HUGO ID Detailed Result 8004


HUGO ID 8004
Symbol NRP1
Name neuropilin 1
#Occurrence 23
#Paper 1

 


PMID Match String Actual String Score Flanking text Edited by Edit
16104843NRP1NRP-10.8VEGF 165 binds the coreceptors NRP-1 (neuropilin-1) neuropilin-1 20 and NRP-2 (neuropilin-2), neuropilin-2 whereas VEGF 145 
16104843NRP1NRP-10.8PlGF-2 is able to bind heparin and the co-receptors NRP-1 and NRP-2 due to the insertion of a highly basic 
16104843NRP1NRP-10.8isoforms bind and activate VEGFR-1 and can also bind to NRP-1 44 ( Figure 2 
16104843NRP1NRP-10.8VEGF-E NZ-2 VEGF-E NZ-10 and VEGF-E D1701 can bind NRP-1 
16104843NRP1NRP-10.8VEGF-E NZ-7 and VEGF-E VR634 however are unable to bind NRP-1 ( Figure 2 
16104843NRP1NRP-10.8vammin and Tf svVEGF are unable to bind VEGFR-3 or NRP-1 but Tf svVEGF binds heparin svVEGFs may contribute to the 
16104843NRP1NRP-10.8NRP-1 and NRP-2 
16104843NRP1NRP-10.8NRP-1 is a 130-140 kDa cell-surface glycoprotein first identified as a 
16104843NRP1NRP-10.8NRP-2 was identified by virtue of its sequence homology with NRP-1 and shares 44% identity at the amino acid level with 
16104843NRP1NRP-10.8and shares 44% identity at the amino acid level with NRP-1 90 
16104843NRP1NRP-10.8NRP-1 is able to bind VEGF 165 VEGF-B PlGF-2 and some 
16104843NRPNRPs0.8The intracellular domains of NRPs are short and do not suffice for the independent transduction 
16104843NRPNRPs0.8It has been shown that both NRPs can join with receptors belonging to the plexin family and 
16104843NRPNRP0.8receptors belonging to the plexin family and such plexin/NRP plexin NRP complexes are able to transduce signals as the physiological receptor 
16104843NRP1NRP-10.8cells that express VEGFR-2 are enhanced in the presence of NRP-1 
16104843NRP1NRP-10.8Thus NRP-1 also seems to function as an enhancer of VEGFR-2 activity 
16104843NRP1NRP-10.8result of the formation of a complex between VEGFR-2 and NRP-1 93 94 
16104843NRP1NRP-10.8An in vivo study with transgenic mice has shown that NRP-1 is important not only for neuronal development but also for 
16104843NRP1NRP-10.8NRP-1 mice suffer from severe defects in the cardiovascular system in 
16104843NRP1NRP-10.8aortic arches and the yolk-sac vasculature suggesting the importance of NRP-1 in embryonic vessel formation 
16104843NRP1NRP-10.8survival of motor neurons during hypoxia through binding VEGFR-2 and NRP-1 161 
16104843NRPNRP0.8T-cell NO nitric oxide NOS NO synthase eNOS endothelial NOS NRP neuropilin PAIP2 polyadenylated-binding protein-interacting protein 2 PDK1 phosphoinositide-dependent kinase 1 
16104843neuropilin 1neuropilin 11.0vegf 165 binds the coreceptors nrp 1 neuropilin 1 [ 20 ] and nrp 2 neuropilin 2 whereas vegf 145 binds only nrp 2 [ 21 ] figure 2 .