe/S Fe S in mitochondrial aconitase and in complex I 20 
15896810aconitaseaconitase1.6mitochondrial respiratory chain complexes I and II/III II III and aconitase activities have been demonstrated in post-mortem cardiac muscle samples from 
15896810aconitaseaconitase1.6sulfur cluster present in numerous enzymes including NADH-ubiquinone oxidoreductase cis -aconitase and NADH succinate oxidoreductase 108 
15896810aconitaseaconitase1.6iron metabolism at the post-transcriptional level by interacting with cytosolic aconitase which after binding NO functions as iron responsive binding protein 
15896810aconitaseaconitase1.6binding NO functions as iron responsive binding protein diminishing its aconitase activity 109 
16188953aconitaseaconitase1.62 O 2 release and by an increase in mitochondrial aconitase activity 
16188953aconitaseaconitase1.6Mitochondrial aconitase is reversibly inactivated by superoxide and has therefore been used 
16188953aconitaseaconitase1.6against the 23 C-terminal amino acids of aconitase-2 (mitochondrial mitochondrial aconitase from rat (nanoTools; nanoTools Antik_amp_ouml rpertechnik Teningen Germany was used 
16188953aconitaseaconitase1.630 mg/kg) mg kg results in an increase in mitochondrial aconitase activity in vivo indicating a reduction of the superoxide steady-state 
16188953aconitaseaconitase1.612 h after the last treatment the increase in mitochondrial aconitase might result from total brain concentrations within the same order 
16188953aconitaseaconitase1.6PPX causes a slight but not significant increase in total aconitase activity in 1-methyl-4-phenylpyridinium-treated SHSY-5Y cells 
16188953aconitaseaconitase1.6specific endpoints such as modification of mitochondrial proteins or mitochondrial aconitase activity 
16188953aconitaseaconitase1.6Activity (A) A and expression (B) B of mitochondrial aconitase after treatment of C57BL/6 C57BL 6 mice with PPX (2 
16188953aconitaseaconitase1.6were isolated after PPX treatment of mice to determine mitochondrial aconitase activity an indicator for steady-state levels of superoxide (Tarpey Tarpey 
16188953aconitaseaconitase1.6days (2 2 x 30 mg/kg) mg kg increased mitochondrial aconitase activity by 42% to 67 _amp_#177 16 mU/mg mU mg 
16188953aconitaseaconitase1.6This was not due to altered expression of mitochondrial aconitase because protein levels were not affected by the PPX treatment 
16227974aconitaseaconitase2.1Studies with the mitochondrial protein aconitase have demonstrated that low levels of ROS caused mild oxidation 
16227974aconitaseaconitase2.1oxidation and stimulated degradation whereas higher levels of ROS caused aconitase to aggregate and become more resistant to proteasomal degradation 20 
16227974aconitaseaconitase2.1the activity of a set of metabolic enzymes such as aconitase and components of mitochondrial complex I that contain Fe-S clusters 
16188953aconitase 2aconitase 21.0detoxification of reactive oxygen species ros by pramipexole is shown in vitro and in vivo by evaluating mitochondrial ros release and aconitase 2 activity respectively.  
16188953aconitase 2, mitochondrialaconitase 2 mitochondrial1.0additionally a monoclonal antibody raised against the 23 c terminal amino acids of aconitase 2 mitochondrial aconitase from rat nanotools; antik_amp_ouml;rpertechnik teningen germany was used to study the expression of the protein in mitochondria.  
16188953aconitase 2aconitase 21.0afterward aconitase 2 expression was analyzed by a standard western blot protocol by probing the used nitrocellulose membranes with the anti aconitase 2 antibody 2 microg/ml using an enhanced chemiluminescence detection system applied biosystems .