HUGO ID Detailed Result 483


HUGO ID 483
Symbol ANG
Name angiogenin, ribonuclease, RNase A family, 5
#Occurrence 12
#Paper 1

 


PMID Match String Actual String Score Flanking text Edited by Edit
17015226ANGANG0.6Mutations in genes encoding angiogenin ( ANG and VEGF and sequence variants in neurofilament genes have also 
17015226ANGANG0.6Angiogenin ( ANG 
17015226ANGANG0.6Mutations in ANG have also been linked to ALS emphasizing a potential link 
17015226ANGANG0.6Swedish and North American populations and therefore suggest that ALS-linked ANG mutations are rare 
17015226ANGANG0.6VAPB or expressed in multiple cells types ( VEGF and ANG 
17015226angiogeninangiogenin1.0mutations in genes encoding angiogenin ang and vegf and sequence variants in neurofilament genes have also been reported for more detailed consideration of the genetics see gros louis et_amp_#xa0;al [2006] .  
17015226angiogeninangiogenin1.0although all have in common disease that affects motor neurons the nomenclature is misleading since only als1 als3 als6 als7 mutations in angiogenin and vegf and a small proportion of incidences of als8 represent the classic late onset neurodegenerative disease with selective killing of upper and lower motor neurons leading to progressive paralys 
17015226angiogeninangiogenin1.0angiogenin ang  
17015226angiogeninangiogenin1.0the manner in which the identified mutations affect angiogenin function and provoke motor neuron disease is still unknown.  
17015226angiogeninangiogenin1.0angiogenin which is expressed within the cns including the motor neurons has a known intranuclear rnase activity that can facilitate rrna synthesis at least in endothelial cells.  
17015226angiogeninangiogenin1.0ingly the majority of the mutations found in als patients are located within the catalytic core and one of them is in the nuclear localization signal both predicting a loss of function of the mutated angiogenin although this remains to be confirmed.  
17015226angiogeninangiogenin1.0whether angiogenin is endowed with neurotrophic properties like vegf in addition to its angiogenic activity is not yet established.