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| 16104843 | hif 1 | hif 1 | 1.0 | it is now well established that hif 1 hypoxia inducible factor 1 is a key mediator of hypoxic responses. | |  |
| 16104843 | hif 1 | hif 1 | 1.0 | hif 1 is a transcriptional activator composed of hif 1 a and hif 1 b subunits. | | |
| 16104843 | hif 1 | hif 1 | 1.0 | both hif 1 a and hif 1 b are constitutively expressed in various types of tumour. | | |
| 16104843 | hif 1 | hif 1 | 1.0 | under normal oxygenation conditions hif 1 a is scarcely detectable because it is targeted for rapid destruction by an e3 ubiquitin ligase containing pvhl von hippel lindau tumour suppressor protein . | | |
| 16104843 | hif 1 | hif 1 | 1.0 | the interaction between pvhl and a specific domain of the hif 1 a subunit is regulated through hydroxylation of a proline residue pro in hif 1 a by prolyl 4 hydroxylase which requires molecular oxygen and iron for its activity. | | |
| 16104843 | hif 1 | hif 1 | 1.0 | under hypoxic conditions hif 1 a expression increases as a result of suppressed prolyl hydroxylation of hif 1 a and decreased ubiquitination and degradation [ 26 27 ]. | | |
| 16104843 | hif 1 | hif 1 | 1.0 | furthermore hypoxia inhibits the oxygen dependent hydroxylation of an asparagine residue asn in hif 1 a in the c terminal transactivation domain of hif 1 a to promote interaction with the p300/cbp [creb camp response element binding protein binding protein] co activator and induce a hre hypoxia response element driven transcription of the vegf gene [ | | |
| 16104843 | hif 1 | hif 1 | 1.0 | consequently hif 1 a protein accumulates under normoxic conditions and the transcription of vegf a is increased [ 29 ]. | | |
| 16104843 | hif 1 | hif 1 | 1.0 | abbreviations: als amyotrophic lateral sclerosis; dscr1 down syndrome critical region protein 1; ecm extracellular matrix; erk extracellular signal regulated kinase; fak focal adhesion kinase; hif 1 hypoxia inducible factor 1; hre hypoxia response element; huvec human umbilical vein endothelial cell; lsec liver sinusoidal endothelial cell; mab monoclonal antibody; mapk mitogen activated protein | | |
| 17582695 | hif 1 | hif 1 | 1.0 | il 1beta and hypoxia inducible factor 1 hif 1 play important roles in influencing vessel plasticity along with vascular endothelial growth factor vegf [22] . | | |