)| PMID |
15507874 ( ) |
|---|---|
| Title | New target against inflammatory diseases: transglutaminase 2. |
| Abstract | Transglutaminase (TGase)2 is an enzyme that is widely used in many biological systems for generic tissue stabilization or immediate defense for wounds. Many reports showed that TGase 2 is aberrantly activated in tissues and cells and contributes to a variety of diseases, including neurodegenerative diseases and autoimmune diseases. In most cases, TGase 2 appears to be a factor in the formation of inappropriate proteinaceous aggregates that may be cytotoxic. However, in other cases, such as celiac disease, arthritis, lupus, and amyotrophic lateral sclerosis, TGase 2 is involved in the generation of autoantibodies. This suggests the possibility that inappropriate expression and/or presentation of TGase 2 to T cells might contribute to these diseases in genetically predisposed individuals. We and others have found that TGase 2 expression is also increased in the inflammation process. Furthermore, we also demonstrated a reversal of inflammation by Tgase inhibition. This review will examine a possibility of TGase inhibitors as therapeutic agents in a variety of inflammatory diseases. University and Burke Medical Research Institute, White Plains, NY 10605, USA. tgase@hanmail.net |
NOTE: Color highlight is limited to the abstract and SciMiner text-mining mode. If you see much more identified targets below from "Targets by SciMiner Summary" and "Targets by SciMiner Full list", they may have been identified from the full text.
Targets by SciMiner Summary
| HUGO ID | Symbol | Target Name | #Occur | ActualStr |
|---|---|---|---|---|
| 11777 | TGM1 | transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase) | 8 | TGase | Tgase | |
| 11778 | TGM2 | transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) | 1 | transglutaminase 2 | |
Targets by SciMiner Full list
| HUGO ID | Symbol | Name | ActualStr | Score | FlankingText |
|---|---|---|---|---|---|
| 11777 | TGM1 | transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase) | TGase | 1.3 | Transglutaminase (TGase)2 TGase 2 is an enzyme that is widely used in many |
| 11777 | TGM1 | transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase) | TGase | 1.3 | Many reports showed that TGase 2 is aberrantly activated in tissues and cells and contributes |
| 11777 | TGM1 | transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase) | TGase | 1.3 | In most cases TGase 2 appears to be a factor in the formation of |
| 11777 | TGM1 | transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase) | TGase | 1.3 | such as celiac disease arthritis lupus and amyotrophic lateral sclerosis TGase 2 is involved in the generation of autoantibodies |
| 11777 | TGM1 | transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase) | TGase | 1.3 | the possibility that inappropriate expression and/or and or presentation of TGase 2 to T cells might contribute to these diseases in |
| 11777 | TGM1 | transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase) | TGase | 1.3 | We and others have found that TGase 2 expression is also increased in the inflammation process |
| 11777 | TGM1 | transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase) | Tgase | 1.3 | Furthermore we also demonstrated a reversal of inflammation by Tgase inhibition |
| 11777 | TGM1 | transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase) | TGase | 1.3 | This review will examine a possibility of TGase inhibitors as therapeutic agents in a variety of inflammatory diseases |
| 11778 | TGM2 | transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) | transglutaminase 2 | 1.0 | new target against inflammatory diseases: transglutaminase 2. |