#GOID GOTerm t-total t+ t- b+ b- b-total p-value t-ratio b-ratio (t-ratio)/(b-ratio) GO:0004871 signal transducer activity 399 54 345 154 401 555 1.271e-07 0.14 0.28 0.5 GO:0060089 molecular transducer activity 399 54 345 154 401 555 1.271e-07 0.14 0.28 0.5 GO:0004872 receptor activity 399 36 363 111 444 555 2.919e-06 0.09 0.20 0.5 GO:0004888 transmembrane receptor activity 399 25 374 79 476 555 8.504e-05 0.06 0.14 0.4 GO:0005102 receptor binding 399 44 355 114 441 555 9.461e-05 0.11 0.21 0.5 GO:0000166 nucleotide binding 399 109 290 100 455 555 8.337e-04 0.27 0.18 1.5 GO:0008026 ATP\-dependent helicase activity 399 10 389 1 554 555 1.054e-03 0.03 0.00 13.9 GO:0019955 cytokine binding 399 2 397 18 537 555 2.570e-03 0.01 0.03 0.2 GO:0043566 structure\-specific DNA binding 399 14 385 4 551 555 2.709e-03 0.04 0.01 4.9 GO:0003824 catalytic activity 399 228 171 264 291 555 3.856e-03 0.57 0.48 1.2 GO:0017076 purine nucleotide binding 399 102 297 99 456 555 4.782e-03 0.26 0.18 1.4 GO:0003684 damaged DNA binding 399 8 391 1 554 555 5.115e-03 0.02 0.00 11.1 GO:0030554 adenyl nucleotide binding 399 94 305 90 465 555 5.949e-03 0.24 0.16 1.5 GO:0004386 helicase activity 399 11 388 3 552 555 6.063e-03 0.03 0.01 5.1 GO:0008233 peptidase activity 399 15 384 45 510 555 6.587e-03 0.04 0.08 0.5 GO:0016817 hydrolase activity\, acting on acid anhydrides 399 34 365 24 531 555 8.853e-03 0.09 0.04 2.0 GO:0016462 pyrophosphatase activity 399 34 365 24 531 555 8.853e-03 0.09 0.04 2.0 GO:0016818 hydrolase activity\, acting on acid anhydrides\, in phosphorus\-containing anhydrides 399 34 365 24 531 555 8.853e-03 0.09 0.04 2.0 GO:0016887 ATPase activity 399 24 375 14 541 555 1.086e-02 0.06 0.03 2.4 GO:0017111 nucleoside\-triphosphatase activity 399 33 366 23 532 555 1.133e-02 0.08 0.04 2.0 GO:0004520 endodeoxyribonuclease activity 399 5 394 0 555 555 1.261e-02 0.01 0.00 bZero GO:0032555 purine ribonucleotide binding 399 86 313 84 471 555 1.275e-02 0.22 0.15 1.4 GO:0032553 ribonucleotide binding 399 86 313 84 471 555 1.275e-02 0.22 0.15 1.4 GO:0004930 G\-protein coupled receptor activity 399 9 390 31 524 555 1.325e-02 0.02 0.06 0.4 GO:0042623 ATPase activity\, coupled 399 22 377 13 542 555 1.365e-02 0.06 0.02 2.4 GO:0032559 adenyl ribonucleotide binding 399 78 321 75 480 555 1.554e-02 0.20 0.14 1.4 GO:0001584 rhodopsin\-like receptor activity 399 8 391 28 527 555 1.561e-02 0.02 0.05 0.4 GO:0008009 chemokine activity 399 1 398 11 544 555 1.797e-02 0.00 0.02 0.1 GO:0042379 chemokine receptor binding 399 1 398 11 544 555 1.797e-02 0.00 0.02 0.1 GO:0003690 double\-stranded DNA binding 399 10 389 3 552 555 1.950e-02 0.03 0.01 4.6 GO:0008094 DNA\-dependent ATPase activity 399 8 391 2 553 555 2.053e-02 0.02 0.00 5.6 GO:0004175 endopeptidase activity 399 14 385 39 516 555 2.146e-02 0.04 0.07 0.5 GO:0004003 ATP\-dependent DNA helicase activity 399 6 393 1 554 555 2.363e-02 0.02 0.00 8.3 GO:0005524 ATP binding 399 74 325 73 482 555 2.888e-02 0.19 0.13 1.4 GO:0005319 lipid transporter activity 399 3 396 15 540 555 3.055e-02 0.01 0.03 0.3 GO:0001664 G\-protein\-coupled receptor binding 399 2 397 13 542 555 3.196e-02 0.01 0.02 0.2 GO:0003678 DNA helicase activity 399 9 390 3 552 555 3.449e-02 0.02 0.01 4.2 GO:0003697 single\-stranded DNA binding 399 7 392 2 553 555 3.936e-02 0.02 0.00 4.9 GO:0004527 exonuclease activity 399 7 392 2 553 555 3.936e-02 0.02 0.00 4.9 GO:0005125 cytokine activity 399 20 379 48 507 555 4.054e-02 0.05 0.09 0.6 GO:0016491 oxidoreductase activity 399 81 318 84 471 555 4.572e-02 0.20 0.15 1.3 GO:0003676 nucleic acid binding 399 91 308 98 457 555 5.806e-02 0.23 0.18 1.3 GO:0004536 deoxyribonuclease activity 399 8 391 3 552 555 6.039e-02 0.02 0.01 3.7 GO:0016788 hydrolase activity\, acting on ester bonds 399 33 366 29 526 555 6.335e-02 0.08 0.05 1.6 GO:0008022 protein C\-terminus binding 399 10 389 5 550 555 6.405e-02 0.03 0.01 2.8 GO:0042578 phosphoric ester hydrolase activity 399 15 384 10 545 555 6.723e-02 0.04 0.02 2.1 GO:0019104 DNA N\-glycosylase activity 399 3 396 0 555 555 7.284e-02 0.01 0.00 bZero GO:0016799 hydrolase activity\, hydrolyzing N\-glycosyl compounds 399 3 396 0 555 555 7.284e-02 0.01 0.00 bZero GO:0005509 calcium ion binding 399 25 374 53 502 555 7.292e-02 0.06 0.10 0.7 GO:0016651 oxidoreductase activity\, acting on NADH or NADPH 399 13 386 8 547 555 7.335e-02 0.03 0.01 2.3 GO:0009055 electron carrier activity 399 41 358 39 516 555 7.689e-02 0.10 0.07 1.5 GO:0008237 metallopeptidase activity 399 2 397 10 545 555 8.501e-02 0.01 0.02 0.3 GO:0030528 transcription regulator activity 399 40 359 76 479 555 8.896e-02 0.10 0.14 0.7 GO:0004674 protein serine/threonine kinase activity 399 29 370 26 529 555 9.344e-02 0.07 0.05 1.6 GO:0001871 pattern binding 399 8 391 22 533 555 9.370e-02 0.02 0.04 0.5 GO:0003677 DNA binding 399 79 320 87 468 555 1.007e-01 0.20 0.16 1.3 GO:0019899 enzyme binding 399 27 372 24 531 555 1.092e-01 0.07 0.04 1.6 GO:0008528 peptide receptor activity\, G\-protein coupled 399 3 396 12 543 555 1.133e-01 0.01 0.02 0.3 GO:0001653 peptide receptor activity 399 3 396 12 543 555 1.133e-01 0.01 0.02 0.3 GO:0004518 nuclease activity 399 13 386 9 546 555 1.251e-01 0.03 0.02 2.0 GO:0050662 coenzyme binding 399 25 374 22 533 555 1.289e-01 0.06 0.04 1.6 GO:0030246 carbohydrate binding 399 11 388 27 528 555 1.302e-01 0.03 0.05 0.6 GO:0015276 ligand\-gated ion channel activity 399 2 397 9 546 555 1.331e-01 0.01 0.02 0.3 GO:0022834 ligand\-gated channel activity 399 2 397 9 546 555 1.331e-01 0.01 0.02 0.3 GO:0005021 vascular endothelial growth factor receptor activity 399 2 397 9 546 555 1.331e-01 0.01 0.02 0.3 GO:0004721 phosphoprotein phosphatase activity 399 5 394 2 553 555 1.363e-01 0.01 0.00 3.5 GO:0051539 4 iron\, 4 sulfur cluster binding 399 5 394 2 553 555 1.363e-01 0.01 0.00 3.5 GO:0051920 peroxiredoxin activity 399 5 394 2 553 555 1.363e-01 0.01 0.00 3.5 GO:0008408 3'\-5' exonuclease activity 399 5 394 2 553 555 1.363e-01 0.01 0.00 3.5 GO:0030145 manganese ion binding 399 8 391 4 551 555 1.375e-01 0.02 0.01 2.8 GO:0008081 phosphoric diester hydrolase activity 399 8 391 4 551 555 1.375e-01 0.02 0.01 2.8 GO:0004519 endonuclease activity 399 8 391 4 551 555 1.375e-01 0.02 0.01 2.8 GO:0004879 ligand\-dependent nuclear receptor activity 399 6 393 17 538 555 1.382e-01 0.02 0.03 0.5 GO:0008083 growth factor activity 399 20 379 42 513 555 1.426e-01 0.05 0.08 0.7 GO:0008238 exopeptidase activity 399 1 398 7 548 555 1.489e-01 0.00 0.01 0.2 GO:0008201 heparin binding 399 7 392 19 536 555 1.577e-01 0.02 0.03 0.5 GO:0005539 glycosaminoglycan binding 399 7 392 19 536 555 1.577e-01 0.02 0.03 0.5 GO:0030247 polysaccharide binding 399 7 392 19 536 555 1.577e-01 0.02 0.03 0.5 GO:0016614 oxidoreductase activity\, acting on CH\-OH group of donors 399 8 391 5 550 555 1.653e-01 0.02 0.01 2.2 GO:0003755 peptidyl\-prolyl cis\-trans isomerase activity 399 4 395 1 554 555 1.673e-01 0.01 0.00 5.6 GO:0016859 cis\-trans isomerase activity 399 4 395 1 554 555 1.673e-01 0.01 0.00 5.6 GO:0015300 solute\:solute antiporter activity 399 2 397 0 555 555 1.747e-01 0.01 0.00 bZero GO:0015297 antiporter activity 399 2 397 0 555 555 1.747e-01 0.01 0.00 bZero GO:0008379 thioredoxin peroxidase activity 399 2 397 0 555 555 1.747e-01 0.01 0.00 bZero GO:0004032 aldehyde reductase activity 399 2 397 0 555 555 1.747e-01 0.01 0.00 bZero GO:0004033 aldo\-keto reductase activity 399 2 397 0 555 555 1.747e-01 0.01 0.00 bZero GO:0030337 DNA polymerase processivity factor activity 399 2 397 0 555 555 1.747e-01 0.01 0.00 bZero GO:0016531 copper chaperone activity 399 2 397 0 555 555 1.747e-01 0.01 0.00 bZero GO:0016530 metallochaperone activity 399 2 397 0 555 555 1.747e-01 0.01 0.00 bZero GO:0051880 G\-quadruplex DNA binding 399 2 397 0 555 555 1.747e-01 0.01 0.00 bZero GO:0000405 bubble DNA binding 399 2 397 0 555 555 1.747e-01 0.01 0.00 bZero GO:0000217 DNA secondary structure binding 399 2 397 0 555 555 1.747e-01 0.01 0.00 bZero GO:0009378 four\-way junction helicase activity 399 2 397 0 555 555 1.747e-01 0.01 0.00 bZero GO:0043138 3'\-5' DNA helicase activity 399 2 397 0 555 555 1.747e-01 0.01 0.00 bZero GO:0004523 ribonuclease H activity 399 2 397 0 555 555 1.747e-01 0.01 0.00 bZero GO:0016891 endoribonuclease activity\, producing 5'\-phosphomonoesters 399 2 397 0 555 555 1.747e-01 0.01 0.00 bZero GO:0016893 endonuclease activity\, active with either ribo\- or deoxyribonucleic acids and producing 5'\-phosphomonoesters 399 2 397 0 555 555 1.747e-01 0.01 0.00 bZero GO:0004357 glutamate\-cysteine ligase activity 399 2 397 0 555 555 1.747e-01 0.01 0.00 bZero GO:0000014 single\-stranded DNA specific endodeoxyribonuclease activity 399 2 397 0 555 555 1.747e-01 0.01 0.00 bZero GO:0042826 histone deacetylase binding 399 2 397 0 555 555 1.747e-01 0.01 0.00 bZero GO:0032404 mismatch repair complex binding 399 2 397 0 555 555 1.747e-01 0.01 0.00 bZero GO:0003746 translation elongation factor activity 399 2 397 0 555 555 1.747e-01 0.01 0.00 bZero GO:0003724 RNA helicase activity 399 2 397 0 555 555 1.747e-01 0.01 0.00 bZero GO:0016653 oxidoreductase activity\, acting on NADH or NADPH\, heme protein as acceptor 399 2 397 0 555 555 1.747e-01 0.01 0.00 bZero GO:0004739 pyruvate dehydrogenase (acetyl\-transferring) activity 399 2 397 0 555 555 1.747e-01 0.01 0.00 bZero GO:0016624 oxidoreductase activity\, acting on the aldehyde or oxo group of donors\, disulfide as acceptor 399 2 397 0 555 555 1.747e-01 0.01 0.00 bZero GO:0004738 pyruvate dehydrogenase activity 399 2 397 0 555 555 1.747e-01 0.01 0.00 bZero GO:0005385 zinc ion transmembrane transporter activity 399 2 397 0 555 555 1.747e-01 0.01 0.00 bZero GO:0008160 protein tyrosine phosphatase activator activity 399 2 397 0 555 555 1.747e-01 0.01 0.00 bZero GO:0019211 phosphatase activator activity 399 2 397 0 555 555 1.747e-01 0.01 0.00 bZero GO:0019888 protein phosphatase regulator activity 399 2 397 0 555 555 1.747e-01 0.01 0.00 bZero GO:0019208 phosphatase regulator activity 399 2 397 0 555 555 1.747e-01 0.01 0.00 bZero GO:0016655 oxidoreductase activity\, acting on NADH or NADPH\, quinone or similar compound as acceptor 399 6 393 3 552 555 1.762e-01 0.02 0.01 2.8 GO:0004601 peroxidase activity 399 12 387 9 546 555 1.808e-01 0.03 0.02 1.9 GO:0016684 oxidoreductase activity\, acting on peroxide as acceptor 399 12 387 9 546 555 1.808e-01 0.03 0.02 1.9 GO:0016787 hydrolase activity 399 87 312 101 454 555 1.868e-01 0.22 0.18 1.2 GO:0016772 transferase activity\, transferring phosphorus\-containing groups 399 46 353 49 506 555 1.886e-01 0.12 0.09 1.3 GO:0022804 active transmembrane transporter activity 399 21 378 19 536 555 1.904e-01 0.05 0.03 1.5 GO:0003700 transcription factor activity 399 28 371 53 502 555 1.953e-01 0.07 0.10 0.7 GO:0016209 antioxidant activity 399 17 382 15 540 555 2.048e-01 0.04 0.03 1.6 GO:0005231 excitatory extracellular ligand\-gated ion channel activity 399 2 397 8 547 555 2.069e-01 0.01 0.01 0.3 GO:0005230 extracellular ligand\-gated ion channel activity 399 2 397 8 547 555 2.069e-01 0.01 0.01 0.3 GO:0016301 kinase activity 399 42 357 45 510 555 2.111e-01 0.11 0.08 1.3 GO:0048037 cofactor binding 399 28 371 28 527 555 2.112e-01 0.07 0.05 1.4 GO:0015082 di\-\, tri\-valent inorganic cation transmembrane transporter activity 399 7 392 4 551 555 2.172e-01 0.02 0.01 2.4 GO:0046915 transition metal ion transmembrane transporter activity 399 7 392 4 551 555 2.172e-01 0.02 0.01 2.4 GO:0015291 secondary active transmembrane transporter activity 399 14 385 12 543 555 2.299e-01 0.04 0.02 1.6 GO:0016757 transferase activity\, transferring glycosyl groups 399 10 389 8 547 555 2.394e-01 0.03 0.01 1.7 GO:0004428 inositol or phosphatidylinositol kinase activity 399 4 395 2 553 555 2.430e-01 0.01 0.00 2.8 GO:0016667 oxidoreductase activity\, acting on sulfur group of donors 399 4 395 2 553 555 2.430e-01 0.01 0.00 2.8 GO:0016903 oxidoreductase activity\, acting on the aldehyde or oxo group of donors 399 4 395 2 553 555 2.430e-01 0.01 0.00 2.8 GO:0003950 NAD\+ ADP\-ribosyltransferase activity 399 4 395 2 553 555 2.430e-01 0.01 0.00 2.8 GO:0001727 lipid kinase activity 399 4 395 2 553 555 2.430e-01 0.01 0.00 2.8 GO:0004629 phospholipase C activity 399 4 395 2 553 555 2.430e-01 0.01 0.00 2.8 GO:0035257 nuclear hormone receptor binding 399 1 398 6 549 555 2.493e-01 0.00 0.01 0.2 GO:0051427 hormone receptor binding 399 1 398 6 549 555 2.493e-01 0.00 0.01 0.2 GO:0016616 oxidoreductase activity\, acting on the CH\-OH group of donors\, NAD or NADP as acceptor 399 7 392 5 550 555 2.554e-01 0.02 0.01 1.9 GO:0016712 oxidoreductase activity\, acting on paired donors\, with incorporation or reduction of molecular oxygen\, reduced flavin or flavoprotein as one donor\, and incorporation of one atom of oxygen 399 3 396 10 545 555 2.575e-01 0.01 0.02 0.4 GO:0004091 carboxylesterase activity 399 3 396 10 545 555 2.575e-01 0.01 0.02 0.4 GO:0017171 serine hydrolase activity 399 3 396 10 545 555 2.575e-01 0.01 0.02 0.4 GO:0003774 motor activity 399 3 396 10 545 555 2.575e-01 0.01 0.02 0.4 GO:0019904 protein domain specific binding 399 16 383 14 541 555 2.588e-01 0.04 0.03 1.6 GO:0004702 receptor signaling protein serine/threonine kinase activity 399 8 391 6 549 555 2.809e-01 0.02 0.01 1.9 GO:0042802 identical protein binding 399 38 361 42 513 555 2.888e-01 0.10 0.08 1.3 GO:0010181 FMN binding 399 5 394 3 552 555 2.899e-01 0.01 0.01 2.3 GO:0004708 MAP kinase kinase activity 399 5 394 3 552 555 2.899e-01 0.01 0.01 2.3 GO:0004712 protein serine/threonine/tyrosine kinase activity 399 5 394 3 552 555 2.899e-01 0.01 0.01 2.3 GO:0016763 transferase activity\, transferring pentosyl groups 399 5 394 3 552 555 2.899e-01 0.01 0.01 2.3 GO:0016798 hydrolase activity\, acting on glycosyl bonds 399 5 394 3 552 555 2.899e-01 0.01 0.01 2.3 GO:0003954 NADH dehydrogenase activity 399 5 394 3 552 555 2.899e-01 0.01 0.01 2.3 GO:0008137 NADH dehydrogenase (ubiquinone) activity 399 5 394 3 552 555 2.899e-01 0.01 0.01 2.3 GO:0050136 NADH dehydrogenase (quinone) activity 399 5 394 3 552 555 2.899e-01 0.01 0.01 2.3 GO:0004197 cysteine\-type endopeptidase activity 399 7 392 16 539 555 2.925e-01 0.02 0.03 0.6 GO:0008234 cysteine\-type peptidase activity 399 7 392 17 538 555 2.945e-01 0.02 0.03 0.6 GO:0000287 magnesium ion binding 399 18 381 17 538 555 2.949e-01 0.05 0.03 1.5 GO:0005057 receptor signaling protein activity 399 12 387 24 531 555 3.082e-01 0.03 0.04 0.7 GO:0019903 protein phosphatase binding 399 3 396 1 554 555 3.144e-01 0.01 0.00 4.2 GO:0019902 phosphatase binding 399 3 396 1 554 555 3.144e-01 0.01 0.00 4.2 GO:0017136 NAD\-dependent histone deacetylase activity 399 3 396 1 554 555 3.144e-01 0.01 0.00 4.2 GO:0004725 protein tyrosine phosphatase activity 399 3 396 1 554 555 3.144e-01 0.01 0.00 4.2 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 399 3 396 1 554 555 3.144e-01 0.01 0.00 4.2 GO:0016303 1\-phosphatidylinositol\-3\-kinase activity 399 3 396 1 554 555 3.144e-01 0.01 0.00 4.2 GO:0035004 phosphoinositide 3\-kinase activity 399 3 396 1 554 555 3.144e-01 0.01 0.00 4.2 GO:0008131 amine oxidase activity 399 3 396 1 554 555 3.144e-01 0.01 0.00 4.2 GO:0050381 unspecific monooxygenase activity 399 2 397 7 548 555 3.178e-01 0.01 0.01 0.4 GO:0016702 oxidoreductase activity\, acting on single donors with incorporation of molecular oxygen\, incorporation of two atoms of oxygen 399 2 397 7 548 555 3.178e-01 0.01 0.01 0.4 GO:0051213 dioxygenase activity 399 2 397 7 548 555 3.178e-01 0.01 0.01 0.4 GO:0016701 oxidoreductase activity\, acting on single donors with incorporation of molecular oxygen 399 2 397 7 548 555 3.178e-01 0.01 0.01 0.4 GO:0004222 metalloendopeptidase activity 399 2 397 7 548 555 3.178e-01 0.01 0.01 0.4 GO:0042165 neurotransmitter binding 399 5 394 13 542 555 3.347e-01 0.01 0.02 0.5 GO:0051287 NAD binding 399 6 393 4 551 555 3.355e-01 0.02 0.01 2.1 GO:0050660 FAD binding 399 16 383 16 539 555 3.656e-01 0.04 0.03 1.4 GO:0008415 acyltransferase activity 399 3 396 9 546 555 3.779e-01 0.01 0.02 0.5 GO:0016747 transferase activity\, transferring groups other than amino\-acyl groups 399 3 396 9 546 555 3.779e-01 0.01 0.02 0.5 GO:0004252 serine\-type endopeptidase activity 399 3 396 9 546 555 3.779e-01 0.01 0.02 0.5 GO:0008236 serine\-type peptidase activity 399 3 396 9 546 555 3.779e-01 0.01 0.02 0.5 GO:0043169 cation binding 399 105 294 161 394 555 3.802e-01 0.26 0.29 0.9 GO:0022857 transmembrane transporter activity 399 44 355 51 504 555 3.810e-01 0.11 0.09 1.2 GO:0042626 ATPase activity\, coupled to transmembrane movement of substances 399 7 392 6 549 555 4.068e-01 0.02 0.01 1.6 GO:0016820 hydrolase activity\, acting on acid anhydrides\, catalyzing transmembrane movement of substances 399 7 392 6 549 555 4.068e-01 0.02 0.01 1.6 GO:0043492 ATPase activity\, coupled to movement of substances 399 7 392 6 549 555 4.068e-01 0.02 0.01 1.6 GO:0015405 P\-P\-bond\-hydrolysis\-driven transmembrane transporter activity 399 7 392 6 549 555 4.068e-01 0.02 0.01 1.6 GO:0015399 primary active transmembrane transporter activity 399 7 392 6 549 555 4.068e-01 0.02 0.01 1.6 GO:0016791 phosphoric monoester hydrolase activity 399 7 392 6 549 555 4.068e-01 0.02 0.01 1.6 GO:0031420 alkali metal ion binding 399 1 398 4 551 555 4.068e-01 0.00 0.01 0.3 GO:0005504 fatty acid binding 399 1 398 4 551 555 4.068e-01 0.00 0.01 0.3 GO:0045735 nutrient reservoir activity 399 1 398 4 551 555 4.068e-01 0.00 0.01 0.3 GO:0005172 vascular endothelial growth factor receptor binding 399 1 398 4 551 555 4.068e-01 0.00 0.01 0.3 GO:0030545 receptor regulator activity 399 1 398 4 551 555 4.068e-01 0.00 0.01 0.3 GO:0035258 steroid hormone receptor binding 399 1 398 4 551 555 4.068e-01 0.00 0.01 0.3 GO:0031072 heat shock protein binding 399 1 398 4 551 555 4.068e-01 0.00 0.01 0.3 GO:0008080 N\-acetyltransferase activity 399 1 398 4 551 555 4.068e-01 0.00 0.01 0.3 GO:0016410 N\-acyltransferase activity 399 1 398 4 551 555 4.068e-01 0.00 0.01 0.3 GO:0001948 glycoprotein binding 399 1 398 4 551 555 4.068e-01 0.00 0.01 0.3 GO:0008168 methyltransferase activity 399 1 398 4 551 555 4.068e-01 0.00 0.01 0.3 GO:0016741 transferase activity\, transferring one\-carbon groups 399 1 398 4 551 555 4.068e-01 0.00 0.01 0.3 GO:0004715 non\-membrane spanning protein tyrosine kinase activity 399 1 398 4 551 555 4.068e-01 0.00 0.01 0.3 GO:0016740 transferase activity 399 64 335 78 477 555 4.076e-01 0.16 0.14 1.1 GO:0016836 hydro\-lyase activity 399 1 398 5 550 555 4.098e-01 0.00 0.01 0.3 GO:0003708 retinoic acid receptor activity 399 1 398 5 550 555 4.098e-01 0.00 0.01 0.3 GO:0048503 GPI anchor binding 399 1 398 5 550 555 4.098e-01 0.00 0.01 0.3 GO:0008369 obsolete molecular function 399 1 398 5 550 555 4.098e-01 0.00 0.01 0.3 GO:0003777 microtubule motor activity 399 1 398 5 550 555 4.098e-01 0.00 0.01 0.3 GO:0016563 transcription activator activity 399 14 385 26 529 555 4.159e-01 0.04 0.05 0.7 GO:0030594 neurotransmitter receptor activity 399 4 395 10 545 555 4.168e-01 0.01 0.02 0.6 GO:0003707 steroid hormone receptor activity 399 4 395 10 545 555 4.168e-01 0.01 0.02 0.6 GO:0016615 malate dehydrogenase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0004111 creatine kinase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0016775 phosphotransferase activity\, nitrogenous group as acceptor 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0004102 choline O\-acetyltransferase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0016413 O\-acetyltransferase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0005471 ATP\:ADP antiporter activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0015207 adenine transmembrane transporter activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0005345 purine transmembrane transporter activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0015205 nucleobase transmembrane transporter activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0015932 nucleobase\, nucleoside\, nucleotide and nucleic acid transmembrane transporter activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0019145 aminobutyraldehyde dehydrogenase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0047105 4\-trimethylammoniobutyraldehyde dehydrogenase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0004148 dihydrolipoyl dehydrogenase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0004363 glutathione synthase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0030332 cyclin binding 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0004345 glucose\-6\-phosphate dehydrogenase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0050038 L\-xylulose reductase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0004351 glutamate decarboxylase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0016831 carboxy\-lyase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0016830 carbon\-carbon lyase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0004108 citrate (Si)\-synthase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0046912 transferase activity\, transferring acyl groups\, acyl groups converted into alkyl on transfer 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0004556 alpha\-amylase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0016160 amylase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0032767 copper\-dependent protein binding 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0016499 orexin receptor activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0004528 phosphodiesterase I activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0004844 uracil DNA N\-glycosylase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0046790 virion binding 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0004884 ecdysteroid hormone receptor activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0004767 sphingomyelin phosphodiesterase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0004579 dolichyl\-diphosphooligosaccharide\-protein glycotransferase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0004576 oligosaccharyl transferase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0043531 ADP binding 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0016595 glutamate binding 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0003905 alkylbase DNA N\-glycosylase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0005068 transmembrane receptor protein tyrosine kinase adaptor protein activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0005066 transmembrane receptor protein tyrosine kinase signaling protein activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0042605 peptide antigen binding 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0035226 glutamate\-cysteine ligase catalytic subunit binding 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0043140 ATP\-dependent 3'\-5' DNA helicase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0002039 p53 binding 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0008309 double\-stranded DNA specific exodeoxyribonuclease activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0008409 5'\-3' exonuclease activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0017108 5'\-flap endonuclease activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0016888 endodeoxyribonuclease activity\, producing 5'\-phosphomonoesters 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0048256 flap endonuclease activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0004176 ATP\-dependent peptidase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0032090 Pyrin domain binding 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0004024 alcohol dehydrogenase activity\, zinc\-dependent 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0004653 polypeptide N\-acetylgalactosaminyltransferase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0008376 acetylgalactosaminyltransferase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0003989 acetyl\-CoA carboxylase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0016421 CoA carboxylase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0016885 ligase activity\, forming carbon\-carbon bonds 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0004658 propionyl\-CoA carboxylase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0047555 3'\,5'\-cyclic\-GMP phosphodiesterase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0004114 3'\,5'\-cyclic\-nucleotide phosphodiesterase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0004112 cyclic\-nucleotide phosphodiesterase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0030553 cGMP binding 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0019002 GMP binding 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0004558 alpha\-glucosidase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0015926 glucosidase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0000150 recombinase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0043142 single\-stranded DNA\-dependent ATPase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0042903 tubulin deacetylase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0005545 phosphatidylinositol binding 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0035014 phosphoinositide 3\-kinase regulator activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0043559 insulin binding 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0017046 peptide hormone binding 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0004677 DNA\-dependent protein kinase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0016851 magnesium chelatase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0051003 ligase activity\, forming nitrogen\-metal bonds\, forming coordination complexes 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0051002 ligase activity\, forming nitrogen\-metal bonds 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0004157 dihydropyrimidinase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0016812 hydrolase activity\, acting on carbon\-nitrogen (but not peptide) bonds\, in cyclic amides 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0032405 MutLalpha complex binding 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0016018 cyclosporin A binding 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0015232 heme transporter activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0030161 calpain inhibitor activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0003840 gamma\-glutamyltransferase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0004004 ATP\-dependent RNA helicase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0008186 RNA\-dependent ATPase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0004413 homoserine kinase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0019202 amino acid kinase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0042708 elastase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0030350 iron\-responsive element binding 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0003955 NAD(P)H dehydrogenase (quinone) activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0004128 cytochrome\-b5 reductase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0008534 oxidized purine base lesion DNA N\-glycosylase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0000702 oxidized base lesion DNA N\-glycosylase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0003958 NADPH\-hemoprotein reductase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0004647 phosphoserine phosphatase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0008853 exodeoxyribonuclease III activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0015633 zinc transporting ATPase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0004510 tryptophan 5\-monooxygenase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0008503 benzodiazepine receptor activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0004503 monophenol monooxygenase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0016716 oxidoreductase activity\, acting on paired donors\, with incorporation or reduction of molecular oxygen\, another compound as one donor\, and incorporation of one atom of oxygen 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0003987 acetate\-CoA ligase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0016878 acid\-thiol ligase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0016877 ligase activity\, forming carbon\-sulfur bonds 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0016405 CoA\-ligase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0047939 L\-glucuronate reductase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0008106 alcohol dehydrogenase (NADP\+) activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0043015 gamma\-tubulin binding 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0031997 N\-terminal myristoylation domain binding 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0008427 calcium\-dependent protein kinase inhibitor activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0004771 sterol esterase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0047710 bis(5'\-adenosyl)\-triphosphatase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0004551 nucleotide diphosphatase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0004462 lactoylglutathione lyase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0004367 glycerol\-3\-phosphate dehydrogenase (NAD\+) activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0004368 glycerol\-3\-phosphate dehydrogenase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0047066 phospholipid\-hydroperoxide glutathione peroxidase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0004416 hydroxyacylglutathione hydrolase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0008301 DNA bending activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0004449 isocitrate dehydrogenase (NAD\+) activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0004448 isocitrate dehydrogenase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0004709 MAP kinase kinase kinase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0008545 JUN kinase kinase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0050178 phenylpyruvate tautomerase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0050699 WW domain binding 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0030586 [methionine synthase] reductase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0016723 oxidoreductase activity\, oxidizing metal ions\, NAD or NADP as acceptor 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0030983 mismatched DNA binding 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0032138 single base insertion or deletion binding 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0032135 DNA insertion or deletion binding 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0032407 MutSalpha complex binding 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0008601 protein phosphatase type 2A regulator activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0051721 protein phosphatase 2A binding 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0015520 tetracycline\:hydrogen antiporter activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0008493 tetracycline transporter activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0042895 antibiotic transporter activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0015307 drug\:hydrogen antiporter activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0015299 solute\:hydrogen antiporter activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0015298 solute\:cation antiporter activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0008785 alkyl hydroperoxide reductase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0016654 oxidoreductase activity\, acting on NADH or NADPH\, disulfide as acceptor 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0004155 6\,7\-dihydropteridine reductase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0005080 protein kinase C binding 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0005024 transforming growth factor beta receptor activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0004675 transmembrane receptor protein serine/threonine kinase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0042162 telomeric DNA binding 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0043047 single\-stranded telomeric DNA binding 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0004998 transferrin receptor activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0004447 iodide peroxidase activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0015349 thyroid hormone transmembrane transporter activity 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0019905 syntaxin binding 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0000149 SNARE binding 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0050998 nitric\-oxide synthase binding 399 1 398 0 555 555 4.182e-01 0.00 0.00 bZero GO:0046873 metal ion transmembrane transporter activity 399 13 386 13 542 555 4.241e-01 0.03 0.02 1.4 GO:0008324 cation transmembrane transporter activity 399 30 369 34 521 555 4.321e-01 0.08 0.06 1.2 GO:0050661 NADP binding 399 8 391 7 548 555 4.323e-01 0.02 0.01 1.6 GO:0003924 GTPase activity 399 8 391 7 548 555 4.323e-01 0.02 0.01 1.6 GO:0016853 isomerase activity 399 14 385 14 541 555 4.379e-01 0.04 0.03 1.4 GO:0042277 peptide binding 399 10 389 19 536 555 4.511e-01 0.03 0.03 0.7 GO:0003779 actin binding 399 5 394 11 544 555 4.523e-01 0.01 0.02 0.6 GO:0051082 unfolded protein binding 399 9 390 8 547 555 4.578e-01 0.02 0.01 1.6 GO:0005249 voltage\-gated potassium channel activity 399 4 395 3 552 555 4.605e-01 0.01 0.01 1.9 GO:0005267 potassium channel activity 399 4 395 3 552 555 4.605e-01 0.01 0.01 1.9 GO:0015036 disulfide oxidoreductase activity 399 4 395 3 552 555 4.605e-01 0.01 0.01 1.9 GO:0016505 apoptotic protease activator activity 399 4 395 3 552 555 4.605e-01 0.01 0.01 1.9 GO:0016504 protease activator activity 399 4 395 3 552 555 4.605e-01 0.01 0.01 1.9 GO:0008194 UDP\-glycosyltransferase activity 399 4 395 3 552 555 4.605e-01 0.01 0.01 1.9 GO:0016790 thiolester hydrolase activity 399 4 395 3 552 555 4.605e-01 0.01 0.01 1.9 GO:0004857 enzyme inhibitor activity 399 11 388 21 534 555 4.673e-01 0.03 0.04 0.7 GO:0016773 phosphotransferase activity\, alcohol group as acceptor 399 35 364 41 514 555 4.679e-01 0.09 0.07 1.2 GO:0005164 tumor necrosis factor receptor binding 399 2 397 6 549 555 4.797e-01 0.01 0.01 0.5 GO:0032813 tumor necrosis factor receptor superfamily binding 399 2 397 6 549 555 4.797e-01 0.01 0.01 0.5 GO:0005083 small GTPase regulator activity 399 2 397 6 549 555 4.797e-01 0.01 0.01 0.5 GO:0004983 neuropeptide Y receptor activity 399 2 397 6 549 555 4.797e-01 0.01 0.01 0.5 GO:0004866 endopeptidase inhibitor activity 399 6 393 13 542 555 4.826e-01 0.02 0.02 0.6 GO:0030414 protease inhibitor activity 399 6 393 13 542 555 4.826e-01 0.02 0.02 0.6 GO:0004714 transmembrane receptor protein tyrosine kinase activity 399 6 393 13 542 555 4.826e-01 0.02 0.02 0.6 GO:0022843 voltage\-gated cation channel activity 399 5 394 4 551 555 5.029e-01 0.01 0.01 1.7 GO:0003682 chromatin binding 399 5 394 4 551 555 5.029e-01 0.01 0.01 1.7 GO:0016705 oxidoreductase activity\, acting on paired donors\, with incorporation or reduction of molecular oxygen 399 14 385 25 530 555 5.093e-01 0.04 0.05 0.8 GO:0022836 gated channel activity 399 8 391 15 540 555 5.292e-01 0.02 0.03 0.7 GO:0019838 growth factor binding 399 8 391 15 540 555 5.292e-01 0.02 0.03 0.7 GO:0008188 neuropeptide receptor activity 399 3 396 7 548 555 5.338e-01 0.01 0.01 0.6 GO:0042923 neuropeptide binding 399 3 396 7 548 555 5.338e-01 0.01 0.01 0.6 GO:0051536 iron\-sulfur cluster binding 399 6 393 5 550 555 5.407e-01 0.02 0.01 1.7 GO:0051540 metal cluster binding 399 6 393 5 550 555 5.407e-01 0.02 0.01 1.7 GO:0047485 protein N\-terminus binding 399 6 393 5 550 555 5.407e-01 0.02 0.01 1.7 GO:0016881 acid\-amino acid ligase activity 399 6 393 5 550 555 5.407e-01 0.02 0.01 1.7 GO:0022890 inorganic cation transmembrane transporter activity 399 12 387 13 542 555 5.434e-01 0.03 0.02 1.3 GO:0008047 enzyme activator activity 399 13 386 14 541 555 5.549e-01 0.03 0.03 1.3 GO:0022891 substrate\-specific transmembrane transporter activity 399 37 362 45 510 555 5.591e-01 0.09 0.08 1.1 GO:0005216 ion channel activity 399 10 389 18 537 555 5.641e-01 0.03 0.03 0.8 GO:0022838 substrate specific channel activity 399 10 389 18 537 555 5.641e-01 0.03 0.03 0.8 GO:0005215 transporter activity 399 51 348 79 476 555 5.663e-01 0.13 0.14 0.9 GO:0016874 ligase activity 399 14 385 15 540 555 5.671e-01 0.04 0.03 1.3 GO:0005244 voltage\-gated ion channel activity 399 6 393 6 549 555 5.705e-01 0.02 0.01 1.4 GO:0022832 voltage\-gated channel activity 399 6 393 6 549 555 5.705e-01 0.02 0.01 1.4 GO:0004707 MAP kinase activity 399 6 393 6 549 555 5.705e-01 0.02 0.01 1.4 GO:0009053 electron donor activity 399 6 393 6 549 555 5.705e-01 0.02 0.01 1.4 GO:0016746 transferase activity\, transferring acyl groups 399 4 395 9 546 555 5.741e-01 0.01 0.02 0.6 GO:0045155 electron transporter\, transferring electrons from CoQH2\-cytochrome c reductase complex and cytochrome c oxidase complex activity 399 2 397 1 554 555 5.748e-01 0.01 0.00 2.8 GO:0051434 BH3 domain binding 399 2 397 1 554 555 5.748e-01 0.01 0.00 2.8 GO:0051400 BH domain binding 399 2 397 1 554 555 5.748e-01 0.01 0.00 2.8 GO:0004861 cyclin\-dependent protein kinase inhibitor activity 399 2 397 1 554 555 5.748e-01 0.01 0.00 2.8 GO:0000739 DNA strand annealing activity 399 2 397 1 554 555 5.748e-01 0.01 0.00 2.8 GO:0015038 glutathione disulfide oxidoreductase activity 399 2 397 1 554 555 5.748e-01 0.01 0.00 2.8 GO:0015037 peptide disulfide oxidoreductase activity 399 2 397 1 554 555 5.748e-01 0.01 0.00 2.8 GO:0016668 oxidoreductase activity\, acting on sulfur group of donors\, NAD or NADP as acceptor 399 2 397 1 554 555 5.748e-01 0.01 0.00 2.8 GO:0016722 oxidoreductase activity\, oxidizing metal ions 399 2 397 1 554 555 5.748e-01 0.01 0.00 2.8 GO:0005344 oxygen transporter activity 399 2 397 1 554 555 5.748e-01 0.01 0.00 2.8 GO:0016671 oxidoreductase activity\, acting on sulfur group of donors\, disulfide as acceptor 399 2 397 1 554 555 5.748e-01 0.01 0.00 2.8 GO:0008113 peptide\-methionine\-(S)\-S\-oxide reductase activity 399 2 397 1 554 555 5.748e-01 0.01 0.00 2.8 GO:0004602 glutathione peroxidase activity 399 2 397 1 554 555 5.748e-01 0.01 0.00 2.8 GO:0043295 glutathione binding 399 2 397 1 554 555 5.748e-01 0.01 0.00 2.8 GO:0016714 oxidoreductase activity\, acting on paired donors\, with incorporation or reduction of molecular oxygen\, reduced pteridine as one donor\, and incorporation of one atom of oxygen 399 2 397 1 554 555 5.748e-01 0.01 0.00 2.8 GO:0015035 protein disulfide oxidoreductase activity 399 2 397 1 554 555 5.748e-01 0.01 0.00 2.8 GO:0004438 phosphatidylinositol\-3\-phosphatase activity 399 2 397 1 554 555 5.748e-01 0.01 0.00 2.8 GO:0004437 inositol or phosphatidylinositol phosphatase activity 399 2 397 1 554 555 5.748e-01 0.01 0.00 2.8 GO:0042577 lipid phosphatase activity 399 2 397 1 554 555 5.748e-01 0.01 0.00 2.8 GO:0016314 phosphatidylinositol\-3\,4\,5\-trisphosphate 3\-phosphatase activity 399 2 397 1 554 555 5.748e-01 0.01 0.00 2.8 GO:0051717 inositol\-1\,3\,4\,5\-tetrakisphosphate 3\-phosphatase activity 399 2 397 1 554 555 5.748e-01 0.01 0.00 2.8 GO:0051800 phosphatidylinositol\-3\,4\-bisphosphate 3\-phosphatase activity 399 2 397 1 554 555 5.748e-01 0.01 0.00 2.8 GO:0046934 phosphatidylinositol\-4\,5\-bisphosphate 3\-kinase activity 399 2 397 1 554 555 5.748e-01 0.01 0.00 2.8 GO:0043130 ubiquitin binding 399 2 397 1 554 555 5.748e-01 0.01 0.00 2.8 GO:0032182 small conjugating protein binding 399 2 397 1 554 555 5.748e-01 0.01 0.00 2.8 GO:0003906 DNA\-(apurinic or apyrimidinic site) lyase activity 399 2 397 1 554 555 5.748e-01 0.01 0.00 2.8 GO:0004521 endoribonuclease activity 399 2 397 1 554 555 5.748e-01 0.01 0.00 2.8 GO:0016895 exodeoxyribonuclease activity\, producing 5'\-phosphomonoesters 399 2 397 1 554 555 5.748e-01 0.01 0.00 2.8 GO:0004529 exodeoxyribonuclease activity 399 2 397 1 554 555 5.748e-01 0.01 0.00 2.8 GO:0030192 Hsp70/Hsc70 protein regulator activity 399 2 397 1 554 555 5.748e-01 0.01 0.00 2.8 GO:0003887 DNA\-directed DNA polymerase activity 399 2 397 1 554 555 5.748e-01 0.01 0.00 2.8 GO:0008135 translation factor activity\, nucleic acid binding 399 2 397 1 554 555 5.748e-01 0.01 0.00 2.8 GO:0015662 ATPase activity\, coupled to transmembrane movement of ions\, phosphorylative mechanism 399 2 397 1 554 555 5.748e-01 0.01 0.00 2.8 GO:0016846 carbon\-sulfur lyase activity 399 2 397 1 554 555 5.748e-01 0.01 0.00 2.8 GO:0015267 channel activity 399 11 388 20 535 555 5.796e-01 0.03 0.04 0.8 GO:0022803 passive transmembrane transporter activity 399 11 388 20 535 555 5.796e-01 0.03 0.04 0.8 GO:0046914 transition metal ion binding 399 93 306 121 434 555 5.829e-01 0.23 0.22 1.1 GO:0046943 carboxylic acid transmembrane transporter activity 399 7 392 7 548 555 5.909e-01 0.02 0.01 1.4 GO:0005342 organic acid transmembrane transporter activity 399 7 392 7 548 555 5.909e-01 0.02 0.01 1.4 GO:0017153 sodium\:dicarboxylate symporter activity 399 7 392 7 548 555 5.909e-01 0.02 0.01 1.4 GO:0015296 anion\:cation symporter activity 399 7 392 7 548 555 5.909e-01 0.02 0.01 1.4 GO:0005343 organic acid\:sodium symporter activity 399 7 392 7 548 555 5.909e-01 0.02 0.01 1.4 GO:0005310 dicarboxylic acid transmembrane transporter activity 399 7 392 7 548 555 5.909e-01 0.02 0.01 1.4 GO:0019900 kinase binding 399 7 392 7 548 555 5.909e-01 0.02 0.01 1.4 GO:0008092 cytoskeletal protein binding 399 13 386 23 532 555 6.059e-01 0.03 0.04 0.8 GO:0005200 structural constituent of cytoskeleton 399 8 391 8 547 555 6.112e-01 0.02 0.01 1.4 GO:0004672 protein kinase activity 399 31 368 38 517 555 6.135e-01 0.08 0.07 1.1 GO:0043167 ion binding 399 117 282 172 383 555 6.173e-01 0.29 0.31 0.9 GO:0032403 protein complex binding 399 6 393 11 544 555 6.299e-01 0.02 0.02 0.8 GO:0015075 ion transmembrane transporter activity 399 36 363 45 510 555 6.388e-01 0.09 0.08 1.1 GO:0030955 potassium ion binding 399 1 398 3 552 555 6.441e-01 0.00 0.01 0.5 GO:0050840 extracellular matrix binding 399 1 398 3 552 555 6.441e-01 0.00 0.01 0.5 GO:0035240 dopamine binding 399 1 398 3 552 555 6.441e-01 0.00 0.01 0.5 GO:0004623 phospholipase A2 activity 399 1 398 3 552 555 6.441e-01 0.00 0.01 0.5 GO:0005518 collagen binding 399 1 398 3 552 555 6.441e-01 0.00 0.01 0.5 GO:0031404 chloride ion binding 399 1 398 3 552 555 6.441e-01 0.00 0.01 0.5 GO:0043168 anion binding 399 1 398 3 552 555 6.441e-01 0.00 0.01 0.5 GO:0042166 acetylcholine binding 399 1 398 3 552 555 6.441e-01 0.00 0.01 0.5 GO:0005154 epidermal growth factor receptor binding 399 1 398 3 552 555 6.441e-01 0.00 0.01 0.5 GO:0004945 angiotensin type II receptor activity 399 1 398 3 552 555 6.441e-01 0.00 0.01 0.5 GO:0001595 angiotensin receptor activity 399 1 398 3 552 555 6.441e-01 0.00 0.01 0.5 GO:0005035 death receptor activity 399 1 398 3 552 555 6.441e-01 0.00 0.01 0.5 GO:0030374 ligand\-dependent nuclear receptor transcription coactivator activity 399 1 398 3 552 555 6.441e-01 0.00 0.01 0.5 GO:0050681 androgen receptor binding 399 1 398 3 552 555 6.441e-01 0.00 0.01 0.5 GO:0016165 lipoxygenase activity 399 1 398 3 552 555 6.441e-01 0.00 0.01 0.5 GO:0004298 threonine endopeptidase activity 399 1 398 3 552 555 6.441e-01 0.00 0.01 0.5 GO:0005099 Ras GTPase activator activity 399 1 398 3 552 555 6.441e-01 0.00 0.01 0.5 GO:0004402 histone acetyltransferase activity 399 1 398 3 552 555 6.441e-01 0.00 0.01 0.5 GO:0004468 lysine N\-acetyltransferase activity 399 1 398 3 552 555 6.441e-01 0.00 0.01 0.5 GO:0016298 lipase activity 399 9 390 10 545 555 6.445e-01 0.02 0.02 1.3 GO:0019199 transmembrane receptor protein kinase activity 399 7 392 13 542 555 6.493e-01 0.02 0.02 0.7 GO:0004784 superoxide dismutase activity 399 3 396 2 553 555 6.547e-01 0.01 0.00 2.1 GO:0016721 oxidoreductase activity\, acting on superoxide radicals as acceptor 399 3 396 2 553 555 6.547e-01 0.01 0.00 2.1 GO:0004722 protein serine/threonine phosphatase activity 399 3 396 2 553 555 6.547e-01 0.01 0.00 2.1 GO:0005375 copper ion transmembrane transporter activity 399 3 396 2 553 555 6.547e-01 0.01 0.00 2.1 GO:0034061 DNA polymerase activity 399 3 396 2 553 555 6.547e-01 0.01 0.00 2.1 GO:0005159 insulin\-like growth factor receptor binding 399 3 396 2 553 555 6.547e-01 0.01 0.00 2.1 GO:0016597 amino acid binding 399 3 396 2 553 555 6.547e-01 0.01 0.00 2.1 GO:0004407 histone deacetylase activity 399 3 396 2 553 555 6.547e-01 0.01 0.00 2.1 GO:0033558 protein deacetylase activity 399 3 396 2 553 555 6.547e-01 0.01 0.00 2.1 GO:0019213 deacetylase activity 399 3 396 2 553 555 6.547e-01 0.01 0.00 2.1 GO:0030551 cyclic nucleotide binding 399 3 396 2 553 555 6.547e-01 0.01 0.00 2.1 GO:0016208 AMP binding 399 3 396 2 553 555 6.547e-01 0.01 0.00 2.1 GO:0005158 insulin receptor binding 399 3 396 2 553 555 6.547e-01 0.01 0.00 2.1 GO:0004435 phosphoinositide phospholipase C activity 399 3 396 2 553 555 6.547e-01 0.01 0.00 2.1 GO:0004434 inositol or phosphatidylinositol phosphodiesterase activity 399 3 396 2 553 555 6.547e-01 0.01 0.00 2.1 GO:0016641 oxidoreductase activity\, acting on the CH\-NH2 group of donors\, oxygen as acceptor 399 3 396 2 553 555 6.547e-01 0.01 0.00 2.1 GO:0016862 intramolecular oxidoreductase activity\, interconverting keto\- and enol\-groups 399 3 396 2 553 555 6.547e-01 0.01 0.00 2.1 GO:0015293 symporter activity 399 10 389 11 544 555 6.569e-01 0.03 0.02 1.3 GO:0015294 solute\:cation symporter activity 399 10 389 11 544 555 6.569e-01 0.03 0.02 1.3 GO:0032561 guanyl ribonucleotide binding 399 10 389 11 544 555 6.569e-01 0.03 0.02 1.3 GO:0019001 guanyl nucleotide binding 399 10 389 11 544 555 6.569e-01 0.03 0.02 1.3 GO:0005507 copper ion binding 399 11 388 12 543 555 6.696e-01 0.03 0.02 1.3 GO:0004713 protein\-tyrosine kinase activity 399 27 372 33 522 555 6.854e-01 0.07 0.06 1.1 GO:0004497 monooxygenase activity 399 10 389 17 538 555 6.947e-01 0.03 0.03 0.8 GO:0005179 hormone activity 399 10 389 17 538 555 6.947e-01 0.03 0.03 0.8 GO:0004517 nitric\-oxide synthase activity 399 3 396 3 552 555 6.987e-01 0.01 0.01 1.4 GO:0004966 galanin receptor activity 399 3 396 3 552 555 6.987e-01 0.01 0.01 1.4 GO:0008656 caspase activator activity 399 3 396 3 552 555 6.987e-01 0.01 0.01 1.4 GO:0008430 selenium binding 399 3 396 3 552 555 6.987e-01 0.01 0.01 1.4 GO:0003714 transcription corepressor activity 399 3 396 3 552 555 6.987e-01 0.01 0.01 1.4 GO:0015485 cholesterol binding 399 3 396 3 552 555 6.987e-01 0.01 0.01 1.4 GO:0032934 sterol binding 399 3 396 3 552 555 6.987e-01 0.01 0.01 1.4 GO:0016628 oxidoreductase activity\, acting on the CH\-CH group of donors\, NAD or NADP as acceptor 399 3 396 3 552 555 6.987e-01 0.01 0.01 1.4 GO:0005520 insulin\-like growth factor binding 399 3 396 3 552 555 6.987e-01 0.01 0.01 1.4 GO:0043121 neurotrophin binding 399 3 396 3 552 555 6.987e-01 0.01 0.01 1.4 GO:0043560 insulin receptor substrate binding 399 3 396 3 552 555 6.987e-01 0.01 0.01 1.4 GO:0035091 phosphoinositide binding 399 3 396 3 552 555 6.987e-01 0.01 0.01 1.4 GO:0016638 oxidoreductase activity\, acting on the CH\-NH2 group of donors 399 3 396 3 552 555 6.987e-01 0.01 0.01 1.4 GO:0016174 NAD(P)H oxidase activity 399 3 396 3 552 555 6.987e-01 0.01 0.01 1.4 GO:0008034 lipoprotein binding 399 2 397 5 550 555 7.056e-01 0.01 0.01 0.6 GO:0004970 ionotropic glutamate receptor activity 399 2 397 5 550 555 7.056e-01 0.01 0.01 0.6 GO:0008066 glutamate receptor activity 399 2 397 5 550 555 7.056e-01 0.01 0.01 0.6 GO:0005234 extracellular\-glutamate\-gated ion channel activity 399 2 397 5 550 555 7.056e-01 0.01 0.01 0.6 GO:0005149 interleukin\-1 receptor binding 399 2 397 5 550 555 7.056e-01 0.01 0.01 0.6 GO:0016407 acetyltransferase activity 399 2 397 5 550 555 7.056e-01 0.01 0.01 0.6 GO:0016765 transferase activity\, transferring alkyl or aryl (other than methyl) groups 399 2 397 5 550 555 7.056e-01 0.01 0.01 0.6 GO:0015026 coreceptor activity 399 2 397 5 550 555 7.056e-01 0.01 0.01 0.6 GO:0004887 thyroid hormone receptor activity 399 2 397 5 550 555 7.056e-01 0.01 0.01 0.6 GO:0046872 metal ion binding 399 117 282 169 386 555 7.207e-01 0.29 0.30 1.0 GO:0042625 ATPase activity\, coupled to transmembrane movement of ions 399 4 395 4 551 555 7.259e-01 0.01 0.01 1.4 GO:0005313 L\-glutamate transmembrane transporter activity 399 4 395 4 551 555 7.259e-01 0.01 0.01 1.4 GO:0043028 caspase regulator activity 399 4 395 4 551 555 7.259e-01 0.01 0.01 1.4 GO:0030165 PDZ domain binding 399 4 395 4 551 555 7.259e-01 0.01 0.01 1.4 GO:0016811 hydrolase activity\, acting on carbon\-nitrogen (but not peptide) bonds\, in linear amides 399 4 395 4 551 555 7.259e-01 0.01 0.01 1.4 GO:0005201 extracellular matrix structural constituent 399 4 395 4 551 555 7.259e-01 0.01 0.01 1.4 GO:0008017 microtubule binding 399 3 396 6 549 555 7.419e-01 0.01 0.01 0.7 GO:0016835 carbon\-oxygen lyase activity 399 3 396 6 549 555 7.419e-01 0.01 0.01 0.7 GO:0030695 GTPase regulator activity 399 3 396 6 549 555 7.419e-01 0.01 0.01 0.7 GO:0030693 caspase activity 399 5 394 5 550 555 7.496e-01 0.01 0.01 1.4 GO:0015172 acidic amino acid transmembrane transporter activity 399 5 394 5 550 555 7.496e-01 0.01 0.01 1.4 GO:0015171 amino acid transmembrane transporter activity 399 5 394 5 550 555 7.496e-01 0.01 0.01 1.4 GO:0015179 L\-amino acid transmembrane transporter activity 399 5 394 5 550 555 7.496e-01 0.01 0.01 1.4 GO:0050664 oxidoreductase activity\, acting on NADH or NADPH\, with oxygen as acceptor 399 5 394 5 550 555 7.496e-01 0.01 0.01 1.4 GO:0016810 hydrolase activity\, acting on carbon\-nitrogen (but not peptide) bonds 399 5 394 5 550 555 7.496e-01 0.01 0.01 1.4 GO:0016758 transferase activity\, transferring hexosyl groups 399 5 394 5 550 555 7.496e-01 0.01 0.01 1.4 GO:0022892 substrate\-specific transporter activity 399 43 356 64 491 555 7.557e-01 0.11 0.12 0.9 GO:0016709 oxidoreductase activity\, acting on paired donors\, with incorporation or reduction of molecular oxygen\, NADH or NADPH as one donor\, and incorporation of one atom of oxygen 399 4 395 7 548 555 7.695e-01 0.01 0.01 0.8 GO:0043176 amine binding 399 4 395 7 548 555 7.695e-01 0.01 0.01 0.8 GO:0008289 lipid binding 399 22 377 28 527 555 7.698e-01 0.06 0.05 1.1 GO:0004867 serine\-type endopeptidase inhibitor activity 399 4 395 8 547 555 7.700e-01 0.01 0.01 0.7 GO:0005529 sugar binding 399 4 395 8 547 555 7.700e-01 0.01 0.01 0.7 GO:0043565 sequence\-specific DNA binding 399 22 377 34 521 555 7.805e-01 0.06 0.06 0.9 GO:0015077 monovalent inorganic cation transmembrane transporter activity 399 5 394 9 546 555 7.875e-01 0.01 0.02 0.8 GO:0005275 amine transmembrane transporter activity 399 7 392 8 547 555 7.939e-01 0.02 0.01 1.2 GO:0004620 phospholipase activity 399 7 392 8 547 555 7.939e-01 0.02 0.01 1.2 GO:0050825 ice binding 399 7 392 8 547 555 7.939e-01 0.02 0.01 1.2 GO:0050824 water binding 399 7 392 8 547 555 7.939e-01 0.02 0.01 1.2 GO:0015370 solute\:sodium symporter activity 399 8 391 9 546 555 8.049e-01 0.02 0.02 1.2 GO:0005496 steroid binding 399 8 391 10 545 555 8.143e-01 0.02 0.02 1.1 GO:0003713 transcription coactivator activity 399 8 391 10 545 555 8.143e-01 0.02 0.02 1.1 GO:0046983 protein dimerization activity 399 37 362 49 506 555 8.196e-01 0.09 0.09 1.1 GO:0005525 GTP binding 399 9 390 11 544 555 8.209e-01 0.02 0.02 1.1 GO:0005516 calmodulin binding 399 8 391 13 542 555 8.251e-01 0.02 0.02 0.9 GO:0016564 transcription repressor activity 399 8 391 13 542 555 8.251e-01 0.02 0.02 0.9 GO:0005126 hematopoietin/interferon\-class (D200\-domain) cytokine receptor binding 399 8 391 13 542 555 8.251e-01 0.02 0.02 0.9 GO:0003712 transcription cofactor activity 399 12 387 15 540 555 8.441e-01 0.03 0.03 1.1 GO:0003702 RNA polymerase II transcription factor activity 399 13 386 17 538 555 8.534e-01 0.03 0.03 1.1 GO:0042803 protein homodimerization activity 399 18 381 24 531 555 8.746e-01 0.05 0.04 1.0 GO:0020037 heme binding 399 18 381 27 528 555 8.775e-01 0.05 0.05 0.9 GO:0046906 tetrapyrrole binding 399 18 381 27 528 555 8.775e-01 0.05 0.05 0.9 GO:0005506 iron ion binding 399 35 364 47 508 555 9.070e-01 0.09 0.08 1.0 GO:0008270 zinc ion binding 399 49 350 67 488 555 9.204e-01 0.12 0.12 1.0 GO:0005488 binding 399 348 51 486 69 555 9.212e-01 0.87 0.88 1.0 GO:0005515 protein binding 399 275 124 384 171 555 9.435e-01 0.69 0.69 1.0 GO:0030346 protein phosphatase 2B binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0051087 chaperone binding 399 3 396 4 551 555 1.000e+00 0.01 0.01 1.0 GO:0046933 hydrogen ion transporting ATP synthase activity\, rotational mechanism 399 2 397 3 552 555 1.000e+00 0.01 0.01 0.9 GO:0015078 hydrogen ion transmembrane transporter activity 399 5 394 8 547 555 1.000e+00 0.01 0.01 0.9 GO:0046961 hydrogen ion transporting ATPase activity\, rotational mechanism 399 2 397 3 552 555 1.000e+00 0.01 0.01 0.9 GO:0019829 cation\-transporting ATPase activity 399 2 397 3 552 555 1.000e+00 0.01 0.01 0.9 GO:0004096 catalase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0030234 enzyme regulator activity 399 31 368 44 511 555 1.000e+00 0.08 0.08 1.0 GO:0033130 acetylcholine receptor binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0008603 cAMP\-dependent protein kinase regulator activity 399 3 396 4 551 555 1.000e+00 0.01 0.01 1.0 GO:0019887 protein kinase regulator activity 399 7 392 11 544 555 1.000e+00 0.02 0.02 0.9 GO:0019207 kinase regulator activity 399 9 390 12 543 555 1.000e+00 0.02 0.02 1.0 GO:0002020 protease binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0046982 protein heterodimerization activity 399 12 387 18 537 555 1.000e+00 0.03 0.03 0.9 GO:0004860 protein kinase inhibitor activity 399 3 396 4 551 555 1.000e+00 0.01 0.01 1.0 GO:0019210 kinase inhibitor activity 399 3 396 4 551 555 1.000e+00 0.01 0.01 1.0 GO:0016566 specific transcriptional repressor activity 399 2 397 4 551 555 1.000e+00 0.01 0.01 0.7 GO:0005261 cation channel activity 399 6 393 9 546 555 1.000e+00 0.02 0.02 0.9 GO:0003735 structural constituent of ribosome 399 2 397 3 552 555 1.000e+00 0.01 0.01 0.9 GO:0005198 structural molecule activity 399 27 372 37 518 555 1.000e+00 0.07 0.07 1.0 GO:0008144 drug binding 399 3 396 5 550 555 1.000e+00 0.01 0.01 0.8 GO:0015643 toxin binding 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0003823 antigen binding 399 2 397 3 552 555 1.000e+00 0.01 0.01 0.9 GO:0019825 oxygen binding 399 5 394 8 547 555 1.000e+00 0.01 0.01 0.9 GO:0030170 pyridoxal phosphate binding 399 3 396 4 551 555 1.000e+00 0.01 0.01 1.0 GO:0019842 vitamin binding 399 4 395 6 549 555 1.000e+00 0.01 0.01 0.9 GO:0008509 anion transmembrane transporter activity 399 7 392 10 545 555 1.000e+00 0.02 0.02 1.0 GO:0001784 phosphotyrosine binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0045309 protein phosphorylated amino acid binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0051219 phosphoprotein binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0015631 tubulin binding 399 5 394 7 548 555 1.000e+00 0.01 0.01 1.0 GO:0017124 SH3 domain binding 399 3 396 4 551 555 1.000e+00 0.01 0.01 1.0 GO:0034187 apolipoprotein E binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0034185 apolipoprotein binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0003994 aconitate hydratase activity 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0016829 lyase activity 399 9 390 13 542 555 1.000e+00 0.02 0.02 1.0 GO:0005351 sugar\:hydrogen symporter activity 399 2 397 2 553 555 1.000e+00 0.01 0.00 1.4 GO:0051119 sugar transmembrane transporter activity 399 2 397 2 553 555 1.000e+00 0.01 0.00 1.4 GO:0015144 carbohydrate transmembrane transporter activity 399 2 397 2 553 555 1.000e+00 0.01 0.00 1.4 GO:0005402 cation\:sugar symporter activity 399 2 397 2 553 555 1.000e+00 0.01 0.00 1.4 GO:0015295 solute\:hydrogen symporter activity 399 2 397 2 553 555 1.000e+00 0.01 0.00 1.4 GO:0015097 mercury ion transmembrane transporter activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0003720 telomerase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0003964 RNA\-directed DNA polymerase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0016779 nucleotidyltransferase activity 399 3 396 4 551 555 1.000e+00 0.01 0.01 1.0 GO:0003723 RNA binding 399 10 389 14 541 555 1.000e+00 0.03 0.03 1.0 GO:0016439 tRNA\-pseudouridine synthase activity 399 4 395 5 550 555 1.000e+00 0.01 0.01 1.1 GO:0009982 pseudouridine synthase activity 399 4 395 5 550 555 1.000e+00 0.01 0.01 1.1 GO:0016866 intramolecular transferase activity 399 4 395 5 550 555 1.000e+00 0.01 0.01 1.1 GO:0004971 alpha\-amino\-3\-hydroxy\-5\-methyl\-4\-isoxazole propionate selective glutamate receptor activity 399 2 397 3 552 555 1.000e+00 0.01 0.01 0.9 GO:0015277 kainate selective glutamate receptor activity 399 2 397 4 551 555 1.000e+00 0.01 0.01 0.7 GO:0004854 xanthine dehydrogenase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0016726 oxidoreductase activity\, acting on CH or CH2 groups\, NAD or NADP as acceptor 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0016725 oxidoreductase activity\, acting on CH or CH2 groups 399 2 397 2 553 555 1.000e+00 0.01 0.00 1.4 GO:0004855 xanthine oxidase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0016727 oxidoreductase activity\, acting on CH or CH2 groups\, oxygen as acceptor 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0030151 molybdenum ion binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0051537 2 iron\, 2 sulfur cluster binding 399 2 397 2 553 555 1.000e+00 0.01 0.00 1.4 GO:0004392 heme oxygenase (decyclizing) activity 399 2 397 2 553 555 1.000e+00 0.01 0.00 1.4 GO:0004630 phospholipase D activity 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0050749 apolipoprotein E receptor binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0034190 apolipoprotein receptor binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0050750 low\-density lipoprotein receptor binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0001540 beta\-amyloid binding 399 2 397 2 553 555 1.000e+00 0.01 0.00 1.4 GO:0017127 cholesterol transporter activity 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0015248 sterol transporter activity 399 2 397 3 552 555 1.000e+00 0.01 0.01 0.9 GO:0046911 metal chelating activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0005543 phospholipid binding 399 5 394 8 547 555 1.000e+00 0.01 0.01 0.9 GO:0048156 tau protein binding 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0005163 nerve growth factor receptor binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0005165 neurotrophin receptor binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0005381 iron ion transmembrane transporter activity 399 2 397 2 553 555 1.000e+00 0.01 0.00 1.4 GO:0003704 specific RNA polymerase II transcription factor activity 399 2 397 3 552 555 1.000e+00 0.01 0.01 0.9 GO:0004362 glutathione\-disulfide reductase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0004365 glyceraldehyde\-3\-phosphate dehydrogenase (phosphorylating) activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0008943 glyceraldehyde\-3\-phosphate dehydrogenase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0016620 oxidoreductase activity\, acting on the aldehyde or oxo group of donors\, NAD or NADP as acceptor 399 2 397 2 553 555 1.000e+00 0.01 0.00 1.4 GO:0008339 MP kinase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0016909 SAP kinase activity 399 3 396 4 551 555 1.000e+00 0.01 0.01 1.0 GO:0030508 thiol\-disulfide exchange intermediate activity 399 2 397 2 553 555 1.000e+00 0.01 0.00 1.4 GO:0015252 hydrogen ion channel activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0016175 superoxide\-generating NADPH oxidase activity 399 2 397 2 553 555 1.000e+00 0.01 0.00 1.4 GO:0004806 triacylglycerol lipase activity 399 2 397 3 552 555 1.000e+00 0.01 0.01 0.9 GO:0004697 protein kinase C activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0004698 calcium\-dependent protein kinase C activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0019992 diacylglycerol binding 399 2 397 2 553 555 1.000e+00 0.01 0.00 1.4 GO:0005152 interleukin\-1 receptor antagonist activity 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0030353 fibroblast growth factor receptor antagonist activity 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0005104 fibroblast growth factor receptor binding 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0048019 receptor antagonist activity 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0030547 receptor inhibitor activity 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0008374 O\-acyltransferase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0004356 glutamate\-ammonia ligase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0016211 ammonia ligase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0016880 acid\-ammonia (or amide) ligase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0016879 ligase activity\, forming carbon\-nitrogen bonds 399 7 392 9 546 555 1.000e+00 0.02 0.02 1.1 GO:0004322 ferroxidase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0016724 oxidoreductase activity\, oxidizing metal ions\, oxygen as acceptor 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0030492 hemoglobin binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0000318 protein\-methionine\-R\-oxide reductase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0003917 DNA topoisomerase type I activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0003916 DNA topoisomerase activity 399 2 397 2 553 555 1.000e+00 0.01 0.00 1.4 GO:0004969 histamine receptor activity 399 2 397 2 553 555 1.000e+00 0.01 0.00 1.4 GO:0008227 amine receptor activity 399 5 394 7 548 555 1.000e+00 0.01 0.01 1.0 GO:0005199 structural constituent of cell wall 399 4 395 5 550 555 1.000e+00 0.01 0.01 1.1 GO:0005522 profilin binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0017048 Rho GTPase binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0017016 Ras GTPase binding 399 2 397 3 552 555 1.000e+00 0.01 0.01 0.9 GO:0031267 small GTPase binding 399 2 397 3 552 555 1.000e+00 0.01 0.01 0.9 GO:0051020 GTPase binding 399 2 397 3 552 555 1.000e+00 0.01 0.01 0.9 GO:0008539 proteasome inhibitor activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0018445 prothoracicotrophic hormone activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0005184 neuropeptide hormone activity 399 3 396 5 550 555 1.000e+00 0.01 0.01 0.8 GO:0004129 cytochrome\-c oxidase activity 399 2 397 4 551 555 1.000e+00 0.01 0.01 0.7 GO:0015002 heme\-copper terminal oxidase activity 399 2 397 4 551 555 1.000e+00 0.01 0.01 0.7 GO:0016676 oxidoreductase activity\, acting on heme group of donors\, oxygen as acceptor 399 2 397 4 551 555 1.000e+00 0.01 0.01 0.7 GO:0016675 oxidoreductase activity\, acting on heme group of donors 399 2 397 4 551 555 1.000e+00 0.01 0.01 0.7 GO:0004705 JUN kinase activity 399 2 397 3 552 555 1.000e+00 0.01 0.01 0.9 GO:0003918 DNA topoisomerase (ATP\-hydrolyzing) activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0008199 ferric iron binding 399 2 397 2 553 555 1.000e+00 0.01 0.00 1.4 GO:0015091 ferric iron transmembrane transporter activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0004029 aldehyde dehydrogenase (NAD) activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0004364 glutathione transferase activity 399 2 397 3 552 555 1.000e+00 0.01 0.01 0.9 GO:0005246 calcium channel regulator activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0016247 channel regulator activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0015457 auxiliary transport protein activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0008134 transcription factor binding 399 17 382 23 532 555 1.000e+00 0.04 0.04 1.0 GO:0005133 interferon\-gamma receptor binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0004511 tyrosine 3\-monooxygenase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0008198 ferrous iron binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0004383 guanylate cyclase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0009975 cyclase activity 399 3 396 5 550 555 1.000e+00 0.01 0.01 0.8 GO:0016849 phosphorus\-oxygen lyase activity 399 3 396 5 550 555 1.000e+00 0.01 0.01 0.8 GO:0004666 prostaglandin\-endoperoxide synthase activity 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0008667 2\,3\-dihydro\-2\,3\-dihydroxybenzoate dehydrogenase activity 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0016627 oxidoreductase activity\, acting on the CH\-CH group of donors 399 3 396 4 551 555 1.000e+00 0.01 0.01 1.0 GO:0005161 platelet\-derived growth factor receptor binding 399 2 397 4 551 555 1.000e+00 0.01 0.01 0.7 GO:0030552 cAMP binding 399 2 397 2 553 555 1.000e+00 0.01 0.00 1.4 GO:0030171 voltage\-gated proton channel activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0003831 beta\-N\-acetylglucosaminylglycopeptide beta\-1\,4\-galactosyltransferase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0035250 UDP\-galactosyltransferase activity 399 2 397 2 553 555 1.000e+00 0.01 0.00 1.4 GO:0008378 galactosyltransferase activity 399 2 397 2 553 555 1.000e+00 0.01 0.00 1.4 GO:0003945 N\-acetyllactosamine synthase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0004461 lactose synthase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0042288 MHC class I protein binding 399 2 397 3 552 555 1.000e+00 0.01 0.01 0.9 GO:0042287 MHC protein binding 399 3 396 4 551 555 1.000e+00 0.01 0.01 1.0 GO:0004849 uridine kinase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0019206 nucleoside kinase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0019205 nucleobase\, nucleoside\, nucleotide kinase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0004812 aminoacyl\-tRNA ligase activity 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0016876 ligase activity\, forming aminoacyl\-tRNA and related compounds 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0016875 ligase activity\, forming carbon\-oxygen bonds 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0004821 histidine\-tRNA ligase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0003706 ligand\-regulated transcription factor activity 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0008158 hedgehog receptor activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0005085 guanyl\-nucleotide exchange factor activity 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0005087 Ran guanyl\-nucleotide exchange factor activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0005088 Ras guanyl\-nucleotide exchange factor activity 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0005089 Rho guanyl\-nucleotide exchange factor activity 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0017112 Rab guanyl\-nucleotide exchange factor activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0017137 Rab GTPase binding 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0030676 Rac guanyl\-nucleotide exchange factor activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0043539 protein serine/threonine kinase activator activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0030295 protein kinase activator activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0019209 kinase activator activity 399 2 397 2 553 555 1.000e+00 0.01 0.00 1.4 GO:0008147 structural constituent of bone 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0016251 general RNA polymerase II transcription factor activity 399 2 397 2 553 555 1.000e+00 0.01 0.00 1.4 GO:0003860 3\-hydroxyisobutyryl\-CoA hydrolase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0016289 CoA hydrolase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0048406 nerve growth factor binding 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0004748 ribonucleoside\-diphosphate reductase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0016728 oxidoreductase activity\, acting on CH or CH2 groups\, disulfide as acceptor 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0042030 ATPase inhibitor activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0043532 angiostatin binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0051117 ATPase binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0004553 hydrolase activity\, hydrolyzing O\-glycosyl compounds 399 2 397 2 553 555 1.000e+00 0.01 0.00 1.4 GO:0004981 muscarinic acetylcholine receptor activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0015464 acetylcholine receptor activity 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0005155 epidermal growth factor receptor activating ligand activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0004946 bombesin receptor activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0004977 melanocortin receptor activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0005328 neurotransmitter\:sodium symporter activity 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0005326 neurotransmitter transporter activity 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0005330 dopamine\:sodium symporter activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0005329 dopamine transmembrane transporter activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0015238 drug transporter activity 399 2 397 2 553 555 1.000e+00 0.01 0.00 1.4 GO:0008504 monoamine transmembrane transporter activity 399 2 397 3 552 555 1.000e+00 0.01 0.01 0.9 GO:0005031 tumor necrosis factor receptor activity 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0043120 tumor necrosis factor binding 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0004993 serotonin receptor activity 399 2 397 2 553 555 1.000e+00 0.01 0.00 1.4 GO:0004221 ubiquitin thiolesterase activity 399 2 397 2 553 555 1.000e+00 0.01 0.00 1.4 GO:0004843 ubiquitin\-specific protease activity 399 2 397 2 553 555 1.000e+00 0.01 0.00 1.4 GO:0019783 small conjugating protein\-specific protease activity 399 2 397 2 553 555 1.000e+00 0.01 0.00 1.4 GO:0008242 omega peptidase activity 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0004540 ribonuclease activity 399 2 397 3 552 555 1.000e+00 0.01 0.01 0.9 GO:0030742 GTP\-dependent protein binding 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0005123 death receptor binding 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0015501 glutamate\:sodium symporter activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0005283 sodium\:amino acid symporter activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0005416 cation\:amino acid symporter activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0004882 androgen receptor activity 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0005497 androgen binding 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0042562 hormone binding 399 3 396 5 550 555 1.000e+00 0.01 0.01 0.8 GO:0004074 biliverdin reductase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0016455 RNA polymerase II transcription mediator activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0030674 protein binding\, bridging 399 3 396 5 550 555 1.000e+00 0.01 0.01 0.8 GO:0060090 molecular adaptor activity 399 2 397 2 553 555 1.000e+00 0.01 0.00 1.4 GO:0008375 acetylglucosaminyltransferase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0015183 L\-aspartate transmembrane transporter activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0016796 exonuclease activity\, active with either ribo\- or deoxyribonucleic acids and producing 5'\-phosphomonoesters 399 2 397 2 553 555 1.000e+00 0.01 0.00 1.4 GO:0004842 ubiquitin\-protein ligase activity 399 3 396 4 551 555 1.000e+00 0.01 0.01 1.0 GO:0019787 small conjugating protein ligase activity 399 3 396 4 551 555 1.000e+00 0.01 0.01 1.0 GO:0030191 Hsp70/Hsc70 protein inhibitor activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0030190 chaperone inhibitor activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0030188 chaperone regulator activity 399 2 397 2 553 555 1.000e+00 0.01 0.00 1.4 GO:0030544 Hsp70 protein binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0030911 TPR domain binding 399 2 397 2 553 555 1.000e+00 0.01 0.00 1.4 GO:0046332 SMAD binding 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0051879 Hsp90 protein binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0004022 alcohol dehydrogenase activity 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0004499 flavin\-containing monooxygenase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0035035 histone acetyltransferase binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0005427 proton\-dependent oligopeptide secondary active transmembrane transporter activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0015322 secondary active oligopeptide transmembrane transporter activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0015198 oligopeptide transporter activity 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0015197 peptide transporter activity 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0008307 structural constituent of muscle 399 2 397 3 552 555 1.000e+00 0.01 0.01 0.9 GO:0005138 interleukin\-6 receptor binding 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0043125 ErbB\-3 class receptor binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0019911 structural constituent of myelin sheath 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0003756 protein disulfide isomerase activity 399 2 397 2 553 555 1.000e+00 0.01 0.00 1.4 GO:0016860 intramolecular oxidoreductase activity 399 4 395 6 549 555 1.000e+00 0.01 0.01 0.9 GO:0016864 intramolecular oxidoreductase activity\, transposing S\-S bonds 399 2 397 2 553 555 1.000e+00 0.01 0.00 1.4 GO:0005528 FK506 binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0005527 macrolide binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0051184 cofactor transporter activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0031702 type 1 angiotensin receptor binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0031701 angiotensin receptor binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0031703 type 2 angiotensin receptor binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0004052 arachidonate 12\-lipoxygenase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0047977 hepoxilin\-epoxide hydrolase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0016803 ether hydrolase activity 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0016801 hydrolase activity\, acting on ether bonds 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0004016 adenylate cyclase activity 399 2 397 4 551 555 1.000e+00 0.01 0.01 0.7 GO:0004289 subtilase activity 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0008294 calcium\- and calmodulin\-responsive adenylate cyclase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0004869 cysteine protease inhibitor activity 399 2 397 2 553 555 1.000e+00 0.01 0.00 1.4 GO:0004516 nicotinate phosphoribosyltransferase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0004537 caspase\-activated deoxyribonuclease activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0003912 DNA nucleotidylexotransferase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0045182 translation regulator activity 399 2 397 2 553 555 1.000e+00 0.01 0.00 1.4 GO:0016755 transferase activity\, transferring amino\-acyl groups 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0043022 ribosome binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0043021 ribonucleoprotein binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0008367 bacterial binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0005010 insulin\-like growth factor receptor activity 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0043548 phosphoinositide 3\-kinase binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0003729 mRNA binding 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0019826 oxygen sensor activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0019901 protein kinase binding 399 5 394 6 549 555 1.000e+00 0.01 0.01 1.2 GO:0005355 glucose transmembrane transporter activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0015149 hexose transmembrane transporter activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0015145 monosaccharide transmembrane transporter activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0003705 RNA polymerase II transcription factor activity\, enhancer binding 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0004228 gelatinase A activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0004012 phospholipid\-translocating ATPase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0015247 aminophospholipid transporter activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0005548 phospholipid transporter activity 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0048038 quinone binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0004035 alkaline phosphatase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0005096 GTPase activator activity 399 2 397 4 551 555 1.000e+00 0.01 0.01 0.7 GO:0005100 Rho GTPase activator activity 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0042169 SH2 domain binding 399 2 397 3 552 555 1.000e+00 0.01 0.01 0.9 GO:0042289 MHC class II protein binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0008499 UDP\-galactose\:beta\-N\-acetylglucosamine beta\-1\,3\-galactosyltransferase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0048531 beta\-1\,3\-galactosyltransferase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0004693 cyclin\-dependent protein kinase activity 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0004104 cholinesterase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0005127 ciliary neurotrophic factor receptor binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0005157 macrophage colony stimulating factor receptor binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0005128 erythropoietin receptor binding 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0004359 glutaminase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0004245 neprilysin activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0016512 endothelin\-converting enzyme 1 activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0016511 endothelin\-converting enzyme activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0030235 nitric\-oxide synthase regulator activity 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0005141 interleukin\-10 receptor binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0005134 interleukin\-2 receptor binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0005136 interleukin\-4 receptor binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0019863 IgE binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0019865 immunoglobulin binding 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0004021 alanine transaminase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0008483 transaminase activity 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0016769 transferase activity\, transferring nitrogenous groups 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0016847 1\-aminocyclopropane\-1\-carboxylate synthase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0000146 microfilament motor activity 399 2 397 3 552 555 1.000e+00 0.01 0.01 0.9 GO:0030898 actin\-dependent ATPase activity 399 2 397 3 552 555 1.000e+00 0.01 0.01 0.9 GO:0051015 actin filament binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0008139 nuclear localization sequence binding 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0005048 signal sequence binding 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0031625 ubiquitin protein ligase binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0051059 NF\-kappaB binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0003725 double\-stranded RNA binding 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0042834 peptidoglycan binding 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0004656 procollagen\-proline 4\-dioxygenase activity 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0031545 peptidyl\-proline 4\-dioxygenase activity 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0031543 peptidyl\-proline dioxygenase activity 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0016706 oxidoreductase activity\, acting on paired donors\, with incorporation or reduction of molecular oxygen\, 2\-oxoglutarate as one donor\, and incorporation of one atom each of oxygen into both donors 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0019798 procollagen\-proline dioxygenase activity 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0004691 cAMP\-dependent protein kinase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0004690 cyclic nucleotide\-dependent protein kinase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0031202 RNA splicing factor activity\, transesterification mechanism 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0043425 bHLH transcription factor binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0016646 oxidoreductase activity\, acting on the CH\-NH group of donors\, NAD or NADP as acceptor 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0016645 oxidoreductase activity\, acting on the CH\-NH group of donors 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0015101 organic cation transmembrane transporter activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0003872 6\-phosphofructokinase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0008443 phosphofructokinase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0019200 carbohydrate kinase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0017050 D\-erythro\-sphingosine kinase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0004143 diacylglycerol kinase activity 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0008481 sphinganine kinase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0005070 SH3/SH2 adaptor activity 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0004796 thromboxane\-A synthase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0005262 calcium channel activity 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0016918 retinal binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0005501 retinoid binding 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0019840 isoprenoid binding 399 1 398 2 553 555 1.000e+00 0.00 0.00 0.7 GO:0019841 retinol binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0017077 oxidative phosphorylation uncoupler activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0008121 ubiquinol\-cytochrome\-c reductase activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0016681 oxidoreductase activity\, acting on diphenols and related substances as donors\, cytochrome as acceptor 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0016679 oxidoreductase activity\, acting on diphenols and related substances as donors 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0048487 beta\-tubulin binding 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4 GO:0043027 caspase inhibitor activity 399 1 398 1 554 555 1.000e+00 0.00 0.00 1.4