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| 14960605 | TLR2 | TLR2 | 5.1 | Activation of innate immunity featured by the expression of TLR2 and several other inflammatory genes takes place in transgenic mice | |  |
| 14960605 | TLR2 | TLR2 | 5.1 | the bacterial cell wall component led to sustained induction of TLR2 receptor strictly within parenchymal microglial cells | | |
| 14960605 | TLR2 | TLR2 | 5.1 | This upregulation of TLR2 was not accompanied by enhanced expression of both endogenous and | | |
| 14960605 | TLR2 | TLR2 | 5.1 | Most importantly the degree of TLR2 induction correlated perfectly with degenerating motor neurons and motor axons | | |
| 14960605 | TLR2 | TLR2 | 5.1 | In addition determining the endogenous ligand of TLR2 would help in deciphering the mechanistic details of its actions | | |
| 14960605 | TLR2 | TLR2 | 5.1 | Effect of a single bolus of LPS on TLR2 gene expression in the brains and spinal cords of SOD1 | | |
| 14960605 | TLR2 | TLR2 | 5.1 | (BF) BF and dark-field photomicrographs depict the expression pattern of TLR2 mRNA 24 hr after a single intraperitoneal injection of vehicle | | |
| 14960605 | TLR2 | TLR2 | 5.1 | Coronal and longitudinal sections were hybridized using a mouse TLR2 cRNA probe and dipped into NTB2 emulsion milk | | |
| 14960605 | TLR2 | TLR2 | 5.1 | hybridization signal for TNF-alpha ( B IL-12 ( C and TLR2 ( D mRNA in the reticular formation just above the | | |
| 14960605 | TLR2 | TLR2 | 5.1 | interest to note that the hybridization signal for IL-12 and TLR2 overlaps with the fluorochrome FJB ( C D vs E | | |
| 14960605 | TLR2 | TLR2 | 5.1 | depict examples of microglial cells containing positive hybridization signal for TLR2 mRNA in the reticular formation | | |
| 14960605 | TLR2 | TLR2 | 5.1 | TLR2 mRNA was thereafter hybridized on the same sections by means | | |
| 14960605 | TLR2 | TLR2 | 5.1 | Note the presence of the mRNA encoding TLR2 within parenchymal microglia (agglomeration agglomeration of silver grains within the | | |
| 14960605 | TLR2 | TLR2 | 5.1 | representative examples of the hybridization signal for TNF-alpha IL-12 and TLR2 mRNA in the L5 segment of the spinal cord ( | | |
| 14960605 | TLR2 | TLR2 | 5.1 | Here also the hybridization signal for IL-12 and TLR2 overlaps with the fluorochrome FJB | | |
| 14960605 | TLR2 | TLR2 | 5.1 | Relative expression levels of TLR2 hybridization signal in the brains of SOD1 mice and their | | |
| 14960605 | TLR2 | TLR2 | 5.1 | Semiquantitative analyses revealed similar increases in expression levels of TLR2 mRNA in different regions of the CNS in both WT | | |
| 14960605 | TLR2 | TLR2 | 5.1 | assessed the transcriptional activation of the receptor of innate immunity TLR2 and the proapoptotic cytokine TNF-alpha in the SOD1 mice challenged | | |
| 14960605 | TLR2 | TLR2 | 5.1 | TLR2 is induced during disease progression of SOD1 mice and especially | | |
| 14960605 | TLR2 | TLR2 | 5.1 | Similarly a chronic expression of TLR2 might also trigger microglial apoptosis and thereby prevent the detrimental | | |
| 14960605 | TLR2 | TLR2 | 5.1 | The robust expression of TLR2 mRNA ( Fig 3 D G is associated with strong | | |
| 16624536 | TLR2 | TLR-2 | 1.6 | pro-inflammatory cytokines and increased expression of toll-like receptor 2 (TLR-2) TLR-2 53 | | |
| 17997855 | TLR2 | TLR2 | 3.7 | of the innate immune system particularly Toll-like receptor 2 (TLR2) TLR2 18 19 | | |
| 17997855 | TLR2 | TLR2 | 3.7 | After stimulation of human neuroblastoma and macrophage co-cultures with the TLR2 agonist Pam 3 CSK 4 for a period of 72 | | |
| 17997855 | TLR2 | TLR2 | 3.7 | Here we demonstrate that activation of macrophages by the TLR2 agonist Pam 3 CSK 4 can also cause neuronal death | | |
| 17997855 | TLR2 | TLR2 | 3.7 | of the monocyte/macrophage/microglia monocyte macrophage microglia type activated by a TLR2 agonist can kill neurons | | |
| 18464925 | TLR2 | TLR2 | 0.3 | Interestingly 15d-PGJ 2 attenuated TLR2 expression the PPR recognizing Staphylococcus aureus | | |
| 18598679 | TLR2 | TLR2 | 0.6 | It has been reported that the expression of TLR2 was upregulated in the spinal cord of mutant SOD1 G37R | | |
| 14960605 | toll-like receptor 2 | toll like receptor 2 | 1.0 | closely associated with the severity of disease is the stronger and restricted upregulation of the receptor of innate immunity toll like receptor 2 and proinflammatory cytokines in degenerating regions of the ventral spinal cord and efferent fiber tracts of the brain from the lps treated sod1 mice. | | |
| 16624536 | toll-like receptor 2 | toll like receptor 2 | 1.0 | tor neuron disease is accelerated by chronic stimulation of inflammation using lps in the sod1 g37r mouse model of als with increasing levels of pro inflammatory cytokines and increased expression of toll like receptor 2 tlr 2 [53] . | | |
| 17582695 | toll-like receptor 2 | toll like receptor 2 | 1.0 | innate immune receptor toll like receptor 2 and proinflammatory cytokines are implicated in a lipopolysaccharide model of als suggesting that environmental factors and innate immunity are linked [42] . | | |
| 17997855 | toll-like receptor 2 | toll like receptor 2 | 1.0 | s pneumoniae the most frequent respiratory pathogen causes damage by the action of the cholesterol binding virulence factor pneumolysin and by stimulation of the innate immune system particularly via toll like receptor 2. | | |
| 17997855 | toll-like receptor 2 | toll like receptor 2 | 1.0 | typical for familial als g93a sod1 and sh sy5y neuroblastoma cells transfected with wildtype sod1 were both exposed to pneumolysin and in co cultures with cultured human macrophages treated with the toll like receptor 2 agonist n palmitoyl s [2 3 bis palmitoyloxy 2rs propyl] [r] cysteinyl [s] seryl [s] lysyl [s] lysyl [s] lysyl [s] lysyl [s] lysine _amp_#x000d7; 3 hcl pam 3 csk 4 . | | |
| 17997855 | toll-like receptor 2 | toll like receptor 2 | 1.0 | s damage by the direct action of the cholesterol binding pore forming hemolysin pneumolysin and through microglia/monocyte activation by agonists of receptors of the innate immune system particularly toll like receptor 2 tlr2 [ 18 19 ]. | | |
| 17997855 | toll-like receptor 2 | toll like receptor 2 | 1.0 | results increased vulnerability of neuroblastoma cells transfected with g93a sod1 to the attack of monocytes stimulated with the toll like receptor 2 agonist pam 3 csk 4 after stimulation of human neuroblastoma and macrophage co cultures with the tlr2 agonist pam 3 csk 4 for a period of 72 hours the release of neuron specific enolase nse was measu | | |