miR-506

  Introduction
    miR-506 is a human microRNA family of three members (hsa-mir506, hsa-mir-507, and hsa-mir-508). This microRNA was identified by Bentwich et al (Nature Genetics, 2005) and is known for its implication in oxidative stress response. One of its major target protein is serine/threonine-protein kinase OSR1 (EC 2.7.1.37) (Oxidative stress responsive 1 protein) [Uniprot: OXSR1_HUMAN, O95747].

Query Summary

Query Type Family Accession Family ID miRBase ID1 miRBase ID2 # of members
mir-506 family MIPF0000176 mir-506 . . 3
 

microRNA family : mir-506 [MIPF0000176] miRBase

 
ID Accession Chromosome Start End Strand Genome MIRANDA1 TARGETSCAN1 MIRANDA2 TARGETSCAN2 Structure
hsa-mir-506 MI0003193 X
 146119930
 146120053
 -
 Coordinate hsa-miR-506 hsa-miR-506     hsa-mir-506
hsa-mir-507 MI0003194 X
 146120194
 146120287
 -
 Coordinate hsa-miR-507 hsa-miR-507     hsa-mir-507
hsa-mir-508 MI0003195 X
 146126123
 146126237
 -
 Coordinate hsa-miR-508 hsa-miR-508     hsa-mir-508

microRNA mature sequence alignment
CLUSTAL W (1.83) multiple sequence alignment
hsa-miR-506 -UAAGGCACCCUUCUG-AGUAGA
hsa-miR-508 UGAUUGUAGCCUUUUGGAGUAGA
hsa-miR-507 -UUUUGCA-CCUUUUGGAGUGAA
                  * * **** ** *** *
microRNA stem-loop sequence alignment 
CLUSTAL W (1.83) multiple sequence alignment

hsa-mir-506      GCCACCACCAUCAGCCAUACUAUGUGUAGUGCCUUAUUCAGGAAGGUGUUACUUA-AUAG
hsa-mir-508      ----CCACCUUCAGC-----UGAGUGUAGUGCCCUACUCCAGAGGGCGUCACUCAUGUAA
hsa-mir-507      ----------------GUGCUGUGUGUAGUGCUUCACUUCAAGAAGUGCCAUGCAUGUGU
                                                                          *  *********   * *       * *  *   *  *  

hsa-mir-506      AUUAAUAUUUGUAAGGCACCCUUCUGAGUAGAGUAAUGUGCAACAUGGACAACAUUUGUG
hsa-mir-508      ACUAAAACAUGAUUGUAGCCUUUUGGAGUAGAGUAAUACACAUCACGUAACGCAUAUUUG
hsa-mir-507      CUAGAAAUAUGUUUUGCACCUUUUGGAGUGAAAUAAUGCACAACAGAUAC----------
                                          * *  **       ** **  ****  * ****   ** **   *           

hsa-mir-506      GUGGC
hsa-mir-508      GUGG-
hsa-mir-507      -----

Conserved Secondary Structure Prediction - By RNAalifold in ViennaRNA package

____CCACC_UCAGC__U_CUGUGUGUAGUGCCUUACUCCAGAAGGUGUCACUCAUGUAAAUUAAAAUAUGUUUGGCACCUUUUGGAGUAGAGUAAUGCACAACACGUAC__CAU_U_UGGUGG_
....(((((...........((((((((.(((.((((((((((((((((((.((((((........)))))).)))))))))))))))))).))).))))).)))..............))))). (-36.41 = -34.74 +  -1.66)
....(((((,..........{(((((((.(((.((((((((((((((((((.((((((........)))))).)))))))))))))))))).))).))))).))}............,}))))). [-38.20] frequency of mfe structure in ensemble 0.0542599