Hur Lab

Computational Biology & Artificial Intelligence

University of North Dakota

Developing computational methods to understand complex biological systems and human diseases

6
Active Grants
20
Software Tools
182
Publications
155 peer-reviewed, 18 preprints, 9 other

Research Highlights

Our interdisciplinary research spans computational biology, AI, and biomedical informatics

Bioinformatics & Systems Biology

Integrative multi-omics analysis and network-based approaches to uncover molecular mechanisms in complex diseases.

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Ontology-Based Knowledge Systems

Biomedical ontology development and knowledge representation for standardized data integration and analysis.

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AI & Machine Learning

Large language models, natural language processing and deep learning for biomedical data: knowledge extraction from the literature, biological age prediction and disease modeling. We are also building agentic AI workflows in which AI agents carry out bioinformatics and data-science analyses under human review.

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Neurological Disorders

Computational analysis of diabetic neuropathy, ALS, and other neurological conditions through transcriptomic profiling.

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Host-Pathogen Interactions

Literature mining and ontology-driven analysis of host-pathogen molecular interactions and immune response networks.

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Systems Pharmacology

Network and cheminformatics modeling of drug-induced adverse events, polypharmacy risk, and drug repurposing.

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Population & Clinical Health

Epidemiological and clinical studies of pregnancy outcomes, sleep, metabolic syndrome, biological aging, and long COVID using national surveys and cohorts.

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Research at a Glance

Publications by year and area, papers led by Dr. Hur, career stages, and funded grants in one view.

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Recent Publications

Latest peer-reviewed research from the Hur Lab

  1. Huang F*, Hu D*, Dai Y*, Geng A, Guan R, Quan H, McGregor BA, Wang Z, Khan N, Zhang H, Zhang J$, Xia M, Gu X, Che D, Hur J$, Cui X, and Guo K$. scGEN: Leveraging an Adaptive Weighting Strategy for Challenging Cell Clustering in Single-Cell RNA-seq. Advanced Science. 2026 Oct 11:e77746. doi: 10.1002/advs.77746. Online ahead of print. [PMID: 42860543] [PMCID: PMC13655258] PubMed
  2. Cheng C, McGregor BA, Hur J, and Combs CK. Bidirectional phenotypic transition in macrophages influences triple-negative breast cancer cell immune evasive patterns and response to chemotherapies in a co-culture spheroid model. PLOS One. 2026 Aug;21(8):e0356198. [PMID: 42599981] PubMed
  3. Monickaraj J*, Rehana H*, Bernardi A, Zheng Y, Lin T, Liu L, Madireddi A, Yeh L, Zheng J$, Hur J$, and He Y$. Vaxjo 2.0: An Ontology- and Large Language Model-Powered Knowledge Base of Vaccine Adjuvants and Mechanisms. Frontiers in Cellular and Infection Microbiology. 2026;16:1763384. [PMID: 42328180] PubMed
  4. Eid SA, Jaisil P, Guo K, Hayes JM, Pacut C, Rigan DM, Carter A, Teener SJ, Kim B, Kiriluk C, Lentz W, Miller CM, Webber-Davis I, McQuown H, Jang DG, Patterson A, Koubek EJ, Bridges D, Hur J, Meyer JD, and Feldman EL. Ketogenic Diet and Exercise Improve Peripheral Neuropathy in a Mouse Model of Metabolic Syndrome. Diabetes. 2026 Jun 1;75(6):991-1006. [PMID: 41861283] PubMed
  5. Zheng J, Lin AY, Huffman A, Masci AM, Racz R, Wu G, Roan K, Ong E, Sarntivijai S, Hu J, Asfaw E, Kahn H, Li X, Zhang X, Monickaraj J, Kosar N, Li J, Manuel W, Abeysinghe R, Rehana H, Bansal B, Pan Y, Guo J, He V, Song J, Seleznev AI, Hur K, He A, Davydov A, Yang Q, Ostropolets A, Vita R, Peters B, Ruttenberg A, Diehl AD, Hoyt CT, Roncaglia P, Huntley RP, Scheuermann RH, Courtot M, Todd T, Sayers S, Chen F, Li X, Yeh FY, Xiang Z, Ozgur A, Whetzel PL, Musen MA, Mungall CJ, Leitner WW, Cui L, Colby LA, Mobley HLT, Athey BD, Omenn GS, Cowell LG, Tao C, Hur J, Smith B, and He Y. VO: The Vaccine Ontology. Scientific Data. 2026 Apr 30;13(1). [PMID: 42062309] PubMed
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Featured Tools

Software developed by our lab for the research community

Funding & Support

Current research funding