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| 14960605 | FasL | FasL | 2.2 | cytoskeletal abnormalities (Wong Wong et al. 1995 Fas ligand (FasL)-mediated FasL -mediated death (Raoul Raoul et al. 2002 and deregulation of | |  |
| 14960605 | FasL | FasL | 2.2 | immune response (Nguyen Nguyen et al. 2002 alpha TNFRI TNFRII FasL and FasR will be essential to clarify the roles of | | |
| 15572176 | FasL | FasL | 2.2 | vulnerable to undergo apoptosis in response to Fas ligand (FasL) FasL 39 | | |
| 15572176 | FasL | FasL | 2.2 | Cytokines and trophic factors produced by activated astrocytes such as FasL TNF-_amp_#x3b1 and NGF are capable of activating death receptors expressed | | |
| 15572176 | FasL | FasL | 2.2 | Although FasL is induced in reactive astrocytes as well as in microglia | | |
| 15572176 | FasL | FasL | 2.2 | Motor neurons co-express Fas and FasL during the embryonic period of naturally occurring cell death however | | |
| 15572176 | FasL | FasL | 2.2 | Similarly increased production of either FasL or NGF does not induce motor neuron apoptosis unless nitric | | |
| 15572176 | FasL | FasL | 2.2 | NO cytokines and pro apoptotic mediators such as NGF or FasL | | |
| 16510725 | FasL | FasL | 3.2 | factor-alpha TNF-alpha and its superfamily member fibroblast-associated cell-surface ligand (FasL) FasL have been implicated in apoptosis | | |
| 16510725 | FasL | FasL | 3.2 | We found increased TNF-alpha and FasL immunoreactivity in lumbar spinal cord sections of ALS patients and | | |
| 16510725 | FasL | FasL | 3.2 | Both increased TNF-alpha and FasL immunostaining in the lumbar spinal cord of the G93A SOD1 | | |
| 16510725 | FasL | FasL | 3.2 | Treated G93A mice showed a reduction in TNF-alpha and FasL immunoreactivity as well as their mRNA in the lumbar spinal | | |
| 16510725 | FasL | FasL | 3.2 | Key words G93A SOD1 thalidomide lenalidomide TNF-alpha FasL | | |
| 16510725 | FasL | FasL | 3.2 | Fibroblast-associated cell-surface ligand (FasL) FasL may play a critical role in the death of motor | | |
| 16510725 | FasL | FasL | 3.2 | mutant SOD1 (Raoul Raoul et al. 2002 alpha can induce FasL (Pinkoski Pinkoski et al. 2002 alpha binds to its receptor | | |
| 16510725 | FasL | FasL | 3.2 | e.g. TNF-R1 similar to the events that take place when FasL binds to Fas then death-inducing signaling complex (DISC) DISC will | | |
| 16510725 | FasL | FasL | 3.2 | present study we examined the temporal pattern of TNF-alpha and FasL immunoreactivity in the lumbar spinal cord of G93A mice | | |
| 16510725 | FasL | FasL | 3.2 | Because previous work showed that the pro-inflammatroy cytokines TNF-alpha and FasL are elevated in both human and mouse models of ALS | | |
| 16510725 | FasL | FasL | 3.2 | were immunostained with antibodies to TNF-alpha (Serotec, Serotec Raleigh NC FasL (Santa Santa Cruz Biotechnology Santa Cruz CA CD40 (Serotec, Serotec | | |
| 16510725 | FasL | FasL | 3.2 | was performed to demonstrate the glial localization of TNF-alpha and FasL | | |
| 16510725 | FasL | FasL | 3.2 | 7 microm thick were prepared and processed for TNF-alpha or FasL immunohistochemistry as described above | | |
| 16510725 | FasL | FasL | 3.2 | TNF-alpha and FasL immunoreactivity in G93A SOD1 mouse model of ALS | | |
| 16510725 | FasL | FasL | 3.2 | We investigated the temporal pattern of TNF-alpha and FasL immunoreactivity in G93A SOD1 mice at 40 and 60 d | | |
| 16510725 | FasL | FasL | 3.2 | TNF-alpha and FasL are important mediators of inflammation and they play a role | | |
| 16510725 | FasL | FasL | 3.2 | FADD caspase-8 pathway (Raoul Raoul et al. 2002 alpha upregulates FasL (Pinkoski Pinkoski et al. 2002 alpha immunostaining was found in | | |
| 16510725 | FasL | FasL | 3.2 | was found in the neurons of adjacent sections suggesting that FasL and TNF-alpha are coexpressed in these neurons ( Fig 3 | | |
| 16510725 | FasL | FasL | 3.2 | Because both TNF-alpha and FasL immunostaining were increased in G93A mice we examined the effects | | |
| 16510725 | FasL | FasL | 3.2 | of TNF-alpha mRNA (Moreira Moreira et al. 1993 alpha and FasL expression in motor neurons of G93A mice There was a | | |
| 16510725 | FasL | FasL | 3.2 | of pro-inflammatory cytokines in ALS and suggest that TNF-alpha and FasL and related cytokines have important triggering roles in the pathogenesis | | |
| 16510725 | FasL | FasL | 3.2 | FasL works in a similar way by binding to Fas/CD95 Fas | | |
| 16510725 | FasL | FasL | 3.2 | FasL immunoreactivity in G93A SOD1 and control mice | | |
| 16510725 | FasL | FasL | 3.2 | FasL immunoreactivity in neurons of the ventral horn of the lumbar | | |
| 16510725 | FasL | FasL | 3.2 | Increases in FasL staining in neurons (arrowheads) arrowheads and neuronal processes occurred as | | |
| 16510725 | FasL | FasL | 3.2 | Thalidomide treatment reduced FasL immunoreactivity (middle middle row left panel | | |
| 16510725 | FasL | FasL | 3.2 | FasL double immunofluorescence with GFAP showed that FasL colocalizes with GFAP | | |
| 16510725 | FasL | FasL | 3.2 | FasL double immunofluorescence with GFAP showed that FasL colocalizes with GFAP in astrocytes | | |
| 16510725 | FasL | FasL | 3.2 | The white arrows point to astrocytes labeled with FasL (green) green and GFAP (red) red and colocalization of FasL | | |
| 16510725 | FasL | FasL | 3.2 | FasL (green) green and GFAP (red) red and colocalization of FasL and GFAP (yellow) yellow | | |
| 16510725 | FasL | FasL | 3.2 | TNF-alpha and FasL immunoreactivity in human ALS and controls | | |
| 16510725 | FasL | FasL | 3.2 | FasL (top top panels and TNF-alpha (bottom bottom panels immunoreactivities in | | |
| 16510725 | FasL | FasL-immunoreactive | 2.7 | We found TNF-alpha- and FasL-immunoreactive neurons in the lumbar spinal cord sections of a familial | | |
| 16510725 | FasL | FasL | 3.2 | Intense TNF-alpha and FasL immunoreactivity occurred predominantly in neurons of ALS patients | | |
| 16510725 | FasL | FasL | 3.2 | Coexistence of TNF-alpha and FasL occurred in the same neurons in adjacent sections of ALS | | |
| 16510725 | FasL | FasL | 3.2 | Strong immunoreactivity for FasL was evident in neurons as early as 40 d | | |
| 16510725 | FasL | FasL | 3.2 | However FasL immunoreactivity was less pronounced at 110 d ( Fig 2 | | |
| 16510725 | FasL | FasL | 3.2 | Both TNF-alpha and FasL immunoreactivity persisted relatively strong in the lumbar spinal cord sections | | |
| 16510725 | FasL | FasL | 3.2 | We also examined the FasL immunoreactivity in astrocytes by double labeling with the astrocyte marker | | |
| 16510725 | FasL | FasL | 3.2 | FasL immunoreactivity colocalized with GFAP indicating that FasL immunostaining was found | | |
| 16510725 | FasL | FasL | 3.2 | FasL immunoreactivity colocalized with GFAP indicating that FasL immunostaining was found in both neurons and astrocytes similar to | | |
| 16510725 | FasL | FasL | 3.2 | TNF-alpha and FasL immunoreactivity in human ALS | | |
| 16510725 | FasL | FasL | 3.2 | the immunohistochemical findings in ALS transgenic mice intense TNF-alpha and FasL immunoreactivity occurred in the lumbar spinal cord sections from an | | |
| 16510725 | FasL | FasL | 3.2 | whereas control tissues showed very little or no TNF-alpha and FasL immunoreactivity ( Fig 3 | | |
| 16510725 | FasL | FasL | 3.2 | TNF-alpha and FasL coexisted in the motor neurons | | |
| 16510725 | FasL | FasL | 3.2 | We show that thalidomide treatment reduced TNF-alpha and FasL immunoreactivity in the spinal cords of G93A mice ( Figs | | |
| 17015226 | FasL | FasL | 1.6 | could therefore be an important player in a Fas-ligand (FasL)-induced FasL -induced apoptosis pathway within motor neurons that is driven by | | |
| 14960605 | fas ligand | fas ligand | 1.0 | posed to account for such toxicity including excitotoxicity bruijn et al. 1997 disruption of the calcium homeostasis morrison et al. 1996 ; roy et al. 1998 cytoskeletal abnormalities wong et al. 1995 fas ligand fasl mediated death raoul et al. 2002 and deregulation of cdk5 cyclin dependent kinase 5 nguyen et al. 2001a . | | |
| 15572176 | fas ligand | fas ligand | 1.0 | in addition reactive astrocytes secrete pro apoptotic mediators such as nerve growth factor ngf or fas ligand a mechanism that may serve to eliminate vulnerable motor neurons. | | |
| 15572176 | fas ligand | fas ligand | 1.0 | f murine astrocytes with tumour necrosis factor alpha tnf _amp_#x3b1; il 1_amp_#x3b2; and ifn_amp_#x3b3; induces il 6 cox 2 and inos and makes the cells vulnerable to undergo apoptosis in response to fas ligand fasl [ 39 ]. | | |
| 16624536 | fas ligand | fas ligand | 1.0 | in vitro experiments have shown that products released by activated microglia can lead to motor neuron death via tnf mediated apoptotic mechanisms [35] and by fas ligand or no induced apoptotic pathways [36] . | | |
| 16624536 | fas ligand | fas ligand | 1.0 | this work may offer an explanation for the sensitivity of motor neurons in particular to fas ligand and no triggered cell death mediated at least in part by neighbouring microglia as trophic deprivation and excitotoxic stimulation did not have similar effects. | | |
| 16624536 | fas ligand | fas ligand | 1.0 | through activation of the phosphatidylinositol 3 kinase/protein kinase b pathway fractalkine will inhibit fas ligand induced microglial apoptosis through down regulation of the pro apoptotic function of bad and up regulation of the anti apoptotic activity of bcl xl [71] thus promoting microglial cell survival. | | |
| 16624536 | fas ligand | fas ligand | 1.0 | fas ligand and tnf produced by reactive astrocytes can also activate death receptors in injured motor neurons. | | |
| 17015226 | fas ligand | fas ligand | 1.0 | microglial cells could therefore be an important player in a fas ligand fasl induced apoptosis pathway within motor neurons that is driven by nitric oxide synthesis discussed in more detail below . | | |