#Level	GOID	GOTerm	t-total	t+	t-	b+	b-	b-total	p-value	t-ratio	b-ratio	(t-ratio)/(b-ratio)
Level2	GO:0005488	binding	1026	919	107	12737	12517	25254	3.184e-153	0.90	0.50	1.8
Level3	GO:0005515	protein binding	1026	717	309	7817	17437	25254	3.810e-138	0.70	0.31	2.3
Level2	GO:0003824	catalytic activity	1026	581	445	5927	19327	25254	2.474e-109	0.57	0.23	2.4
Level3	GO:0016491	oxidoreductase activity	1026	164	862	950	24304	25254	8.343e-51	0.16	0.04	4.2
Level4	GO:0005102	receptor binding	1026	161	865	968	24286	25254	5.691e-48	0.16	0.04	4.1
Level5	GO:0030554	adenyl nucleotide binding	1026	197	829	1799	23455	25254	7.875e-35	0.19	0.07	2.7
Level3	GO:0016740	transferase activity	1026	210	816	2049	23205	25254	1.714e-33	0.20	0.08	2.5
Level4	GO:0046872	metal ion binding	1026	346	680	4562	20692	25254	1.128e-31	0.34	0.18	1.9
Level4	GO:0017076	purine nucleotide binding	1026	213	813	2163	23091	25254	1.253e-31	0.21	0.09	2.4
Level4	GO:0009055	electron carrier activity	1026	77	949	330	24924	25254	3.299e-31	0.08	0.01	5.7
Level3	GO:0043167	ion binding	1026	349	677	4652	20602	25254	4.984e-31	0.34	0.18	1.8
Level2	GO:0060089	molecular transducer activity	1026	257	769	2965	22289	25254	1.869e-30	0.25	0.12	2.1
Level3	GO:0004871	signal transducer activity	1026	257	769	2965	22289	25254	1.869e-30	0.25	0.12	2.1
Level3	GO:0000166	nucleotide binding	1026	228	798	2516	22738	25254	3.497e-29	0.22	0.10	2.2
Level4	GO:0046983	protein dimerization activity	1026	82	944	422	24832	25254	2.085e-28	0.08	0.02	4.8
Level5	GO:0016301	kinase activity	1026	129	897	1020	24234	25254	1.012e-27	0.13	0.04	3.1
Level4	GO:0016772	transferase activity\, transferring phosphorus\-containing groups	1026	139	887	1169	24085	25254	1.858e-27	0.14	0.05	2.9
Level5	GO:0016773	phosphotransferase activity\, alcohol group as acceptor	1026	115	911	880	24374	25254	8.293e-26	0.11	0.03	3.2
Level4	GO:0042802	identical protein binding	1026	82	944	471	24783	25254	1.331e-25	0.08	0.02	4.3
Level4	GO:0032553	ribonucleotide binding	1026	192	834	2072	23182	25254	2.125e-25	0.19	0.08	2.3
Level5	GO:0032555	purine ribonucleotide binding	1026	192	834	2072	23182	25254	2.125e-25	0.19	0.08	2.3
Level3	GO:0048037	cofactor binding	1026	63	963	276	24978	25254	2.861e-25	0.06	0.01	5.6
Level4	GO:0043169	cation binding	1026	308	718	4228	21026	25254	1.193e-24	0.30	0.17	1.8
Level3	GO:0016787	hydrolase activity	1026	218	808	2642	22612	25254	7.710e-23	0.21	0.10	2.0
Level4	GO:0050662	coenzyme binding	1026	46	980	196	25058	25254	3.427e-19	0.04	0.01	5.8
Level5	GO:0008083	growth factor activity	1026	49	977	225	25029	25254	3.445e-19	0.05	0.01	5.4
Level3	GO:0046906	tetrapyrrole binding	1026	44	982	178	25076	25254	3.801e-19	0.04	0.01	6.1
Level4	GO:0020037	heme binding	1026	44	982	178	25076	25254	3.801e-19	0.04	0.01	6.1
Level4	GO:0005057	receptor signaling protein activity	1026	44	982	182	25072	25254	7.832e-19	0.04	0.01	6.0
Level5	GO:0046914	transition metal ion binding	1026	224	802	2996	22258	25254	2.022e-18	0.22	0.12	1.8
Level2	GO:0016209	antioxidant activity	1026	26	1000	63	25191	25254	3.461e-16	0.03	0.00	10.2
Level5	GO:0004175	endopeptidase activity	1026	66	960	494	24760	25254	1.328e-15	0.06	0.02	3.3
Level5	GO:0005125	cytokine activity	1026	50	976	300	24954	25254	2.166e-15	0.05	0.01	4.1
Level5	GO:0042803	protein homodimerization activity	1026	42	984	215	25039	25254	3.374e-15	0.04	0.01	4.8
Level4	GO:0019899	enzyme binding	1026	52	974	336	24918	25254	8.558e-15	0.05	0.01	3.8
Level5	GO:0000287	magnesium ion binding	1026	62	964	471	24783	25254	1.813e-14	0.06	0.02	3.2
Level5	GO:0005509	calcium ion binding	1026	109	917	1179	24075	25254	2.465e-14	0.11	0.05	2.3
Level5	GO:0046982	protein heterodimerization activity	1026	33	993	142	25112	25254	4.759e-14	0.03	0.01	5.7
Level4	GO:0008134	transcription factor binding	1026	64	962	511	24743	25254	5.363e-14	0.06	0.02	3.1
Level5	GO:0005179	hormone activity	1026	37	989	183	25071	25254	5.965e-14	0.04	0.01	5.0
Level4	GO:0004872	receptor activity	1026	177	849	2469	22785	25254	5.568e-13	0.17	0.10	1.8
Level4	GO:0008233	peptidase activity	1026	77	949	741	24513	25254	1.131e-12	0.08	0.03	2.6
Level3	GO:0001871	pattern binding	1026	30	996	140	25114	25254	3.996e-12	0.03	0.01	5.3
Level3	GO:0016563	transcription activator activity	1026	50	976	382	24872	25254	7.773e-12	0.05	0.02	3.2
Level3	GO:0004601	peroxidase activity	1026	19	1007	49	25205	25254	8.049e-12	0.02	0.00	9.5
Level4	GO:0016684	oxidoreductase activity\, acting on peroxide as acceptor	1026	19	1007	49	25205	25254	8.049e-12	0.02	0.00	9.5
Level5	GO:0050660	FAD binding	1026	24	1002	89	25165	25254	9.567e-12	0.02	0.00	6.6
Level2	GO:0030234	enzyme regulator activity	1026	87	939	954	24300	25254	2.488e-11	0.08	0.04	2.2
Level3	GO:0016829	lyase activity	1026	34	992	196	25058	25254	2.572e-11	0.03	0.01	4.3
Level4	GO:0030247	polysaccharide binding	1026	27	999	125	25129	25254	4.035e-11	0.03	0.00	5.3
Level5	GO:0042578	phosphoric ester hydrolase activity	1026	49	977	389	24865	25254	4.265e-11	0.05	0.02	3.1
Level4	GO:0016788	hydrolase activity\, acting on ester bonds	1026	75	951	770	24484	25254	4.428e-11	0.07	0.03	2.4
Level5	GO:0005539	glycosaminoglycan binding	1026	26	1000	118	25136	25254	6.335e-11	0.03	0.00	5.4
Level2	GO:0030528	transcription regulator activity	1026	126	900	1681	23573	25254	1.951e-10	0.12	0.07	1.8
Level4	GO:0016705	oxidoreductase activity\, acting on paired donors\, with incorporation or reduction of molecular oxygen	1026	28	998	149	25105	25254	2.950e-10	0.03	0.01	4.6
Level2	GO:0005215	transporter activity	1026	127	899	1746	23508	25254	9.044e-10	0.12	0.07	1.8
Level3	GO:0008289	lipid binding	1026	50	976	445	24809	25254	9.812e-10	0.05	0.02	2.8
Level4	GO:0032403	protein complex binding	1026	25	1001	128	25126	25254	1.312e-09	0.02	0.01	4.8
Level3	GO:0004857	enzyme inhibitor activity	1026	41	985	326	24928	25254	1.730e-09	0.04	0.01	3.1
Level4	GO:0019904	protein domain specific binding	1026	26	1000	143	25111	25254	2.334e-09	0.03	0.01	4.5
Level3	GO:0022892	substrate\-specific transporter activity	1026	108	918	1433	23821	25254	3.710e-09	0.11	0.06	1.9
Level4	GO:0016614	oxidoreductase activity\, acting on CH\-OH group of donors	1026	27	999	160	25094	25254	4.781e-09	0.03	0.01	4.2
Level3	GO:0022857	transmembrane transporter activity	1026	99	927	1283	23971	25254	5.049e-09	0.10	0.05	1.9
Level5	GO:0003700	transcription factor activity	1026	90	936	1123	24131	25254	5.059e-09	0.09	0.04	2.0
Level5	GO:0009053	electron donor activity	1026	11	1015	18	25236	25254	5.521e-09	0.01	0.00	15.0
Level3	GO:0030246	carbohydrate binding	1026	42	984	363	24891	25254	1.006e-08	0.04	0.01	2.8
Level3	GO:0016853	isomerase activity	1026	31	995	217	25037	25254	1.220e-08	0.03	0.01	3.5
Level4	GO:0004497	monooxygenase activity	1026	25	1001	147	25107	25254	1.538e-08	0.02	0.01	4.2
Level5	GO:0019900	kinase binding	1026	22	1004	117	25137	25254	2.312e-08	0.02	0.00	4.6
Level5	GO:0003712	transcription cofactor activity	1026	41	985	362	24892	25254	2.586e-08	0.04	0.01	2.8
Level5	GO:0016616	oxidoreductase activity\, acting on the CH\-OH group of donors\, NAD or NADP as acceptor	1026	24	1002	143	25111	25254	3.711e-08	0.02	0.01	4.1
Level3	GO:0019842	vitamin binding	1026	25	1001	155	25099	25254	3.878e-08	0.02	0.01	4.0
Level3	GO:0019207	kinase regulator activity	1026	22	1004	124	25130	25254	5.748e-08	0.02	0.00	4.4
Level3	GO:0016564	transcription repressor activity	1026	32	994	271	24983	25254	3.757e-07	0.03	0.01	2.9
Level4	GO:0016835	carbon\-oxygen lyase activity	1026	16	1010	79	25175	25254	7.903e-07	0.02	0.00	5.0
Level5	GO:0004888	transmembrane receptor activity	1026	118	908	1808	23446	25254	9.050e-07	0.12	0.07	1.6
Level5	GO:0015399	primary active transmembrane transporter activity	1026	25	1001	189	25065	25254	1.109e-06	0.02	0.01	3.3
Level3	GO:0019825	oxygen binding	1026	13	1013	53	25201	25254	1.358e-06	0.01	0.00	6.0
Level5	GO:0042169	SH2 domain binding	1026	9	1017	21	25233	25254	1.388e-06	0.01	0.00	10.5
Level4	GO:0016627	oxidoreductase activity\, acting on the CH\-CH group of donors	1026	17	1009	95	25159	25254	1.632e-06	0.02	0.00	4.4
Level5	GO:0050661	NADP binding	1026	10	1016	30	25224	25254	2.295e-06	0.01	0.00	8.2
Level4	GO:0030170	pyridoxal phosphate binding	1026	14	1012	66	25188	25254	2.388e-06	0.01	0.00	5.2
Level4	GO:0019955	cytokine binding	1026	22	1004	159	25095	25254	2.493e-06	0.02	0.01	3.4
Level4	GO:0008022	protein C\-terminus binding	1026	17	1009	100	25154	25254	3.024e-06	0.02	0.00	4.2
Level5	GO:0043565	sequence\-specific DNA binding	1026	53	973	637	24617	25254	3.249e-06	0.05	0.03	2.0
Level4	GO:0022804	active transmembrane transporter activity	1026	48	978	559	24695	25254	3.828e-06	0.05	0.02	2.1
Level4	GO:0022891	substrate\-specific transmembrane transporter activity	1026	83	943	1190	24064	25254	5.079e-06	0.08	0.05	1.7
Level4	GO:0019887	protein kinase regulator activity	1026	17	1009	105	25149	25254	5.408e-06	0.02	0.00	4.0
Level5	GO:0001664	G\-protein\-coupled receptor binding	1026	16	1010	96	25158	25254	7.331e-06	0.02	0.00	4.1
Level4	GO:0019838	growth factor binding	1026	17	1009	108	25146	25254	7.544e-06	0.02	0.00	3.9
Level5	GO:0004866	endopeptidase inhibitor activity	1026	22	1004	174	25080	25254	9.185e-06	0.02	0.01	3.1
Level5	GO:0008234	cysteine\-type peptidase activity	1026	22	1004	174	25080	25254	9.185e-06	0.02	0.01	3.1
Level4	GO:0016860	intramolecular oxidoreductase activity	1026	11	1015	47	25207	25254	1.287e-05	0.01	0.00	5.8
Level5	GO:0008237	metallopeptidase activity	1026	26	1000	237	25017	25254	1.486e-05	0.03	0.01	2.7
Level4	GO:0030414	protease inhibitor activity	1026	22	1004	181	25073	25254	1.605e-05	0.02	0.01	3.0
Level5	GO:0016820	hydrolase activity\, acting on acid anhydrides\, catalyzing transmembrane movement of substances	1026	21	1005	169	25085	25254	1.842e-05	0.02	0.01	3.1
Level4	GO:0051219	phosphoprotein binding	1026	7	1019	16	25238	25254	1.917e-05	0.01	0.00	10.8
Level4	GO:0005246	calcium channel regulator activity	1026	7	1019	16	25238	25254	1.917e-05	0.01	0.00	10.8
Level4	GO:0004602	glutathione peroxidase activity	1026	6	1020	10	25244	25254	1.995e-05	0.01	0.00	14.8
Level4	GO:0003677	DNA binding	1026	157	869	2749	22505	25254	2.363e-05	0.15	0.11	1.4
Level4	GO:0016651	oxidoreductase activity\, acting on NADH or NADPH	1026	13	1013	72	25182	25254	2.474e-05	0.01	0.00	4.4
Level4	GO:0019210	kinase inhibitor activity	1026	10	1016	42	25212	25254	2.800e-05	0.01	0.00	5.9
Level5	GO:0050664	oxidoreductase activity\, acting on NADH or NADPH\, with oxygen as acceptor	1026	5	1021	6	25248	25254	3.409e-05	0.00	0.00	20.5
Level5	GO:0015144	carbohydrate transmembrane transporter activity	1026	11	1015	56	25198	25254	5.275e-05	0.01	0.00	4.8
Level4	GO:0005496	steroid binding	1026	14	1012	90	25164	25254	5.286e-05	0.01	0.00	3.8
Level5	GO:0016836	hydro\-lyase activity	1026	12	1014	67	25187	25254	5.399e-05	0.01	0.00	4.4
Level3	GO:0003702	RNA polymerase II transcription factor activity	1026	27	999	271	24983	25254	5.473e-05	0.03	0.01	2.5
Level4	GO:0043560	insulin receptor substrate binding	1026	5	1021	7	25247	25254	5.656e-05	0.00	0.00	17.6
Level4	GO:0016504	protease activator activity	1026	7	1019	21	25233	25254	7.804e-05	0.01	0.00	8.2
Level4	GO:0001948	glycoprotein binding	1026	5	1021	8	25246	25254	8.895e-05	0.00	0.00	15.4
Level5	GO:0045309	protein phosphorylated amino acid binding	1026	5	1021	8	25246	25254	8.895e-05	0.00	0.00	15.4
Level4	GO:0008034	lipoprotein binding	1026	8	1018	30	25224	25254	9.044e-05	0.01	0.00	6.6
Level4	GO:0005516	calmodulin binding	1026	20	1006	177	25077	25254	9.624e-05	0.02	0.01	2.8
Level5	GO:0004860	protein kinase inhibitor activity	1026	9	1017	40	25214	25254	1.023e-04	0.01	0.00	5.5
Level5	GO:0016298	lipase activity	1026	16	1010	124	25130	25254	1.190e-04	0.02	0.00	3.2
Level4	GO:0016638	oxidoreductase activity\, acting on the CH\-NH2 group of donors	1026	7	1019	23	25231	25254	1.253e-04	0.01	0.00	7.5
Level4	GO:0017171	serine hydrolase activity	1026	24	1002	238	25016	25254	1.326e-04	0.02	0.01	2.5
Level5	GO:0004879	ligand\-dependent nuclear receptor activity	1026	20	1006	186	25068	25254	1.770e-04	0.02	0.01	2.6
Level4	GO:0008092	cytoskeletal protein binding	1026	40	986	508	24746	25254	1.901e-04	0.04	0.02	1.9
Level3	GO:0050840	extracellular matrix binding	1026	5	1021	10	25244	25254	1.944e-04	0.00	0.00	12.3
Level4	GO:0015036	disulfide oxidoreductase activity	1026	6	1020	18	25236	25254	2.565e-04	0.01	0.00	8.2
Level5	GO:0016831	carboxy\-lyase activity	1026	8	1018	36	25218	25254	2.665e-04	0.01	0.00	5.5
Level5	GO:0008236	serine\-type peptidase activity	1026	23	1003	237	25017	25254	2.713e-04	0.02	0.01	2.4
Level4	GO:0016801	hydrolase activity\, acting on ether bonds	1026	5	1021	11	25243	25254	2.737e-04	0.00	0.00	11.2
Level4	GO:0005518	collagen binding	1026	7	1019	27	25227	25254	2.890e-04	0.01	0.00	6.4
Level5	GO:0051287	NAD binding	1026	9	1017	47	25207	25254	2.956e-04	0.01	0.00	4.7
Level3	GO:0042562	hormone binding	1026	8	1018	37	25217	25254	3.131e-04	0.01	0.00	5.3
Level5	GO:0003995	acyl\-CoA dehydrogenase activity	1026	6	1020	19	25235	25254	3.264e-04	0.01	0.00	7.8
Level4	GO:0005319	lipid transporter activity	1026	13	1013	96	25158	25254	3.311e-04	0.01	0.00	3.3
Level4	GO:0016830	carbon\-carbon lyase activity	1026	9	1017	48	25206	25254	3.390e-04	0.01	0.00	4.6
Level3	GO:0051540	metal cluster binding	1026	10	1016	60	25194	25254	3.725e-04	0.01	0.00	4.1
Level4	GO:0051536	iron\-sulfur cluster binding	1026	10	1016	60	25194	25254	3.725e-04	0.01	0.00	4.1
Level5	GO:0005159	insulin\-like growth factor receptor binding	1026	5	1021	12	25242	25254	3.754e-04	0.00	0.00	10.3
Level4	GO:0043236	laminin binding	1026	4	1022	6	25248	25254	4.016e-04	0.00	0.00	16.4
Level4	GO:0005543	phospholipid binding	1026	17	1009	157	25097	25254	4.891e-04	0.02	0.01	2.7
Level4	GO:0047485	protein N\-terminus binding	1026	9	1017	51	25203	25254	5.019e-04	0.01	0.00	4.3
Level4	GO:0005542	folic acid binding	1026	5	1021	13	25241	25254	5.031e-04	0.00	0.00	9.5
Level5	GO:0019965	interleukin binding	1026	11	1015	75	25179	25254	5.124e-04	0.01	0.00	3.6
Level5	GO:0016714	oxidoreductase activity\, acting on paired donors\, with incorporation or reduction of molecular oxygen\, reduced pteridine as one donor\, and incorporation of one atom of oxygen	1026	4	1022	7	25247	25254	6.116e-04	0.00	0.00	14.1
Level5	GO:0015075	ion transmembrane transporter activity	1026	69	957	1096	24158	25254	6.219e-04	0.07	0.04	1.5
Level5	GO:0016712	oxidoreductase activity\, acting on paired donors\, with incorporation or reduction of molecular oxygen\, reduced flavin or flavoprotein as one donor\, and incorporation of one atom of oxygen	1026	8	1018	42	25212	25254	6.566e-04	0.01	0.00	4.7
Level3	GO:0043028	caspase regulator activity	1026	6	1020	23	25231	25254	7.663e-04	0.01	0.00	6.4
Level5	GO:0005158	insulin receptor binding	1026	6	1020	23	25231	25254	7.663e-04	0.01	0.00	6.4
Level4	GO:0019992	diacylglycerol binding	1026	10	1016	67	25187	25254	8.060e-04	0.01	0.00	3.7
Level4	GO:0016645	oxidoreductase activity\, acting on the CH\-NH group of donors	1026	7	1019	33	25221	25254	8.172e-04	0.01	0.00	5.2
Level5	GO:0010181	FMN binding	1026	5	1021	15	25239	25254	8.531e-04	0.00	0.00	8.2
Level5	GO:0004368	glycerol\-3\-phosphate dehydrogenase activity	1026	4	1022	8	25246	25254	8.891e-04	0.00	0.00	12.3
Level3	GO:0008047	enzyme activator activity	1026	30	996	372	24882	25254	9.779e-04	0.03	0.01	2.0
Level5	GO:0005178	integrin binding	1026	9	1017	57	25197	25254	1.020e-03	0.01	0.00	3.9
Level3	GO:0003682	chromatin binding	1026	15	1011	139	25115	25254	1.057e-03	0.01	0.01	2.7
Level4	GO:0008656	caspase activator activity	1026	5	1021	16	25238	25254	1.084e-03	0.00	0.00	7.7
Level3	GO:0042910	xenobiotic transporter activity	1026	3	1023	3	25251	25254	1.086e-03	0.00	0.00	24.6
Level4	GO:0043295	glutathione binding	1026	3	1023	3	25251	25254	1.086e-03	0.00	0.00	24.6
Level5	GO:0051539	4 iron\, 4 sulfur cluster binding	1026	6	1020	25	25229	25254	1.111e-03	0.01	0.00	5.9
Level4	GO:0016866	intramolecular transferase activity	1026	9	1017	59	25195	25254	1.268e-03	0.01	0.00	3.8
Level4	GO:0016741	transferase activity\, transferring one\-carbon groups	1026	18	1008	187	25067	25254	1.467e-03	0.02	0.01	2.4
Level2	GO:0015457	auxiliary transport protein activity	1026	8	1018	49	25205	25254	1.590e-03	0.01	0.00	4.0
Level5	GO:0030169	low\-density lipoprotein binding	1026	5	1021	18	25236	25254	1.680e-03	0.00	0.00	6.8
Level5	GO:0016641	oxidoreductase activity\, acting on the CH\-NH2 group of donors\, oxygen as acceptor	1026	5	1021	18	25236	25254	1.680e-03	0.00	0.00	6.8
Level5	GO:0016505	apoptotic protease activator activity	1026	5	1021	18	25236	25254	1.680e-03	0.00	0.00	6.8
Level5	GO:0003779	actin binding	1026	27	999	343	24911	25254	1.743e-03	0.03	0.01	1.9
Level4	GO:0016721	oxidoreductase activity\, acting on superoxide radicals as acceptor	1026	3	1023	4	25250	25254	1.845e-03	0.00	0.00	18.5
Level4	GO:0015239	multidrug transporter activity	1026	3	1023	4	25250	25254	1.845e-03	0.00	0.00	18.5
Level5	GO:0004784	superoxide dismutase activity	1026	3	1023	4	25250	25254	1.845e-03	0.00	0.00	18.5
Level5	GO:0000104	succinate dehydrogenase activity	1026	3	1023	4	25250	25254	1.845e-03	0.00	0.00	18.5
Level4	GO:0016769	transferase activity\, transferring nitrogenous groups	1026	7	1019	39	25215	25254	1.916e-03	0.01	0.00	4.4
Level4	GO:0016566	specific transcriptional repressor activity	1026	5	1021	19	25235	25254	2.055e-03	0.00	0.00	6.5
Level3	GO:0005199	structural constituent of cell wall	1026	10	1016	77	25177	25254	2.073e-03	0.01	0.00	3.2
Level4	GO:0030551	cyclic nucleotide binding	1026	6	1020	29	25225	25254	2.146e-03	0.01	0.00	5.1
Level5	GO:0005520	insulin\-like growth factor binding	1026	6	1020	29	25225	25254	2.146e-03	0.01	0.00	5.1
Level5	GO:0043566	structure\-specific DNA binding	1026	13	1013	121	25133	25254	2.298e-03	0.01	0.00	2.6
Level5	GO:0008168	methyltransferase activity	1026	17	1009	181	25073	25254	2.409e-03	0.02	0.01	2.3
Level4	GO:0015002	heme\-copper terminal oxidase activity	1026	6	1020	30	25224	25254	2.491e-03	0.01	0.00	4.9
Level4	GO:0016675	oxidoreductase activity\, acting on heme group of donors	1026	6	1020	30	25224	25254	2.491e-03	0.01	0.00	4.9
Level5	GO:0004129	cytochrome\-c oxidase activity	1026	6	1020	30	25224	25254	2.491e-03	0.01	0.00	4.9
Level5	GO:0016676	oxidoreductase activity\, acting on heme group of donors\, oxygen as acceptor	1026	6	1020	30	25224	25254	2.491e-03	0.01	0.00	4.9
Level5	GO:0002020	protease binding	1026	3	1023	5	25249	25254	2.867e-03	0.00	0.00	14.8
Level5	GO:0030165	PDZ domain binding	1026	6	1020	31	25223	25254	2.876e-03	0.01	0.00	4.8
Level4	GO:0001540	beta\-amyloid binding	1026	4	1022	12	25242	25254	2.885e-03	0.00	0.00	8.2
Level5	GO:0005154	epidermal growth factor receptor binding	1026	4	1022	12	25242	25254	2.885e-03	0.00	0.00	8.2
Level5	GO:0015250	water channel activity	1026	4	1022	12	25242	25254	2.885e-03	0.00	0.00	8.2
Level5	GO:0015035	protein disulfide oxidoreductase activity	1026	4	1022	12	25242	25254	2.885e-03	0.00	0.00	8.2
Level4	GO:0016597	amino acid binding	1026	5	1021	21	25233	25254	2.981e-03	0.00	0.00	5.9
Level5	GO:0033558	protein deacetylase activity	1026	5	1021	21	25233	25254	2.981e-03	0.00	0.00	5.9
Level2	GO:0005198	structural molecule activity	1026	62	964	1026	24228	25254	2.990e-03	0.06	0.04	1.5
Level4	GO:0005504	fatty acid binding	1026	6	1020	32	25222	25254	3.305e-03	0.01	0.00	4.6
Level5	GO:0019865	immunoglobulin binding	1026	5	1021	22	25232	25254	3.542e-03	0.00	0.00	5.6
Level3	GO:0043176	amine binding	1026	9	1017	70	25184	25254	3.621e-03	0.01	0.00	3.2
Level5	GO:0019956	chemokine binding	1026	9	1017	70	25184	25254	3.621e-03	0.01	0.00	3.2
Level3	GO:0008367	bacterial binding	1026	4	1022	13	25241	25254	3.658e-03	0.00	0.00	7.6
Level4	GO:0005372	water transporter activity	1026	4	1022	13	25241	25254	3.658e-03	0.00	0.00	7.6
Level4	GO:0043621	protein self\-association	1026	4	1022	13	25241	25254	3.658e-03	0.00	0.00	7.6
Level5	GO:0030228	lipoprotein receptor activity	1026	4	1022	13	25241	25254	3.658e-03	0.00	0.00	7.6
Level3	GO:0016247	channel regulator activity	1026	7	1019	45	25209	25254	3.912e-03	0.01	0.00	3.8
Level3	GO:0016874	ligase activity	1026	32	994	449	24805	25254	3.942e-03	0.03	0.02	1.8
Level5	GO:0030508	thiol\-disulfide exchange intermediate activity	1026	3	1023	6	25248	25254	4.176e-03	0.00	0.00	12.3
Level5	GO:0016803	ether hydrolase activity	1026	3	1023	6	25248	25254	4.176e-03	0.00	0.00	12.3
Level5	GO:0008483	transaminase activity	1026	6	1020	34	25220	25254	4.302e-03	0.01	0.00	4.3
Level4	GO:0016746	transferase activity\, transferring acyl groups	1026	19	1007	227	25027	25254	4.406e-03	0.02	0.01	2.1
Level5	GO:0015248	sterol transporter activity	1026	4	1022	14	25240	25254	4.559e-03	0.00	0.00	7.0
Level5	GO:0016747	transferase activity\, transferring groups other than amino\-acyl groups	1026	18	1008	207	25047	25254	4.575e-03	0.02	0.01	2.1
Level3	GO:0005200	structural constituent of cytoskeleton	1026	12	1014	117	25137	25254	4.683e-03	0.01	0.00	2.5
Level3	GO:0008307	structural constituent of muscle	1026	7	1019	47	25207	25254	4.843e-03	0.01	0.00	3.7
Level3	GO:0008430	selenium binding	1026	5	1021	24	25230	25254	4.886e-03	0.00	0.00	5.1
Level4	GO:0019213	deacetylase activity	1026	5	1021	24	25230	25254	4.886e-03	0.00	0.00	5.1
Level5	GO:0016775	phosphotransferase activity\, nitrogenous group as acceptor	1026	5	1021	24	25230	25254	4.886e-03	0.00	0.00	5.1
Level4	GO:0017046	peptide hormone binding	1026	4	1022	15	25239	25254	5.599e-03	0.00	0.00	6.6
Level4	GO:0008320	protein transmembrane transporter activity	1026	5	1021	25	25229	25254	5.678e-03	0.00	0.00	4.9
Level3	GO:0008147	structural constituent of bone	1026	3	1023	7	25247	25254	5.794e-03	0.00	0.00	10.5
Level4	GO:0030492	hemoglobin binding	1026	3	1023	7	25247	25254	5.794e-03	0.00	0.00	10.5
Level4	GO:0051920	peroxiredoxin activity	1026	3	1023	7	25247	25254	5.794e-03	0.00	0.00	10.5
Level4	GO:0016903	oxidoreductase activity\, acting on the aldehyde or oxo group of donors	1026	6	1020	37	25217	25254	6.190e-03	0.01	0.00	4.0
Level3	GO:0005201	extracellular matrix structural constituent	1026	12	1014	122	25132	25254	6.328e-03	0.01	0.00	2.4
Level5	GO:0051537	2 iron\, 2 sulfur cluster binding	1026	4	1022	16	25238	25254	6.785e-03	0.00	0.00	6.2
Level5	GO:0030545	receptor regulator activity	1026	4	1022	16	25238	25254	6.785e-03	0.00	0.00	6.2
Level5	GO:0016811	hydrolase activity\, acting on carbon\-nitrogen (but not peptide) bonds\, in linear amides	1026	8	1018	64	25190	25254	6.907e-03	0.01	0.00	3.1
Level5	GO:0016818	hydrolase activity\, acting on acid anhydrides\, in phosphorus\-containing anhydrides	1026	52	974	867	24387	25254	7.123e-03	0.05	0.03	1.5
Level5	GO:0030552	cAMP binding	1026	4	1022	17	25237	25254	8.126e-03	0.00	0.00	5.8
Level5	GO:0009982	pseudouridine synthase activity	1026	6	1020	40	25214	25254	8.618e-03	0.01	0.00	3.7
Level4	GO:0017077	oxidative phosphorylation uncoupler activity	1026	2	1024	2	25252	25254	8.669e-03	0.00	0.00	24.6
Level4	GO:0060228	phosphatidylcholine\-sterol O\-acyltransferase activator activity	1026	2	1024	2	25252	25254	8.669e-03	0.00	0.00	24.6
Level4	GO:0045569	TRAIL binding	1026	2	1024	2	25252	25254	8.669e-03	0.00	0.00	24.6
Level5	GO:0045155	electron transporter\, transferring electrons from CoQH2\-cytochrome c reductase complex and cytochrome c oxidase complex activity	1026	2	1024	2	25252	25254	8.669e-03	0.00	0.00	24.6
Level5	GO:0043559	insulin binding	1026	2	1024	2	25252	25254	8.669e-03	0.00	0.00	24.6
Level5	GO:0004666	prostaglandin\-endoperoxide synthase activity	1026	2	1024	2	25252	25254	8.669e-03	0.00	0.00	24.6
Level5	GO:0004392	heme oxygenase (decyclizing) activity	1026	2	1024	2	25252	25254	8.669e-03	0.00	0.00	24.6
Level5	GO:0016635	oxidoreductase activity\, acting on the CH\-CH group of donors\, quinone or related compound as acceptor	1026	2	1024	2	25252	25254	8.669e-03	0.00	0.00	24.6
Level5	GO:0043237	laminin\-1 binding	1026	2	1024	2	25252	25254	8.669e-03	0.00	0.00	24.6
Level5	GO:0035226	glutamate\-cysteine ligase catalytic subunit binding	1026	2	1024	2	25252	25254	8.669e-03	0.00	0.00	24.6
Level4	GO:0016810	hydrolase activity\, acting on carbon\-nitrogen (but not peptide) bonds	1026	13	1013	138	25116	25254	8.782e-03	0.01	0.01	2.3
Level4	GO:0016817	hydrolase activity\, acting on acid anhydrides	1026	52	974	869	24385	25254	9.038e-03	0.05	0.03	1.5
Level5	GO:0004091	carboxylesterase activity	1026	11	1015	113	25141	25254	9.348e-03	0.01	0.00	2.4
Level5	GO:0016709	oxidoreductase activity\, acting on paired donors\, with incorporation or reduction of molecular oxygen\, NADH or NADPH as one donor\, and incorporation of one atom of oxygen	1026	6	1020	41	25213	25254	9.561e-03	0.01	0.00	3.6
Level3	GO:0043021	ribonucleoprotein binding	1026	4	1022	18	25236	25254	9.630e-03	0.00	0.00	5.5
Level4	GO:0005344	oxygen transporter activity	1026	4	1022	18	25236	25254	9.630e-03	0.00	0.00	5.5
Level5	GO:0008395	steroid hydroxylase activity	1026	4	1022	18	25236	25254	9.630e-03	0.00	0.00	5.5
Level5	GO:0008603	cAMP\-dependent protein kinase regulator activity	1026	5	1021	29	25225	25254	9.754e-03	0.00	0.00	4.2
Level4	GO:0035014	phosphoinositide 3\-kinase regulator activity	1026	3	1023	9	25245	25254	1.002e-02	0.00	0.00	8.2
Level4	GO:0043022	ribosome binding	1026	3	1023	9	25245	25254	1.002e-02	0.00	0.00	8.2
Level4	GO:0005527	macrolide binding	1026	3	1023	9	25245	25254	1.002e-02	0.00	0.00	8.2
Level5	GO:0016624	oxidoreductase activity\, acting on the aldehyde or oxo group of donors\, disulfide as acceptor	1026	3	1023	9	25245	25254	1.002e-02	0.00	0.00	8.2
Level5	GO:0043120	tumor necrosis factor binding	1026	3	1023	9	25245	25254	1.002e-02	0.00	0.00	8.2
Level5	GO:0003906	DNA\-(apurinic or apyrimidinic site) lyase activity	1026	3	1023	9	25245	25254	1.002e-02	0.00	0.00	8.2
Level5	GO:0005528	FK506 binding	1026	3	1023	9	25245	25254	1.002e-02	0.00	0.00	8.2
Level5	GO:0051427	hormone receptor binding	1026	8	1018	69	25185	25254	1.025e-02	0.01	0.00	2.9
Level5	GO:0016628	oxidoreductase activity\, acting on the CH\-CH group of donors\, NAD or NADP as acceptor	1026	7	1019	55	25199	25254	1.029e-02	0.01	0.00	3.1
Level5	GO:0004364	glutathione transferase activity	1026	5	1021	31	25223	25254	1.240e-02	0.00	0.00	4.0
Level4	GO:0016885	ligase activity\, forming carbon\-carbon bonds	1026	3	1023	10	25244	25254	1.265e-02	0.00	0.00	7.4
Level5	GO:0016717	oxidoreductase activity\, acting on paired donors\, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	1026	3	1023	10	25244	25254	1.265e-02	0.00	0.00	7.4
Level5	GO:0016862	intramolecular oxidoreductase activity\, interconverting keto\- and enol\-groups	1026	3	1023	10	25244	25254	1.265e-02	0.00	0.00	7.4
Level4	GO:0016667	oxidoreductase activity\, acting on sulfur group of donors	1026	4	1022	20	25234	25254	1.315e-02	0.00	0.00	4.9
Level5	GO:0015026	coreceptor activity	1026	4	1022	20	25234	25254	1.315e-02	0.00	0.00	4.9
Level4	GO:0030332	cyclin binding	1026	2	1024	3	25251	25254	1.408e-02	0.00	0.00	16.4
Level5	GO:0015037	peptide disulfide oxidoreductase activity	1026	2	1024	3	25251	25254	1.408e-02	0.00	0.00	16.4
Level5	GO:0034190	apolipoprotein receptor binding	1026	2	1024	3	25251	25254	1.408e-02	0.00	0.00	16.4
Level5	GO:0048156	tau protein binding	1026	2	1024	3	25251	25254	1.408e-02	0.00	0.00	16.4
Level5	GO:0051400	BH domain binding	1026	2	1024	3	25251	25254	1.408e-02	0.00	0.00	16.4
Level5	GO:0016724	oxidoreductase activity\, oxidizing metal ions\, oxygen as acceptor	1026	2	1024	3	25251	25254	1.408e-02	0.00	0.00	16.4
Level5	GO:0004738	pyruvate dehydrogenase activity	1026	2	1024	3	25251	25254	1.408e-02	0.00	0.00	16.4
Level5	GO:0031432	titin binding	1026	2	1024	3	25251	25254	1.408e-02	0.00	0.00	16.4
Level5	GO:0008410	CoA\-transferase activity	1026	2	1024	3	25251	25254	1.408e-02	0.00	0.00	16.4
Level5	GO:0019855	calcium channel inhibitor activity	1026	2	1024	3	25251	25254	1.408e-02	0.00	0.00	16.4
Level5	GO:0031210	phosphatidylcholine binding	1026	2	1024	3	25251	25254	1.408e-02	0.00	0.00	16.4
Level3	GO:0042165	neurotransmitter binding	1026	20	1006	272	24982	25254	1.421e-02	0.02	0.01	1.8
Level5	GO:0017022	myosin binding	1026	4	1022	21	25233	25254	1.519e-02	0.00	0.00	4.7
Level4	GO:0016879	ligase activity\, forming carbon\-nitrogen bonds	1026	19	1007	250	25004	25254	1.588e-02	0.02	0.01	1.9
Level3	GO:0042277	peptide binding	1026	32	994	499	24755	25254	1.666e-02	0.03	0.02	1.6
Level5	GO:0015450	P\-P\-bond\-hydrolysis\-driven protein transmembrane transporter activity	1026	4	1022	22	25232	25254	1.741e-02	0.00	0.00	4.5
Level5	GO:0022884	macromolecule transmembrane transporter activity	1026	4	1022	22	25232	25254	1.741e-02	0.00	0.00	4.5
Level5	GO:0016646	oxidoreductase activity\, acting on the CH\-NH group of donors\, NAD or NADP as acceptor	1026	4	1022	23	25231	25254	1.982e-02	0.00	0.00	4.3
Level4	GO:0048154	S100 beta binding	1026	2	1024	4	25250	25254	2.057e-02	0.00	0.00	12.3
Level4	GO:0034185	apolipoprotein binding	1026	2	1024	4	25250	25254	2.057e-02	0.00	0.00	12.3
Level4	GO:0016822	hydrolase activity\, acting on acid carbon\-carbon bonds	1026	2	1024	4	25250	25254	2.057e-02	0.00	0.00	12.3
Level5	GO:0005062	hematopoietin/interferon\-class (D200\-domain) cytokine receptor signal transducer activity	1026	2	1024	4	25250	25254	2.057e-02	0.00	0.00	12.3
Level5	GO:0008294	calcium\- and calmodulin\-responsive adenylate cyclase activity	1026	2	1024	4	25250	25254	2.057e-02	0.00	0.00	12.3
Level5	GO:0051117	ATPase binding	1026	2	1024	4	25250	25254	2.057e-02	0.00	0.00	12.3
Level5	GO:0042975	peroxisome proliferator activated receptor binding	1026	2	1024	4	25250	25254	2.057e-02	0.00	0.00	12.3
Level5	GO:0016823	hydrolase activity\, acting on acid carbon\-carbon bonds\, in ketonic substances	1026	2	1024	4	25250	25254	2.057e-02	0.00	0.00	12.3
Level5	GO:0005160	transforming growth factor beta receptor binding	1026	3	1023	13	25241	25254	2.271e-02	0.00	0.00	5.7
Level5	GO:0004518	nuclease activity	1026	14	1012	178	25076	25254	2.295e-02	0.01	0.01	1.9
Level4	GO:0016765	transferase activity\, transferring alkyl or aryl (other than methyl) groups	1026	7	1019	66	25188	25254	2.367e-02	0.01	0.00	2.6
Level5	GO:0019902	phosphatase binding	1026	4	1022	25	25229	25254	2.523e-02	0.00	0.00	3.9
Level5	GO:0016799	hydrolase activity\, hydrolyzing N\-glycosyl compounds	1026	4	1022	25	25229	25254	2.523e-02	0.00	0.00	3.9
Level5	GO:0005066	transmembrane receptor protein tyrosine kinase signaling protein activity	1026	3	1023	14	25240	25254	2.680e-02	0.00	0.00	5.3
Level3	GO:0030235	nitric\-oxide synthase regulator activity	1026	2	1024	5	25249	25254	2.806e-02	0.00	0.00	9.8
Level4	GO:0015643	toxin binding	1026	2	1024	5	25249	25254	2.806e-02	0.00	0.00	9.8
Level4	GO:0001530	lipopolysaccharide binding	1026	2	1024	5	25249	25254	2.806e-02	0.00	0.00	9.8
Level4	GO:0005497	androgen binding	1026	2	1024	5	25249	25254	2.806e-02	0.00	0.00	9.8
Level5	GO:0016802	trialkylsulfonium hydrolase activity	1026	2	1024	5	25249	25254	2.806e-02	0.00	0.00	9.8
Level3	GO:0008144	drug binding	1026	4	1022	26	25228	25254	2.824e-02	0.00	0.00	3.8
Level5	GO:0032934	sterol binding	1026	4	1022	26	25228	25254	2.824e-02	0.00	0.00	3.8
Level3	GO:0050824	water binding	1026	15	1011	196	25058	25254	2.911e-02	0.01	0.01	1.9
Level4	GO:0050825	ice binding	1026	15	1011	196	25058	25254	2.911e-02	0.01	0.01	1.9
Level5	GO:0000062	acyl\-CoA binding	1026	3	1023	15	25239	25254	3.124e-02	0.00	0.00	4.9
Level5	GO:0003684	damaged DNA binding	1026	6	1020	55	25199	25254	3.136e-02	0.01	0.00	2.7
Level5	GO:0017124	SH3 domain binding	1026	4	1022	27	25227	25254	3.145e-02	0.00	0.00	3.6
Level3	GO:0009975	cyclase activity	1026	4	1022	28	25226	25254	3.487e-02	0.00	0.00	3.5
Level4	GO:0016849	phosphorus\-oxygen lyase activity	1026	4	1022	28	25226	25254	3.487e-02	0.00	0.00	3.5
Level5	GO:0016620	oxidoreductase activity\, acting on the aldehyde or oxo group of donors\, NAD or NADP as acceptor	1026	4	1022	28	25226	25254	3.487e-02	0.00	0.00	3.5
Level5	GO:0016868	intramolecular transferase activity\, phosphotransferases	1026	3	1023	16	25238	25254	3.605e-02	0.00	0.00	4.6
Level4	GO:0005522	profilin binding	1026	2	1024	6	25248	25254	3.646e-02	0.00	0.00	8.2
Level4	GO:0001846	opsonin binding	1026	2	1024	6	25248	25254	3.646e-02	0.00	0.00	8.2
Level4	GO:0009374	biotin binding	1026	2	1024	6	25248	25254	3.646e-02	0.00	0.00	8.2
Level5	GO:0035035	histone acetyltransferase binding	1026	2	1024	6	25248	25254	3.646e-02	0.00	0.00	8.2
Level5	GO:0016783	sulfurtransferase activity	1026	2	1024	6	25248	25254	3.646e-02	0.00	0.00	8.2
Level4	GO:0016798	hydrolase activity\, acting on glycosyl bonds	1026	12	1014	152	25102	25254	3.860e-02	0.01	0.01	1.9
Level4	GO:0016846	carbon\-sulfur lyase activity	1026	3	1023	17	25237	25254	4.122e-02	0.00	0.00	4.3
Level4	GO:0032182	small conjugating protein binding	1026	3	1023	17	25237	25254	4.122e-02	0.00	0.00	4.3
Level5	GO:0016863	intramolecular oxidoreductase activity\, transposing C=C bonds	1026	3	1023	17	25237	25254	4.122e-02	0.00	0.00	4.3
Level4	GO:0030594	neurotransmitter receptor activity	1026	18	1008	268	24986	25254	4.447e-02	0.02	0.01	1.7
Level2	GO:0008369	obsolete molecular function	1026	10	1016	126	25128	25254	4.513e-02	0.01	0.00	2.0
Level4	GO:0005529	sugar binding	1026	16	1010	231	25023	25254	4.560e-02	0.02	0.01	1.7
Level3	GO:0042301	phosphate binding	1026	2	1024	7	25247	25254	4.568e-02	0.00	0.00	7.0
Level4	GO:0016725	oxidoreductase activity\, acting on CH or CH2 groups	1026	2	1024	7	25247	25254	4.568e-02	0.00	0.00	7.0
Level5	GO:0016668	oxidoreductase activity\, acting on sulfur group of donors\, NAD or NADP as acceptor	1026	2	1024	7	25247	25254	4.568e-02	0.00	0.00	7.0
Level5	GO:0016713	oxidoreductase activity\, acting on paired donors\, with incorporation or reduction of molecular oxygen\, reduced iron\-sulfur protein as one donor\, and incorporation of one atom of oxygen	1026	2	1024	7	25247	25254	4.568e-02	0.00	0.00	7.0
Level5	GO:0005071	transmembrane receptor protein serine/threonine kinase signaling protein activity	1026	2	1024	7	25247	25254	4.568e-02	0.00	0.00	7.0
Level5	GO:0005123	death receptor binding	1026	2	1024	7	25247	25254	4.568e-02	0.00	0.00	7.0
Level5	GO:0016671	oxidoreductase activity\, acting on sulfur group of donors\, disulfide as acceptor	1026	2	1024	7	25247	25254	4.568e-02	0.00	0.00	7.0
Level5	GO:0003755	peptidyl\-prolyl cis\-trans isomerase activity	1026	5	1021	46	25208	25254	4.811e-02	0.00	0.00	2.7
Level4	GO:0003704	specific RNA polymerase II transcription factor activity	1026	5	1021	47	25207	25254	5.159e-02	0.00	0.00	2.6
Level3	GO:0060090	molecular adaptor activity	1026	6	1020	63	25191	25254	5.234e-02	0.01	0.00	2.3
Level5	GO:0051059	NF\-kappaB binding	1026	4	1022	33	25221	25254	5.506e-02	0.00	0.00	3.0
Level4	GO:0016859	cis\-trans isomerase activity	1026	5	1021	48	25206	25254	5.521e-02	0.00	0.00	2.6
Level3	GO:0008641	small protein activating enzyme activity	1026	2	1024	8	25246	25254	5.565e-02	0.00	0.00	6.2
Level5	GO:0016653	oxidoreductase activity\, acting on NADH or NADPH\, heme protein as acceptor	1026	2	1024	8	25246	25254	5.565e-02	0.00	0.00	6.2
Level3	GO:0000146	microfilament motor activity	1026	3	1023	20	25234	25254	5.879e-02	0.00	0.00	3.7
Level4	GO:0051087	chaperone binding	1026	3	1023	20	25234	25254	5.879e-02	0.00	0.00	3.7
Level4	GO:0046332	SMAD binding	1026	3	1023	20	25234	25254	5.879e-02	0.00	0.00	3.7
Level5	GO:0003916	DNA topoisomerase activity	1026	4	1022	35	25219	25254	6.457e-02	0.00	0.00	2.8
Level4	GO:0016722	oxidoreductase activity\, oxidizing metal ions	1026	2	1024	9	25245	25254	6.630e-02	0.00	0.00	5.5
Level5	GO:0016421	CoA carboxylase activity	1026	2	1024	9	25245	25254	6.630e-02	0.00	0.00	5.5
Level5	GO:0016615	malate dehydrogenase activity	1026	2	1024	9	25245	25254	6.630e-02	0.00	0.00	5.5
Level5	GO:0032404	mismatch repair complex binding	1026	2	1024	9	25245	25254	6.630e-02	0.00	0.00	5.5
Level5	GO:0016864	intramolecular oxidoreductase activity\, transposing S\-S bonds	1026	2	1024	9	25245	25254	6.630e-02	0.00	0.00	5.5
Level5	GO:0016405	CoA\-ligase activity	1026	2	1024	9	25245	25254	6.630e-02	0.00	0.00	5.5
Level5	GO:0050811	GABA receptor binding	1026	2	1024	9	25245	25254	6.630e-02	0.00	0.00	5.5
Level4	GO:0016701	oxidoreductase activity\, acting on single donors with incorporation of molecular oxygen	1026	6	1020	68	25186	25254	6.894e-02	0.01	0.00	2.2
Level5	GO:0042287	MHC protein binding	1026	3	1023	22	25232	25254	7.214e-02	0.00	0.00	3.4
Level4	GO:0022803	passive transmembrane transporter activity	1026	33	993	589	24665	25254	7.417e-02	0.03	0.02	1.4
Level5	GO:0015267	channel activity	1026	33	993	589	24665	25254	7.417e-02	0.03	0.02	1.4
Level3	GO:0003676	nucleic acid binding	1026	176	850	3812	21442	25254	7.572e-02	0.17	0.15	1.1
Level3	GO:0004362	glutathione\-disulfide reductase activity	1026	1	1025	1	25253	25254	7.656e-02	0.00	0.00	24.6
Level3	GO:0033237	11\-beta\-hydroxysteroid dehydrogenase (NADP\+) activity	1026	1	1025	1	25253	25254	7.656e-02	0.00	0.00	24.6
Level3	GO:0046904	calcium oxalate binding	1026	1	1025	1	25253	25254	7.656e-02	0.00	0.00	24.6
Level4	GO:0016176	superoxide\-generating NADPH oxidase activator activity	1026	1	1025	1	25253	25254	7.656e-02	0.00	0.00	24.6
Level4	GO:0047066	phospholipid\-hydroperoxide glutathione peroxidase activity	1026	1	1025	1	25253	25254	7.656e-02	0.00	0.00	24.6
Level4	GO:0019103	pyrimidine nucleotide binding	1026	1	1025	1	25253	25254	7.656e-02	0.00	0.00	24.6
Level4	GO:0030984	kininogen binding	1026	1	1025	1	25253	25254	7.656e-02	0.00	0.00	24.6
Level4	GO:0030613	oxidoreductase activity\, acting on phosphorus or arsenic in donors	1026	1	1025	1	25253	25254	7.656e-02	0.00	0.00	24.6
Level5	GO:0016727	oxidoreductase activity\, acting on CH or CH2 groups\, oxygen as acceptor	1026	1	1025	1	25253	25254	7.656e-02	0.00	0.00	24.6
Level5	GO:0046911	metal chelating activity	1026	1	1025	1	25253	25254	7.656e-02	0.00	0.00	24.6
Level5	GO:0004796	thromboxane\-A synthase activity	1026	1	1025	1	25253	25254	7.656e-02	0.00	0.00	24.6
Level5	GO:0033130	acetylcholine receptor binding	1026	1	1025	1	25253	25254	7.656e-02	0.00	0.00	24.6
Level5	GO:0004148	dihydrolipoyl dehydrogenase activity	1026	1	1025	1	25253	25254	7.656e-02	0.00	0.00	24.6
Level5	GO:0004736	pyruvate carboxylase activity	1026	1	1025	1	25253	25254	7.656e-02	0.00	0.00	24.6
Level5	GO:0032183	SUMO binding	1026	1	1025	1	25253	25254	7.656e-02	0.00	0.00	24.6
Level5	GO:0009054	electron acceptor activity	1026	1	1025	1	25253	25254	7.656e-02	0.00	0.00	24.6
Level5	GO:0030567	prothrombin activator activity	1026	1	1025	1	25253	25254	7.656e-02	0.00	0.00	24.6
Level5	GO:0003958	NADPH\-hemoprotein reductase activity	1026	1	1025	1	25253	25254	7.656e-02	0.00	0.00	24.6
Level5	GO:0043398	HLH domain binding	1026	1	1025	1	25253	25254	7.656e-02	0.00	0.00	24.6
Level5	GO:0050113	inositol oxygenase activity	1026	1	1025	1	25253	25254	7.656e-02	0.00	0.00	24.6
Level5	GO:0047865	dimethylglycine dehydrogenase activity	1026	1	1025	1	25253	25254	7.656e-02	0.00	0.00	24.6
Level5	GO:0008480	sarcosine dehydrogenase activity	1026	1	1025	1	25253	25254	7.656e-02	0.00	0.00	24.6
Level5	GO:0032145	succinate\-semialdehyde dehydrogenase binding	1026	1	1025	1	25253	25254	7.656e-02	0.00	0.00	24.6
Level5	GO:0008794	arsenate reductase (glutaredoxin) activity	1026	1	1025	1	25253	25254	7.656e-02	0.00	0.00	24.6
Level5	GO:0030614	oxidoreductase activity\, acting on phosphorus or arsenic in donors\, with disulfide as acceptor	1026	1	1025	1	25253	25254	7.656e-02	0.00	0.00	24.6
Level5	GO:0004418	hydroxymethylbilane synthase activity	1026	1	1025	1	25253	25254	7.656e-02	0.00	0.00	24.6
Level5	GO:0042610	CD8 receptor binding	1026	1	1025	1	25253	25254	7.656e-02	0.00	0.00	24.6
Level5	GO:0015266	protein channel activity	1026	1	1025	1	25253	25254	7.656e-02	0.00	0.00	24.6
Level4	GO:0016840	carbon\-nitrogen lyase activity	1026	2	1024	10	25244	25254	7.756e-02	0.00	0.00	4.9
Level4	GO:0008093	cytoskeletal adaptor activity	1026	2	1024	10	25244	25254	7.756e-02	0.00	0.00	4.9
Level5	GO:0016774	phosphotransferase activity\, carboxyl group as acceptor	1026	2	1024	10	25244	25254	7.756e-02	0.00	0.00	4.9
Level5	GO:0015198	oligopeptide transporter activity	1026	2	1024	10	25244	25254	7.756e-02	0.00	0.00	4.9
Level5	GO:0016881	acid\-amino acid ligase activity	1026	14	1012	208	25046	25254	7.819e-02	0.01	0.01	1.7
Level3	GO:0015238	drug transporter activity	1026	4	1022	38	25216	25254	8.033e-02	0.00	0.00	2.6
Level5	GO:0016814	hydrolase activity\, acting on carbon\-nitrogen (but not peptide) bonds\, in cyclic amidines	1026	4	1022	39	25215	25254	8.596e-02	0.00	0.00	2.5
Level3	GO:0031406	carboxylic acid binding	1026	2	1024	11	25243	25254	8.936e-02	0.00	0.00	4.5
Level5	GO:0016634	oxidoreductase activity\, acting on the CH\-CH group of donors\, oxygen as acceptor	1026	2	1024	11	25243	25254	8.936e-02	0.00	0.00	4.5
Level4	GO:0016782	transferase activity\, transferring sulfur\-containing groups	1026	5	1021	58	25196	25254	9.921e-02	0.00	0.00	2.1
Level3	GO:0048503	GPI anchor binding	1026	9	1017	118	25136	25254	9.996e-02	0.01	0.00	1.9
Level4	GO:0004383	guanylate cyclase activity	1026	2	1024	12	25242	25254	1.016e-01	0.00	0.00	4.1
Level4	GO:0016248	channel inhibitor activity	1026	2	1024	12	25242	25254	1.016e-01	0.00	0.00	4.1
Level5	GO:0030553	cGMP binding	1026	2	1024	12	25242	25254	1.016e-01	0.00	0.00	4.1
Level5	GO:0050998	nitric\-oxide synthase binding	1026	2	1024	12	25242	25254	1.016e-01	0.00	0.00	4.1
Level5	GO:0016861	intramolecular oxidoreductase activity\, interconverting aldoses and ketoses	1026	2	1024	12	25242	25254	1.016e-01	0.00	0.00	4.1
Level5	GO:0008200	ion channel inhibitor activity	1026	2	1024	12	25242	25254	1.016e-01	0.00	0.00	4.1
Level4	GO:0016877	ligase activity\, forming carbon\-sulfur bonds	1026	3	1023	27	25227	25254	1.107e-01	0.00	0.00	2.7
Level5	GO:0019905	syntaxin binding	1026	3	1023	27	25227	25254	1.107e-01	0.00	0.00	2.7
Level3	GO:0002054	nucleobase binding	1026	1	1025	2	25252	25254	1.126e-01	0.00	0.00	12.3
Level3	GO:0030337	DNA polymerase processivity factor activity	1026	1	1025	2	25252	25254	1.126e-01	0.00	0.00	12.3
Level3	GO:0017163	negative regulator of basal transcription activity	1026	1	1025	2	25252	25254	1.126e-01	0.00	0.00	12.3
Level3	GO:0015460	transport accessory protein activity	1026	1	1025	2	25252	25254	1.126e-01	0.00	0.00	12.3
Level3	GO:0000150	recombinase activity	1026	1	1025	2	25252	25254	1.126e-01	0.00	0.00	12.3
Level4	GO:0004096	catalase activity	1026	1	1025	2	25252	25254	1.126e-01	0.00	0.00	12.3
Level4	GO:0019826	oxygen sensor activity	1026	1	1025	2	25252	25254	1.126e-01	0.00	0.00	12.3
Level4	GO:0008539	proteasome inhibitor activity	1026	1	1025	2	25252	25254	1.126e-01	0.00	0.00	12.3
Level4	GO:0048155	S100 alpha binding	1026	1	1025	2	25252	25254	1.126e-01	0.00	0.00	12.3
Level4	GO:0002060	purine binding	1026	1	1025	2	25252	25254	1.126e-01	0.00	0.00	12.3
Level4	GO:0001918	farnesylated protein binding	1026	1	1025	2	25252	25254	1.126e-01	0.00	0.00	12.3
Level4	GO:0043499	eukaryotic cell surface binding	1026	1	1025	2	25252	25254	1.126e-01	0.00	0.00	12.3
Level4	GO:0017129	triglyceride binding	1026	1	1025	2	25252	25254	1.126e-01	0.00	0.00	12.3
Level4	GO:0043008	ATP\-dependent protein binding	1026	1	1025	2	25252	25254	1.126e-01	0.00	0.00	12.3
Level4	GO:0004839	ubiquitin activating enzyme activity	1026	1	1025	2	25252	25254	1.126e-01	0.00	0.00	12.3
Level4	GO:0030611	arsenate reductase activity	1026	1	1025	2	25252	25254	1.126e-01	0.00	0.00	12.3
Level4	GO:0004447	iodide peroxidase activity	1026	1	1025	2	25252	25254	1.126e-01	0.00	0.00	12.3
Level4	GO:0045294	alpha\-catenin binding	1026	1	1025	2	25252	25254	1.126e-01	0.00	0.00	12.3
Level5	GO:0016726	oxidoreductase activity\, acting on CH or CH2 groups\, NAD or NADP as acceptor	1026	1	1025	2	25252	25254	1.126e-01	0.00	0.00	12.3
Level5	GO:0051425	PTB domain binding	1026	1	1025	2	25252	25254	1.126e-01	0.00	0.00	12.3
Level5	GO:0034189	very\-low\-density lipoprotein binding	1026	1	1025	2	25252	25254	1.126e-01	0.00	0.00	12.3
Level5	GO:0016642	oxidoreductase activity\, acting on the CH\-NH2 group of donors\, disulfide as acceptor	1026	1	1025	2	25252	25254	1.126e-01	0.00	0.00	12.3
Level5	GO:0032841	calcitonin binding	1026	1	1025	2	25252	25254	1.126e-01	0.00	0.00	12.3
Level5	GO:0016716	oxidoreductase activity\, acting on paired donors\, with incorporation or reduction of molecular oxygen\, another compound as one donor\, and incorporation of one atom of oxygen	1026	1	1025	2	25252	25254	1.126e-01	0.00	0.00	12.3
Level5	GO:0048407	platelet\-derived growth factor binding	1026	1	1025	2	25252	25254	1.126e-01	0.00	0.00	12.3
Level5	GO:0051538	3 iron\, 4 sulfur cluster binding	1026	1	1025	2	25252	25254	1.126e-01	0.00	0.00	12.3
Level5	GO:0005061	aryl hydrocarbon receptor nuclear translocator activity	1026	1	1025	2	25252	25254	1.126e-01	0.00	0.00	12.3
Level5	GO:0050682	AF\-2 domain binding	1026	1	1025	2	25252	25254	1.126e-01	0.00	0.00	12.3
Level5	GO:0048187	inhibin beta\-B binding	1026	1	1025	2	25252	25254	1.126e-01	0.00	0.00	12.3
Level5	GO:0016652	oxidoreductase activity\, acting on NADH or NADPH\, NAD or NADP as acceptor	1026	1	1025	2	25252	25254	1.126e-01	0.00	0.00	12.3
Level5	GO:0008116	prostaglandin\-I synthase activity	1026	1	1025	2	25252	25254	1.126e-01	0.00	0.00	12.3
Level5	GO:0016899	oxidoreductase activity\, acting on the CH\-OH group of donors\, oxygen as acceptor	1026	1	1025	2	25252	25254	1.126e-01	0.00	0.00	12.3
Level5	GO:0001872	zymosan binding	1026	1	1025	2	25252	25254	1.126e-01	0.00	0.00	12.3
Level5	GO:0001849	complement component C1q binding	1026	1	1025	2	25252	25254	1.126e-01	0.00	0.00	12.3
Level5	GO:0008393	fatty acid (omega\-1)\-hydroxylase activity	1026	1	1025	2	25252	25254	1.126e-01	0.00	0.00	12.3
Level5	GO:0008160	protein tyrosine phosphatase activator activity	1026	1	1025	2	25252	25254	1.126e-01	0.00	0.00	12.3
Level5	GO:0042609	CD4 receptor binding	1026	1	1025	2	25252	25254	1.126e-01	0.00	0.00	12.3
Level5	GO:0015234	thiamin transmembrane transporter activity	1026	1	1025	2	25252	25254	1.126e-01	0.00	0.00	12.3
Level4	GO:0030742	GTP\-dependent protein binding	1026	2	1024	13	25241	25254	1.144e-01	0.00	0.00	3.8
Level4	GO:0004016	adenylate cyclase activity	1026	2	1024	13	25241	25254	1.144e-01	0.00	0.00	3.8
Level4	GO:0048306	calcium\-dependent protein binding	1026	2	1024	13	25241	25254	1.144e-01	0.00	0.00	3.8
Level4	GO:0015197	peptide transporter activity	1026	2	1024	13	25241	25254	1.144e-01	0.00	0.00	3.8
Level4	GO:0042166	acetylcholine binding	1026	4	1022	45	25209	25254	1.236e-01	0.00	0.00	2.2
Level5	GO:0050750	low\-density lipoprotein receptor binding	1026	2	1024	14	25240	25254	1.274e-01	0.00	0.00	3.5
Level5	GO:0015291	secondary active transmembrane transporter activity	1026	20	1006	340	24914	25254	1.290e-01	0.02	0.01	1.4
Level4	GO:0000149	SNARE binding	1026	3	1023	30	25224	25254	1.368e-01	0.00	0.00	2.5
Level4	GO:0050839	cell adhesion molecule binding	1026	2	1024	15	25239	25254	1.409e-01	0.00	0.00	3.3
Level2	GO:0045735	nutrient reservoir activity	1026	6	1020	77	25177	25254	1.421e-01	0.01	0.00	1.9
Level5	GO:0008188	neuropeptide receptor activity	1026	10	1016	150	25104	25254	1.453e-01	0.01	0.01	1.6
Level4	GO:0042923	neuropeptide binding	1026	10	1016	151	25103	25254	1.469e-01	0.01	0.01	1.6
Level4	GO:0030023	extracellular matrix constituent conferring elasticity	1026	1	1025	3	25251	25254	1.473e-01	0.00	0.00	8.2
Level4	GO:0042030	ATPase inhibitor activity	1026	1	1025	3	25251	25254	1.473e-01	0.00	0.00	8.2
Level4	GO:0008368	Gram\-negative bacterial binding	1026	1	1025	3	25251	25254	1.473e-01	0.00	0.00	8.2
Level4	GO:0019211	phosphatase activator activity	1026	1	1025	3	25251	25254	1.473e-01	0.00	0.00	8.2
Level5	GO:0004462	lactoylglutathione lyase activity	1026	1	1025	3	25251	25254	1.473e-01	0.00	0.00	8.2
Level5	GO:0016649	oxidoreductase activity\, acting on the CH\-NH group of donors\, quinone or similar compound as acceptor	1026	1	1025	3	25251	25254	1.473e-01	0.00	0.00	8.2
Level5	GO:0004329	formate\-tetrahydrofolate ligase activity	1026	1	1025	3	25251	25254	1.473e-01	0.00	0.00	8.2
Level5	GO:0004075	biotin carboxylase activity	1026	1	1025	3	25251	25254	1.473e-01	0.00	0.00	8.2
Level5	GO:0034187	apolipoprotein E binding	1026	1	1025	3	25251	25254	1.473e-01	0.00	0.00	8.2
Level5	GO:0004802	transketolase activity	1026	1	1025	3	25251	25254	1.473e-01	0.00	0.00	8.2
Level5	GO:0043425	bHLH transcription factor binding	1026	1	1025	3	25251	25254	1.473e-01	0.00	0.00	8.2
Level5	GO:0016838	carbon\-oxygen lyase activity\, acting on phosphates	1026	1	1025	3	25251	25254	1.473e-01	0.00	0.00	8.2
Level5	GO:0004055	argininosuccinate synthase activity	1026	1	1025	3	25251	25254	1.473e-01	0.00	0.00	8.2
Level5	GO:0050220	prostaglandin\-E synthase activity	1026	1	1025	3	25251	25254	1.473e-01	0.00	0.00	8.2
Level5	GO:0048186	inhibin beta\-A binding	1026	1	1025	3	25251	25254	1.473e-01	0.00	0.00	8.2
Level5	GO:0030156	benzodiazepine receptor binding	1026	1	1025	3	25251	25254	1.473e-01	0.00	0.00	8.2
Level5	GO:0031014	troponin T binding	1026	1	1025	3	25251	25254	1.473e-01	0.00	0.00	8.2
Level5	GO:0019215	intermediate filament binding	1026	1	1025	3	25251	25254	1.473e-01	0.00	0.00	8.2
Level5	GO:0030226	apolipoprotein receptor activity	1026	1	1025	3	25251	25254	1.473e-01	0.00	0.00	8.2
Level5	GO:0004478	methionine adenosyltransferase activity	1026	1	1025	3	25251	25254	1.473e-01	0.00	0.00	8.2
Level5	GO:0005121	Toll binding	1026	1	1025	3	25251	25254	1.473e-01	0.00	0.00	8.2
Level5	GO:0000268	peroxisome targeting sequence binding	1026	1	1025	3	25251	25254	1.473e-01	0.00	0.00	8.2
Level5	GO:0005113	patched binding	1026	1	1025	3	25251	25254	1.473e-01	0.00	0.00	8.2
Level5	GO:0005076	receptor signaling protein serine/threonine kinase signaling protein activity	1026	1	1025	3	25251	25254	1.473e-01	0.00	0.00	8.2
Level5	GO:0016639	oxidoreductase activity\, acting on the CH\-NH2 group of donors\, NAD or NADP as acceptor	1026	1	1025	3	25251	25254	1.473e-01	0.00	0.00	8.2
Level5	GO:0030911	TPR domain binding	1026	1	1025	3	25251	25254	1.473e-01	0.00	0.00	8.2
Level5	GO:0004019	adenylosuccinate synthase activity	1026	1	1025	3	25251	25254	1.473e-01	0.00	0.00	8.2
Level5	GO:0016655	oxidoreductase activity\, acting on NADH or NADPH\, quinone or similar compound as acceptor	1026	4	1022	49	25205	25254	1.519e-01	0.00	0.00	2.0
Level3	GO:0019840	isoprenoid binding	1026	2	1024	16	25238	25254	1.546e-01	0.00	0.00	3.1
Level4	GO:0005501	retinoid binding	1026	2	1024	16	25238	25254	1.546e-01	0.00	0.00	3.1
Level5	GO:0016455	RNA polymerase II transcription mediator activity	1026	2	1024	16	25238	25254	1.546e-01	0.00	0.00	3.1
Level5	GO:0043130	ubiquitin binding	1026	2	1024	16	25238	25254	1.546e-01	0.00	0.00	3.1
Level5	GO:0016878	acid\-thiol ligase activity	1026	2	1024	16	25238	25254	1.546e-01	0.00	0.00	3.1
Level5	GO:0005548	phospholipid transporter activity	1026	3	1023	32	25222	25254	1.553e-01	0.00	0.00	2.3
Level5	GO:0016758	transferase activity\, transferring hexosyl groups	1026	13	1013	212	25042	25254	1.622e-01	0.01	0.01	1.5
Level4	GO:0031177	phosphopantetheine binding	1026	2	1024	17	25237	25254	1.685e-01	0.00	0.00	2.9
Level5	GO:0005275	amine transmembrane transporter activity	1026	6	1020	86	25168	25254	1.760e-01	0.01	0.00	1.7
Level3	GO:0046848	hydroxyapatite binding	1026	1	1025	4	25250	25254	1.806e-01	0.00	0.00	6.2
Level3	GO:0043498	cell surface binding	1026	1	1025	4	25250	25254	1.806e-01	0.00	0.00	6.2
Level4	GO:0004800	thyroxine 5'\-deiodinase activity	1026	1	1025	4	25250	25254	1.806e-01	0.00	0.00	6.2
Level4	GO:0016744	transferase activity\, transferring aldehyde or ketonic groups	1026	1	1025	4	25250	25254	1.806e-01	0.00	0.00	6.2
Level4	GO:0002039	p53 binding	1026	1	1025	4	25250	25254	1.806e-01	0.00	0.00	6.2
Level5	GO:0016595	glutamate binding	1026	1	1025	4	25250	25254	1.806e-01	0.00	0.00	6.2
Level5	GO:0016842	amidine\-lyase activity	1026	1	1025	4	25250	25254	1.806e-01	0.00	0.00	6.2
Level5	GO:0016654	oxidoreductase activity\, acting on NADH or NADPH\, disulfide as acceptor	1026	1	1025	4	25250	25254	1.806e-01	0.00	0.00	6.2
Level5	GO:0042608	T cell receptor binding	1026	1	1025	4	25250	25254	1.806e-01	0.00	0.00	6.2
Level5	GO:0030172	troponin C binding	1026	1	1025	4	25250	25254	1.806e-01	0.00	0.00	6.2
Level5	GO:0008035	high\-density lipoprotein binding	1026	1	1025	4	25250	25254	1.806e-01	0.00	0.00	6.2
Level5	GO:0016728	oxidoreductase activity\, acting on CH or CH2 groups\, disulfide as acceptor	1026	1	1025	4	25250	25254	1.806e-01	0.00	0.00	6.2
Level4	GO:0016757	transferase activity\, transferring glycosyl groups	1026	17	1009	304	24950	25254	1.907e-01	0.02	0.01	1.4
Level5	GO:0008194	UDP\-glycosyltransferase activity	1026	9	1017	139	25115	25254	1.941e-01	0.01	0.01	1.6
Level3	GO:0003735	structural constituent of ribosome	1026	6	1020	259	24995	25254	2.012e-01	0.01	0.01	0.6
Level4	GO:0051213	dioxygenase activity	1026	5	1021	67	25187	25254	2.066e-01	0.00	0.00	1.8
Level4	GO:0035240	dopamine binding	1026	5	1021	67	25187	25254	2.066e-01	0.00	0.00	1.8
Level5	GO:0016702	oxidoreductase activity\, acting on single donors with incorporation of molecular oxygen\, incorporation of two atoms of oxygen	1026	5	1021	67	25187	25254	2.066e-01	0.00	0.00	1.8
Level5	GO:0048029	monosaccharide binding	1026	2	1024	20	25234	25254	2.114e-01	0.00	0.00	2.5
Level5	GO:0004176	ATP\-dependent peptidase activity	1026	2	1024	20	25234	25254	2.114e-01	0.00	0.00	2.5
Level5	GO:0004859	phospholipase inhibitor activity	1026	2	1024	20	25234	25254	2.114e-01	0.00	0.00	2.5
Level4	GO:0048038	quinone binding	1026	1	1025	5	25249	25254	2.126e-01	0.00	0.00	4.9
Level4	GO:0046977	TAP binding	1026	1	1025	5	25249	25254	2.126e-01	0.00	0.00	4.9
Level4	GO:0048184	follistatin binding	1026	1	1025	5	25249	25254	2.126e-01	0.00	0.00	4.9
Level5	GO:0046978	TAP1 binding	1026	1	1025	5	25249	25254	2.126e-01	0.00	0.00	4.9
Level5	GO:0046979	TAP2 binding	1026	1	1025	5	25249	25254	2.126e-01	0.00	0.00	4.9
Level5	GO:0030976	thiamin pyrophosphate binding	1026	1	1025	5	25249	25254	2.126e-01	0.00	0.00	4.9
Level5	GO:0017134	fibroblast growth factor binding	1026	1	1025	5	25249	25254	2.126e-01	0.00	0.00	4.9
Level5	GO:0042924	neuromedin U binding	1026	1	1025	5	25249	25254	2.126e-01	0.00	0.00	4.9
Level5	GO:0016743	carboxyl\- or carbamoyltransferase activity	1026	1	1025	5	25249	25254	2.126e-01	0.00	0.00	4.9
Level5	GO:0016841	ammonia\-lyase activity	1026	1	1025	5	25249	25254	2.126e-01	0.00	0.00	4.9
Level5	GO:0030971	receptor tyrosine kinase binding	1026	1	1025	5	25249	25254	2.126e-01	0.00	0.00	4.9
Level5	GO:0019001	guanyl nucleotide binding	1026	23	1003	435	24819	25254	2.216e-01	0.02	0.02	1.3
Level4	GO:0005085	guanyl\-nucleotide exchange factor activity	1026	3	1023	159	25095	25254	2.219e-01	0.00	0.01	0.5
Level4	GO:0005048	signal sequence binding	1026	2	1024	21	25233	25254	2.259e-01	0.00	0.00	2.3
Level4	GO:0055102	lipase inhibitor activity	1026	2	1024	21	25233	25254	2.259e-01	0.00	0.00	2.3
Level5	GO:0030159	receptor signaling complex scaffold activity	1026	2	1024	22	25232	25254	2.405e-01	0.00	0.00	2.2
Level4	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor protein activity	1026	1	1025	6	25248	25254	2.433e-01	0.00	0.00	4.1
Level4	GO:0043027	caspase inhibitor activity	1026	1	1025	6	25248	25254	2.433e-01	0.00	0.00	4.1
Level4	GO:0016018	cyclosporin A binding	1026	1	1025	6	25248	25254	2.433e-01	0.00	0.00	4.1
Level4	GO:0016944	RNA polymerase II transcription elongation factor activity	1026	1	1025	6	25248	25254	2.433e-01	0.00	0.00	4.1
Level4	GO:0008517	folic acid transporter activity	1026	1	1025	6	25248	25254	2.433e-01	0.00	0.00	4.1
Level4	GO:0005521	lamin binding	1026	1	1025	6	25248	25254	2.433e-01	0.00	0.00	4.1
Level5	GO:0016019	peptidoglycan receptor activity	1026	1	1025	6	25248	25254	2.433e-01	0.00	0.00	4.1
Level5	GO:0008494	translation activator activity	1026	1	1025	6	25248	25254	2.433e-01	0.00	0.00	4.1
Level5	GO:0016832	aldehyde\-lyase activity	1026	1	1025	6	25248	25254	2.433e-01	0.00	0.00	4.1
Level5	GO:0035197	siRNA binding	1026	1	1025	6	25248	25254	2.433e-01	0.00	0.00	4.1
Level5	GO:0008607	phosphorylase kinase regulator activity	1026	1	1025	6	25248	25254	2.433e-01	0.00	0.00	4.1
Level5	GO:0005088	Ras guanyl\-nucleotide exchange factor activity	1026	1	1025	89	25165	25254	2.687e-01	0.00	0.00	0.3
Level4	GO:0019209	kinase activator activity	1026	2	1024	24	25230	25254	2.698e-01	0.00	0.00	2.1
Level4	GO:0032947	protein complex scaffold	1026	2	1024	24	25230	25254	2.698e-01	0.00	0.00	2.1
Level5	GO:0003727	single\-stranded RNA binding	1026	2	1024	24	25230	25254	2.698e-01	0.00	0.00	2.1
Level2	GO:0042056	chemoattractant activity	1026	1	1025	7	25247	25254	2.729e-01	0.00	0.00	3.5
Level3	GO:0001882	nucleoside binding	1026	1	1025	7	25247	25254	2.729e-01	0.00	0.00	3.5
Level4	GO:0031405	lipoic acid binding	1026	1	1025	7	25247	25254	2.729e-01	0.00	0.00	3.5
Level4	GO:0030021	extracellular matrix structural constituent conferring compression resistance	1026	1	1025	7	25247	25254	2.729e-01	0.00	0.00	3.5
Level4	GO:0001848	complement binding	1026	1	1025	7	25247	25254	2.729e-01	0.00	0.00	3.5
Level5	GO:0004128	cytochrome\-b5 reductase activity	1026	1	1025	7	25247	25254	2.729e-01	0.00	0.00	3.5
Level5	GO:0004086	carbamoyl\-phosphate synthase activity	1026	1	1025	7	25247	25254	2.729e-01	0.00	0.00	3.5
Level5	GO:0016847	1\-aminocyclopropane\-1\-carboxylate synthase activity	1026	1	1025	7	25247	25254	2.729e-01	0.00	0.00	3.5
Level5	GO:0043121	neurotrophin binding	1026	1	1025	7	25247	25254	2.729e-01	0.00	0.00	3.5
Level5	GO:0001786	phosphatidylserine binding	1026	1	1025	7	25247	25254	2.729e-01	0.00	0.00	3.5
Level3	GO:0051184	cofactor transporter activity	1026	2	1024	25	25229	25254	2.845e-01	0.00	0.00	2.0
Level5	GO:0015932	nucleobase\, nucleoside\, nucleotide and nucleic acid transmembrane transporter activity	1026	2	1024	25	25229	25254	2.845e-01	0.00	0.00	2.0
Level5	GO:0003729	mRNA binding	1026	4	1022	54	25200	25254	2.893e-01	0.00	0.00	1.8
Level5	GO:0016779	nucleotidyltransferase activity	1026	8	1018	140	25114	25254	2.906e-01	0.01	0.01	1.4
Level4	GO:0030674	protein binding\, bridging	1026	6	1020	97	25157	25254	3.001e-01	0.01	0.00	1.5
Level3	GO:0008907	integrase activity	1026	1	1025	8	25246	25254	3.013e-01	0.00	0.00	3.1
Level5	GO:0008503	benzodiazepine receptor activity	1026	1	1025	8	25246	25254	3.013e-01	0.00	0.00	3.1
Level4	GO:0003723	RNA binding	1026	25	1001	770	24484	25254	3.057e-01	0.02	0.03	0.8
Level5	GO:0005342	organic acid transmembrane transporter activity	1026	9	1017	160	25094	25254	3.161e-01	0.01	0.01	1.4
Level4	GO:0051018	protein kinase A binding	1026	1	1025	9	25245	25254	3.285e-01	0.00	0.00	2.7
Level5	GO:0046912	transferase activity\, transferring acyl groups\, acyl groups converted into alkyl on transfer	1026	1	1025	9	25245	25254	3.285e-01	0.00	0.00	2.7
Level5	GO:0016538	cyclin\-dependent protein kinase regulator activity	1026	1	1025	9	25245	25254	3.285e-01	0.00	0.00	2.7
Level5	GO:0008139	nuclear localization sequence binding	1026	1	1025	9	25245	25254	3.285e-01	0.00	0.00	2.7
Level3	GO:0003823	antigen binding	1026	4	1022	63	25191	25254	3.347e-01	0.00	0.00	1.6
Level5	GO:0004952	dopamine receptor activity	1026	4	1022	66	25188	25254	3.532e-01	0.00	0.00	1.5
Level4	GO:0048185	activin binding	1026	1	1025	10	25244	25254	3.548e-01	0.00	0.00	2.5
Level5	GO:0048019	receptor antagonist activity	1026	1	1025	10	25244	25254	3.548e-01	0.00	0.00	2.5
Level5	GO:0003706	ligand\-regulated transcription factor activity	1026	1	1025	10	25244	25254	3.548e-01	0.00	0.00	2.5
Level5	GO:0008238	exopeptidase activity	1026	7	1019	122	25132	25254	3.560e-01	0.01	0.00	1.4
Level5	GO:0004553	hydrolase activity\, hydrolyzing O\-glycosyl compounds	1026	7	1019	122	25132	25254	3.560e-01	0.01	0.00	1.4
Level4	GO:0043168	anion binding	1026	1	1025	73	25181	25254	3.725e-01	0.00	0.00	0.3
Level5	GO:0031404	chloride ion binding	1026	1	1025	73	25181	25254	3.725e-01	0.00	0.00	0.3
Level3	GO:0051183	vitamin transporter activity	1026	1	1025	11	25243	25254	3.800e-01	0.00	0.00	2.2
Level4	GO:0042834	peptidoglycan binding	1026	1	1025	11	25243	25254	3.800e-01	0.00	0.00	2.2
Level4	GO:0004000	adenosine deaminase activity	1026	1	1025	11	25243	25254	3.800e-01	0.00	0.00	2.2
Level4	GO:0005095	GTPase inhibitor activity	1026	1	1025	11	25243	25254	3.800e-01	0.00	0.00	2.2
Level4	GO:0016679	oxidoreductase activity\, acting on diphenols and related substances as donors	1026	1	1025	11	25243	25254	3.800e-01	0.00	0.00	2.2
Level5	GO:0008329	pattern recognition receptor activity	1026	1	1025	11	25243	25254	3.800e-01	0.00	0.00	2.2
Level5	GO:0045296	cadherin binding	1026	1	1025	11	25243	25254	3.800e-01	0.00	0.00	2.2
Level5	GO:0005112	Notch binding	1026	1	1025	11	25243	25254	3.800e-01	0.00	0.00	2.2
Level5	GO:0019841	retinol binding	1026	1	1025	11	25243	25254	3.800e-01	0.00	0.00	2.2
Level5	GO:0016681	oxidoreductase activity\, acting on diphenols and related substances as donors\, cytochrome as acceptor	1026	1	1025	11	25243	25254	3.800e-01	0.00	0.00	2.2
Level3	GO:0030695	GTPase regulator activity	1026	13	1013	428	24826	25254	3.836e-01	0.01	0.02	0.7
Level4	GO:0001653	peptide receptor activity	1026	21	1005	431	24823	25254	3.905e-01	0.02	0.02	1.2
Level5	GO:0008528	peptide receptor activity\, G\-protein coupled	1026	21	1005	431	24823	25254	3.905e-01	0.02	0.02	1.2
Level5	GO:0005544	calcium\-dependent phospholipid binding	1026	2	1024	33	25221	25254	3.991e-01	0.00	0.00	1.5
Level5	GO:0035091	phosphoinositide binding	1026	5	1021	84	25170	25254	4.005e-01	0.00	0.00	1.5
Level4	GO:0015232	heme transporter activity	1026	1	1025	12	25242	25254	4.042e-01	0.00	0.00	2.1
Level4	GO:0008013	beta\-catenin binding	1026	1	1025	12	25242	25254	4.042e-01	0.00	0.00	2.1
Level5	GO:0015645	fatty\-acid ligase activity	1026	1	1025	12	25242	25254	4.042e-01	0.00	0.00	2.1
Level5	GO:0031625	ubiquitin protein ligase binding	1026	1	1025	12	25242	25254	4.042e-01	0.00	0.00	2.1
Level5	GO:0016918	retinal binding	1026	1	1025	12	25242	25254	4.042e-01	0.00	0.00	2.1
Level5	GO:0003725	double\-stranded RNA binding	1026	3	1023	43	25211	25254	4.269e-01	0.00	0.00	1.7
Level3	GO:0003709	RNA polymerase III transcription factor activity	1026	1	1025	13	25241	25254	4.275e-01	0.00	0.00	1.9
Level5	GO:0051020	GTPase binding	1026	5	1021	91	25163	25254	4.276e-01	0.00	0.00	1.4
Level5	GO:0016790	thiolester hydrolase activity	1026	5	1021	91	25163	25254	4.276e-01	0.00	0.00	1.4
Level5	GO:0015464	acetylcholine receptor activity	1026	3	1023	44	25210	25254	4.314e-01	0.00	0.00	1.7
Level5	GO:0003954	NADH dehydrogenase activity	1026	3	1023	44	25210	25254	4.314e-01	0.00	0.00	1.7
Level4	GO:0005083	small GTPase regulator activity	1026	8	1018	275	24979	25254	4.395e-01	0.01	0.01	0.7
Level5	GO:0042826	histone deacetylase binding	1026	1	1025	14	25240	25254	4.498e-01	0.00	0.00	1.8
Level4	GO:0005070	SH3/SH2 adaptor activity	1026	3	1023	49	25205	25254	4.574e-01	0.00	0.00	1.5
Level4	GO:0042605	peptide antigen binding	1026	1	1025	15	25239	25254	4.713e-01	0.00	0.00	1.6
Level5	GO:0008301	DNA bending activity	1026	1	1025	15	25239	25254	4.713e-01	0.00	0.00	1.6
Level5	GO:0016813	hydrolase activity\, acting on carbon\-nitrogen (but not peptide) bonds\, in linear amidines	1026	1	1025	15	25239	25254	4.713e-01	0.00	0.00	1.6
Level5	GO:0030295	protein kinase activator activity	1026	1	1025	16	25238	25254	4.920e-01	0.00	0.00	1.5
Level5	GO:0016763	transferase activity\, transferring pentosyl groups	1026	3	1023	56	25198	25254	5.017e-01	0.00	0.00	1.3
Level5	GO:0016780	phosphotransferase activity\, for other substituted phosphate groups	1026	1	1025	18	25236	25254	5.309e-01	0.00	0.00	1.4
Level3	GO:0005212	structural constituent of eye lens	1026	1	1025	19	25235	25254	5.492e-01	0.00	0.00	1.3
Level5	GO:0008484	sulfuric ester hydrolase activity	1026	1	1025	20	25234	25254	5.668e-01	0.00	0.00	1.2
Level4	GO:0016875	ligase activity\, forming carbon\-oxygen bonds	1026	4	1022	79	25175	25254	5.675e-01	0.00	0.00	1.2
Level5	GO:0016876	ligase activity\, forming aminoacyl\-tRNA and related compounds	1026	4	1022	79	25175	25254	5.675e-01	0.00	0.00	1.2
Level2	GO:0003774	motor activity	1026	9	1017	180	25074	25254	5.680e-01	0.01	0.01	1.2
Level3	GO:0003711	transcription elongation regulator activity	1026	1	1025	21	25233	25254	5.838e-01	0.00	0.00	1.2
Level5	GO:0000049	tRNA binding	1026	1	1025	22	25232	25254	6.000e-01	0.00	0.00	1.1
Level3	GO:0003777	microtubule motor activity	1026	5	1021	97	25157	25254	6.019e-01	0.00	0.00	1.3
Level5	GO:0005099	Ras GTPase activator activity	1026	5	1021	103	25151	25254	6.160e-01	0.00	0.00	1.2
Level5	GO:0031420	alkali metal ion binding	1026	12	1014	257	24997	25254	6.329e-01	0.01	0.01	1.1
Level4	GO:0008135	translation factor activity\, nucleic acid binding	1026	6	1020	131	25123	25254	6.594e-01	0.01	0.01	1.1
Level4	GO:0003724	RNA helicase activity	1026	2	1024	37	25217	25254	6.646e-01	0.00	0.00	1.3
Level4	GO:0016229	steroid dehydrogenase activity	1026	2	1024	37	25217	25254	6.646e-01	0.00	0.00	1.3
Level4	GO:0016251	general RNA polymerase II transcription factor activity	1026	2	1024	41	25213	25254	6.847e-01	0.00	0.00	1.2
Level4	GO:0003678	DNA helicase activity	1026	2	1024	48	25206	25254	7.226e-01	0.00	0.00	1.0
Level5	GO:0003743	translation initiation factor activity	1026	2	1024	77	25177	25254	7.715e-01	0.00	0.00	0.6
Level5	GO:0015631	tubulin binding	1026	4	1022	86	25168	25254	7.810e-01	0.00	0.00	1.1
Level4	GO:0051082	unfolded protein binding	1026	6	1020	141	25113	25254	8.301e-01	0.01	0.01	1.0
Level4	GO:0008565	protein transporter activity	1026	7	1019	161	25093	25254	8.401e-01	0.01	0.01	1.1
Level4	GO:0005096	GTPase activator activity	1026	9	1017	254	25000	25254	8.723e-01	0.01	0.01	0.9
Level2	GO:0045182	translation regulator activity	1026	6	1020	150	25104	25254	1.000e+00	0.01	0.01	1.0
Level3	GO:0004386	helicase activity	1026	6	1020	171	25083	25254	1.000e+00	0.01	0.01	0.9
Level3	GO:0019208	phosphatase regulator activity	1026	2	1024	62	25192	25254	1.000e+00	0.00	0.00	0.8
Level3	GO:0019239	deaminase activity	1026	1	1025	35	25219	25254	1.000e+00	0.00	0.00	0.7
Level3	GO:0031202	RNA splicing factor activity\, transesterification mechanism	1026	1	1025	27	25227	25254	1.000e+00	0.00	0.00	0.9
Level3	GO:0005326	neurotransmitter transporter activity	1026	1	1025	33	25221	25254	1.000e+00	0.00	0.00	0.7
Level4	GO:0008026	ATP\-dependent helicase activity	1026	4	1022	118	25136	25254	1.000e+00	0.00	0.00	0.8
Level4	GO:0031072	heat shock protein binding	1026	2	1024	65	25189	25254	1.000e+00	0.00	0.00	0.8
Level4	GO:0019888	protein phosphatase regulator activity	1026	2	1024	60	25194	25254	1.000e+00	0.00	0.00	0.8
Level4	GO:0042895	antibiotic transporter activity	1026	1	1025	29	25225	25254	1.000e+00	0.00	0.00	0.8
Level4	GO:0015307	drug\:hydrogen antiporter activity	1026	1	1025	28	25226	25254	1.000e+00	0.00	0.00	0.9
Level4	GO:0005328	neurotransmitter\:sodium symporter activity	1026	1	1025	29	25225	25254	1.000e+00	0.00	0.00	0.8
Level5	GO:0016776	phosphotransferase activity\, phosphate group as acceptor	1026	2	1024	51	25203	25254	1.000e+00	0.00	0.00	1.0
Level5	GO:0016755	transferase activity\, transferring amino\-acyl groups	1026	1	1025	25	25229	25254	1.000e+00	0.00	0.00	1.0
Level5	GO:0008493	tetracycline transporter activity	1026	1	1025	29	25225	25254	1.000e+00	0.00	0.00	0.8
Level5	GO:0004004	ATP\-dependent RNA helicase activity	1026	1	1025	24	25230	25254	1.000e+00	0.00	0.00	1.0
Level5	GO:0016706	oxidoreductase activity\, acting on paired donors\, with incorporation or reduction of molecular oxygen\, 2\-oxoglutarate as one donor\, and incorporation of one atom each of oxygen into both donors	1026	1	1025	28	25226	25254	1.000e+00	0.00	0.00	0.9
Level5	GO:0008060	ARF GTPase activator activity	1026	1	1025	32	25222	25254	1.000e+00	0.00	0.00	0.8
Level5	GO:0004003	ATP\-dependent DNA helicase activity	1026	1	1025	27	25227	25254	1.000e+00	0.00	0.00	0.9
Level5	GO:0003746	translation elongation factor activity	1026	1	1025	25	25229	25254	1.000e+00	0.00	0.00	1.0
Level5	GO:0008601	protein phosphatase type 2A regulator activity	1026	1	1025	25	25229	25254	1.000e+00	0.00	0.00	1.0
Level5	GO:0008146	sulfotransferase activity	1026	1	1025	49	25205	25254	1.000e+00	0.00	0.00	0.5