HUGO ID Detailed Result 3767


HUGO ID 3767
Symbol FLT4
Name fms-related tyrosine kinase 4
#Occurrence 16
#Paper 1

 


PMID Match String Actual String Score Flanking text Edited by Edit
16104843VEGFR3VEGFR-30.6Both VEGF-C and VEGF-D bind and activate VEGFR-3 (Flt-4; Flt-4 a member of the VEGFR family that does 
16104843FLT4Flt-40.6Both VEGF-C and VEGF-D bind and activate VEGFR-3 (Flt-4; Flt-4 a member of the VEGFR family that does not bind 
16104843VEGFR3VEGFR-30.6the precursor generates a form with a moderate affinity for VEGFR-3 but a second proteolytic step is required to produce the 
16104843VEGFR3VEGFR-30.6processed form with a high affinity for both VEGFR-2 and VEGFR-3 49 
16104843VEGFR3VEGFR-30.6variants studied bind and activate VEGFR-2 but not VEGFR-1 or VEGFR-3 
16104843VEGFR3VEGFR-30.6Both vammin and Tf svVEGF are unable to bind VEGFR-3 or NRP-1 but Tf svVEGF binds heparin svVEGFs may contribute 
16104843VEGFR3VEGFR-30.6VEGFR-3 
16104843VEGFR3VEGFR-30.6VEGFR-3 is a 195 kDa high-affinity receptor for VEGF-C and VEGF-D 
16104843VEGFR3VEGFR-30.6Unlike VEGFR-1 and VEGFR-2 VEGFR-3 is proteolytically cleaved within the fifth extracellular Ig loop into 
16104843VEGFR3VEGFR-30.6Overexpression of a soluble VEGFR-3 in the skin of mice inhibits fetal lymphangiogenesis and induces 
16104843VEGFR3VEGFR-30.6on the blood vessel architecture 87 indicating that stimulation of VEGFR-3 alone is sufficient to induce lymphangiogenesis 
16104843VEGFR3VEGFR-30.6The stimulation of VEGFR-3 also protects the lymphatic endothelial cells from serum deprivation-induced apoptosis 
16104843VEGFR3VEGFR-30.6The phosphorylation of VEGFR-3 has been shown to lead to a PI3K-dependent activation of 
16104843VEGFR3VEGFR-30.6A recent study 89 has demonstrated that blockade of VEGFR-3 signalling significantly suppresses corneal dendritic cell trafficking to draining lymph 
16104843VEGFR3VEGFR-30.6hypersensitivity and rejection of corneal transplants suggesting a role for VEGFR-3 in adaptive immunity 
16104843VEGFR3VEGFR-30.6An association between VEGFR-2 and VEGFR-3 has also been reported 166