)| PMID |
17439481 ( ) |
|---|---|
| Title | Recombinant human erythropoietin suppresses symptom onset and progression of G93A-SOD1 mouse model of ALS by preventing motor neuron death and inflammation. |
| Abstract | Multifactorial pathogenic mechanisms, including inflammation, attenuated survival signals and enhanced death signals, are involved in amyotrophic lateral sclerosis (ALS). Erythropoietin (EPO) has recently been highlighted as a cytokine with various potent neuroprotective effects, including reduction of inflammation, enhancement of survival signals and prevention of neuronal cell death. This study was undertaken to evaluate the effect of recombinant human EPO (rhEPO) on ALS model mice. We treated 96 ALS model mice with vehicle only, or 1, 2.5 or 5 imu of rhEPO/g of mouse once every other week after they were 60 days old. The treatment significantly prolonged symptom onset and life span, preserved more motor neurons, enhanced survival signals, and attenuated inflammatory signals in a dose-dependent manner. These data suggest that treatment with rhEPO represents a potential therapeutic strategy for ALS. Korea. |
NOTE: Color highlight is limited to the abstract and SciMiner text-mining mode. If you see much more identified targets below from "Targets by SciMiner Summary" and "Targets by SciMiner Full list", they may have been identified from the full text.
Targets by SciMiner Summary
| HUGO ID | Symbol | Target Name | #Occur | ActualStr |
|---|---|---|---|---|
| 3415 | EPO | erythropoietin | 5 | EPO | erythropoietin | |
Targets by SciMiner Full list
| HUGO ID | Symbol | Name | ActualStr | Score | FlankingText |
|---|---|---|---|---|---|
| 3415 | EPO | erythropoietin | EPO | 1.0 | Erythropoietin (EPO) EPO has recently been highlighted as a cytokine with various potent |
| 3415 | EPO | erythropoietin | EPO | 1.0 | study was undertaken to evaluate the effect of recombinant human EPO (rhEPO) rhEPO on ALS model mice |
| 3415 | EPO | erythropoietin | erythropoietin | 1.0 | recombinant human erythropoietin suppresses symptom onset and progression of g93a sod1 mouse model of als by preventing motor neuron death and inflammation. |
| 3415 | EPO | erythropoietin | erythropoietin | 1.0 | erythropoietin epo has recently been highlighted as a cytokine with various potent neuroprotective effects including reduction of inflammation enhancement of survival signals and prevention of neuronal cell death. |
| 3415 | EPO | erythropoietin | erythropoietin | 1.0 | erythropoietin recombinant|dinoprostone|superoxide dismutase 1|superoxide dismutase| |