HUGO ID Detailed Result 7889

PMID	Match String	Actual String	Score	Flanking text	Edited by	Edit
17853944	NOX1	Nox1	4.2	dysregulated redox stress in ALS mice caused by NADPH oxidases Nox1 and Nox2 significantly influenced the progression of motor neuron disease
17853944	NOX1	Nox1	4.2	rates were enhanced significantly more by Nox2 deletion than by Nox1 deletion
17853944	NOX1	Nox1	4.2	Interestingly female ALS mice containing only 1 active X-linked Nox1 or Nox2 gene also had significantly delayed disease onset but
17853944	NOX1	Nox1	4.2	Seven known NADPH oxidases (Nox1, Nox1 Nox2 Nox3 Nox4 Nox5 Duox1 and Duox2 are thought to
17853944	NOX1	Nox1	4.2	Nox1 and Nox2 are closely related homologs in the Nox gene
17853944	NOX1	Nox1	4.2	end we performed studies comparing the contribution of Nox2 or Nox1 deletion on disease progression in mixed hybrid SOD1 G93A ALS
17853944	NOX1	Nox1	4.2	show that disrupting either of these NADPH oxidase genes ( Nox1 or Nox2 significantly delayed the progression of motor neuron disease
17853944	NOX1	Nox1	4.2	female ALS mice lacking a single copy of the X-chromosomal Nox1 or Nox2 genes also exhibited significantly increased survival rates
17853944	NOX1	Nox1	4.2	in the setting of random X-inactivation a 50% reduction in Nox1 - or Nox2 -expressing cells has a substantial therapeutic benefit
17853944	NOX1	Nox1	4.2	(c) c Nox1 KO mice ( 24 were a kind gift from K.H
17853944	NOX1	Nox1	4.2	of SOD1 G93A transgenic mice on the Nox2 -KO or Nox1 -KO backgrounds were achieved using the following breeding scheme
17853944	NOX1	NOX1	4.2	Because both Nox2 and Nox1 genes are on the X chromosome 2 rounds
17853944	NOX1	Nox1	4.2	Because both Nox2 and Nox1 genes are on the X chromosome 2 rounds of breeding
17853944	NOX1	Nox1	4.2	transgenic males were bred to Nox2 _amp_#x02013;/_amp_#x02013; _amp_#x02013 _amp_#x02013 or Nox1 _amp_#x02013;/_amp_#x02013; _amp_#x02013 _amp_#x02013 females
17853944	NOX1	Nox1	4.2	_amp_#x02013 _amp_#x000d7 SOD1 G93A / Nox2 _amp_#x02013;/Y _amp_#x02013 Y or Nox1 +/_amp_#x02013; _amp_#x02013 _amp_#x000d7 SOD1 G93A / Nox1 _amp_#x02013;/Y _amp_#x02013 Y
17853944	NOX1	Nox1	4.2	_amp_#x02013 Y or Nox1 +/_amp_#x02013; _amp_#x02013 _amp_#x000d7 SOD1 G93A / Nox1 _amp_#x02013;/Y _amp_#x02013 Y to give rise to mixed litters containing
17853944	NOX1	Nox1	4.2	+/_amp_#x02013; _amp_#x02013 _amp_#x000d7 SOD1 G93A / Nox2 +/Y Y or Nox1 +/_amp_#x02013; _amp_#x02013 _amp_#x000d7 SOD1 G93A / Nox1 +/Y Y to
17853944	NOX1	Nox1	4.2	+/Y Y or Nox1 +/_amp_#x02013; _amp_#x02013 _amp_#x000d7 SOD1 G93A / Nox1 +/Y Y to give rise to mixed litters containing Nox
17853944	NOX1	Nox1	4.2	Nox1 PCR genotypes were performed as previously described ( 24
17853944	NOX1	Nox1	4.2	None of the mice on the Nox1 -KO background failed the weight criteria
17853944	NOX1	Nox1	4.2	Results and Discussion Gene deletion of Nox1 or Nox2 increases survival and slows disease progression in SOD1
17853944	NOX1	Nox1	4.2	We bred female Nox1 -KO and Nox2 -KO mice to hemizygous male SOD1 G93A
17853944	NOX1	Nox1	4.2	possible genotypes in both male and female siblings because both Nox1 and Nox2 are on the X chromosome
17853944	NOX1	Nox1	4.2	The Nox1 and Nox2 mice were both maintained on the C57BL/6 C57BL
17853944	NOX1	Nox1	4.2	Nox2 mice were inbred to greater than 13 generations ( Nox1 KO mice were backcrossed about 7 generations onto the C57BL/6
17853944	NOX1	Nox1	4.2	Homozygous deletion of either Nox1 or Nox2 significantly delayed the death of hemizygous SOD1 G93A
17853944	NOX1	Nox1-deficient	1.9	Nox1-deficient mice gave rise to a much smaller but still significant
17853944	NOX1	Nox1	4.2	but still significant protective effect in terms of survival ( Nox1 -WT 129 days Nox1 -KO 162 days but not survival
17853944	NOX1	Nox1	4.2	effect in terms of survival ( Nox1 -WT 129 days Nox1 -KO 162 days but not survival index (Figure Figure 1
17853944	NOX1	Nox1	4.2	seen in our studies (129 129 and 132 days for Nox1 and Nox2 backgrounds respectively were very similar to SOD1 G93A
17853944	NOX1	Nox1	4.2	degree of variability in survival among siblings for the various Nox1 and Nox2 SOD1 G93A genotypes in the F1 and F2
17853944	NOX1	Nox1	4.2	a limited but significant heterozygous effect on increased survival in Nox1 -HET female ALS mice (Figure Figure 1 A
17853944	NOX1	Nox1	4.2	Both Nox1 and Nox2 genes reside on the X chromosome
17853944	NOX1	Nox1	4.2	survival and delayed disease onset when 2 related Nox genes Nox1 and Nox2 were deleted
17853944	NOX1	Nox1	4.2	However the marginal increase in life span seen in the Nox1 -KO compared with the Nox2 -KO ALS mice would suggest
17853944	NOX1	Nox1	4.2	studies also demonstrate that more than 1 Nox gene ( Nox1 and Nox2 can influence disease progression in ALS mice
17853944	NOX1	Nox1	4.2	Figure 1 Deletion of NADPH oxidase genes ( Nox1 or Nox2 enhances survival and survival index in ALS mice
18598679	NOX1	Nox1	0.9	mice ( Wu et al. 2006 and deletion of either Nox1 or Nox2 gene significantly slowed disease progression and improved survival
17853944	nadph oxidase 1	nadph oxidase 1	1.0	membrane glycoproteins|superoxide dismutase 1|superoxide dismutase|nadh nadph oxidoreductases|cybb protein mouse|nadph oxidase|nadph oxidase 1|