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| 16120782 | SOCS-3 | SOCS-3 | 3.5 | cytokine signaling (SOCS)-1, SOCS -1 forward 5'-AGC-AGC-TCG-AAA-AGG-CAG-TC-3' and reverse 5'-ACA-CTC-ACT-TCC-GCA-CCT-TC-3' SOCS-3 forward 5'-ACC-AGC-GCC-ACT-TCT-TCA-CG-3' and reverse 5'-GTG-GAG-CAT-CAT-ACT-GAT-CC-3' mouse SOD1 forward 5'-GTC-CGT-CGG-CTT-CTC-GTC-T-3' and | |  |
| 16120782 | SOCS-3 | SOCS-3 | 3.5 | 5'-TCA-CCA-GGG-CTG-CCA-TTT-GC-3' and reverse 5'-GAC-TCC-ACG-ACA-TAC-TCA-GC-3' were used as housekeeping control for SOCS-1 and 3 beta-actin forward 5'-CAC-AGC-TTC-TTT-GCA-GCT-CCT-T-3' and reverse 5'-TCA-GGA-TAC-CTC-TCT-TGC-TCT-GG-3' were used | | |
| 16120782 | SOCS-3 | SOCS-3 | 3.5 | reduction was paralleled by a marked transcriptional upregulation of anti-inflammatory SOCS-1 and SOCS-3 genes ( Fig 3 c in both Pio-treated | | |
| 16120782 | SOCS-3 | SOCS-3 | 3.5 | paralleled by a marked transcriptional upregulation of anti-inflammatory SOCS-1 and SOCS-3 genes ( Fig 3 c in both Pio-treated groups ( | | |
| 16120782 | SOCS-3 | SOCS-3 | 3.5 | 0.001 compared with the respective nontreated group c Quantification of SOCS-1 and SOCS-3 mRNA levels in the spinal cord at day | | |
| 16120782 | SOCS-3 | SOCS-3 | 3.5 | with the respective nontreated group c Quantification of SOCS-1 and SOCS-3 mRNA levels in the spinal cord at day 90 of | | |
| 16120782 | SOCS-3 | SOCS-3 | 3.5 | Interestingly SOCS-1 and SOCS-3 have been reported to increase in response to | | |
| 16120782 | SOCS-3 | SOCS-3 | 3.5 | Interestingly SOCS-1 and SOCS-3 have been reported to increase in response to TZDs in | | |
| 16120782 | SOCS-3 | SOCS-3 | 3.5 | Because the ability of SOCS-1 and SOCS-3 to suppress cytokine stimulation has also been confirmed | | |
| 16120782 | SOCS-3 | SOCS-3 | 3.5 | Because the ability of SOCS-1 and SOCS-3 to suppress cytokine stimulation has also been confirmed by in | | |
| 16120782 | SOCS-3 | SOCS-3 | 3.5 | Suzuki et al. 2001 it seems likely that upregulation of SOCS-1 and SOCS-3 levels in response to Pio treatment reflects one | | |
| 16120782 | SOCS-3 | SOCS-3 | 3.5 | al. 2001 it seems likely that upregulation of SOCS-1 and SOCS-3 levels in response to Pio treatment reflects one mechanism of | | |
| 17555556 | SOCS-3 | SOCS-3 | 2.5 | SOCS-1 and SOCS-3 are critical factors down-regulating the toxic effects of | | |
| 17555556 | SOCS-3 | SOCS-3 | 2.5 | SOCS-1 and SOCS-3 are critical factors down-regulating the toxic effects of LPS ( | | |
| 18464922 | SOCS-3 | SOCS-3 | 1.5 | suppressor genes suppressor of cytokine signaling 1 and 3 (SOCS-1 SOCS-1 and -3 were increased as assessed by semiquantitative RT-PCR 39 | | |
| 18464922 | SOCS-3 | SOCS-3 | 1.5 | Others have reported similar increase in SOCS-1 and -3 in response to TZDs in microglia and astrocytes | | |
| 18464922 | SOCS-3 | SOCS-3 | 1.5 | The increase in SOCS-1 and -3 is implicated with the inhibition of Janus kinase-signal | | |
| 16120782 | socs 3 | socs 3 | 1.0 | the primers were the following: suppressor of cytokine signaling socs 1 forward 5' agc agc tcg aaa agg cag tc 3' and reverse 5' aca ctc act tcc gca cct tc 3'; socs 3 forward 5' acc agc gcc act tct tca cg 3' and reverse 5' gtg gag cat cat act gat cc 3'; mouse sod1 forward 5' gtc cgt cgg ctt ctc gtc t 3' and reverse 5' cac aac tgg ttc acc gct tg 3'; human sod1 forw | | |
| 16120782 | socs 3 | socs 3 | 1.0 | notably this reduction was paralleled by a marked transcriptional upregulation of anti inflammatory socs 1 and socs 3 genes fig 3 c in both pio treated groups n = 5 for all groups . | | |
| 16120782 | socs 3 | socs 3 | 1.0 | blots n = 4 for all groups from spinal cord samples derived from 90 d old mice b are shown. p _lt_ 0.01 and p _lt_ 0.001 compared with the respective nontreated group. c quantification of socs 1 and socs 3 mrna levels in the spinal cord at day 90 of life n = 5 for all groups . | | |
| 16120782 | socs 3 | socs 3 | 1.0 | interestingly socs 1 and socs 3 have been reported to increase in response to tzds in microglia and astrocytes in vitro which in turn inhibit janus kinase signal transducer and activator of transcription jak stat inflammatory signa | | |
| 16120782 | socs 3 | socs 3 | 1.0 | because the ability of socs 1 and socs 3 to suppress cytokine stimulation has also been confirmed by in vivo experiments using knock out mice shouda et al. 2001 ; suzuki et al. 2001 it seems likely that upregulation of socs 1 and socs 3 lev | | |
| 16120782 | socs 3 | socs 3 | 1.0 | to suppress cytokine stimulation has also been confirmed by in vivo experiments using knock out mice shouda et al. 2001 ; suzuki et al. 2001 it seems likely that upregulation of socs 1 and socs 3 levels in response to pio treatment reflects one mechanism of the anti inflammatory effect observed and antagonizing the jak stat pathway contributes to the observed suppression of inos and cox 2 exp | | |
| 17555556 | socs 3 | socs 3 | 1.0 | socs 1 and socs 3 are critical factors down regulating the toxic effects of lps berlato et al 2002 ; nakagawa et al 2002 and may well influence the toxic effects of msod1 microglia. | | |