Document Information

PMID 15962273  (  )
Title Production of monocyte chemoattractant protein-1 in amyotrophic lateral sclerosis.
Abstract The presence of activated microglia in the spinal cord of amyotrophic lateral sclerosis (ALS) patients is usually accompanied by inflammatory biochemical changes, but these are largely unexplored. Monocyte chemoattractant protein-1 (MCP-1) is critical for recruitment of inflammatory cells of monocytic lineage after inflammation or injury to the central nervous system. MCP-1 concentrations were measured by an enzyme-linked immunosorbent assay in the cerebrospinal fluid (CSF) and the serum of 27 patients with ALS and 30 patients with noninflammatory neurological diseases. In ALS, circulating MCP-1 levels were significantly increased in the serum and particularly in the CSF. Immunoreactivity for MCP-1 in ALS spinal cord was detected mostly in astrocytes but also in microglia, neurons, and within the vasculature of the cord. Our findings suggest a role for MCP-1 as an important molecular mediator of the injury response in ALS. Milan Medical School, IRCCS Ospedale Maggiore Policlinico, Via S. Sforza 35, 20122 Milan, Italy. pierluigi.baron@unimi.it

NOTE: Color highlight is limited to the abstract and SciMiner text-mining mode. If you see much more identified targets below from "Targets by SciMiner Summary" and "Targets by SciMiner Full list", they may have been identified from the full text.


Targets by SciMiner Summary

HUGO ID Symbol Target Name #Occur ActualStr
10618CCL2chemokine (C-C motif) ligand 212monocyte chemoattractant protein 1 | mcp 1 | MCP-1 |

 

Targets by SciMiner Full list

HUGO ID Symbol Name ActualStr Score FlankingText
10618CCL2chemokine (C-C motif) ligand 2MCP-12.8Monocyte chemoattractant protein-1 (MCP-1) MCP-1 is critical for recruitment of inflammatory cells of monocytic lineage
10618CCL2chemokine (C-C motif) ligand 2MCP-12.8MCP-1 concentrations were measured by an enzyme-linked immunosorbent assay in the
10618CCL2chemokine (C-C motif) ligand 2MCP-12.8In ALS circulating MCP-1 levels were significantly increased in the serum and particularly in
10618CCL2chemokine (C-C motif) ligand 2MCP-12.8Immunoreactivity for MCP-1 in ALS spinal cord was detected mostly in astrocytes but
10618CCL2chemokine (C-C motif) ligand 2MCP-12.8Our findings suggest a role for MCP-1 as an important molecular mediator of the injury response in
10618CCL2chemokine (C-C motif) ligand 2monocyte chemoattractant protein 11.0production of monocyte chemoattractant protein 1 in amyotrophic lateral sclerosis.
10618CCL2chemokine (C-C motif) ligand 2mcp 11.0monocyte chemoattractant protein 1 mcp 1 is critical for recruitment of inflammatory cells of monocytic lineage after inflammation or injury to the central nervous system.
10618CCL2chemokine (C-C motif) ligand 2monocyte chemoattractant protein 11.0monocyte chemoattractant protein 1 mcp 1 is critical for recruitment of inflammatory cells of monocytic lineage after inflammation or injury to the central nervous system.
10618CCL2chemokine (C-C motif) ligand 2mcp 11.0mcp 1 concentrations were measured by an enzyme linked immunosorbent assay in the cerebrospinal fluid csf and the serum of 27 patients with als and 30 patients with noninflammatory neurological diseases.
10618CCL2chemokine (C-C motif) ligand 2mcp 11.0in als circulating mcp 1 levels were significantly increased in the serum and particularly in the csf.
10618CCL2chemokine (C-C motif) ligand 2mcp 11.0immunoreactivity for mcp 1 in als spinal cord was detected mostly in astrocytes but also in microglia neurons and within the vasculature of the cord.
10618CCL2chemokine (C-C motif) ligand 2mcp 11.0our findings suggest a role for mcp 1 as an important molecular mediator of the injury response in als.