#PathwayID Name t-total t+ t- t+uniq common b+uniq b+ b- b-total p-value t-ratiot b-ratio (t-ratio)/(b-ratio) SigTest 73894 DNA Repair 399 18 381 18 0 1 1 554 555 1.425e-06 0.05 0.00 25.0 Nominal_Sig 73890 Double-Strand Break Repair 399 8 391 8 0 0 0 555 555 8.985e-04 0.02 0.00 bZero Nominal_Sig hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) 399 8 391 3 5 29 34 521 555 2.082e-03 0.02 0.06 0.3 Nominal_Sig hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human) 399 20 379 2 18 39 57 498 555 3.613e-03 0.05 0.10 0.5 Nominal_Sig 73951 Homologous recombination repair of replication-independent double-strand breaks 399 6 393 6 0 0 0 555 555 5.236e-03 0.02 0.00 bZero Nominal_Sig 157579 Telomere Maintenance 399 6 393 6 0 0 0 555 555 5.236e-03 0.02 0.00 bZero Nominal_Sig 73888 Homologous Recombination Repair 399 6 393 6 0 0 0 555 555 5.236e-03 0.02 0.00 bZero Nominal_Sig hsa04514 Cell adhesion molecules (CAMs) - Homo sapiens (human) 399 3 396 0 3 13 16 539 555 1.954e-02 0.01 0.03 0.3 Nominal_Sig hsa00620 Pyruvate metabolism - Homo sapiens (human) 399 8 391 8 0 2 2 553 555 2.053e-02 0.02 0.00 5.6 Nominal_Sig hsa04610 Complement and coagulation cascades - Homo sapiens (human) 399 1 398 0 1 9 10 545 555 3.052e-02 0.00 0.02 0.1 Nominal_Sig hsa00480 Glutathione metabolism - Homo sapiens (human) 399 9 390 6 3 1 4 551 555 5.094e-02 0.02 0.01 3.1 Not_Sig hsa05214 Glioma - Homo sapiens (human) 399 19 380 11 8 6 14 541 555 7.265e-02 0.05 0.03 1.9 Not_Sig 76010 Homologous DNA pairing and strand exchange 399 3 396 3 0 0 0 555 555 7.284e-02 0.01 0.00 bZero Not_Sig 69190 DNA strand elongation 399 3 396 3 0 0 0 555 555 7.284e-02 0.01 0.00 bZero Not_Sig hsa02010 ABC transporters - General - Homo sapiens (human) 399 3 396 3 0 0 0 555 555 7.284e-02 0.01 0.00 bZero Not_Sig 75154 Recruitment of repair and signaling proteins to double-strand breaks 399 3 396 3 0 0 0 555 555 7.284e-02 0.01 0.00 bZero Not_Sig 69481 G2/M Checkpoints 399 3 396 3 0 0 0 555 555 7.284e-02 0.01 0.00 bZero Not_Sig 76003 Presynaptic phase of homologous DNA pairing and strand exchange 399 3 396 3 0 0 0 555 555 7.284e-02 0.01 0.00 bZero Not_Sig 69242 S Phase 399 6 393 5 1 1 2 553 555 7.413e-02 0.02 0.00 4.2 Not_Sig hsa03320 PPAR signaling pathway - Homo sapiens (human) 399 2 397 1 1 9 10 545 555 8.501e-02 0.01 0.02 0.3 Not_Sig hsa04115 p53 signaling pathway - Homo sapiens (human) 399 14 385 7 7 2 9 546 555 8.505e-02 0.04 0.02 2.2 Not_Sig 69239 Synthesis of DNA 399 5 394 4 1 0 1 554 555 8.782e-02 0.01 0.00 7.0 Not_Sig hsa04630 Jak-STAT signaling pathway - Homo sapiens (human) 399 14 385 4 10 23 33 522 555 9.615e-02 0.04 0.06 0.6 Not_Sig hsa05222 Small cell lung cancer - Homo sapiens (human) 399 22 377 9 13 5 18 537 555 1.012e-01 0.06 0.03 1.7 Not_Sig 187037 TRKA signalling from the plasma membrane 399 15 384 7 8 3 11 544 555 1.088e-01 0.04 0.02 1.9 Not_Sig hsa04012 ErbB signaling pathway - Homo sapiens (human) 399 20 379 9 11 5 16 539 555 1.199e-01 0.05 0.03 1.7 Not_Sig 166520 Signalling by NGF 399 20 379 9 11 5 16 539 555 1.199e-01 0.05 0.03 1.7 Not_Sig hsa00190 Oxidative phosphorylation - Homo sapiens (human) 399 10 389 8 2 4 6 549 555 1.238e-01 0.03 0.01 2.3 Not_Sig 69278 Cell Cycle, Mitotic 399 10 389 9 1 5 6 549 555 1.238e-01 0.03 0.01 2.3 Not_Sig hsa00790 Folate biosynthesis - Homo sapiens (human) 399 5 394 3 2 0 2 553 555 1.363e-01 0.01 0.00 3.5 Not_Sig hsa00650 Butanoate metabolism - Homo sapiens (human) 399 5 394 4 1 1 2 553 555 1.363e-01 0.01 0.00 3.5 Not_Sig hsa00350 Tyrosine metabolism - Homo sapiens (human) 399 8 391 6 2 2 4 551 555 1.375e-01 0.02 0.01 2.8 Not_Sig hsa00010 Glycolysis / Gluconeogenesis - Homo sapiens (human) 399 8 391 7 1 3 4 551 555 1.375e-01 0.02 0.01 2.8 Not_Sig hsa05213 Endometrial cancer - Homo sapiens (human) 399 14 385 8 6 4 10 545 555 1.407e-01 0.04 0.02 1.9 Not_Sig 114608 Platelet degranulation 399 4 395 0 4 9 13 542 555 1.425e-01 0.01 0.02 0.4 Not_Sig 114611 Exocytosis of Alpha granule 399 4 395 0 4 9 13 542 555 1.425e-01 0.01 0.02 0.4 Not_Sig hsa05220 Chronic myeloid leukemia - Homo sapiens (human) 399 17 382 8 9 5 14 541 555 1.427e-01 0.04 0.03 1.7 Not_Sig 140192 Metabolism of xenobiotics 399 11 388 7 4 4 8 547 555 1.649e-01 0.03 0.01 1.9 Not_Sig 69620 Cell Cycle Checkpoints 399 8 391 6 2 3 5 550 555 1.653e-01 0.02 0.01 2.2 Not_Sig hsa04070 Phosphatidylinositol signaling system - Homo sapiens (human) 399 8 391 4 4 1 5 550 555 1.653e-01 0.02 0.01 2.2 Not_Sig 69306 DNA Replication 399 8 391 7 1 4 5 550 555 1.653e-01 0.02 0.01 2.2 Not_Sig hsa00020 Citrate cycle (TCA cycle) - Homo sapiens (human) 399 4 395 3 1 0 1 554 555 1.673e-01 0.01 0.00 5.6 Not_Sig 69166 Removal of the Flap Intermediate 399 2 397 2 0 0 0 555 555 1.747e-01 0.01 0.00 bZero Not_Sig hsa04340 Hedgehog signaling pathway - Homo sapiens (human) 399 2 397 2 0 0 0 555 555 1.747e-01 0.01 0.00 bZero Not_Sig 110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 399 2 397 2 0 0 0 555 555 1.747e-01 0.01 0.00 bZero Not_Sig hsa00290 Valine, leucine and isoleucine biosynthesis - Homo sapiens (human) 399 2 397 2 0 0 0 555 555 1.747e-01 0.01 0.00 bZero Not_Sig hsa00430 Taurine and hypotaurine metabolism - Homo sapiens (human) 399 2 397 2 0 0 0 555 555 1.747e-01 0.01 0.00 bZero Not_Sig hsa04740 Olfactory transduction - Homo sapiens (human) 399 2 397 2 0 0 0 555 555 1.747e-01 0.01 0.00 bZero Not_Sig 110362 Removal of DNA patch containing abasic residue 399 2 397 2 0 0 0 555 555 1.747e-01 0.01 0.00 bZero Not_Sig 140179 Amine Oxidase reactions 399 2 397 2 0 0 0 555 555 1.747e-01 0.01 0.00 bZero Not_Sig 174414 Processive synthesis on the C-strand of the telomere 399 2 397 2 0 0 0 555 555 1.747e-01 0.01 0.00 bZero Not_Sig 141333 Monoamines are oxidized to aldehydes, producing NH3 and H2O2 399 2 397 2 0 0 0 555 555 1.747e-01 0.01 0.00 bZero Not_Sig 83572 MRN complex relocalizes to nuclear foci 399 2 397 2 0 0 0 555 555 1.747e-01 0.01 0.00 bZero Not_Sig 75177 Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks 399 2 397 2 0 0 0 555 555 1.747e-01 0.01 0.00 bZero Not_Sig 75924 Processing of DNA ends prior to end rejoining 399 2 397 2 0 0 0 555 555 1.747e-01 0.01 0.00 bZero Not_Sig 69186 Lagging Strand Synthesis 399 2 397 2 0 0 0 555 555 1.747e-01 0.01 0.00 bZero Not_Sig 71384 Ethanol catabolism 399 2 397 2 0 0 0 555 555 1.747e-01 0.01 0.00 bZero Not_Sig 73889 Nonhomologous End-joining (NHEJ) 399 2 397 2 0 0 0 555 555 1.747e-01 0.01 0.00 bZero Not_Sig hsa00040 Pentose and glucuronate interconversions - Homo sapiens (human) 399 2 397 2 0 0 0 555 555 1.747e-01 0.01 0.00 bZero Not_Sig 162592 Integration of provirus 399 2 397 2 0 0 0 555 555 1.747e-01 0.01 0.00 bZero Not_Sig 180786 Extension of Telomeres 399 2 397 2 0 0 0 555 555 1.747e-01 0.01 0.00 bZero Not_Sig 174417 Telomere C-strand (Lagging Strand) Synthesis 399 2 397 2 0 0 0 555 555 1.747e-01 0.01 0.00 bZero Not_Sig 176187 Activation of ATR in response to replication stress 399 2 397 2 0 0 0 555 555 1.747e-01 0.01 0.00 bZero Not_Sig 73933 Resolution of Abasic Sites (AP sites) 399 2 397 2 0 0 0 555 555 1.747e-01 0.01 0.00 bZero Not_Sig 174437 Removal of the Flap Intermediate from the C-strand 399 2 397 2 0 0 0 555 555 1.747e-01 0.01 0.00 bZero Not_Sig 69183 Processive synthesis on the lagging strand 399 2 397 2 0 0 0 555 555 1.747e-01 0.01 0.00 bZero Not_Sig 76000 Assembly of the RAD51-ssDNA nucleoprotein complex 399 2 397 2 0 0 0 555 555 1.747e-01 0.01 0.00 bZero Not_Sig 73884 Base Excision Repair 399 2 397 2 0 0 0 555 555 1.747e-01 0.01 0.00 bZero Not_Sig 71406 Pyruvate metabolism and TCA cycle 399 6 393 5 1 2 3 552 555 1.762e-01 0.02 0.01 2.8 Not_Sig hsa05223 Non-small cell lung cancer - Homo sapiens (human) 399 16 383 8 8 5 13 542 555 1.801e-01 0.04 0.02 1.7 Not_Sig hsa04916 Melanogenesis - Homo sapiens (human) 399 12 387 6 6 3 9 546 555 1.808e-01 0.03 0.02 1.9 Not_Sig 198203 PI3K/AKT signalling 399 9 390 4 5 1 6 549 555 1.887e-01 0.02 0.01 2.1 Not_Sig hsa04920 Adipocytokine signaling pathway - Homo sapiens (human) 399 9 390 0 9 12 21 534 555 1.945e-01 0.02 0.04 0.6 Not_Sig hsa05218 Melanoma - Homo sapiens (human) 399 17 382 9 8 7 15 540 555 2.048e-01 0.04 0.03 1.6 Not_Sig 163200 Electron Transport Chain 399 10 389 8 2 5 7 548 555 2.138e-01 0.03 0.01 2.0 Not_Sig hsa00251 Glutamate metabolism - Homo sapiens (human) 399 7 392 4 3 1 4 551 555 2.172e-01 0.02 0.01 2.4 Not_Sig hsa04720 Long-term potentiation - Homo sapiens (human) 399 10 389 4 6 2 8 547 555 2.394e-01 0.03 0.01 1.7 Not_Sig 76005 Response to elevated platelet cytosolic Ca++ 399 5 394 0 5 9 14 541 555 2.398e-01 0.01 0.03 0.5 Not_Sig 170984 ARMS-mediated activation 399 4 395 2 2 0 2 553 555 2.430e-01 0.01 0.00 2.8 Not_Sig 169893 Prolonged ERK activation events 399 4 395 2 2 0 2 553 555 2.430e-01 0.01 0.00 2.8 Not_Sig 170968 Frs2-mediated activation 399 4 395 2 2 0 2 553 555 2.430e-01 0.01 0.00 2.8 Not_Sig 71403 Citric acid cycle (TCA cycle) 399 4 395 3 1 1 2 553 555 2.430e-01 0.01 0.00 2.8 Not_Sig 187706 Signalling to p38 via RIT and RIN 399 4 395 2 2 0 2 553 555 2.430e-01 0.01 0.00 2.8 Not_Sig 71408 Metabolism of small molecules 399 4 395 2 2 0 2 553 555 2.430e-01 0.01 0.00 2.8 Not_Sig 69615 G1/S DNA Damage Checkpoints 399 4 395 2 2 0 2 553 555 2.430e-01 0.01 0.00 2.8 Not_Sig 77388 SHC-related events 399 4 395 2 2 0 2 553 555 2.430e-01 0.01 0.00 2.8 Not_Sig 190236 Signaling by FGFR 399 1 398 0 1 5 6 549 555 2.493e-01 0.00 0.01 0.2 Not_Sig 190376 FGFR ligand binding and activation 399 1 398 0 1 5 6 549 555 2.493e-01 0.00 0.01 0.2 Not_Sig 74751 Insulin receptor signalling cascade 399 7 392 3 4 1 5 550 555 2.554e-01 0.02 0.01 1.9 Not_Sig 77389 IRS-related events 399 7 392 3 4 1 5 550 555 2.554e-01 0.02 0.01 1.9 Not_Sig 109606 Intrinsic Pathway for Apoptosis 399 11 388 3 8 1 9 546 555 2.564e-01 0.03 0.02 1.7 Not_Sig hsa05210 Colorectal cancer - Homo sapiens (human) 399 21 378 8 13 7 20 535 555 2.573e-01 0.05 0.04 1.5 Not_Sig 194138 Signaling by VEGF 399 3 396 0 3 7 10 545 555 2.575e-01 0.01 0.02 0.4 Not_Sig hsa00340 Histidine metabolism - Homo sapiens (human) 399 5 394 3 2 1 3 552 555 2.899e-01 0.01 0.01 2.3 Not_Sig hsa00562 Inositol phosphate metabolism - Homo sapiens (human) 399 5 394 2 3 0 3 552 555 2.899e-01 0.01 0.01 2.3 Not_Sig 162909 Host Interactions of HIV factors 399 5 394 2 3 0 3 552 555 2.899e-01 0.01 0.01 2.3 Not_Sig hsa00260 Glycine, serine and threonine metabolism - Homo sapiens (human) 399 5 394 4 1 2 3 552 555 2.899e-01 0.01 0.01 2.3 Not_Sig 73923 Lipid and lipoprotein metabolism 399 7 392 4 3 13 16 539 555 2.925e-01 0.02 0.03 0.6 Not_Sig 74752 Signaling by Insulin receptor 399 9 390 4 5 2 7 548 555 3.076e-01 0.02 0.01 1.8 Not_Sig 15869 Nucleotide metabolism 399 9 390 3 6 1 7 548 555 3.076e-01 0.02 0.01 1.8 Not_Sig 69304 Regulation of DNA replication 399 3 396 2 1 0 1 554 555 3.144e-01 0.01 0.00 4.2 Not_Sig 69052 Switching of origins to a post-replicative state 399 3 396 2 1 0 1 554 555 3.144e-01 0.01 0.00 4.2 Not_Sig 156902 Peptide chain elongation 399 3 396 2 1 0 1 554 555 3.144e-01 0.01 0.00 4.2 Not_Sig 69580 p53-Dependent G1/S DNA damage checkpoint 399 3 396 2 1 0 1 554 555 3.144e-01 0.01 0.00 4.2 Not_Sig 72766 Translation 399 3 396 2 1 0 1 554 555 3.144e-01 0.01 0.00 4.2 Not_Sig 112410 SHC-mediated signalling 399 3 396 2 1 0 1 554 555 3.144e-01 0.01 0.00 4.2 Not_Sig 156842 Eukaryotic Translation Elongation 399 3 396 2 1 0 1 554 555 3.144e-01 0.01 0.00 4.2 Not_Sig 162594 Early Phase of HIV Life Cycle 399 3 396 2 1 0 1 554 555 3.144e-01 0.01 0.00 4.2 Not_Sig hsa00930 Caprolactam degradation - Homo sapiens (human) 399 3 396 2 1 0 1 554 555 3.144e-01 0.01 0.00 4.2 Not_Sig 71397 Oxidative decarboxylation of pyruvate to acetyl CoA by pyruvate dehydrogenase 399 3 396 3 0 1 1 554 555 3.144e-01 0.01 0.00 4.2 Not_Sig 180292 Gab1 signalosome 399 3 396 2 1 0 1 554 555 3.144e-01 0.01 0.00 4.2 Not_Sig 69206 G1/S Transition 399 3 396 2 1 0 1 554 555 3.144e-01 0.01 0.00 4.2 Not_Sig 112412 SOS-mediated signalling 399 3 396 2 1 0 1 554 555 3.144e-01 0.01 0.00 4.2 Not_Sig 109869 MAP kinase cascade 399 3 396 2 1 0 1 554 555 3.144e-01 0.01 0.00 4.2 Not_Sig hsa00500 Starch and sucrose metabolism - Homo sapiens (human) 399 3 396 2 1 0 1 554 555 3.144e-01 0.01 0.00 4.2 Not_Sig 69563 p53-Dependent G1 DNA Damage Response 399 3 396 2 1 0 1 554 555 3.144e-01 0.01 0.00 4.2 Not_Sig 204174 Regulation of pyruvate dehydrogenase complex (PDC) 399 3 396 3 0 1 1 554 555 3.144e-01 0.01 0.00 4.2 Not_Sig hsa00120 Bile acid biosynthesis - Homo sapiens (human) 399 3 396 3 0 1 1 554 555 3.144e-01 0.01 0.00 4.2 Not_Sig 68949 Orc1 removal from chromatin 399 3 396 2 1 0 1 554 555 3.144e-01 0.01 0.00 4.2 Not_Sig 69300 Removal of licensing factors from origins 399 3 396 2 1 0 1 554 555 3.144e-01 0.01 0.00 4.2 Not_Sig hsa04910 Insulin signaling pathway - Homo sapiens (human) 399 19 380 7 12 7 19 536 555 3.171e-01 0.05 0.03 1.4 Not_Sig 198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 399 2 397 0 2 5 7 548 555 3.178e-01 0.01 0.01 0.4 Not_Sig hsa04730 Long-term depression - Homo sapiens (human) 399 14 385 3 11 2 13 542 555 3.245e-01 0.04 0.02 1.5 Not_Sig hsa04360 Axon guidance - Homo sapiens (human) 399 5 394 1 4 8 12 543 555 3.326e-01 0.01 0.02 0.6 Not_Sig 167044 Signalling to RAS 399 6 393 3 3 1 4 551 555 3.355e-01 0.02 0.01 2.1 Not_Sig 112399 IRS-mediated signalling 399 6 393 3 3 1 4 551 555 3.355e-01 0.02 0.01 2.1 Not_Sig hsa05020 Parkinson's disease - Homo sapiens (human) 399 6 393 3 3 1 4 551 555 3.355e-01 0.02 0.01 2.1 Not_Sig 187687 Signalling to ERKs 399 6 393 3 3 1 4 551 555 3.355e-01 0.02 0.01 2.1 Not_Sig hsa00360 Phenylalanine metabolism - Homo sapiens (human) 399 6 393 4 2 2 4 551 555 3.355e-01 0.02 0.01 2.1 Not_Sig hsa00380 Tryptophan metabolism - Homo sapiens (human) 399 6 393 4 2 2 4 551 555 3.355e-01 0.02 0.01 2.1 Not_Sig hsa04912 GnRH signaling pathway - Homo sapiens (human) 399 15 384 7 8 6 14 541 555 3.394e-01 0.04 0.03 1.5 Not_Sig hsa05030 Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human) 399 15 384 1 14 0 14 541 555 3.394e-01 0.04 0.03 1.5 Not_Sig hsa04530 Tight junction - Homo sapiens (human) 399 10 389 4 6 3 9 546 555 3.555e-01 0.03 0.02 1.5 Not_Sig hsa04662 B cell receptor signaling pathway - Homo sapiens (human) 399 10 389 2 8 1 9 546 555 3.555e-01 0.03 0.02 1.5 Not_Sig hsa05211 Renal cell carcinoma - Homo sapiens (human) 399 11 388 4 7 15 22 533 555 3.714e-01 0.03 0.04 0.7 Not_Sig hsa04210 Apoptosis - Homo sapiens (human) 399 32 367 7 25 11 36 519 555 3.743e-01 0.08 0.06 1.2 Not_Sig hsa01510 Neurodegenerative Diseases - Homo sapiens (human) 399 25 374 4 21 6 27 528 555 3.866e-01 0.06 0.05 1.3 Not_Sig 177929 Signaling by EGFR 399 7 392 4 3 3 6 549 555 4.068e-01 0.02 0.01 1.6 Not_Sig 163685 Integration of energy metabolism 399 7 392 4 3 3 6 549 555 4.068e-01 0.02 0.01 1.6 Not_Sig 202733 Cell surface interactions at the vascular wall 399 7 392 4 3 3 6 549 555 4.068e-01 0.02 0.01 1.6 Not_Sig 168176 Toll Like Receptor 5 (TLR5) Cascade 399 1 398 1 0 4 4 551 555 4.068e-01 0.00 0.01 0.3 Not_Sig 166058 MyD88 cascade 399 1 398 1 0 4 4 551 555 4.068e-01 0.00 0.01 0.3 Not_Sig 168142 Toll Like Receptor 10 (TLR10) Cascade 399 1 398 1 0 4 4 551 555 4.068e-01 0.00 0.01 0.3 Not_Sig 168188 Toll Like Receptor TLR6:TLR2 Cascade 399 1 398 1 0 4 4 551 555 4.068e-01 0.00 0.01 0.3 Not_Sig 181438 Toll Like Receptor 2 Cascade 399 1 398 1 0 4 4 551 555 4.068e-01 0.00 0.01 0.3 Not_Sig 168179 Toll Like Receptor TLR1:TLR2 Cascade 399 1 398 1 0 4 4 551 555 4.068e-01 0.00 0.01 0.3 Not_Sig hsa00361 gamma-Hexachlorocyclohexane degradation - Homo sapiens (human) 399 1 398 0 1 3 4 551 555 4.068e-01 0.00 0.01 0.3 Not_Sig 168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 399 1 398 1 0 4 4 551 555 4.068e-01 0.00 0.01 0.3 Not_Sig 195721 Signaling by Wnt 399 1 398 1 0 4 4 551 555 4.068e-01 0.00 0.01 0.3 Not_Sig 166054 Activated TLR4 signalling 399 1 398 1 0 4 4 551 555 4.068e-01 0.00 0.01 0.3 Not_Sig 190322 FGFR4 ligand binding and activation 399 1 398 0 1 3 4 551 555 4.068e-01 0.00 0.01 0.3 Not_Sig 166016 Toll Like Receptor 4 (TLR4) Cascade 399 1 398 1 0 4 4 551 555 4.068e-01 0.00 0.01 0.3 Not_Sig 140181 Cytochrome p450 399 1 398 0 1 3 4 551 555 4.068e-01 0.00 0.01 0.3 Not_Sig 174800 Chylomicron-mediated lipid transport 399 1 398 0 1 4 5 550 555 4.098e-01 0.00 0.01 0.3 Not_Sig 190241 FGFR2 ligand binding and activation 399 1 398 0 1 4 5 550 555 4.098e-01 0.00 0.01 0.3 Not_Sig 190375 FGFR2c ligand binding and activation 399 1 398 0 1 4 5 550 555 4.098e-01 0.00 0.01 0.3 Not_Sig 190242 FGFR1 ligand binding and activation 399 1 398 0 1 4 5 550 555 4.098e-01 0.00 0.01 0.3 Not_Sig 190373 FGFR1c ligand binding and activation 399 1 398 0 1 4 5 550 555 4.098e-01 0.00 0.01 0.3 Not_Sig 174824 Lipoprotein metabolism 399 1 398 0 1 4 5 550 555 4.098e-01 0.00 0.01 0.3 Not_Sig 168138 Toll Like Receptor 9 (TLR9) Cascade 399 1 398 1 0 5 5 550 555 4.098e-01 0.00 0.01 0.3 Not_Sig 168769 BoNT Light Chain Types B, D, and F cleave VAMP/Synaptobrevin 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 168273 Influenza Viral RNA Transcription and Replication 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 73728 RNA Polymerase I Promoter Opening 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 70172 Phosphorylase kinase activates glycogen phosphorylase 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 109979 Gap-filling DNA repair synthesis and ligation in TC-NER 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 191650 Regulation of gap junction activity 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 74969 Gap-filling DNA repair synthesis and ligation in GG-NER 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 168255 Influenza Life Cycle 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 174403 Glutathione synthesis 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 188108 MyD88 Cascade (Murine) 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 164843 2-LTR circle formation 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 73621 Pyrimidine catabolism 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 180897 Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 68962 Activation of the pre-replicative complex 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig hsa00950 Alkaloid biosynthesis I - Homo sapiens (human) 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig hsa03030 DNA replication - Homo sapiens (human) 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig hsa00770 Pantothenate and CoA biosynthesis - Homo sapiens (human) 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 171306 Packaging Of Telomere Ends 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 162585 Uncoating of the HIV Virion 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 83542 ATM mediated response to DNA double-strand break 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 168782 Proteolytic cleavage of SNARE complex proteins 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 112407 RAF phosphorylates MEK 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 71336 Pentose phosphate pathway (hexose monophosphate shunt) 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 168799 Botulinum neurotoxicity 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 70845 Isoleucine catabolism 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 180689 APOBEC3G mediated resistance to HIV-1 infection 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 71037 Oxidative decarboxylation of alpha-ketoadipate to glutaryl CoA by alpha-ketoglutarate dehydrogenase 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 69091 Polymerase switching 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 71383 Acetate, ATP, and coenzyme A react to form acetyl CoA, AMP, and pyrophosphate 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 110049 MEK activation 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 168325 Viral Messenger RNA Synthesis 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 73930 Base-free sugar-phosphate removal via the single-nucleotide replacement pathway 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 73927 Depurination 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 69109 Leading Strand Synthesis 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 68886 M Phase 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 176033 Interactions of Vpr with host cellular proteins 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 71064 Lysine catabolism 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 71338 Ethanol is oxidized by NAD+ to form acetaldehyde, NADH, and H+ 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig hsa00740 Riboflavin metabolism - Homo sapiens (human) 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig hsa00460 Cyanoamino acid metabolism - Homo sapiens (human) 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 114294 Activation, translocation and oligomerization of BAX 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 162589 Reverse Transcription of HIV RNA 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 70853 Oxidative decarboxylation of alpha-ketoisovalerate to isobutyryl-CoA by branched-chain alpha-ketoacid dehydrogenase 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 77378 Formation of Cytosolic Glycerol-3-phosphate 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 110056 ERK1 activation 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 68875 Mitotic Prophase 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 164525 Plus-strand DNA synthesis 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 163358 PKA-mediated phosphorylation of key metabolic factors 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 73929 Base-Excision Repair, AP Site Formation 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig hsa01030 Glycan structures - biosynthesis 1 - Homo sapiens (human) 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 109977 Repair synthesis for gap-filling by DNA polymerase in TC-NER 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 192456 Digestion of dietary lipid 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 174411 Polymerase switching on the C-strand of the telomere 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 110381 Resolution of AP sites via the single-nucleotide replacement pathway 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 163560 Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig hsa00052 Galactose metabolism - Homo sapiens (human) 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 210991 Basigin interactions 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 69473 G2/M DNA damage checkpoint 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 71401 Oxidative decarboxylation of alpha-ketoglutarate to succinyl CoA by alpha-ketoglutarate dehydrogenase 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 110330 Recognition and association of DNA glycosylase with site containing an affected purine 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 164516 Minus-strand DNA synthesis 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig hsa00030 Pentose phosphate pathway - Homo sapiens (human) 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 111452 Activation and oligomerization of BAK protein 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 142045 Alcohol Dehydrogenase 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig hsa00510 N-Glycan biosynthesis - Homo sapiens (human) 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 71182 Phenylalanine and tyrosine catabolism 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 142033 Ethanol Catabolism 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 110331 Cleavage of the damaged purine 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 70726 Oxidative decarboxylation of alpha-ketoisocaproate to isovaleryl-CoA by branched-chain alpha-ketoacid dehydrogenase 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig hsa04130 SNARE interactions in vesicular transport - Homo sapiens (human) 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 188081 Toll Like Receptor 11 (TLR11) Cascade (Murine) 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 74967 Repair synthesis of patch ~27-30 bases long by DNA polymerase 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig hsa00051 Fructose and mannose metabolism - Homo sapiens (human) 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 176974 Unwinding of DNA 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 71032 Propionyl-CoA catabolism 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 187577 SCF(Skp2)-mediated degradation of p27/p21 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 110357 Displacement of DNA glycosylase by APE1 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 70221 Glycogen breakdown (glycogenolysis) 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 75148 ATM mediated phosphorylation of repair proteins 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 162658 Golgi Cisternae Pericentriolar Stack Reorganization 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 191647 c-src mediated regulation of Cx43 function and closure of gap junctions 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 70794 Oxidative decarboxylation of alpha-keto-beta-methylvalerate to alpha-methylbutyryl-CoA by branched-chain alpha-ketoacid dehydrogenase 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig 75894 Synthesis of lysophosphatidic acid from glycerol-3-phosphate 399 1 398 1 0 0 0 555 555 4.182e-01 0.00 0.00 bZero Not_Sig hsa04370 VEGF signaling pathway - Homo sapiens (human) 399 20 379 6 14 7 21 534 555 4.189e-01 0.05 0.04 1.3 Not_Sig hsa05221 Acute myeloid leukemia - Homo sapiens (human) 399 13 386 5 8 5 13 542 555 4.241e-01 0.03 0.02 1.4 Not_Sig 109582 Hemostasis 399 17 382 6 11 19 30 525 555 4.519e-01 0.04 0.05 0.8 Not_Sig 194840 Rho GTPase cycle 399 4 395 2 2 1 3 552 555 4.605e-01 0.01 0.01 1.9 Not_Sig 202131 Metabolism of nitric oxide 399 4 395 1 3 0 3 552 555 4.605e-01 0.01 0.01 1.9 Not_Sig 114509 Platelet activation triggers 399 4 395 1 3 0 3 552 555 4.605e-01 0.01 0.01 1.9 Not_Sig hsa00252 Alanine and aspartate metabolism - Homo sapiens (human) 399 4 395 4 0 3 3 552 555 4.605e-01 0.01 0.01 1.9 Not_Sig 76002 Platelet Activation 399 4 395 1 3 0 3 552 555 4.605e-01 0.01 0.01 1.9 Not_Sig 71387 Metabolism of carbohydrates 399 4 395 2 2 1 3 552 555 4.605e-01 0.01 0.01 1.9 Not_Sig 198725 Nuclear Events (kinase and transcription factor activation) 399 4 395 1 3 0 3 552 555 4.605e-01 0.01 0.01 1.9 Not_Sig 164378 PKA activation in glucagon signalling 399 4 395 1 3 0 3 552 555 4.605e-01 0.01 0.01 1.9 Not_Sig hsa00410 beta-Alanine metabolism - Homo sapiens (human) 399 4 395 3 1 2 3 552 555 4.605e-01 0.01 0.01 1.9 Not_Sig hsa05215 Prostate cancer - Homo sapiens (human) 399 23 376 9 14 12 26 529 555 4.612e-01 0.06 0.05 1.2 Not_Sig 75153 Apoptotic execution phase 399 2 397 0 2 4 6 549 555 4.797e-01 0.01 0.01 0.5 Not_Sig 111465 Cleavage of cellular proteins by active caspases 399 2 397 0 2 4 6 549 555 4.797e-01 0.01 0.01 0.5 Not_Sig 202403 TCR signaling 399 9 390 2 7 2 9 546 555 4.808e-01 0.02 0.02 1.4 Not_Sig 162906 HIV Infection 399 9 390 5 4 5 9 546 555 4.808e-01 0.02 0.02 1.4 Not_Sig hsa04930 Type II diabetes mellitus - Homo sapiens (human) 399 9 390 3 6 3 9 546 555 4.808e-01 0.02 0.02 1.4 Not_Sig hsa04010 MAPK signaling pathway - Homo sapiens (human) 399 37 362 9 28 16 44 511 555 4.813e-01 0.09 0.08 1.2 Not_Sig hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human) 399 17 382 5 12 6 18 537 555 4.856e-01 0.04 0.03 1.3 Not_Sig hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human) 399 13 386 5 8 16 24 531 555 4.972e-01 0.03 0.04 0.8 Not_Sig hsa00561 Glycerolipid metabolism - Homo sapiens (human) 399 5 394 5 0 4 4 551 555 5.029e-01 0.01 0.01 1.7 Not_Sig hsa04660 T cell receptor signaling pathway - Homo sapiens (human) 399 18 381 3 15 5 20 535 555 5.050e-01 0.05 0.04 1.3 Not_Sig hsa04670 Leukocyte transendothelial migration - Homo sapiens (human) 399 14 385 3 11 14 25 530 555 5.093e-01 0.04 0.05 0.8 Not_Sig hsa00980 Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human) 399 3 396 1 2 5 7 548 555 5.338e-01 0.01 0.01 0.6 Not_Sig 194313 VEGF ligand-receptor interactions 399 3 396 0 3 4 7 548 555 5.338e-01 0.01 0.01 0.6 Not_Sig 168180 TRAF6 Mediated Induction of the antiviral cytokine IFN-alpha/beta cascade 399 6 393 1 5 0 5 550 555 5.407e-01 0.02 0.01 1.7 Not_Sig 168164 Toll Like Receptor 3 (TLR3) Cascade 399 6 393 1 5 0 5 550 555 5.407e-01 0.02 0.01 1.7 Not_Sig hsa00230 Purine metabolism - Homo sapiens (human) 399 6 393 3 3 2 5 550 555 5.407e-01 0.02 0.01 1.7 Not_Sig 75178 Formation of Platelet plug 399 9 390 1 8 9 17 538 555 5.473e-01 0.02 0.03 0.7 Not_Sig 73847 Purine metabolism 399 6 393 1 5 1 6 549 555 5.705e-01 0.02 0.01 1.4 Not_Sig hsa01430 Cell Communication - Homo sapiens (human) 399 4 395 1 3 6 9 546 555 5.741e-01 0.01 0.02 0.6 Not_Sig 202670 ERKs are inactivated 399 2 397 1 1 0 1 554 555 5.748e-01 0.01 0.00 2.8 Not_Sig 68867 Assembly of the pre-replicative complex 399 2 397 1 1 0 1 554 555 5.748e-01 0.01 0.00 2.8 Not_Sig 69202 Cyclin E associated events during G1/S transition 399 2 397 1 1 0 1 554 555 5.748e-01 0.01 0.00 2.8 Not_Sig 210993 Tie2 Signaling 399 2 397 1 1 0 1 554 555 5.748e-01 0.01 0.00 2.8 Not_Sig 72613 Eukaryotic Translation Initiation 399 2 397 1 1 0 1 554 555 5.748e-01 0.01 0.00 2.8 Not_Sig 69236 G1 Phase 399 2 397 2 0 1 1 554 555 5.748e-01 0.01 0.00 2.8 Not_Sig 70894 Valine catabolism 399 2 397 1 1 0 1 554 555 5.748e-01 0.01 0.00 2.8 Not_Sig hsa00641 3-Chloroacrylic acid degradation - Homo sapiens (human) 399 2 397 2 0 1 1 554 555 5.748e-01 0.01 0.00 2.8 Not_Sig 173107 Binding and entry of HIV virion 399 2 397 1 1 0 1 554 555 5.748e-01 0.01 0.00 2.8 Not_Sig 111742 Reduction of cytosolic ribonucleoside 5'-diphosphates to deoxyribonucleoside 5'-diphosphates (glutaredoxin) 399 2 397 1 1 0 1 554 555 5.748e-01 0.01 0.00 2.8 Not_Sig 156590 Glutathione conjugation 399 2 397 1 1 0 1 554 555 5.748e-01 0.01 0.00 2.8 Not_Sig 156580 Phase II conjugation 399 2 397 1 1 0 1 554 555 5.748e-01 0.01 0.00 2.8 Not_Sig hsa00630 Glyoxylate and dicarboxylate metabolism - Homo sapiens (human) 399 2 397 1 1 0 1 554 555 5.748e-01 0.01 0.00 2.8 Not_Sig 157279 3' -UTR-mediated translational regulation 399 2 397 1 1 0 1 554 555 5.748e-01 0.01 0.00 2.8 Not_Sig hsa00720 Reductive carboxylate cycle (CO2 fixation) - Homo sapiens (human) 399 2 397 1 1 0 1 554 555 5.748e-01 0.01 0.00 2.8 Not_Sig 114604 Collagen-mediated activation cascade 399 2 397 1 1 0 1 554 555 5.748e-01 0.01 0.00 2.8 Not_Sig 69002 DNA Replication Pre-Initiation 399 2 397 1 1 0 1 554 555 5.748e-01 0.01 0.00 2.8 Not_Sig 72737 Cap-dependent Translation Initiation 399 2 397 1 1 0 1 554 555 5.748e-01 0.01 0.00 2.8 Not_Sig 68874 M/G1 Transition 399 2 397 1 1 0 1 554 555 5.748e-01 0.01 0.00 2.8 Not_Sig 69231 Cyclin D associated events in G1 399 2 397 2 0 1 1 554 555 5.748e-01 0.01 0.00 2.8 Not_Sig 72764 Eukaryotic Translation Termination 399 2 397 1 1 0 1 554 555 5.748e-01 0.01 0.00 2.8 Not_Sig 111747 Reduction of cytosolic ribonucleoside 5'-diphosphates to deoxyribonucleoside 5'-diphosphates by ribonucleotide reductase and glutaredoxin 399 2 397 1 1 0 1 554 555 5.748e-01 0.01 0.00 2.8 Not_Sig 74749 Signal attenuation 399 2 397 1 1 0 1 554 555 5.748e-01 0.01 0.00 2.8 Not_Sig 171007 p38MAPK events 399 2 397 1 1 0 1 554 555 5.748e-01 0.01 0.00 2.8 Not_Sig 69656 Cyclin A:Cdk2-associated events at S phase entry 399 2 397 1 1 0 1 554 555 5.748e-01 0.01 0.00 2.8 Not_Sig hsa00600 Sphingolipid metabolism - Homo sapiens (human) 399 2 397 1 1 0 1 554 555 5.748e-01 0.01 0.00 2.8 Not_Sig 112409 ERK activation 399 2 397 1 1 0 1 554 555 5.748e-01 0.01 0.00 2.8 Not_Sig 69541 Stabilization of p53 399 2 397 1 1 0 1 554 555 5.748e-01 0.01 0.00 2.8 Not_Sig 72706 GTP hydrolysis and joining of the 60S ribosomal subunit 399 2 397 1 1 0 1 554 555 5.748e-01 0.01 0.00 2.8 Not_Sig 72689 Formation of a pool of free 40S subunits 399 2 397 1 1 0 1 554 555 5.748e-01 0.01 0.00 2.8 Not_Sig 156827 L13a-mediated translational silencing of Ceruloplasmin expression 399 2 397 1 1 0 1 554 555 5.748e-01 0.01 0.00 2.8 Not_Sig 74160 Gene Expression 399 7 392 4 3 4 7 548 555 5.909e-01 0.02 0.01 1.4 Not_Sig hsa05060 Prion disease - Homo sapiens (human) 399 7 392 1 6 1 7 548 555 5.909e-01 0.02 0.01 1.4 Not_Sig 71291 Metabolism of amino acids 399 7 392 4 3 4 7 548 555 5.909e-01 0.02 0.01 1.4 Not_Sig hsa05216 Thyroid cancer - Homo sapiens (human) 399 7 392 3 4 3 7 548 555 5.909e-01 0.02 0.01 1.4 Not_Sig hsa04640 Hematopoietic cell lineage - Homo sapiens (human) 399 12 387 2 10 11 21 534 555 5.923e-01 0.03 0.04 0.8 Not_Sig 202424 Downstream TCR signaling 399 8 391 2 6 2 8 547 555 6.112e-01 0.02 0.01 1.4 Not_Sig hsa05212 Pancreatic cancer - Homo sapiens (human) 399 20 379 9 11 13 24 531 555 6.410e-01 0.05 0.04 1.2 Not_Sig hsa00903 Limonene and pinene degradation - Homo sapiens (human) 399 1 398 1 0 3 3 552 555 6.441e-01 0.00 0.01 0.5 Not_Sig hsa04950 Maturity onset diabetes of the young - Homo sapiens (human) 399 1 398 0 1 2 3 552 555 6.441e-01 0.00 0.01 0.5 Not_Sig hsa04614 Renin-angiotensin system - Homo sapiens (human) 399 1 398 0 1 2 3 552 555 6.441e-01 0.00 0.01 0.5 Not_Sig 164385 G(s)-alpha mediated events in glucagon signalling 399 1 398 0 1 2 3 552 555 6.441e-01 0.00 0.01 0.5 Not_Sig 190239 FGFR3 ligand binding and activation 399 1 398 0 1 2 3 552 555 6.441e-01 0.00 0.01 0.5 Not_Sig 157858 Gap junction trafficking and regulation 399 1 398 1 0 3 3 552 555 6.441e-01 0.00 0.01 0.5 Not_Sig 190372 FGFR3c ligand binding and activation 399 1 398 0 1 2 3 552 555 6.441e-01 0.00 0.01 0.5 Not_Sig 111748 Synthesis of deoxyribonucleoside 5'-diphosphates from ribonucleoside 5'-diphosphates 399 3 396 1 2 0 2 553 555 6.547e-01 0.01 0.00 2.1 Not_Sig 73848 Pyrimidine metabolism 399 3 396 1 2 0 2 553 555 6.547e-01 0.01 0.00 2.1 Not_Sig 70326 Glucose metabolism 399 3 396 1 2 0 2 553 555 6.547e-01 0.01 0.00 2.1 Not_Sig hsa04320 Dorso-ventral axis formation - Homo sapiens (human) 399 3 396 2 1 1 2 553 555 6.547e-01 0.01 0.00 2.1 Not_Sig 198323 AKT phosphorylates targets in the cytosol 399 3 396 2 1 1 2 553 555 6.547e-01 0.01 0.00 2.1 Not_Sig 111458 Formation of apoptosome 399 3 396 1 2 0 2 553 555 6.547e-01 0.01 0.00 2.1 Not_Sig 203615 eNOS activation 399 3 396 1 2 0 2 553 555 6.547e-01 0.01 0.00 2.1 Not_Sig hsa00240 Pyrimidine metabolism - Homo sapiens (human) 399 3 396 2 1 1 2 553 555 6.547e-01 0.01 0.00 2.1 Not_Sig 199418 Negative regulation of the PI3K/AKT network 399 3 396 1 2 0 2 553 555 6.547e-01 0.01 0.00 2.1 Not_Sig 203765 eNOS activation and regulation 399 3 396 1 2 0 2 553 555 6.547e-01 0.01 0.00 2.1 Not_Sig 198753 ERK/MAPK targets 399 3 396 1 2 0 2 553 555 6.547e-01 0.01 0.00 2.1 Not_Sig hsa04540 Gap junction - Homo sapiens (human) 399 11 388 7 4 9 13 542 555 6.815e-01 0.03 0.02 1.2 Not_Sig 162587 HIV Life Cycle 399 3 396 2 1 2 3 552 555 6.987e-01 0.01 0.01 1.4 Not_Sig 74226 ATP formation 399 3 396 1 2 1 3 552 555 6.987e-01 0.01 0.01 1.4 Not_Sig 111463 SMAC binds to IAPs 399 3 396 1 2 1 3 552 555 6.987e-01 0.01 0.01 1.4 Not_Sig 109704 PI3K Cascade 399 3 396 1 2 1 3 552 555 6.987e-01 0.01 0.01 1.4 Not_Sig 114452 Activation of BH3-only proteins 399 3 396 0 3 0 3 552 555 6.987e-01 0.01 0.01 1.4 Not_Sig 111469 SMAC-mediated apoptotic response 399 3 396 1 2 1 3 552 555 6.987e-01 0.01 0.01 1.4 Not_Sig 111464 SMAC-mediated dissociation of IAP:caspase complexes 399 3 396 1 2 1 3 552 555 6.987e-01 0.01 0.01 1.4 Not_Sig 75983 Formation and Maturation of mRNA Transcript 399 2 397 1 1 4 5 550 555 7.056e-01 0.01 0.01 0.6 Not_Sig 196849 Metabolism of water-soluble vitamins and cofactors 399 2 397 1 1 4 5 550 555 7.056e-01 0.01 0.01 0.6 Not_Sig 196854 Metabolism of vitamins and cofactors 399 2 397 1 1 4 5 550 555 7.056e-01 0.01 0.01 0.6 Not_Sig 194315 Signaling by Rho GTPases 399 4 395 2 2 2 4 551 555 7.259e-01 0.01 0.01 1.4 Not_Sig 111459 Activation of caspases through apoptosome-mediated cleavage 399 4 395 1 3 1 4 551 555 7.259e-01 0.01 0.01 1.4 Not_Sig hsa00220 Urea cycle and metabolism of amino groups - Homo sapiens (human) 399 4 395 3 1 3 4 551 555 7.259e-01 0.01 0.01 1.4 Not_Sig 75157 FasL/ CD95L signaling 399 4 395 0 4 0 4 551 555 7.259e-01 0.01 0.01 1.4 Not_Sig hsa00860 Porphyrin and chlorophyll metabolism - Homo sapiens (human) 399 4 395 0 4 0 4 551 555 7.259e-01 0.01 0.01 1.4 Not_Sig 111461 Cytochrome c-mediated apoptotic response 399 4 395 1 3 1 4 551 555 7.259e-01 0.01 0.01 1.4 Not_Sig hsa04512 ECM-receptor interaction - Homo sapiens (human) 399 3 396 2 1 5 6 549 555 7.419e-01 0.01 0.01 0.7 Not_Sig 140191 Phase 1 functionalization 399 5 394 3 2 3 5 550 555 7.496e-01 0.01 0.01 1.4 Not_Sig 74231 Purine biosynthesis 399 5 394 1 4 1 5 550 555 7.496e-01 0.01 0.01 1.4 Not_Sig 111471 Apoptotic factor-mediated response 399 5 394 1 4 1 5 550 555 7.496e-01 0.01 0.01 1.4 Not_Sig 109581 Apoptosis 399 19 380 4 15 9 24 531 555 7.541e-01 0.05 0.04 1.1 Not_Sig hsa04110 Cell cycle - Homo sapiens (human) 399 6 393 5 1 6 7 548 555 7.825e-01 0.02 0.01 1.2 Not_Sig hsa04510 Focal adhesion - Homo sapiens (human) 399 28 371 11 17 19 36 519 555 7.935e-01 0.07 0.06 1.1 Not_Sig 168898 Toll Receptor Cascades 399 8 391 3 5 5 10 545 555 8.143e-01 0.02 0.02 1.1 Not_Sig 168249 Innate Immunity Signaling 399 8 391 3 5 5 10 545 555 8.143e-01 0.02 0.02 1.1 Not_Sig hsa05219 Bladder cancer - Homo sapiens (human) 399 10 389 6 4 8 12 543 555 8.277e-01 0.03 0.02 1.2 Not_Sig hsa05040 Huntington's disease - Homo sapiens (human) 399 9 390 2 7 7 14 541 555 8.342e-01 0.02 0.03 0.9 Not_Sig hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human) 399 16 383 5 11 10 21 534 555 8.665e-01 0.04 0.04 1.1 Not_Sig 168256 Signaling in Immune system 399 24 375 10 14 18 32 523 555 8.896e-01 0.06 0.06 1.0 Not_Sig hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human) 399 23 376 6 17 15 32 523 555 1.000e+00 0.06 0.06 1.0 Not_Sig hsa04310 Wnt signaling pathway - Homo sapiens (human) 399 11 388 3 8 7 15 540 555 1.000e+00 0.03 0.03 1.0 Not_Sig hsa04020 Calcium signaling pathway - Homo sapiens (human) 399 11 388 4 7 8 15 540 555 1.000e+00 0.03 0.03 1.0 Not_Sig hsa04150 mTOR signaling pathway - Homo sapiens (human) 399 10 389 3 7 7 14 541 555 1.000e+00 0.03 0.03 1.0 Not_Sig hsa05120 Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) 399 10 389 1 9 5 14 541 555 1.000e+00 0.03 0.03 1.0 Not_Sig hsa04940 Type I diabetes mellitus - Homo sapiens (human) 399 10 389 1 9 4 13 542 555 1.000e+00 0.03 0.02 1.1 Not_Sig hsa05010 Alzheimer's disease - Homo sapiens (human) 399 10 389 1 9 6 15 540 555 1.000e+00 0.03 0.03 0.9 Not_Sig hsa04612 Antigen processing and presentation - Homo sapiens (human) 399 8 391 2 6 6 12 543 555 1.000e+00 0.02 0.02 0.9 Not_Sig hsa00590 Arachidonic acid metabolism - Homo sapiens (human) 399 7 392 2 5 6 11 544 555 1.000e+00 0.02 0.02 0.9 Not_Sig hsa04350 TGF-beta signaling pathway - Homo sapiens (human) 399 7 392 2 5 4 9 546 555 1.000e+00 0.02 0.02 1.1 Not_Sig hsa04520 Adherens junction - Homo sapiens (human) 399 6 393 3 3 6 9 546 555 1.000e+00 0.02 0.02 0.9 Not_Sig 73887 Death Receptor Signalling 399 5 394 0 5 3 8 547 555 1.000e+00 0.01 0.01 0.9 Not_Sig 74159 Transcription 399 5 394 3 2 4 6 549 555 1.000e+00 0.01 0.01 1.2 Not_Sig hsa05050 Dentatorubropallidoluysian atrophy (DRPLA) - Homo sapiens (human) 399 5 394 0 5 1 6 549 555 1.000e+00 0.01 0.01 1.2 Not_Sig hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human) 399 5 394 2 3 4 7 548 555 1.000e+00 0.01 0.01 1.0 Not_Sig 109607 Extrinsic Pathway for Apoptosis 399 5 394 0 5 3 8 547 555 1.000e+00 0.01 0.01 0.9 Not_Sig 163359 Glucagon signaling in metabolic regulation 399 4 395 1 3 2 5 550 555 1.000e+00 0.01 0.01 1.1 Not_Sig 140534 Caspase-8 is formed from procaspase-8 399 4 395 0 4 2 6 549 555 1.000e+00 0.01 0.01 0.9 Not_Sig hsa05130 Pathogenic Escherichia coli infection - EHEC - Homo sapiens (human) 399 4 395 2 2 4 6 549 555 1.000e+00 0.01 0.01 0.9 Not_Sig hsa00330 Arginine and proline metabolism - Homo sapiens (human) 399 4 395 1 3 3 6 549 555 1.000e+00 0.01 0.01 0.9 Not_Sig hsa05131 Pathogenic Escherichia coli infection - EPEC - Homo sapiens (human) 399 4 395 2 2 4 6 549 555 1.000e+00 0.01 0.01 0.9 Not_Sig 69416 Activation of Pro-Caspase 8 399 4 395 0 4 2 6 549 555 1.000e+00 0.01 0.01 0.9 Not_Sig hsa00680 Methane metabolism - Homo sapiens (human) 399 3 396 1 2 2 4 551 555 1.000e+00 0.01 0.01 1.0 Not_Sig 195399 VEGF binds to VEGFR leading to receptor dimerization 399 3 396 0 3 2 5 550 555 1.000e+00 0.01 0.01 0.8 Not_Sig 194306 Neurophilin interactions with VEGF and VEGFR 399 3 396 0 3 2 5 550 555 1.000e+00 0.01 0.01 0.8 Not_Sig 75071 mRNA Processing 399 3 396 2 1 3 4 551 555 1.000e+00 0.01 0.01 1.0 Not_Sig 75893 TNF signaling 399 3 396 0 3 1 4 551 555 1.000e+00 0.01 0.01 1.0 Not_Sig 196836 Vitamin C (ascorbate) metabolism 399 2 397 1 1 1 2 553 555 1.000e+00 0.01 0.00 1.4 Not_Sig hsa00960 Alkaloid biosynthesis II - Homo sapiens (human) 399 2 397 0 2 1 3 552 555 1.000e+00 0.01 0.01 0.9 Not_Sig 163210 Formation of ATP by chemiosmotic coupling 399 2 397 0 2 1 3 552 555 1.000e+00 0.01 0.01 0.9 Not_Sig 111807 Reduction of nuclear ribonucleoside 5'-diphosphates to deoxyribonucleoside 5'-diphosphates by ribonucleotide reductase and thioredoxin 399 2 397 0 2 0 2 553 555 1.000e+00 0.01 0.00 1.4 Not_Sig hsa00280 Valine, leucine and isoleucine degradation - Homo sapiens (human) 399 2 397 2 0 2 2 553 555 1.000e+00 0.01 0.00 1.4 Not_Sig 72163 mRNA Splicing - Major Pathway 399 2 397 1 1 2 3 552 555 1.000e+00 0.01 0.01 0.9 Not_Sig hsa00910 Nitrogen metabolism - Homo sapiens (human) 399 2 397 0 2 1 3 552 555 1.000e+00 0.01 0.01 0.9 Not_Sig 111752 Reduction of cytosolic ribonucleoside 5'-diphosphates to deoxyribonucleoside 5'-diphosphates by ribonucleotide reductase and thioredoxin 399 2 397 0 2 0 2 553 555 1.000e+00 0.01 0.00 1.4 Not_Sig 73857 RNA Polymerase II Transcription 399 2 397 1 1 3 4 551 555 1.000e+00 0.01 0.01 0.7 Not_Sig 187015 Activation of TRKA receptors 399 2 397 1 1 1 2 553 555 1.000e+00 0.01 0.00 1.4 Not_Sig 168254 Influenza Infection 399 2 397 1 1 1 2 553 555 1.000e+00 0.01 0.00 1.4 Not_Sig hsa00100 Biosynthesis of steroids - Homo sapiens (human) 399 2 397 2 0 2 2 553 555 1.000e+00 0.01 0.00 1.4 Not_Sig 70171 Glycolysis 399 2 397 0 2 0 2 553 555 1.000e+00 0.01 0.00 1.4 Not_Sig 112295 Elongation and Processing of Capped Transcripts 399 2 397 1 1 3 4 551 555 1.000e+00 0.01 0.01 0.7 Not_Sig 157212 A third proteolytic cleavage releases NICD 399 2 397 0 2 0 2 553 555 1.000e+00 0.01 0.00 1.4 Not_Sig 74219 dGTP formation 399 2 397 0 2 0 2 553 555 1.000e+00 0.01 0.00 1.4 Not_Sig 114696 Thrombin-activated activation cascade 399 2 397 0 2 0 2 553 555 1.000e+00 0.01 0.00 1.4 Not_Sig 76043 Elongation of Intron-Containing Transcripts and co-transcriptional mRNA splicing 399 2 397 1 1 3 4 551 555 1.000e+00 0.01 0.01 0.7 Not_Sig 70268 Cori Cycle (interconversion of glucose and lactate) 399 2 397 0 2 0 2 553 555 1.000e+00 0.01 0.00 1.4 Not_Sig hsa00564 Glycerophospholipid metabolism - Homo sapiens (human) 399 2 397 2 0 4 4 551 555 1.000e+00 0.01 0.01 0.7 Not_Sig 75815 Ubiquitin-dependent degradation of Cyclin D 399 2 397 1 1 1 2 553 555 1.000e+00 0.01 0.00 1.4 Not_Sig 72187 mRNA 3'-end processing 399 2 397 1 1 1 2 553 555 1.000e+00 0.01 0.00 1.4 Not_Sig 112296 Post-Elongation Processing of Intron-Containing pre-mRNA 399 2 397 1 1 1 2 553 555 1.000e+00 0.01 0.00 1.4 Not_Sig 164952 The role of Nef in HIV-1 replication and disease pathogenesis 399 2 397 0 2 0 2 553 555 1.000e+00 0.01 0.00 1.4 Not_Sig 69229 Ubiquitin-dependent degradation of Cyclin D1 399 2 397 1 1 1 2 553 555 1.000e+00 0.01 0.00 1.4 Not_Sig 114665 G-protein cascades 399 2 397 0 2 0 2 553 555 1.000e+00 0.01 0.00 1.4 Not_Sig 202433 Generation of second messenger molecules 399 2 397 0 2 1 3 552 555 1.000e+00 0.01 0.01 0.9 Not_Sig hsa00940 Phenylpropanoid biosynthesis - Homo sapiens (human) 399 2 397 1 1 1 2 553 555 1.000e+00 0.01 0.00 1.4 Not_Sig 168927 Viral dsRNA:TLR3:TRIF Complex Activates RIP1 399 2 397 0 2 0 2 553 555 1.000e+00 0.01 0.00 1.4 Not_Sig hsa04140 Regulation of autophagy - Homo sapiens (human) 399 2 397 0 2 2 4 551 555 1.000e+00 0.01 0.01 0.7 Not_Sig 192076 Steroid metabolism 399 2 397 1 1 2 3 552 555 1.000e+00 0.01 0.01 0.9 Not_Sig 112168 Processing of Capped pre-mRNA 399 2 397 1 1 2 3 552 555 1.000e+00 0.01 0.01 0.9 Not_Sig 70614 Aspartate, asparagine, glutamate, and glutamine metabolism 399 2 397 0 2 0 2 553 555 1.000e+00 0.01 0.00 1.4 Not_Sig 210990 PECAM1 interactions 399 2 397 1 1 1 2 553 555 1.000e+00 0.01 0.00 1.4 Not_Sig 198693 AKT phosphorylates targets in the nucleus 399 2 397 0 2 0 2 553 555 1.000e+00 0.01 0.00 1.4 Not_Sig 109688 Cleavage of Growing Transcript in the Termination Region 399 2 397 1 1 1 2 553 555 1.000e+00 0.01 0.00 1.4 Not_Sig hsa00071 Fatty acid metabolism - Homo sapiens (human) 399 2 397 2 0 2 2 553 555 1.000e+00 0.01 0.00 1.4 Not_Sig 76044 Post-Elongation Processing of the Transcript 399 2 397 1 1 1 2 553 555 1.000e+00 0.01 0.00 1.4 Not_Sig 111447 Activation of BAD and translocation to mitochondria 399 2 397 0 2 0 2 553 555 1.000e+00 0.01 0.00 1.4 Not_Sig 73856 RNA Polymerase II Transcription Termination 399 2 397 1 1 1 2 553 555 1.000e+00 0.01 0.00 1.4 Not_Sig 72202 Transport of Mature Transcript to Cytoplasm 399 2 397 1 1 1 2 553 555 1.000e+00 0.01 0.00 1.4 Not_Sig 75158 TRAIL signaling 399 2 397 0 2 2 4 551 555 1.000e+00 0.01 0.01 0.7 Not_Sig 74230 dATP formation 399 2 397 0 2 0 2 553 555 1.000e+00 0.01 0.00 1.4 Not_Sig hsa05217 Basal cell carcinoma - Homo sapiens (human) 399 2 397 1 1 1 2 553 555 1.000e+00 0.01 0.00 1.4 Not_Sig 111457 Release of apoptotic factors from the mitochondria 399 2 397 0 2 0 2 553 555 1.000e+00 0.01 0.00 1.4 Not_Sig hsa05110 Cholera - Infection - Homo sapiens (human) 399 2 397 0 2 0 2 553 555 1.000e+00 0.01 0.00 1.4 Not_Sig 70895 Branched-chain amino acid catabolism 399 2 397 1 1 1 2 553 555 1.000e+00 0.01 0.00 1.4 Not_Sig 111804 Reduction of nuclear ribonucleoside 5'-diphosphates to deoxyribonucleoside 5'-diphosphates (thioredoxin) 399 2 397 0 2 0 2 553 555 1.000e+00 0.01 0.00 1.4 Not_Sig 72172 mRNA Splicing 399 2 397 1 1 2 3 552 555 1.000e+00 0.01 0.01 0.9 Not_Sig hsa00640 Propanoate metabolism - Homo sapiens (human) 399 2 397 2 0 3 3 552 555 1.000e+00 0.01 0.01 0.9 Not_Sig 187024 NGF-independant TRKA activation 399 2 397 1 1 1 2 553 555 1.000e+00 0.01 0.00 1.4 Not_Sig hsa04330 Notch signaling pathway - Homo sapiens (human) 399 2 397 0 2 2 4 551 555 1.000e+00 0.01 0.01 0.7 Not_Sig hsa00760 Nicotinate and nicotinamide metabolism - Homo sapiens (human) 399 2 397 1 1 1 2 553 555 1.000e+00 0.01 0.00 1.4 Not_Sig 167021 PLC-gamma1 signalling 399 2 397 0 2 0 2 553 555 1.000e+00 0.01 0.00 1.4 Not_Sig 73648 Pyrimidine biosynthesis (interconversion) 399 2 397 0 2 0 2 553 555 1.000e+00 0.01 0.00 1.4 Not_Sig 111751 Reduction of cytosolic ribonucleoside 5'-diphosphates to deoxyribonucleoside 5'-diphosphates (thioredoxin) 399 2 397 0 2 0 2 553 555 1.000e+00 0.01 0.00 1.4 Not_Sig 157118 Signaling by Notch 399 2 397 0 2 0 2 553 555 1.000e+00 0.01 0.00 1.4 Not_Sig 72203 Processing of Capped Intron-Containing Pre-mRNA 399 2 397 1 1 2 3 552 555 1.000e+00 0.01 0.01 0.9 Not_Sig 109970 Global Genomic NER (GG-NER) 399 1 398 1 0 1 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig hsa00550 Peptidoglycan biosynthesis - Homo sapiens (human) 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 166207 S6K1-mediated signalling 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 69610 p53-Independent DNA Damage Response 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 194068 Metabolism of bile acids and bile salts 399 1 398 0 1 1 2 553 555 1.000e+00 0.00 0.00 0.7 Not_Sig 72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 140180 COX reactions 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 199920 CREB phosphorylation 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 202427 Phosphorylation of CD3 and TCR zeta chains 399 1 398 0 1 1 2 553 555 1.000e+00 0.00 0.00 0.7 Not_Sig 74744 SHC activation 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 114592 Collagen adhesion via alpha 2 beta 1 glycoprotein 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 202430 Translocation of ZAP-70 to Immunological synapse 399 1 398 0 1 1 2 553 555 1.000e+00 0.00 0.00 0.7 Not_Sig hsa00450 Selenoamino acid metabolism - Homo sapiens (human) 399 1 398 1 0 1 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig hsa00310 Lysine degradation - Homo sapiens (human) 399 1 398 1 0 1 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 190370 FGFR1b ligand binding and activation 399 1 398 0 1 1 2 553 555 1.000e+00 0.00 0.00 0.7 Not_Sig 70108 Glyceraldehyde 3-phosphate, NAD+, and orthophosphate react to form 1,3-bisphosphoglycerate, NADH, and H+ 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig hsa00053 Ascorbate and aldarate metabolism - Homo sapiens (human) 399 1 398 1 0 1 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 166208 mTORC1-mediated signalling 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 112297 Post-Elongation Processing of Intronless pre-mRNA 399 1 398 0 1 1 2 553 555 1.000e+00 0.00 0.00 0.7 Not_Sig 70263 Gluconeogenesis 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 75108 Activation, myristolyation of BID and translocation to mitochondria 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 72695 Formation of the ternary complex, and subsequently, the 43S complex 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 74257 Xanthine formation 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 187042 TRKA activation by NGF 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 164938 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 114508 Phospholipase-mediated signalling 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 167826 The fatty acid cycling model 399 1 398 0 1 1 2 553 555 1.000e+00 0.00 0.00 0.7 Not_Sig 177504 Retrograde neurotrophin signalling 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 114516 Disinhibition of SNARE formation 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 159234 Transport of Mature mRNAs Derived from Intronless Transcripts 399 1 398 0 1 1 2 553 555 1.000e+00 0.00 0.00 0.7 Not_Sig 72165 mRNA Splicing - Minor Pathway 399 1 398 1 0 1 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 74713 IRS activation 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 140187 P450 Prostaglandin isomerizations 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 159231 Transport of Mature mRNA Derived from an Intronless Transcript 399 1 398 0 1 1 2 553 555 1.000e+00 0.00 0.00 0.7 Not_Sig hsa00624 1- and 2-Methylnaphthalene degradation - Homo sapiens (human) 399 1 398 1 0 1 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 72702 Ribosomal scanning and start codon recognition 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 180534 Vpu mediated degradation of CD4 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 165159 mTOR signalling 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 167590 Nef Mediated CD4 Down-regulation 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 164944 Nef and signal transduction 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig hsa00471 D-Glutamine and D-glutamate metabolism - Homo sapiens (human) 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 166187 Mitochondrial Uncoupling Proteins 399 1 398 0 1 1 2 553 555 1.000e+00 0.00 0.00 0.7 Not_Sig 114664 G alpha 12 cascade 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 70525 Alanine metabolism 399 1 398 1 0 1 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 69613 p53-Independent G1/S DNA damage checkpoint 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 114711 vWF interaction with collagen 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig hsa03022 Basal transcription factors - Homo sapiens (human) 399 1 398 0 1 1 2 553 555 1.000e+00 0.00 0.00 0.7 Not_Sig 69017 CDK-mediated phosphorylation and removal of Cdc6 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 190371 FGFR3b ligand binding and activation 399 1 398 0 1 1 2 553 555 1.000e+00 0.00 0.00 0.7 Not_Sig 72649 Translation initiation complex formation 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 114593 Collagen adhesion via Gp IV 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig hsa04742 Taste transduction - Homo sapiens (human) 399 1 398 1 0 2 2 553 555 1.000e+00 0.00 0.00 0.7 Not_Sig 68827 CDT1 association with the CDC6:ORC:origin complex 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 77595 Processing of Intronless Pre-mRNAs 399 1 398 0 1 1 2 553 555 1.000e+00 0.00 0.00 0.7 Not_Sig hsa00130 Ubiquinone biosynthesis - Homo sapiens (human) 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 139910 Activation of BMF and translocation to mitochondria 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 112411 ERK2 activation 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 111446 Activation of BIM and translocation to mitochondria 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig hsa00970 Aminoacyl-tRNA biosynthesis - Homo sapiens (human) 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 75877 Conversion of Fatty Acyl-CoA to Phosphatidic Acid 399 1 398 1 0 1 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 77387 Insulin receptor recycling 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 109703 PKB-mediated events 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 74259 Purine catabolism 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 70793 Leucine catabolism 399 1 398 1 0 1 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 73854 RNA Polymerase I Promoter Clearance 399 1 398 1 0 1 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 73937 Transcription-coupled NER (TC-NER) 399 1 398 1 0 1 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 191273 Cholesterol biosynthesis 399 1 398 1 0 1 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 165720 S6K1 signalling 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 75109 Triacylglyceride Biosynthesis 399 1 398 1 0 1 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 75892 Platelet Adhesion to exposed collagen 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 159418 Recycling of bile acids and salts 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 190377 FGFR2b ligand binding and activation 399 1 398 0 1 1 2 553 555 1.000e+00 0.00 0.00 0.7 Not_Sig 73885 Nucleotide Excision Repair 399 1 398 1 0 1 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 114666 G alpha Q cascade 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 212718 EGFR interacts with phospholipase C-gamma 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 75067 Processing of Capped Intronless Pre-mRNA 399 1 398 0 1 1 2 553 555 1.000e+00 0.00 0.00 0.7 Not_Sig 191345 Transformation of lanosterol to cholesterol 399 1 398 1 0 1 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 139943 PLC-mediated hydrolysis 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig hsa00232 Caffeine metabolism - Homo sapiens (human) 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 167827 The proton buffering model 399 1 398 0 1 1 2 553 555 1.000e+00 0.00 0.00 0.7 Not_Sig 111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 198745 Signalling to STAT3 399 1 398 0 1 1 2 553 555 1.000e+00 0.00 0.00 0.7 Not_Sig 69298 Association of licensing factors with the pre-replicative complex 399 1 398 0 1 0 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig 73864 RNA Polymerase I Transcription 399 1 398 1 0 1 1 554 555 1.000e+00 0.00 0.00 1.4 Not_Sig