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| 16227974 | SIR2 | SIR-2 | 1.3 | melanogaster and Caenorhabditis elegans overexpression of the NAD-dependent histone deacetylase SIR-2 results in an increased lifespan 48 49 | |  |
| 16227974 | SIR2 | SIR-2 | 1.3 | The closest mammalian orthologue of SIR-2 is SIRT1 and it is presently not known whether overexpression | |  |
| 16227974 | SIR2 | Sir2 | 1.3 | For instance yeast Sir2 seems to be important in protecting cells from accumulation of | |  |
| 16227974 | SIR2 | SIR-2 | 1.3 | model of the neurodegenerative condition Huntington's disease upregulated expression of SIR-2 increased neuronal survival 54 | |  |
| 16227974 | SIR2 | SIR-2 | 1.3 | has also been recently proposed to increase the activity of SIR-2 (Ref Ref 55 | |  |