HUGO ID Detailed Result 12716


HUGO ID 12716
Symbol TRPV1
Name transient receptor potential cation channel, subfamily V, member 1
#Occurrence 14
#Paper 1

 


PMID Match String Actual String Score Flanking text Edited by Edit
17350694TRPV1TRPV10.6_amp_#x2022 Signaling through TRPV1 receptors 
17350694TRPV1TRPV10.6characterized ECS elements often includes the type-1 vanilloid receptor (TRPV1), TRPV1 although this receptor does not strictly belong to the ECS 
17350694TRPV1TRPV10.6In fact TRPV1 has emerged as a key target of the amide N 
17350694TRPV1TRPV10.6dopamine cell survival by potentiating the toxic effects of the TRPV1 agonist capsaicin 37 
17350694TRPV1TRPV10.6thus conceivable that endocannabinoids such as AEA which activates both TRPV1 and CB 1 receptors 33 might contribute to PD pathophysiology 
17350694TRPV1TRPV10.6the synthesis of new AEA after the direct activation of TRPV1 by AM404 rather than to AMT inhibition 
17350694TRPV1TRPV10.6have distinct pharmacological profiles on CB 1 CB 2 and TRPV1 receptors thus it can be anticipated that differential modulation of 
17350694TRPV1TRPV10.6with the fact that AEA but not 2-AG binds to TRPV1 33 suggests that agents that can modulate 2-AG levels within 
17350694TRPV1TRPV10.6By contrast stimulation of TRPV1 favors inflammation 27 as a result modulation of AEA-dependent activation 
17350694TRPV1TRPV10.6that our hypothesis that a balance between CB receptors and TRPV1 modulates the dual nature of neurological diseases finds a nice 
17350694TRPV1TRPV10.6in pathological pain sensation where it has been demonstrated that TRPV1 functions to oppose CB-receptor-dependent effects 62 
17350694TRPV1TRPV10.6TRPV1 is another key molecular target of AEA but importantly not 
17350694TRPV1TRPV10.6CB 1 or CB 2 receptors and by AEA through TRPV1 are summarized in Box 1 along with the biological actions 
17350694TRPV1TRPV10.6one hand AEA might control inflammatory processes by binding to TRPV1 such that drugs that are able to modulate the AEA