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| 16104843 | VEGFR1 | VEGFR-1 | 0.6 | tumour vascularization mainly by interacting with two tyrosine kinase receptors VEGFR-1 also known as Flt-1 (Fms-like Fms-like tyrosine kinase-1 and VEGFR-2 | |  |
| 16104843 | FLT1 | Flt-1 | 0.6 | interacting with two tyrosine kinase receptors VEGFR-1 also known as Flt-1 (Fms-like Fms-like tyrosine kinase-1 and VEGFR-2 also known as Flk-1 | | |
| 16104843 | VEGFR1 | VEGFR-1 | 0.6 | PlGF binds VEGFR-1 but not VEGFR-2 35 36 | | |
| 16104843 | VEGFR1 | VEGFR-1 | 0.6 | PlGF and VEGF-A bind to the same binding interface of VEGFR-1 in a very similar fashion 41 | | |
| 16104843 | VEGFR1 | VEGFR-1 | 0.6 | in VEGF-A N-glycosylation in PlGF plays an important role in VEGFR-1 binding 42 | | |
| 16104843 | VEGFR1 | VEGFR-1 | 0.6 | ischaemia inflammation wound healing and cancer indicating the importance of VEGFR-1 signalling in pathological conditions | | |
| 16104843 | VEGFR1 | VEGFR-1 | 0.6 | The VEGF-B isoforms bind and activate VEGFR-1 and can also bind to NRP-1 44 ( Figure 2 | | |
| 16104843 | VEGFR1 | VEGFR-1 | 0.6 | All VEGF-E variants studied bind and activate VEGFR-2 but not VEGFR-1 or VEGFR-3 | | |
| 16104843 | VEGFR1 | VEGFR-1 | 0.6 | Vammin does not bind VEGFR-1 but binds VEGFR-2 with high affinity as well as VEGF | | |
| 16104843 | VEGFR1 | VEGFR-1 | 0.6 | However Tf svVEGF binds VEGFR-1 with high affinity and VEGFR-2 with low affinity compared with | | |
| 16104843 | VEGFR1 | VEGFR-1 | 0.6 | VEGFR-1 | | |
| 16104843 | VEGFR1 | VEGFR-1 | 0.6 | VEGFR-1 is a 180 kDa high-affinity receptor for VEGF-A VEGF-B PlGF | | |
| 16104843 | VEGFR1 | VEGFR-1 | 0.6 | The second Ig domain of VEGFR-1 is the major binding site for VEGF-A and PlGF 16 | | |
| 16104843 | VEGFR1 | VEGFR-1 | 0.6 | VEGFR-1 binds VEGF-A with at least 10-fold higher affinity than VEGFR-2 | | |
| 16104843 | VEGFR1 | VEGFR-1 | 0.6 | VEGFR-1 is a negative regulator of angiogenesis during early development but | | |
| 16104843 | VEGFR1 | VEGFR-1 | 0.6 | endothelial cells in response to VEGF-A indicating the involvement of VEGFR-1 in endothelial cell migration 68 | | |
| 16104843 | VEGFR1 | VEGFR-1 | 0.6 | VEGFR-1 signalling is also involved in the migration of monocytes/macrophages monocytes | | |
| 16104843 | VEGFR1 | VEGFR-1 | 0.6 | An alternatively spliced form of VEGFR-1 that encodes a soluble truncated form of the receptor containing | | |
| 16104843 | VEGFR1 | VEGFR-1 | 0.6 | cloned from a HUVEC cDNA library 16 sVEGFR-1 (soluble soluble VEGFR-1 inhibits VEGF-A activity by sequestering VEGF-A from signalling receptors and | | |
| 16104843 | VEGFR1 | VEGFR-1 | 0.6 | Unlike VEGFR-1 and VEGFR-2 VEGFR-3 is proteolytically cleaved within the fifth extracellular | | |
| 16104843 | VEGFR1 | VEGFR-1 | 0.6 | Homozygous loss of the VEGFR-1 or VEGFR-2 gene results in embryonic lethality between days 8.5 | | |
| 16104843 | VEGFR1 | VEGFR-1 | 0.6 | On the other hand VEGFR-1 mice die due to an overgrowth of endothelial cells and | | |
| 16104843 | VEGFR1 | VEGFR-1 | 0.6 | vascular development in mice lacking the tyrosine kinase domain of VEGFR-1 103 has indicated that VEGFR-2 is the major positive signal | | |
| 16104843 | VEGFR1 | VEGFR-1 | 0.6 | indicated that VEGFR-2 is the major positive signal transducer whereas VEGFR-1 has a negative regulatory role in angiogenesis early in embryogenesis | | |
| 16104843 | VEGFR1 | VEGFR-1 | 0.6 | enhancement of vascular permeability is intensified by the activation of VEGFR-1 more than the proliferation of endothelial cells under some active | | |
| 16104843 | VEGFR1 | VEGFR-1 | 0.6 | This finding indicates the importance of VEGFR-1 signalling in vascular permeability | | |
| 16104843 | VEGFR1 | VEGFR-1 | 0.6 | Unlike in physiological angiogenesis VEGFR-1 signalling plays an important role in angiogenesis under pathological conditions | | |
| 16104843 | VEGFR1 | VEGFR-1 | 0.6 | have proposed that PlGF regulates inter- and intra-molecular cross-talk between VEGFR-1 and VEGFR-2 amplifying VEGF-driven angiogenesis through VEGFR-2 | | |
| 16104843 | VEGFR1 | VEGFR-1 | 0.6 | Hiratsuka et al 138 have shown that VEGFR-1 signalling is also involved in tumour metastasis being linked to | | |
| 16104843 | VEGFR1 | VEGFR-1 | 0.6 | diminished and abbreviated inflammatory response 145 suggesting the importance of VEGFR-1 signalling in chronic skin inflammation | | |
| 16104843 | VEGFR1 | VEGFR-1 | 0.6 | by suppressing synovial inflammation and neovascularization emphasizing the importance of VEGFR-1 signalling in the destruction | | |
| 16104843 | VEGFR1 | VEGFR-1 | 0.6 | in VEGF-B mice 47 also implies a critical role for VEGFR-1 signalling in RA | | |
| 16104843 | VEGFR1 | VEGFR-1 | 0.6 | al 165 recently provided evidence for a novel function of VEGFR-1 in LSECs (liver liver sinusoidal endothelial cells | | |
| 16104843 | VEGFR1 | VEGFR-1 | 0.6 | The activation of VEGFR-1 results in the paracrine release of HGF (hepatocyte hepatocyte growth | | |
| 16104843 | VEGFR1 | VEGFR-1 | 0.6 | A VEGFR-1 agonist protected the liver from CCl 4 -induced damage in | | |
| 16104843 | VEGFR1 | VEGFR-1 | 0.6 | VEGFR-1 has a negative regulatory role in embryonic angiogenesis but functions | | |
| 16104843 | VEGFR1 | VEGFR-1 | 0.6 | VEGF vascular endothelial growth factor VEGFR VEGF receptor sVEGFR-1 soluble VEGFR-1 svVEGF snake venom VEGF Tf svVEGF Trimeresurus flavoviridis svVEGF VPF | | |