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| 17350694 | TRPV1 | TRPV1 | 0.6 | _amp_#x2022 Signaling through TRPV1 receptors | |  |
| 17350694 | TRPV1 | TRPV1 | 0.6 | characterized ECS elements often includes the type-1 vanilloid receptor (TRPV1), TRPV1 although this receptor does not strictly belong to the ECS | |  |
| 17350694 | TRPV1 | TRPV1 | 0.6 | In fact TRPV1 has emerged as a key target of the amide N | |  |
| 17350694 | TRPV1 | TRPV1 | 0.6 | dopamine cell survival by potentiating the toxic effects of the TRPV1 agonist capsaicin 37 | |  |
| 17350694 | TRPV1 | TRPV1 | 0.6 | thus conceivable that endocannabinoids such as AEA which activates both TRPV1 and CB 1 receptors 33 might contribute to PD pathophysiology | |  |
| 17350694 | TRPV1 | TRPV1 | 0.6 | the synthesis of new AEA after the direct activation of TRPV1 by AM404 rather than to AMT inhibition | |  |
| 17350694 | TRPV1 | TRPV1 | 0.6 | have distinct pharmacological profiles on CB 1 CB 2 and TRPV1 receptors thus it can be anticipated that differential modulation of | |  |
| 17350694 | TRPV1 | TRPV1 | 0.6 | with the fact that AEA but not 2-AG binds to TRPV1 33 suggests that agents that can modulate 2-AG levels within | |  |
| 17350694 | TRPV1 | TRPV1 | 0.6 | By contrast stimulation of TRPV1 favors inflammation 27 as a result modulation of AEA-dependent activation | |  |
| 17350694 | TRPV1 | TRPV1 | 0.6 | that our hypothesis that a balance between CB receptors and TRPV1 modulates the dual nature of neurological diseases finds a nice | |  |
| 17350694 | TRPV1 | TRPV1 | 0.6 | in pathological pain sensation where it has been demonstrated that TRPV1 functions to oppose CB-receptor-dependent effects 62 | |  |
| 17350694 | TRPV1 | TRPV1 | 0.6 | TRPV1 is another key molecular target of AEA but importantly not | |  |
| 17350694 | TRPV1 | TRPV1 | 0.6 | CB 1 or CB 2 receptors and by AEA through TRPV1 are summarized in Box 1 along with the biological actions | |  |
| 17350694 | TRPV1 | TRPV1 | 0.6 | one hand AEA might control inflammatory processes by binding to TRPV1 such that drugs that are able to modulate the AEA | |  |